Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein - conserved

Species:

Leishmania infantum

UniProt:

A4I3A5_LEIIN

TriTrypDb:

LINF_280008100

Length:

426

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4I3A5

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4I3A5

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	88	92	PF00656	0.483
CLV_PCSK_KEX2_1	115	117	PF00082	0.485
CLV_PCSK_KEX2_1	70	72	PF00082	0.466
CLV_PCSK_PC1ET2_1	115	117	PF00082	0.485
CLV_PCSK_PC1ET2_1	70	72	PF00082	0.466
CLV_PCSK_SKI1_1	122	126	PF00082	0.461
CLV_PCSK_SKI1_1	281	285	PF00082	0.413
CLV_PCSK_SKI1_1	327	331	PF00082	0.378
CLV_PCSK_SKI1_1	372	376	PF00082	0.428
CLV_PCSK_SKI1_1	389	393	PF00082	0.323
CLV_PCSK_SKI1_1	39	43	PF00082	0.434
CLV_PCSK_SKI1_1	8	12	PF00082	0.469
DEG_SCF_FBW7_1	252	259	PF00400	0.651
DOC_CKS1_1	185	190	PF01111	0.494
DOC_MAPK_DCC_7	378	388	PF00069	0.394
DOC_MAPK_gen_1	276	285	PF00069	0.545
DOC_MAPK_gen_1	380	388	PF00069	0.552
DOC_MAPK_gen_1	412	420	PF00069	0.428
DOC_MAPK_gen_1	8	18	PF00069	0.459
DOC_MAPK_MEF2A_6	313	320	PF00069	0.507
DOC_MAPK_MEF2A_6	380	388	PF00069	0.397
DOC_MAPK_MEF2A_6	54	63	PF00069	0.438
DOC_PP1_RVXF_1	105	111	PF00149	0.433
DOC_USP7_MATH_1	264	268	PF00917	0.651
DOC_USP7_MATH_1	355	359	PF00917	0.430
DOC_USP7_UBL2_3	236	240	PF12436	0.685
DOC_USP7_UBL2_3	406	410	PF12436	0.545
DOC_USP7_UBL2_3	50	54	PF12436	0.469
DOC_USP7_UBL2_3	66	70	PF12436	0.462
DOC_WW_Pin1_4	184	189	PF00397	0.488
DOC_WW_Pin1_4	252	257	PF00397	0.761
DOC_WW_Pin1_4	297	302	PF00397	0.658
LIG_14-3-3_CanoR_1	231	239	PF00244	0.602
LIG_14-3-3_CanoR_1	269	273	PF00244	0.446
LIG_14-3-3_CanoR_1	281	286	PF00244	0.559
LIG_14-3-3_CanoR_1	350	354	PF00244	0.497
LIG_14-3-3_CanoR_1	82	87	PF00244	0.492
LIG_APCC_ABBA_1	22	27	PF00400	0.339
LIG_BIR_II_1	1	5	PF00653	0.550
LIG_BRCT_BRCA1_1	19	23	PF00533	0.403
LIG_BRCT_BRCA1_1	384	388	PF00533	0.474
LIG_BRCT_BRCA1_1	54	58	PF00533	0.517
LIG_FHA_1	101	107	PF00498	0.433
LIG_FHA_1	205	211	PF00498	0.472
LIG_FHA_1	219	225	PF00498	0.311
LIG_FHA_1	253	259	PF00498	0.759
LIG_FHA_1	366	372	PF00498	0.509
LIG_FHA_2	185	191	PF00498	0.545
LIG_FHA_2	240	246	PF00498	0.770
LIG_LIR_Apic_2	184	188	PF02991	0.484
LIG_LIR_Gen_1	109	117	PF02991	0.363
LIG_LIR_Gen_1	325	332	PF02991	0.432
LIG_LIR_Gen_1	334	343	PF02991	0.305
LIG_LIR_Gen_1	83	91	PF02991	0.457
LIG_LIR_Nem_3	109	113	PF02991	0.346
LIG_LIR_Nem_3	325	331	PF02991	0.436
LIG_LIR_Nem_3	334	340	PF02991	0.304
LIG_LIR_Nem_3	385	391	PF02991	0.432
LIG_LIR_Nem_3	55	61	PF02991	0.401
LIG_LIR_Nem_3	83	89	PF02991	0.448
LIG_SH2_CRK	185	189	PF00017	0.490
LIG_SH2_NCK_1	185	189	PF00017	0.564
LIG_SH2_STAP1	195	199	PF00017	0.502
LIG_SH2_STAP1	308	312	PF00017	0.445
LIG_SH2_STAT5	185	188	PF00017	0.487
LIG_SH2_STAT5	195	198	PF00017	0.418
LIG_SH2_STAT5	25	28	PF00017	0.421
LIG_SH3_3	221	227	PF00018	0.448
LIG_SH3_4	410	417	PF00018	0.458
LIG_SH3_4	50	57	PF00018	0.488
LIG_TRAF2_1	241	244	PF00917	0.561
MOD_CK1_1	120	126	PF00069	0.437
MOD_CK1_1	184	190	PF00069	0.575
MOD_CK1_1	259	265	PF00069	0.633
MOD_CK1_1	300	306	PF00069	0.656
MOD_CK1_1	37	43	PF00069	0.437
MOD_CK1_1	44	50	PF00069	0.429
MOD_CK1_1	74	80	PF00069	0.562
MOD_CK2_1	184	190	PF00069	0.500
MOD_CK2_1	384	390	PF00069	0.484
MOD_GlcNHglycan	119	122	PF01048	0.507
MOD_GlcNHglycan	261	264	PF01048	0.687
MOD_GlcNHglycan	266	269	PF01048	0.633
MOD_GlcNHglycan	304	307	PF01048	0.582
MOD_GlcNHglycan	324	327	PF01048	0.442
MOD_GlcNHglycan	357	360	PF01048	0.429
MOD_GlcNHglycan	36	39	PF01048	0.453
MOD_GlcNHglycan	46	49	PF01048	0.429
MOD_GlcNHglycan	54	57	PF01048	0.484
MOD_GSK3_1	248	255	PF00069	0.750
MOD_GSK3_1	264	271	PF00069	0.432
MOD_GSK3_1	281	288	PF00069	0.501
MOD_GSK3_1	316	323	PF00069	0.354
MOD_GSK3_1	327	334	PF00069	0.349
MOD_GSK3_1	33	40	PF00069	0.450
MOD_GSK3_1	390	397	PF00069	0.491
MOD_GSK3_1	80	87	PF00069	0.429
MOD_N-GLC_1	264	269	PF02516	0.685
MOD_N-GLC_1	281	286	PF02516	0.487
MOD_NEK2_1	117	122	PF00069	0.525
MOD_NEK2_1	125	130	PF00069	0.355
MOD_NEK2_1	154	159	PF00069	0.570
MOD_NEK2_1	181	186	PF00069	0.551
MOD_NEK2_1	191	196	PF00069	0.517
MOD_NEK2_1	218	223	PF00069	0.398
MOD_NEK2_1	320	325	PF00069	0.459
MOD_NEK2_1	42	47	PF00069	0.423
MOD_NEK2_1	52	57	PF00069	0.389
MOD_NEK2_1	81	86	PF00069	0.472
MOD_NEK2_2	349	354	PF00069	0.444
MOD_NEK2_2	384	389	PF00069	0.492
MOD_PIKK_1	154	160	PF00454	0.387
MOD_PIKK_1	171	177	PF00454	0.536
MOD_PIKK_1	256	262	PF00454	0.714
MOD_PKA_2	268	274	PF00069	0.426
MOD_PKA_2	349	355	PF00069	0.535
MOD_PKA_2	81	87	PF00069	0.486
MOD_Plk_1	154	160	PF00069	0.508
MOD_Plk_1	234	240	PF00069	0.735
MOD_Plk_1	281	287	PF00069	0.450
MOD_Plk_4	120	126	PF00069	0.402
MOD_Plk_4	17	23	PF00069	0.466
MOD_Plk_4	218	224	PF00069	0.395
MOD_Plk_4	37	43	PF00069	0.425
MOD_Plk_4	394	400	PF00069	0.541
MOD_ProDKin_1	184	190	PF00069	0.487
MOD_ProDKin_1	252	258	PF00069	0.760
MOD_ProDKin_1	297	303	PF00069	0.653
MOD_SUMO_rev_2	243	249	PF00179	0.770
MOD_SUMO_rev_2	271	280	PF00179	0.615
MOD_SUMO_rev_2	358	368	PF00179	0.409
TRG_ENDOCYTIC_2	147	150	PF00928	0.407
TRG_ENDOCYTIC_2	25	28	PF00928	0.364
TRG_NES_CRM1_1	390	403	PF08389	0.460

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IJS3	Leptomonas seymouri	53%	100%
A0A0S4KFQ7	Bodo saltans	27%	100%
A0A1X0NYM7	Trypanosomatidae	30%	87%
A0A3R7KQG6	Trypanosoma rangeli	38%	95%
A0A3S7X164	Leishmania donovani	99%	100%
D0A828	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	27%	100%
E9AZK3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	90%	100%
Q4Q8M8	Leishmania major	91%	100%
V5B0U4	Trypanosoma cruzi	33%	90%