Uncharacterized protein

Quick info Annotations Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein - conserved

Species:

Leishmania infantum

UniProt:

A4I3B3_LEIIN

TriTrypDb:

LINF_280008800

Length:

252

Annotations

Annotations by Jardim et al.

Uncharacterized Protein, Uncharacterized

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4I3B3

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4I3B3

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	183	187	PF00656	0.493
CLV_C14_Caspase3-7	72	76	PF00656	0.618
CLV_NRD_NRD_1	164	166	PF00675	0.591
CLV_NRD_NRD_1	2	4	PF00675	0.615
CLV_NRD_NRD_1	212	214	PF00675	0.606
CLV_NRD_NRD_1	60	62	PF00675	0.418
CLV_PCSK_KEX2_1	138	140	PF00082	0.447
CLV_PCSK_KEX2_1	2	4	PF00082	0.615
CLV_PCSK_KEX2_1	60	62	PF00082	0.422
CLV_PCSK_PC1ET2_1	138	140	PF00082	0.447
CLV_PCSK_PC1ET2_1	2	4	PF00082	0.615
CLV_PCSK_SKI1_1	49	53	PF00082	0.592
CLV_PCSK_SKI1_1	61	65	PF00082	0.364
DEG_Kelch_actinfilin_1	168	172	PF01344	0.576
DEG_Nend_UBRbox_1	1	4	PF02207	0.617
DOC_CKS1_1	198	203	PF01111	0.447
DOC_MAPK_gen_1	165	172	PF00069	0.555
DOC_USP7_MATH_1	181	185	PF00917	0.614
DOC_USP7_MATH_1	28	32	PF00917	0.458
DOC_WW_Pin1_4	116	121	PF00397	0.532
DOC_WW_Pin1_4	144	149	PF00397	0.545
DOC_WW_Pin1_4	174	179	PF00397	0.608
DOC_WW_Pin1_4	185	190	PF00397	0.443
DOC_WW_Pin1_4	197	202	PF00397	0.368
LIG_APCC_ABBA_1	109	114	PF00400	0.465
LIG_BIR_III_2	117	121	PF00653	0.577
LIG_BIR_III_4	95	99	PF00653	0.618
LIG_CtBP_PxDLS_1	21	25	PF00389	0.419
LIG_eIF4E_1	198	204	PF01652	0.413
LIG_FHA_1	198	204	PF00498	0.413
LIG_FHA_1	32	38	PF00498	0.374
LIG_FHA_1	6	12	PF00498	0.580
LIG_FHA_2	111	117	PF00498	0.490
LIG_FHA_2	28	34	PF00498	0.494
LIG_FHA_2	70	76	PF00498	0.596
LIG_LIR_Nem_3	108	112	PF02991	0.455
LIG_LIR_Nem_3	188	194	PF02991	0.368
LIG_LIR_Nem_3	238	244	PF02991	0.540
LIG_LYPXL_S_1	190	194	PF13949	0.352
LIG_LYPXL_yS_3	191	194	PF13949	0.350
LIG_SH3_3	167	173	PF00018	0.592
LIG_SH3_3	175	181	PF00018	0.459
LIG_SH3_3	186	192	PF00018	0.460
LIG_SH3_3	8	14	PF00018	0.767
LIG_SUMO_SIM_par_1	230	236	PF11976	0.599
LIG_WRC_WIRS_1	106	111	PF05994	0.442
MOD_CDC14_SPxK_1	147	150	PF00782	0.588
MOD_CDK_SPxK_1	144	150	PF00069	0.553
MOD_CK1_1	31	37	PF00069	0.382
MOD_CK1_1	71	77	PF00069	0.730
MOD_CK2_1	116	122	PF00069	0.555
MOD_CK2_1	27	33	PF00069	0.613
MOD_CK2_1	63	69	PF00069	0.464
MOD_CK2_1	74	80	PF00069	0.605
MOD_GlcNHglycan	227	230	PF01048	0.667
MOD_GlcNHglycan	235	238	PF01048	0.543
MOD_GlcNHglycan	249	252	PF01048	0.452
MOD_GlcNHglycan	30	33	PF01048	0.478
MOD_GSK3_1	153	160	PF00069	0.556
MOD_GSK3_1	181	188	PF00069	0.623
MOD_GSK3_1	27	34	PF00069	0.453
MOD_GSK3_1	71	78	PF00069	0.684
MOD_PKA_2	152	158	PF00069	0.571
MOD_Plk_1	68	74	PF00069	0.679
MOD_Plk_1	79	85	PF00069	0.551
MOD_Plk_2-3	69	75	PF00069	0.588
MOD_Plk_4	102	108	PF00069	0.487
MOD_Plk_4	127	133	PF00069	0.461
MOD_Plk_4	244	250	PF00069	0.535
MOD_Plk_4	31	37	PF00069	0.382
MOD_ProDKin_1	116	122	PF00069	0.532
MOD_ProDKin_1	144	150	PF00069	0.553
MOD_ProDKin_1	174	180	PF00069	0.601
MOD_ProDKin_1	185	191	PF00069	0.434
MOD_ProDKin_1	197	203	PF00069	0.371
MOD_SUMO_rev_2	160	168	PF00179	0.593
TRG_DiLeu_BaEn_1	22	27	PF01217	0.397
TRG_DiLeu_BaLyEn_6	239	244	PF01217	0.557
TRG_ENDOCYTIC_2	191	194	PF00928	0.353
TRG_ER_diArg_1	59	61	PF00400	0.402
TRG_NLS_MonoExtC_3	212	218	PF00514	0.510
TRG_Pf-PMV_PEXEL_1	49	53	PF00026	0.490

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P7G9	Leptomonas seymouri	46%	96%
A0A3S7X157	Leishmania donovani	98%	100%
A4HG70	Leishmania braziliensis	78%	100%
E9AZJ0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	88%	100%
Q4Q8P1	Leishmania major	90%	100%