Katanin p60 ATPase-containing subunit A1

Quick info Annotations Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

katanin - putative

Species:

Leishmania infantum

UniProt:

A4I3C0_LEIIN

TriTrypDb:

LINF_280009900

Length:

602

Annotations

LeishMANIAdb annotations

A large and likely artifical grouping of protease domain carrying proteins related to proteasomal proteases. Only a tiny subgroup (the AFG3-related mitochondrail proteins) seem to have a TM segment.. Localization: Cytoplasmic (by homology) / Mitochondrial (by homology)

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 5

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	12
GO:0005874	microtubule	6	12
GO:0099080	supramolecular complex	2	12
GO:0099081	supramolecular polymer	3	12
GO:0099512	supramolecular fiber	4	12
GO:0099513	polymeric cytoskeletal fiber	5	12
GO:0110165	cellular anatomical entity	1	12
GO:0005856	cytoskeleton	5	1
GO:0015630	microtubule cytoskeleton	6	1
GO:0043226	organelle	2	1
GO:0043228	non-membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043232	intracellular non-membrane-bounded organelle	4	1
GO:0051286	cell tip	3	1
GO:0060187	cell pole	2	1

Expansion

Sequence features

A4I3C0

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4I3C0

Function

Biological processes
Term	Name	Level	Count
GO:0000226	microtubule cytoskeleton organization	3	12
GO:0006996	organelle organization	4	12
GO:0007010	cytoskeleton organization	5	12
GO:0007017	microtubule-based process	2	12
GO:0009987	cellular process	1	12
GO:0016043	cellular component organization	3	12
GO:0051013	microtubule severing	4	12
GO:0071840	cellular component organization or biogenesis	2	12

Molecular functions
Term	Name	Level	Count
GO:0000166	nucleotide binding	3	12
GO:0003824	catalytic activity	1	12
GO:0005488	binding	1	12
GO:0005515	protein binding	2	12
GO:0005524	ATP binding	5	12
GO:0008017	microtubule binding	5	12
GO:0008092	cytoskeletal protein binding	3	12
GO:0008568	microtubule severing ATPase activity	2	12
GO:0015631	tubulin binding	4	12
GO:0016462	pyrophosphatase activity	5	12
GO:0016787	hydrolase activity	2	12
GO:0016817	hydrolase activity, acting on acid anhydrides	3	12
GO:0016818	hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides	4	12
GO:0016853	isomerase activity	2	12
GO:0016887	ATP hydrolysis activity	7	12
GO:0017076	purine nucleotide binding	4	12
GO:0017111	ribonucleoside triphosphate phosphatase activity	6	12
GO:0030554	adenyl nucleotide binding	5	12
GO:0032553	ribonucleotide binding	3	12
GO:0032555	purine ribonucleotide binding	4	12
GO:0032559	adenyl ribonucleotide binding	5	12
GO:0035639	purine ribonucleoside triphosphate binding	4	12
GO:0036094	small molecule binding	2	12
GO:0043167	ion binding	2	12
GO:0043168	anion binding	3	12
GO:0097159	organic cyclic compound binding	2	12
GO:0097367	carbohydrate derivative binding	2	12
GO:0140096	catalytic activity, acting on a protein	2	12
GO:0140657	ATP-dependent activity	1	12
GO:0140776	protein-containing complex destabilizing activity	1	12
GO:1901265	nucleoside phosphate binding	3	12
GO:1901363	heterocyclic compound binding	2	12

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	417	421	PF00656	0.244
CLV_NRD_NRD_1	158	160	PF00675	0.609
CLV_NRD_NRD_1	20	22	PF00675	0.541
CLV_NRD_NRD_1	23	25	PF00675	0.527
CLV_NRD_NRD_1	348	350	PF00675	0.342
CLV_NRD_NRD_1	436	438	PF00675	0.218
CLV_NRD_NRD_1	475	477	PF00675	0.228
CLV_NRD_NRD_1	540	542	PF00675	0.228
CLV_PCSK_FUR_1	21	25	PF00082	0.461
CLV_PCSK_KEX2_1	157	159	PF00082	0.609
CLV_PCSK_KEX2_1	20	22	PF00082	0.458
CLV_PCSK_KEX2_1	23	25	PF00082	0.458
CLV_PCSK_KEX2_1	327	329	PF00082	0.449
CLV_PCSK_KEX2_1	348	350	PF00082	0.342
CLV_PCSK_KEX2_1	436	438	PF00082	0.218
CLV_PCSK_KEX2_1	474	476	PF00082	0.228
CLV_PCSK_KEX2_1	479	481	PF00082	0.228
CLV_PCSK_KEX2_1	540	542	PF00082	0.228
CLV_PCSK_PC1ET2_1	157	159	PF00082	0.557
CLV_PCSK_PC1ET2_1	327	329	PF00082	0.449
CLV_PCSK_PC1ET2_1	479	481	PF00082	0.228
CLV_PCSK_PC7_1	475	481	PF00082	0.228
CLV_PCSK_SKI1_1	327	331	PF00082	0.297
CLV_PCSK_SKI1_1	352	356	PF00082	0.228
CLV_PCSK_SKI1_1	364	368	PF00082	0.228
CLV_PCSK_SKI1_1	400	404	PF00082	0.228
CLV_PCSK_SKI1_1	436	440	PF00082	0.228
CLV_PCSK_SKI1_1	44	48	PF00082	0.347
CLV_PCSK_SKI1_1	500	504	PF00082	0.386
CLV_PCSK_SKI1_1	541	545	PF00082	0.324
CLV_PCSK_SKI1_1	64	68	PF00082	0.311
CLV_PCSK_SKI1_1	98	102	PF00082	0.424
DEG_APCC_DBOX_1	490	498	PF00400	0.295
DEG_APCC_KENBOX_2	551	555	PF00400	0.374
DEG_SPOP_SBC_1	244	248	PF00917	0.579
DEG_SPOP_SBC_1	4	8	PF00917	0.395
DOC_CYCLIN_RxL_1	397	404	PF00134	0.228
DOC_MAPK_gen_1	474	485	PF00069	0.244
DOC_MAPK_gen_1	500	510	PF00069	0.350
DOC_MAPK_gen_1	595	602	PF00069	0.441
DOC_MAPK_gen_1	62	69	PF00069	0.340
DOC_MAPK_MEF2A_6	476	485	PF00069	0.228
DOC_PP1_RVXF_1	398	404	PF00149	0.228
DOC_PP4_FxxP_1	15	18	PF00568	0.434
DOC_PP4_FxxP_1	150	153	PF00568	0.514
DOC_USP7_MATH_1	230	234	PF00917	0.590
DOC_USP7_MATH_1	244	248	PF00917	0.408
DOC_USP7_MATH_1	268	272	PF00917	0.636
DOC_USP7_MATH_1	370	374	PF00917	0.244
DOC_USP7_UBL2_3	496	500	PF12436	0.366
DOC_USP7_UBL2_3	544	548	PF12436	0.248
DOC_USP7_UBL2_3	83	87	PF12436	0.342
DOC_WW_Pin1_4	239	244	PF00397	0.525
DOC_WW_Pin1_4	34	39	PF00397	0.412
DOC_WW_Pin1_4	380	385	PF00397	0.228
DOC_WW_Pin1_4	56	61	PF00397	0.348
DOC_WW_Pin1_4	6	11	PF00397	0.400
LIG_14-3-3_CanoR_1	168	178	PF00244	0.697
LIG_14-3-3_CanoR_1	188	194	PF00244	0.714
LIG_14-3-3_CanoR_1	232	241	PF00244	0.618
LIG_14-3-3_CanoR_1	44	54	PF00244	0.340
LIG_APCC_ABBA_1	147	152	PF00400	0.461
LIG_BRCT_BRCA1_1	241	245	PF00533	0.535
LIG_BRCT_BRCA1_1	411	415	PF00533	0.228
LIG_CtBP_PxDLS_1	566	570	PF00389	0.249
LIG_deltaCOP1_diTrp_1	592	598	PF00928	0.228
LIG_FHA_1	113	119	PF00498	0.392
LIG_FHA_1	27	33	PF00498	0.465
LIG_FHA_1	411	417	PF00498	0.255
LIG_FHA_1	451	457	PF00498	0.329
LIG_FHA_1	497	503	PF00498	0.308
LIG_FHA_1	526	532	PF00498	0.244
LIG_FHA_2	141	147	PF00498	0.413
LIG_FHA_2	314	320	PF00498	0.478
LIG_FHA_2	548	554	PF00498	0.336
LIG_GBD_Chelix_1	300	308	PF00786	0.323
LIG_Integrin_RGD_1	392	394	PF01839	0.244
LIG_LIR_Apic_2	14	18	PF02991	0.431
LIG_LIR_Gen_1	124	133	PF02991	0.457
LIG_LIR_Gen_1	236	245	PF02991	0.519
LIG_LIR_Gen_1	316	323	PF02991	0.315
LIG_LIR_Gen_1	507	517	PF02991	0.245
LIG_LIR_Nem_3	124	129	PF02991	0.469
LIG_LIR_Nem_3	236	241	PF02991	0.528
LIG_LIR_Nem_3	316	320	PF02991	0.327
LIG_LIR_Nem_3	342	347	PF02991	0.350
LIG_LIR_Nem_3	377	382	PF02991	0.230
LIG_LIR_Nem_3	507	513	PF02991	0.230
LIG_LYPXL_S_1	335	339	PF13949	0.308
LIG_LYPXL_yS_3	336	339	PF13949	0.313
LIG_MYND_1	337	341	PF01753	0.323
LIG_NRBOX	512	518	PF00104	0.293
LIG_PDZ_Class_2	597	602	PF00595	0.504
LIG_Pex14_1	594	598	PF04695	0.228
LIG_Pex14_2	42	46	PF04695	0.353
LIG_SH2_CRK	104	108	PF00017	0.460
LIG_SH2_CRK	238	242	PF00017	0.655
LIG_SH2_CRK	344	348	PF00017	0.440
LIG_SH2_CRK	357	361	PF00017	0.228
LIG_SH2_NCK_1	238	242	PF00017	0.526
LIG_SH2_PTP2	482	485	PF00017	0.228
LIG_SH2_SRC	409	412	PF00017	0.244
LIG_SH2_STAT5	482	485	PF00017	0.228
LIG_SH2_STAT5	94	97	PF00017	0.399
LIG_SH3_3	218	224	PF00018	0.554
LIG_SH3_3	238	244	PF00018	0.603
LIG_SH3_3	249	255	PF00018	0.569
LIG_SH3_3	331	337	PF00018	0.295
LIG_SH3_3	50	56	PF00018	0.349
LIG_SH3_3	7	13	PF00018	0.401
LIG_TRAF2_1	295	298	PF00917	0.379
LIG_TYR_ITIM	334	339	PF00017	0.303
LIG_UBA3_1	494	500	PF00899	0.332
LIG_UBA3_1	536	544	PF00899	0.307
LIG_WW_3	59	63	PF00397	0.328
MOD_CDC14_SPxK_1	59	62	PF00782	0.338
MOD_CDK_SPxK_1	56	62	PF00069	0.351
MOD_CK1_1	169	175	PF00069	0.654
MOD_CK1_1	196	202	PF00069	0.576
MOD_CK1_1	233	239	PF00069	0.664
MOD_CK1_1	271	277	PF00069	0.694
MOD_CK1_1	286	292	PF00069	0.560
MOD_CK1_1	383	389	PF00069	0.269
MOD_CK1_1	76	82	PF00069	0.445
MOD_CK2_1	140	146	PF00069	0.477
MOD_CK2_1	168	174	PF00069	0.682
MOD_CK2_1	547	553	PF00069	0.384
MOD_GlcNHglycan	171	174	PF01048	0.694
MOD_GlcNHglycan	195	198	PF01048	0.676
MOD_GlcNHglycan	232	235	PF01048	0.677
MOD_GlcNHglycan	247	250	PF01048	0.553
MOD_GlcNHglycan	271	274	PF01048	0.669
MOD_GlcNHglycan	285	288	PF01048	0.599
MOD_GlcNHglycan	47	50	PF01048	0.482
MOD_GlcNHglycan	522	525	PF01048	0.322
MOD_GSK3_1	121	128	PF00069	0.498
MOD_GSK3_1	189	196	PF00069	0.619
MOD_GSK3_1	22	29	PF00069	0.495
MOD_GSK3_1	230	237	PF00069	0.600
MOD_GSK3_1	239	246	PF00069	0.513
MOD_GSK3_1	370	377	PF00069	0.293
MOD_GSK3_1	69	76	PF00069	0.472
MOD_N-GLC_1	166	171	PF02516	0.561
MOD_N-GLC_1	199	204	PF02516	0.500
MOD_N-GLC_1	375	380	PF02516	0.239
MOD_N-GLC_1	567	572	PF02516	0.249
MOD_NEK2_1	193	198	PF00069	0.639
MOD_NEK2_1	245	250	PF00069	0.463
MOD_NEK2_1	460	465	PF00069	0.228
MOD_NEK2_1	73	78	PF00069	0.488
MOD_NEK2_2	103	108	PF00069	0.399
MOD_NEK2_2	375	380	PF00069	0.228
MOD_NEK2_2	535	540	PF00069	0.228
MOD_PIKK_1	121	127	PF00454	0.475
MOD_PIKK_1	140	146	PF00454	0.406
MOD_PIKK_1	511	517	PF00454	0.356
MOD_PKA_2	140	146	PF00069	0.406
MOD_PKA_2	167	173	PF00069	0.678
MOD_PKA_2	22	28	PF00069	0.466
MOD_PKA_2	69	75	PF00069	0.340
MOD_PKB_1	24	32	PF00069	0.470
MOD_Plk_1	199	205	PF00069	0.498
MOD_Plk_1	375	381	PF00069	0.299
MOD_Plk_1	546	552	PF00069	0.293
MOD_Plk_2-3	547	553	PF00069	0.447
MOD_Plk_4	125	131	PF00069	0.471
MOD_Plk_4	362	368	PF00069	0.247
MOD_Plk_4	375	381	PF00069	0.149
MOD_Plk_4	410	416	PF00069	0.228
MOD_Plk_4	438	444	PF00069	0.244
MOD_ProDKin_1	239	245	PF00069	0.507
MOD_ProDKin_1	34	40	PF00069	0.407
MOD_ProDKin_1	380	386	PF00069	0.228
MOD_ProDKin_1	56	62	PF00069	0.351
MOD_ProDKin_1	6	12	PF00069	0.401
MOD_SUMO_rev_2	319	329	PF00179	0.322
TRG_DiLeu_BaEn_1	299	304	PF01217	0.340
TRG_DiLeu_BaEn_1	325	330	PF01217	0.334
TRG_DiLeu_BaEn_2	145	151	PF01217	0.529
TRG_DiLeu_BaLyEn_6	50	55	PF01217	0.347
TRG_DiLeu_LyEn_5	325	330	PF01217	0.445
TRG_ENDOCYTIC_2	104	107	PF00928	0.306
TRG_ENDOCYTIC_2	238	241	PF00928	0.529
TRG_ENDOCYTIC_2	336	339	PF00928	0.361
TRG_ENDOCYTIC_2	344	347	PF00928	0.399
TRG_ENDOCYTIC_2	482	485	PF00928	0.228
TRG_ER_diArg_1	20	23	PF00400	0.458
TRG_ER_diArg_1	279	282	PF00400	0.645
TRG_ER_diArg_1	347	349	PF00400	0.361
TRG_ER_diArg_1	473	476	PF00400	0.228
TRG_ER_diArg_1	539	541	PF00400	0.228
TRG_ER_diArg_1	67	70	PF00400	0.364
TRG_NLS_MonoCore_2	184	189	PF00514	0.669
TRG_NLS_MonoExtC_3	183	188	PF00514	0.602
TRG_NLS_MonoExtN_4	184	189	PF00514	0.607
TRG_Pf-PMV_PEXEL_1	116	120	PF00026	0.411
TRG_Pf-PMV_PEXEL_1	327	331	PF00026	0.297
TRG_Pf-PMV_PEXEL_1	400	404	PF00026	0.228

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HRH8	Leptomonas seymouri	70%	100%
A0A0S4IUM1	Bodo saltans	51%	100%
A0A1X0NYV7	Trypanosomatidae	57%	100%
A0A3Q8IJS0	Leishmania donovani	35%	100%
A0A3S7X163	Leishmania donovani	100%	100%
A0A3S7X2R4	Leishmania donovani	42%	100%
A0A422P1K0	Trypanosoma rangeli	57%	100%
A4HG81	Leishmania braziliensis	88%	98%
A4HPV3	Leishmania braziliensis	35%	100%
A4I4W4	Leishmania infantum	42%	100%
A4IE38	Leishmania infantum	35%	100%
B2RYN7	Rattus norvegicus	38%	100%
D0A833	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	58%	100%
E9AEB2	Leishmania major	42%	100%
E9ATM0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	35%	100%
E9AZK1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	93%	99%
O75449	Homo sapiens	41%	100%
Q0IIR9	Xenopus tropicalis	42%	100%
Q1HGK7	Gallus gallus	43%	100%
Q4Q0X8	Leishmania major	35%	100%
Q4Q8N0	Leishmania major	95%	100%
Q4R407	Macaca fascicularis	42%	100%
Q5U3S1	Danio rerio	42%	100%
Q9PUL2	Xenopus laevis	42%	100%
Q9SEX2	Arabidopsis thaliana	42%	100%
V5B0U7	Trypanosoma cruzi	56%	100%