Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein - conserved

Species:

Leishmania infantum

UniProt:

A4I3C1_LEIIN

TriTrypDb:

LINF_280009800

Length:

929

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005634	nucleus	5	1
GO:0005819	spindle	5	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043228	non-membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1
GO:0043232	intracellular non-membrane-bounded organelle	4	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A4I3C1

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4I3C1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	606	610	PF00656	0.420
CLV_NRD_NRD_1	14	16	PF00675	0.744
CLV_NRD_NRD_1	158	160	PF00675	0.440
CLV_NRD_NRD_1	410	412	PF00675	0.503
CLV_NRD_NRD_1	447	449	PF00675	0.531
CLV_NRD_NRD_1	484	486	PF00675	0.627
CLV_NRD_NRD_1	655	657	PF00675	0.483
CLV_NRD_NRD_1	827	829	PF00675	0.521
CLV_NRD_NRD_1	879	881	PF00675	0.547
CLV_NRD_NRD_1	900	902	PF00675	0.603
CLV_PCSK_FUR_1	11	15	PF00082	0.700
CLV_PCSK_FUR_1	877	881	PF00082	0.607
CLV_PCSK_KEX2_1	13	15	PF00082	0.748
CLV_PCSK_KEX2_1	158	160	PF00082	0.443
CLV_PCSK_KEX2_1	328	330	PF00082	0.498
CLV_PCSK_KEX2_1	410	412	PF00082	0.526
CLV_PCSK_KEX2_1	447	449	PF00082	0.586
CLV_PCSK_KEX2_1	549	551	PF00082	0.485
CLV_PCSK_KEX2_1	655	657	PF00082	0.483
CLV_PCSK_KEX2_1	826	828	PF00082	0.521
CLV_PCSK_KEX2_1	879	881	PF00082	0.502
CLV_PCSK_KEX2_1	899	901	PF00082	0.307
CLV_PCSK_PC1ET2_1	328	330	PF00082	0.498
CLV_PCSK_PC1ET2_1	549	551	PF00082	0.511
CLV_PCSK_PC1ET2_1	899	901	PF00082	0.512
CLV_PCSK_PC7_1	823	829	PF00082	0.459
CLV_PCSK_SKI1_1	207	211	PF00082	0.509
CLV_PCSK_SKI1_1	237	241	PF00082	0.507
CLV_PCSK_SKI1_1	242	246	PF00082	0.511
CLV_PCSK_SKI1_1	307	311	PF00082	0.523
CLV_PCSK_SKI1_1	317	321	PF00082	0.482
CLV_PCSK_SKI1_1	329	333	PF00082	0.469
CLV_PCSK_SKI1_1	458	462	PF00082	0.504
CLV_PCSK_SKI1_1	481	485	PF00082	0.501
CLV_PCSK_SKI1_1	553	557	PF00082	0.571
CLV_PCSK_SKI1_1	592	596	PF00082	0.424
CLV_PCSK_SKI1_1	605	609	PF00082	0.559
CLV_PCSK_SKI1_1	655	659	PF00082	0.488
CLV_PCSK_SKI1_1	673	677	PF00082	0.314
CLV_PCSK_SKI1_1	847	851	PF00082	0.534
CLV_Separin_Metazoa	482	486	PF03568	0.355
DEG_APCC_DBOX_1	604	612	PF00400	0.607
DEG_SCF_FBW7_1	54	61	PF00400	0.566
DOC_CKS1_1	113	118	PF01111	0.459
DOC_CKS1_1	55	60	PF01111	0.637
DOC_CYCLIN_yCln2_LP_2	800	806	PF00134	0.537
DOC_MAPK_gen_1	105	113	PF00069	0.526
DOC_MAPK_gen_1	158	164	PF00069	0.463
DOC_MAPK_gen_1	407	417	PF00069	0.490
DOC_MAPK_gen_1	522	531	PF00069	0.423
DOC_MAPK_gen_1	549	556	PF00069	0.524
DOC_MAPK_gen_1	720	729	PF00069	0.459
DOC_MAPK_MEF2A_6	158	166	PF00069	0.453
DOC_MAPK_MEF2A_6	384	393	PF00069	0.447
DOC_MAPK_MEF2A_6	410	419	PF00069	0.486
DOC_PP1_RVXF_1	551	557	PF00149	0.530
DOC_USP7_MATH_1	382	386	PF00917	0.405
DOC_USP7_MATH_1	475	479	PF00917	0.575
DOC_USP7_MATH_1	487	491	PF00917	0.510
DOC_USP7_MATH_1	562	566	PF00917	0.512
DOC_USP7_MATH_1	603	607	PF00917	0.539
DOC_USP7_MATH_1	685	689	PF00917	0.493
DOC_USP7_MATH_1	757	761	PF00917	0.677
DOC_USP7_MATH_1	79	83	PF00917	0.539
DOC_WW_Pin1_4	112	117	PF00397	0.512
DOC_WW_Pin1_4	46	51	PF00397	0.722
DOC_WW_Pin1_4	54	59	PF00397	0.677
DOC_WW_Pin1_4	67	72	PF00397	0.748
LIG_14-3-3_CanoR_1	112	116	PF00244	0.598
LIG_14-3-3_CanoR_1	207	212	PF00244	0.564
LIG_14-3-3_CanoR_1	362	368	PF00244	0.495
LIG_14-3-3_CanoR_1	384	390	PF00244	0.393
LIG_14-3-3_CanoR_1	410	419	PF00244	0.426
LIG_14-3-3_CanoR_1	671	680	PF00244	0.526
LIG_APCC_ABBAyCdc20_2	172	178	PF00400	0.350
LIG_BIR_II_1	1	5	PF00653	0.694
LIG_BRCT_BRCA1_1	759	763	PF00533	0.567
LIG_CaM_IQ_9	907	922	PF13499	0.510
LIG_Clathr_ClatBox_1	416	420	PF01394	0.537
LIG_deltaCOP1_diTrp_1	573	582	PF00928	0.412
LIG_deltaCOP1_diTrp_1	713	717	PF00928	0.578
LIG_FHA_1	151	157	PF00498	0.530
LIG_FHA_1	227	233	PF00498	0.541
LIG_FHA_1	386	392	PF00498	0.645
LIG_FHA_1	546	552	PF00498	0.613
LIG_FHA_1	55	61	PF00498	0.639
LIG_FHA_1	786	792	PF00498	0.542
LIG_FHA_2	113	119	PF00498	0.575
LIG_FHA_2	238	244	PF00498	0.614
LIG_LIR_Gen_1	216	226	PF02991	0.491
LIG_LIR_Gen_1	250	261	PF02991	0.559
LIG_LIR_Gen_1	383	393	PF02991	0.498
LIG_LIR_Gen_1	430	438	PF02991	0.506
LIG_LIR_Gen_1	573	583	PF02991	0.573
LIG_LIR_Gen_1	713	719	PF02991	0.534
LIG_LIR_Nem_3	216	221	PF02991	0.493
LIG_LIR_Nem_3	250	256	PF02991	0.578
LIG_LIR_Nem_3	383	389	PF02991	0.487
LIG_LIR_Nem_3	430	436	PF02991	0.539
LIG_LIR_Nem_3	573	578	PF02991	0.586
LIG_LIR_Nem_3	621	625	PF02991	0.500
LIG_LIR_Nem_3	674	680	PF02991	0.364
LIG_LIR_Nem_3	713	718	PF02991	0.451
LIG_PCNA_yPIPBox_3	690	704	PF02747	0.420
LIG_RPA_C_Fungi	674	686	PF08784	0.423
LIG_SH2_CRK	386	390	PF00017	0.534
LIG_SH2_NCK_1	708	712	PF00017	0.467
LIG_SH2_NCK_1	755	759	PF00017	0.615
LIG_SH2_SRC	225	228	PF00017	0.514
LIG_SH2_SRC	311	314	PF00017	0.402
LIG_SH2_SRC	708	711	PF00017	0.565
LIG_SH2_SRC	755	758	PF00017	0.614
LIG_SH2_STAP1	144	148	PF00017	0.478
LIG_SH2_STAP1	227	231	PF00017	0.464
LIG_SH2_STAP1	401	405	PF00017	0.621
LIG_SH2_STAP1	680	684	PF00017	0.583
LIG_SH2_STAP1	715	719	PF00017	0.548
LIG_SH2_STAT3	171	174	PF00017	0.524
LIG_SH2_STAT3	227	230	PF00017	0.515
LIG_SH2_STAT3	642	645	PF00017	0.555
LIG_SH2_STAT5	186	189	PF00017	0.508
LIG_SH2_STAT5	352	355	PF00017	0.489
LIG_SH2_STAT5	624	627	PF00017	0.414
LIG_SH3_1	13	19	PF00018	0.718
LIG_SH3_3	13	19	PF00018	0.718
LIG_SH3_3	49	55	PF00018	0.658
LIG_SUMO_SIM_anti_2	153	158	PF11976	0.558
LIG_SUMO_SIM_par_1	415	421	PF11976	0.479
LIG_SUMO_SIM_par_1	728	734	PF11976	0.514
LIG_SUMO_SIM_par_1	815	822	PF11976	0.500
LIG_TRAF2_1	284	287	PF00917	0.417
LIG_TRAF2_1	521	524	PF00917	0.538
LIG_TRAF2_1	588	591	PF00917	0.532
LIG_TRAF2_1	615	618	PF00917	0.461
LIG_TRAF2_1	743	746	PF00917	0.654
LIG_TRAF2_1	830	833	PF00917	0.457
MOD_CDK_SPxxK_3	112	119	PF00069	0.463
MOD_CK1_1	131	137	PF00069	0.559
MOD_CK1_1	25	31	PF00069	0.652
MOD_CK1_1	385	391	PF00069	0.349
MOD_CK1_1	688	694	PF00069	0.613
MOD_CK1_1	699	705	PF00069	0.542
MOD_CK2_1	112	118	PF00069	0.554
MOD_CK2_1	122	128	PF00069	0.433
MOD_CK2_1	143	149	PF00069	0.512
MOD_CK2_1	237	243	PF00069	0.610
MOD_CK2_1	277	283	PF00069	0.508
MOD_CK2_1	512	518	PF00069	0.495
MOD_CK2_1	740	746	PF00069	0.693
MOD_CK2_1	867	873	PF00069	0.576
MOD_CMANNOS	714	717	PF00535	0.511
MOD_Cter_Amidation	326	329	PF01082	0.539
MOD_Cter_Amidation	445	448	PF01082	0.496
MOD_Cter_Amidation	824	827	PF01082	0.430
MOD_GlcNHglycan	124	127	PF01048	0.381
MOD_GlcNHglycan	322	325	PF01048	0.560
MOD_GlcNHglycan	489	492	PF01048	0.424
MOD_GlcNHglycan	514	517	PF01048	0.414
MOD_GlcNHglycan	605	608	PF01048	0.508
MOD_GlcNHglycan	662	667	PF01048	0.346
MOD_GlcNHglycan	700	704	PF01048	0.517
MOD_GlcNHglycan	809	812	PF01048	0.491
MOD_GSK3_1	107	114	PF00069	0.531
MOD_GSK3_1	18	25	PF00069	0.763
MOD_GSK3_1	199	206	PF00069	0.492
MOD_GSK3_1	26	33	PF00069	0.777
MOD_GSK3_1	277	284	PF00069	0.477
MOD_GSK3_1	363	370	PF00069	0.458
MOD_GSK3_1	46	53	PF00069	0.640
MOD_GSK3_1	512	519	PF00069	0.605
MOD_GSK3_1	54	61	PF00069	0.620
MOD_GSK3_1	867	874	PF00069	0.588
MOD_GSK3_1	882	889	PF00069	0.607
MOD_LATS_1	235	241	PF00433	0.496
MOD_N-GLC_1	247	252	PF02516	0.621
MOD_NEK2_1	111	116	PF00069	0.421
MOD_NEK2_1	277	282	PF00069	0.482
MOD_NEK2_1	582	587	PF00069	0.523
MOD_NEK2_1	886	891	PF00069	0.540
MOD_NEK2_1	919	924	PF00069	0.485
MOD_OFUCOSY	579	586	PF10250	0.468
MOD_PIKK_1	226	232	PF00454	0.488
MOD_PIKK_1	248	254	PF00454	0.626
MOD_PIKK_1	530	536	PF00454	0.534
MOD_PIKK_1	650	656	PF00454	0.477
MOD_PIKK_1	888	894	PF00454	0.511
MOD_PKA_1	410	416	PF00069	0.521
MOD_PKA_2	111	117	PF00069	0.633
MOD_PKA_2	219	225	PF00069	0.496
MOD_PKA_2	26	32	PF00069	0.727
MOD_PKA_2	363	369	PF00069	0.494
MOD_PKA_2	410	416	PF00069	0.521
MOD_PKA_2	65	71	PF00069	0.698
MOD_PKA_2	871	877	PF00069	0.541
MOD_PKB_1	15	23	PF00069	0.722
MOD_PKB_1	528	536	PF00069	0.532
MOD_Plk_1	248	254	PF00069	0.626
MOD_Plk_1	382	388	PF00069	0.401
MOD_Plk_1	475	481	PF00069	0.604
MOD_Plk_2-3	128	134	PF00069	0.568
MOD_Plk_2-3	150	156	PF00069	0.595
MOD_Plk_4	143	149	PF00069	0.483
MOD_Plk_4	385	391	PF00069	0.482
MOD_Plk_4	468	474	PF00069	0.485
MOD_Plk_4	757	763	PF00069	0.568
MOD_ProDKin_1	112	118	PF00069	0.504
MOD_ProDKin_1	46	52	PF00069	0.721
MOD_ProDKin_1	54	60	PF00069	0.677
MOD_ProDKin_1	67	73	PF00069	0.746
MOD_SUMO_rev_2	617	625	PF00179	0.420
MOD_SUMO_rev_2	908	916	PF00179	0.505
TRG_DiLeu_BaEn_1	262	267	PF01217	0.518
TRG_DiLeu_BaEn_1	725	730	PF01217	0.554
TRG_DiLeu_BaEn_4	590	596	PF01217	0.393
TRG_DiLeu_BaEn_4	863	869	PF01217	0.506
TRG_DiLeu_BaLyEn_6	527	532	PF01217	0.532
TRG_DiLeu_LyEn_5	725	730	PF01217	0.514
TRG_ENDOCYTIC_2	386	389	PF00928	0.528
TRG_ENDOCYTIC_2	708	711	PF00928	0.520
TRG_ENDOCYTIC_2	715	718	PF00928	0.457
TRG_ER_diArg_1	11	14	PF00400	0.739
TRG_ER_diArg_1	137	140	PF00400	0.430
TRG_ER_diArg_1	15	18	PF00400	0.746
TRG_ER_diArg_1	157	159	PF00400	0.285
TRG_ER_diArg_1	290	293	PF00400	0.576
TRG_ER_diArg_1	339	342	PF00400	0.446
TRG_ER_diArg_1	356	359	PF00400	0.426
TRG_ER_diArg_1	447	449	PF00400	0.505
TRG_ER_diArg_1	528	531	PF00400	0.466
TRG_ER_diArg_1	741	744	PF00400	0.524
TRG_ER_diArg_1	826	828	PF00400	0.447
TRG_ER_diArg_1	879	881	PF00400	0.584
TRG_ER_diArg_1	900	902	PF00400	0.517
TRG_Pf-PMV_PEXEL_1	264	269	PF00026	0.602
TRG_Pf-PMV_PEXEL_1	530	534	PF00026	0.459
TRG_Pf-PMV_PEXEL_1	900	904	PF00026	0.504

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PB25	Leptomonas seymouri	56%	100%
A0A1X0NYM1	Trypanosomatidae	26%	100%
A0A3Q8ICZ1	Leishmania donovani	100%	100%
A0A3R7NTV6	Trypanosoma rangeli	28%	100%
A4HG80	Leishmania braziliensis	81%	100%
D0A834	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	26%	100%
E9AZK0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	90%	100%
Q4Q8N1	Leishmania major	92%	100%
V5BKX1	Trypanosoma cruzi	27%	100%