HIT-type domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

HIT zinc finger/Zinc finger C-x8-C-x5-C-x3-H type (and similar) - putative

Species:

Leishmania infantum

UniProt:

A4I3B4_LEIIN

TriTrypDb:

LINF_280008900

Length:

633

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Cellular components
Term	Name	Level	Count
GO:0005634	nucleus	5	1
GO:0032991	protein-containing complex	1	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1
GO:0070761	pre-snoRNP complex	3	1
GO:0110165	cellular anatomical entity	1	1
GO:1990904	ribonucleoprotein complex	2	1

Expansion

Sequence features

A4I3B4

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4I3B4

Function

Biological processes
Term	Name	Level	Count
GO:0000463	maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)	10	1
GO:0000470	maturation of LSU-rRNA	9	1
GO:0000491	small nucleolar ribonucleoprotein complex assembly	7	1
GO:0000492	box C/D snoRNP assembly	8	1
GO:0006139	nucleobase-containing compound metabolic process	3	1
GO:0006364	rRNA processing	8	1
GO:0006396	RNA processing	6	1
GO:0006403	RNA localization	3	1
GO:0006725	cellular aromatic compound metabolic process	3	1
GO:0006807	nitrogen compound metabolic process	2	1
GO:0008152	metabolic process	1	1
GO:0009987	cellular process	1	1
GO:0016043	cellular component organization	3	1
GO:0016070	RNA metabolic process	5	1
GO:0016072	rRNA metabolic process	7	1
GO:0022607	cellular component assembly	4	1
GO:0022618	ribonucleoprotein complex assembly	6	1
GO:0033036	macromolecule localization	2	1
GO:0034470	ncRNA processing	7	1
GO:0034641	cellular nitrogen compound metabolic process	3	1
GO:0034660	ncRNA metabolic process	6	1
GO:0043170	macromolecule metabolic process	3	1
GO:0043933	protein-containing complex organization	4	1
GO:0044237	cellular metabolic process	2	1
GO:0044238	primary metabolic process	2	1
GO:0046483	heterocycle metabolic process	3	1
GO:0048254	snoRNA localization	4	1
GO:0051179	localization	1	1
GO:0065003	protein-containing complex assembly	5	1
GO:0071704	organic substance metabolic process	2	1
GO:0071826	ribonucleoprotein complex subunit organization	5	1
GO:0071840	cellular component organization or biogenesis	2	1
GO:0090304	nucleic acid metabolic process	4	1
GO:1901360	organic cyclic compound metabolic process	3	1

Molecular functions
Term	Name	Level	Count
GO:0005488	binding	1	10
GO:0043167	ion binding	2	10
GO:0043169	cation binding	3	10
GO:0046872	metal ion binding	4	10
GO:0003676	nucleic acid binding	3	1
GO:0003723	RNA binding	4	1
GO:0097159	organic cyclic compound binding	2	1
GO:1901363	heterocyclic compound binding	2	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	30	34	PF00656	0.687
CLV_C14_Caspase3-7	328	332	PF00656	0.722
CLV_NRD_NRD_1	122	124	PF00675	0.330
CLV_NRD_NRD_1	170	172	PF00675	0.402
CLV_NRD_NRD_1	205	207	PF00675	0.455
CLV_NRD_NRD_1	217	219	PF00675	0.471
CLV_NRD_NRD_1	228	230	PF00675	0.439
CLV_NRD_NRD_1	286	288	PF00675	0.566
CLV_NRD_NRD_1	378	380	PF00675	0.531
CLV_NRD_NRD_1	456	458	PF00675	0.555
CLV_NRD_NRD_1	507	509	PF00675	0.547
CLV_NRD_NRD_1	527	529	PF00675	0.265
CLV_NRD_NRD_1	580	582	PF00675	0.427
CLV_PCSK_KEX2_1	122	124	PF00082	0.330
CLV_PCSK_KEX2_1	170	172	PF00082	0.402
CLV_PCSK_KEX2_1	204	206	PF00082	0.406
CLV_PCSK_KEX2_1	219	221	PF00082	0.418
CLV_PCSK_KEX2_1	286	288	PF00082	0.580
CLV_PCSK_KEX2_1	378	380	PF00082	0.579
CLV_PCSK_KEX2_1	456	458	PF00082	0.432
CLV_PCSK_KEX2_1	509	511	PF00082	0.538
CLV_PCSK_KEX2_1	527	529	PF00082	0.510
CLV_PCSK_KEX2_1	582	584	PF00082	0.453
CLV_PCSK_PC1ET2_1	219	221	PF00082	0.502
CLV_PCSK_PC1ET2_1	509	511	PF00082	0.590
CLV_PCSK_PC1ET2_1	582	584	PF00082	0.453
CLV_PCSK_PC7_1	200	206	PF00082	0.481
CLV_PCSK_PC7_1	523	529	PF00082	0.454
CLV_PCSK_PC7_1	578	584	PF00082	0.550
CLV_PCSK_SKI1_1	301	305	PF00082	0.651
CLV_PCSK_SKI1_1	441	445	PF00082	0.429
CLV_PCSK_SKI1_1	456	460	PF00082	0.272
CLV_PCSK_SKI1_1	527	531	PF00082	0.402
CLV_PCSK_SKI1_1	554	558	PF00082	0.337
DEG_APCC_DBOX_1	261	269	PF00400	0.339
DEG_SCF_FBW7_1	316	321	PF00400	0.540
DEG_SCF_FBW7_2	89	96	PF00400	0.581
DOC_CKS1_1	406	411	PF01111	0.429
DOC_CYCLIN_yCln2_LP_2	192	198	PF00134	0.385
DOC_CYCLIN_yCln2_LP_2	383	389	PF00134	0.539
DOC_MAPK_gen_1	122	130	PF00069	0.467
DOC_MAPK_MEF2A_6	123	132	PF00069	0.515
DOC_MAPK_MEF2A_6	143	151	PF00069	0.288
DOC_MAPK_MEF2A_6	393	401	PF00069	0.508
DOC_PP1_RVXF_1	454	461	PF00149	0.332
DOC_PP2B_LxvP_1	192	195	PF13499	0.396
DOC_PP2B_LxvP_1	383	386	PF13499	0.552
DOC_PP2B_LxvP_1	399	402	PF13499	0.381
DOC_PP4_FxxP_1	625	628	PF00568	0.665
DOC_USP7_MATH_1	15	19	PF00917	0.736
DOC_USP7_MATH_1	181	185	PF00917	0.547
DOC_USP7_MATH_1	318	322	PF00917	0.541
DOC_USP7_MATH_1	374	378	PF00917	0.652
DOC_USP7_MATH_1	488	492	PF00917	0.480
DOC_USP7_UBL2_3	134	138	PF12436	0.420
DOC_WW_Pin1_4	314	319	PF00397	0.546
DOC_WW_Pin1_4	405	410	PF00397	0.495
DOC_WW_Pin1_4	543	548	PF00397	0.496
DOC_WW_Pin1_4	590	595	PF00397	0.488
DOC_WW_Pin1_4	87	92	PF00397	0.653
LIG_14-3-3_CanoR_1	122	128	PF00244	0.471
LIG_14-3-3_CanoR_1	182	186	PF00244	0.522
LIG_14-3-3_CanoR_1	477	481	PF00244	0.454
LIG_14-3-3_CanoR_1	490	494	PF00244	0.565
LIG_14-3-3_CanoR_1	508	515	PF00244	0.373
LIG_14-3-3_CanoR_1	567	571	PF00244	0.344
LIG_14-3-3_CanoR_1	73	81	PF00244	0.541
LIG_14-3-3_CterR_2	629	633	PF00244	0.628
LIG_APCC_ABBA_1	130	135	PF00400	0.554
LIG_BIR_III_4	14	18	PF00653	0.502
LIG_EVH1_1	399	403	PF00568	0.508
LIG_FHA_1	222	228	PF00498	0.431
LIG_FHA_1	229	235	PF00498	0.378
LIG_FHA_1	345	351	PF00498	0.656
LIG_FHA_1	84	90	PF00498	0.670
LIG_FHA_2	315	321	PF00498	0.808
LIG_FHA_2	326	332	PF00498	0.625
LIG_FHA_2	338	344	PF00498	0.597
LIG_FHA_2	406	412	PF00498	0.503
LIG_FHA_2	448	454	PF00498	0.333
LIG_FHA_2	480	486	PF00498	0.387
LIG_FHA_2	544	550	PF00498	0.491
LIG_LIR_Gen_1	162	167	PF02991	0.394
LIG_LIR_Gen_1	425	433	PF02991	0.447
LIG_LIR_Gen_1	446	455	PF02991	0.350
LIG_LIR_Gen_1	555	563	PF02991	0.423
LIG_LIR_Nem_3	162	166	PF02991	0.395
LIG_LIR_Nem_3	425	430	PF02991	0.450
LIG_LIR_Nem_3	446	451	PF02991	0.390
LIG_LIR_Nem_3	462	467	PF02991	0.308
LIG_LIR_Nem_3	555	559	PF02991	0.372
LIG_Pex14_1	185	189	PF04695	0.481
LIG_Pex14_1	236	240	PF04695	0.327
LIG_Pex14_2	417	421	PF04695	0.453
LIG_Pex14_2	460	464	PF04695	0.311
LIG_SH2_CRK	115	119	PF00017	0.447
LIG_SH2_CRK	189	193	PF00017	0.548
LIG_SH2_CRK	448	452	PF00017	0.410
LIG_SH2_NCK_1	115	119	PF00017	0.447
LIG_SH2_NCK_1	288	292	PF00017	0.488
LIG_SH2_PTP2	427	430	PF00017	0.428
LIG_SH2_STAP1	395	399	PF00017	0.496
LIG_SH2_STAT5	115	118	PF00017	0.447
LIG_SH2_STAT5	271	274	PF00017	0.347
LIG_SH2_STAT5	294	297	PF00017	0.676
LIG_SH2_STAT5	427	430	PF00017	0.417
LIG_SH2_STAT5	442	445	PF00017	0.296
LIG_SH2_STAT5	61	64	PF00017	0.617
LIG_SH3_3	144	150	PF00018	0.380
LIG_SH3_3	359	365	PF00018	0.609
LIG_SH3_3	394	400	PF00018	0.536
LIG_SH3_3	403	409	PF00018	0.492
LIG_SUMO_SIM_anti_2	340	347	PF11976	0.538
LIG_TRFH_1	443	447	PF08558	0.415
MOD_CDC14_SPxK_1	593	596	PF00782	0.499
MOD_CDK_SPK_2	405	410	PF00069	0.414
MOD_CDK_SPxK_1	590	596	PF00069	0.494
MOD_CK1_1	101	107	PF00069	0.594
MOD_CK1_1	152	158	PF00069	0.408
MOD_CK1_1	27	33	PF00069	0.741
MOD_CK1_1	492	498	PF00069	0.581
MOD_CK1_1	72	78	PF00069	0.585
MOD_CK1_1	87	93	PF00069	0.615
MOD_CK2_1	374	380	PF00069	0.571
MOD_CK2_1	405	411	PF00069	0.436
MOD_CK2_1	428	434	PF00069	0.384
MOD_CK2_1	447	453	PF00069	0.277
MOD_CK2_1	508	514	PF00069	0.475
MOD_CK2_1	543	549	PF00069	0.477
MOD_CK2_1	79	85	PF00069	0.650
MOD_Cter_Amidation	120	123	PF01082	0.311
MOD_GlcNHglycan	243	246	PF01048	0.484
MOD_GlcNHglycan	28	32	PF01048	0.651
MOD_GlcNHglycan	297	300	PF01048	0.650
MOD_GlcNHglycan	320	323	PF01048	0.690
MOD_GlcNHglycan	333	336	PF01048	0.686
MOD_GlcNHglycan	383	386	PF01048	0.514
MOD_GlcNHglycan	64	67	PF01048	0.595
MOD_GlcNHglycan	76	79	PF01048	0.529
MOD_GSK3_1	249	256	PF00069	0.467
MOD_GSK3_1	295	302	PF00069	0.688
MOD_GSK3_1	314	321	PF00069	0.616
MOD_GSK3_1	344	351	PF00069	0.701
MOD_GSK3_1	35	42	PF00069	0.721
MOD_GSK3_1	488	495	PF00069	0.631
MOD_GSK3_1	79	86	PF00069	0.680
MOD_N-GLC_1	222	227	PF02516	0.398
MOD_N-GLC_1	35	40	PF02516	0.654
MOD_N-GLC_1	590	595	PF02516	0.464
MOD_NEK2_1	137	142	PF00069	0.468
MOD_NEK2_1	84	89	PF00069	0.625
MOD_OFUCOSY	120	125	PF10250	0.247
MOD_PIKK_1	96	102	PF00454	0.653
MOD_PKA_1	508	514	PF00069	0.582
MOD_PKA_2	121	127	PF00069	0.530
MOD_PKA_2	15	21	PF00069	0.736
MOD_PKA_2	181	187	PF00069	0.499
MOD_PKA_2	228	234	PF00069	0.400
MOD_PKA_2	289	295	PF00069	0.534
MOD_PKA_2	476	482	PF00069	0.476
MOD_PKA_2	489	495	PF00069	0.357
MOD_PKA_2	519	525	PF00069	0.452
MOD_PKA_2	566	572	PF00069	0.313
MOD_PKA_2	62	68	PF00069	0.606
MOD_PKA_2	72	78	PF00069	0.466
MOD_Plk_1	222	228	PF00069	0.396
MOD_Plk_1	249	255	PF00069	0.468
MOD_Plk_1	348	354	PF00069	0.588
MOD_Plk_1	69	75	PF00069	0.560
MOD_Plk_1	84	90	PF00069	0.464
MOD_Plk_4	123	129	PF00069	0.564
MOD_Plk_4	230	236	PF00069	0.391
MOD_ProDKin_1	314	320	PF00069	0.545
MOD_ProDKin_1	405	411	PF00069	0.485
MOD_ProDKin_1	543	549	PF00069	0.498
MOD_ProDKin_1	590	596	PF00069	0.494
MOD_ProDKin_1	87	93	PF00069	0.658
MOD_SUMO_rev_2	135	140	PF00179	0.469
MOD_SUMO_rev_2	222	231	PF00179	0.534
MOD_SUMO_rev_2	483	488	PF00179	0.462
TRG_DiLeu_BaEn_2	462	468	PF01217	0.423
TRG_DiLeu_BaEn_4	516	522	PF01217	0.518
TRG_DiLeu_BaLyEn_6	275	280	PF01217	0.498
TRG_DiLeu_BaLyEn_6	607	612	PF01217	0.501
TRG_ENDOCYTIC_2	163	166	PF00928	0.512
TRG_ENDOCYTIC_2	189	192	PF00928	0.559
TRG_ENDOCYTIC_2	395	398	PF00928	0.578
TRG_ENDOCYTIC_2	427	430	PF00928	0.417
TRG_ENDOCYTIC_2	442	445	PF00928	0.296
TRG_ENDOCYTIC_2	448	451	PF00928	0.364
TRG_ER_diArg_1	170	172	PF00400	0.391
TRG_ER_diArg_1	204	206	PF00400	0.502
TRG_ER_diArg_1	217	220	PF00400	0.519
TRG_ER_diArg_1	262	265	PF00400	0.371
TRG_ER_diArg_1	286	288	PF00400	0.581
TRG_ER_diArg_1	455	457	PF00400	0.428
TRG_ER_diArg_1	507	510	PF00400	0.540
TRG_ER_diArg_1	527	529	PF00400	0.389
TRG_ER_diArg_1	595	598	PF00400	0.644
TRG_ER_diArg_1	628	631	PF00400	0.681
TRG_NES_CRM1_1	449	463	PF08389	0.389
TRG_NLS_MonoExtC_3	580	585	PF00514	0.446
TRG_NLS_MonoExtN_4	494	500	PF00514	0.411
TRG_NLS_MonoExtN_4	578	585	PF00514	0.559
TRG_Pf-PMV_PEXEL_1	157	162	PF00026	0.415
TRG_Pf-PMV_PEXEL_1	533	538	PF00026	0.414

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I0N9	Leptomonas seymouri	58%	100%
A0A3Q8IQB2	Leishmania donovani	100%	100%
A0A422N6T6	Trypanosoma rangeli	46%	100%
A4HG71	Leishmania braziliensis	78%	100%
D0A7T3	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	45%	100%
E9AZJ1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	89%	100%
Q4Q8P0	Leishmania major	91%	100%
V5BJ07	Trypanosoma cruzi	47%	100%