LeishMANIAdb
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Carbonic anhydrase-like protein

Quick info Annotations Function or PPIs Localization Phosphorylation Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
Carbonic anhydrase-like protein
Gene product:
carbonic anhydrase-like protein
Species:
Leishmania infantum
UniProt:
A4I3A0_LEIIN
TriTrypDb:
LINF_280007600
Length:
628

Annotations

LeishMANIAdb annotations

Carbonic anhydrase protein (luminal). Based on its distant eukaryotic relatives, it probably has a signal peptide on its N-terminus and a membrane anchor at the C-terminus

Annotations by Jardim et al.

Pentose Phosphate Pathway, Carbonic anhydrase-like

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 5
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 8
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 yes yes: 6, no: 0
NetGPI no yes: 0, no: 6
Cellular components
Term Name Level Count
GO:0016020 membrane 2 4
GO:0110165 cellular anatomical entity 1 4

Phosphorylation

Amastigote: 610

Expansion

Sequence features

A4I3A0
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4I3A0

Function

Biological processes
Term Name Level Count
GO:0006730 one-carbon metabolic process 3 1
GO:0008152 metabolic process 1 1
GO:0009987 cellular process 1 1
GO:0044237 cellular metabolic process 2 1
GO:0044281 small molecule metabolic process 2 1
Molecular functions
Term Name Level Count
GO:0003824 catalytic activity 1 7
GO:0004089 carbonate dehydratase activity 5 7
GO:0005488 binding 1 7
GO:0008270 zinc ion binding 6 7
GO:0016829 lyase activity 2 7
GO:0016835 carbon-oxygen lyase activity 3 7
GO:0016836 hydro-lyase activity 4 7
GO:0043167 ion binding 2 7
GO:0043169 cation binding 3 7
GO:0046872 metal ion binding 4 7
GO:0046914 transition metal ion binding 5 7

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 282 286 PF00656 0.326
CLV_C14_Caspase3-7 316 320 PF00656 0.357
CLV_C14_Caspase3-7 527 531 PF00656 0.413
CLV_NRD_NRD_1 333 335 PF00675 0.608
CLV_NRD_NRD_1 592 594 PF00675 0.483
CLV_NRD_NRD_1 71 73 PF00675 0.499
CLV_PCSK_KEX2_1 220 222 PF00082 0.462
CLV_PCSK_KEX2_1 516 518 PF00082 0.674
CLV_PCSK_KEX2_1 592 594 PF00082 0.483
CLV_PCSK_KEX2_1 612 614 PF00082 0.460
CLV_PCSK_KEX2_1 71 73 PF00082 0.499
CLV_PCSK_PC1ET2_1 220 222 PF00082 0.499
CLV_PCSK_PC1ET2_1 516 518 PF00082 0.674
CLV_PCSK_PC1ET2_1 612 614 PF00082 0.460
CLV_PCSK_SKI1_1 100 104 PF00082 0.471
CLV_PCSK_SKI1_1 144 148 PF00082 0.436
CLV_PCSK_SKI1_1 186 190 PF00082 0.473
CLV_PCSK_SKI1_1 307 311 PF00082 0.454
CLV_PCSK_SKI1_1 543 547 PF00082 0.587
CLV_PCSK_SKI1_1 569 573 PF00082 0.320
DEG_APCC_DBOX_1 568 576 PF00400 0.345
DEG_SCF_FBW7_2 484 489 PF00400 0.465
DEG_SPOP_SBC_1 201 205 PF00917 0.258
DEG_SPOP_SBC_1 393 397 PF00917 0.519
DEG_SPOP_SBC_1 492 496 PF00917 0.507
DOC_ANK_TNKS_1 314 321 PF00023 0.349
DOC_CYCLIN_yCln2_LP_2 271 277 PF00134 0.299
DOC_MAPK_gen_1 184 193 PF00069 0.293
DOC_MAPK_gen_1 589 597 PF00069 0.679
DOC_MAPK_gen_1 71 78 PF00069 0.299
DOC_MAPK_HePTP_8 181 193 PF00069 0.254
DOC_MAPK_MEF2A_6 184 193 PF00069 0.240
DOC_MAPK_MEF2A_6 569 577 PF00069 0.276
DOC_MAPK_MEF2A_6 61 68 PF00069 0.299
DOC_PP1_RVXF_1 305 311 PF00149 0.254
DOC_PP1_RVXF_1 92 98 PF00149 0.277
DOC_PP4_FxxP_1 45 48 PF00568 0.451
DOC_USP7_MATH_1 241 245 PF00917 0.270
DOC_USP7_MATH_1 340 344 PF00917 0.456
DOC_USP7_MATH_1 423 427 PF00917 0.626
DOC_USP7_MATH_1 448 452 PF00917 0.606
DOC_USP7_MATH_1 454 458 PF00917 0.520
DOC_USP7_MATH_1 462 466 PF00917 0.540
DOC_USP7_MATH_1 467 471 PF00917 0.463
DOC_USP7_MATH_1 48 52 PF00917 0.489
DOC_USP7_MATH_1 484 488 PF00917 0.526
DOC_USP7_MATH_1 544 548 PF00917 0.381
DOC_USP7_MATH_1 555 559 PF00917 0.363
DOC_USP7_MATH_1 607 611 PF00917 0.653
DOC_WW_Pin1_4 265 270 PF00397 0.274
DOC_WW_Pin1_4 369 374 PF00397 0.547
DOC_WW_Pin1_4 388 393 PF00397 0.633
DOC_WW_Pin1_4 394 399 PF00397 0.640
DOC_WW_Pin1_4 44 49 PF00397 0.453
DOC_WW_Pin1_4 482 487 PF00397 0.527
DOC_WW_Pin1_4 71 76 PF00397 0.274
LIG_14-3-3_CanoR_1 144 149 PF00244 0.236
LIG_14-3-3_CanoR_1 221 229 PF00244 0.274
LIG_14-3-3_CanoR_1 383 393 PF00244 0.533
LIG_14-3-3_CanoR_1 455 459 PF00244 0.476
LIG_14-3-3_CanoR_1 52 56 PF00244 0.414
LIG_14-3-3_CanoR_1 543 549 PF00244 0.414
LIG_14-3-3_CanoR_1 94 104 PF00244 0.253
LIG_Actin_WH2_2 181 198 PF00022 0.236
LIG_BIR_II_1 1 5 PF00653 0.414
LIG_BIR_III_1 1 5 PF00653 0.414
LIG_BIR_III_3 1 5 PF00653 0.414
LIG_Clathr_ClatBox_1 356 360 PF01394 0.431
LIG_deltaCOP1_diTrp_1 330 339 PF00928 0.374
LIG_eIF4E_1 38 44 PF01652 0.447
LIG_FHA_1 176 182 PF00498 0.297
LIG_FHA_1 224 230 PF00498 0.274
LIG_FHA_1 256 262 PF00498 0.310
LIG_FHA_1 265 271 PF00498 0.243
LIG_FHA_1 38 44 PF00498 0.395
LIG_FHA_1 412 418 PF00498 0.509
LIG_FHA_1 454 460 PF00498 0.503
LIG_FHA_1 620 626 PF00498 0.696
LIG_FHA_1 63 69 PF00498 0.236
LIG_FHA_2 135 141 PF00498 0.308
LIG_FHA_2 426 432 PF00498 0.462
LIG_FHA_2 483 489 PF00498 0.528
LIG_FHA_2 503 509 PF00498 0.475
LIG_FHA_2 51 57 PF00498 0.367
LIG_Integrin_isoDGR_2 305 307 PF01839 0.462
LIG_LIR_Gen_1 120 130 PF02991 0.308
LIG_LIR_Gen_1 234 241 PF02991 0.243
LIG_LIR_Gen_1 291 300 PF02991 0.262
LIG_LIR_Gen_1 54 64 PF02991 0.351
LIG_LIR_Gen_1 542 553 PF02991 0.362
LIG_LIR_Gen_1 77 86 PF02991 0.274
LIG_LIR_Nem_3 120 126 PF02991 0.308
LIG_LIR_Nem_3 147 153 PF02991 0.338
LIG_LIR_Nem_3 234 239 PF02991 0.291
LIG_LIR_Nem_3 243 248 PF02991 0.261
LIG_LIR_Nem_3 291 295 PF02991 0.262
LIG_LIR_Nem_3 54 60 PF02991 0.356
LIG_LIR_Nem_3 542 548 PF02991 0.369
LIG_LIR_Nem_3 62 66 PF02991 0.274
LIG_LIR_Nem_3 77 81 PF02991 0.287
LIG_NBox_RRM_1 5 15 PF00076 0.403
LIG_PCNA_yPIPBox_3 184 194 PF02747 0.293
LIG_Pex14_2 328 332 PF04695 0.344
LIG_SH2_CRK 57 61 PF00017 0.401
LIG_SH2_GRB2like 443 446 PF00017 0.464
LIG_SH2_GRB2like 57 60 PF00017 0.344
LIG_SH2_NCK_1 443 447 PF00017 0.458
LIG_SH2_NCK_1 562 566 PF00017 0.402
LIG_SH2_STAP1 365 369 PF00017 0.471
LIG_SH2_STAT5 245 248 PF00017 0.274
LIG_SH2_STAT5 57 60 PF00017 0.332
LIG_SH2_STAT5 596 599 PF00017 0.636
LIG_SH3_3 135 141 PF00018 0.326
LIG_SH3_3 367 373 PF00018 0.566
LIG_SUMO_SIM_par_1 267 273 PF11976 0.299
LIG_SUMO_SIM_par_1 355 360 PF11976 0.435
LIG_SxIP_EBH_1 232 242 PF03271 0.299
LIG_TRAF2_1 104 107 PF00917 0.299
LIG_TRAF2_1 122 125 PF00917 0.194
LIG_TRFH_1 236 240 PF08558 0.258
LIG_UBA3_1 91 100 PF00899 0.258
MOD_CDC14_SPxK_1 397 400 PF00782 0.604
MOD_CDK_SPxK_1 394 400 PF00069 0.600
MOD_CK1_1 119 125 PF00069 0.355
MOD_CK1_1 134 140 PF00069 0.261
MOD_CK1_1 175 181 PF00069 0.310
MOD_CK1_1 234 240 PF00069 0.294
MOD_CK1_1 372 378 PF00069 0.618
MOD_CK1_1 444 450 PF00069 0.744
MOD_CK1_1 457 463 PF00069 0.583
MOD_CK1_1 47 53 PF00069 0.549
MOD_CK1_1 470 476 PF00069 0.639
MOD_CK1_1 479 485 PF00069 0.753
MOD_CK1_1 487 493 PF00069 0.624
MOD_CK1_1 494 500 PF00069 0.620
MOD_CK1_1 523 529 PF00069 0.778
MOD_CK1_1 536 542 PF00069 0.431
MOD_CK1_1 74 80 PF00069 0.321
MOD_CK2_1 119 125 PF00069 0.245
MOD_CK2_1 29 35 PF00069 0.626
MOD_CK2_1 352 358 PF00069 0.696
MOD_CK2_1 425 431 PF00069 0.616
MOD_CK2_1 463 469 PF00069 0.689
MOD_CK2_1 502 508 PF00069 0.570
MOD_Cter_Amidation 513 516 PF01082 0.553
MOD_Cter_Amidation 69 72 PF01082 0.345
MOD_GlcNHglycan 197 200 PF01048 0.320
MOD_GlcNHglycan 204 207 PF01048 0.272
MOD_GlcNHglycan 24 27 PF01048 0.570
MOD_GlcNHglycan 366 369 PF01048 0.651
MOD_GlcNHglycan 379 382 PF01048 0.588
MOD_GlcNHglycan 460 463 PF01048 0.579
MOD_GlcNHglycan 465 468 PF01048 0.545
MOD_GlcNHglycan 472 475 PF01048 0.598
MOD_GlcNHglycan 480 484 PF01048 0.552
MOD_GlcNHglycan 488 492 PF01048 0.654
MOD_GlcNHglycan 508 512 PF01048 0.648
MOD_GlcNHglycan 609 612 PF01048 0.586
MOD_GSK3_1 144 151 PF00069 0.358
MOD_GSK3_1 223 230 PF00069 0.294
MOD_GSK3_1 379 386 PF00069 0.737
MOD_GSK3_1 388 395 PF00069 0.570
MOD_GSK3_1 425 432 PF00069 0.631
MOD_GSK3_1 44 51 PF00069 0.551
MOD_GSK3_1 444 451 PF00069 0.711
MOD_GSK3_1 453 460 PF00069 0.581
MOD_GSK3_1 463 470 PF00069 0.592
MOD_GSK3_1 478 485 PF00069 0.605
MOD_GSK3_1 487 494 PF00069 0.740
MOD_GSK3_1 495 502 PF00069 0.726
MOD_GSK3_1 503 510 PF00069 0.648
MOD_GSK3_1 520 527 PF00069 0.522
MOD_GSK3_1 539 546 PF00069 0.569
MOD_GSK3_1 617 624 PF00069 0.588
MOD_GSK3_1 62 69 PF00069 0.272
MOD_N-GLC_1 142 147 PF02516 0.310
MOD_N-GLC_1 201 206 PF02516 0.310
MOD_N-GLC_1 340 345 PF02516 0.559
MOD_N-GLC_1 383 388 PF02516 0.641
MOD_N-GLC_1 401 406 PF02516 0.661
MOD_N-GLC_1 423 428 PF02516 0.602
MOD_N-GLC_1 436 441 PF02516 0.686
MOD_N-GLC_1 444 449 PF02516 0.603
MOD_N-GLC_1 524 529 PF02516 0.568
MOD_NEK2_1 142 147 PF00069 0.310
MOD_NEK2_1 172 177 PF00069 0.310
MOD_NEK2_1 195 200 PF00069 0.310
MOD_NEK2_1 229 234 PF00069 0.287
MOD_NEK2_1 352 357 PF00069 0.588
MOD_NEK2_1 556 561 PF00069 0.453
MOD_NEK2_1 582 587 PF00069 0.466
MOD_NEK2_1 66 71 PF00069 0.310
MOD_NEK2_1 95 100 PF00069 0.282
MOD_NEK2_2 223 228 PF00069 0.310
MOD_NEK2_2 544 549 PF00069 0.425
MOD_PIKK_1 105 111 PF00454 0.294
MOD_PIKK_1 248 254 PF00454 0.358
MOD_PK_1 549 555 PF00069 0.445
MOD_PKA_2 241 247 PF00069 0.297
MOD_PKA_2 454 460 PF00069 0.591
MOD_PKA_2 492 498 PF00069 0.596
MOD_PKA_2 51 57 PF00069 0.507
MOD_Plk_1 105 111 PF00069 0.345
MOD_Plk_1 134 140 PF00069 0.349
MOD_Plk_1 142 148 PF00069 0.277
MOD_Plk_1 313 319 PF00069 0.480
MOD_Plk_1 340 346 PF00069 0.602
MOD_Plk_1 448 454 PF00069 0.509
MOD_Plk_1 467 473 PF00069 0.541
MOD_Plk_2-3 29 35 PF00069 0.589
MOD_Plk_2-3 313 319 PF00069 0.397
MOD_Plk_4 134 140 PF00069 0.474
MOD_Plk_4 231 237 PF00069 0.320
MOD_Plk_4 241 247 PF00069 0.295
MOD_Plk_4 29 35 PF00069 0.589
MOD_Plk_4 352 358 PF00069 0.536
MOD_Plk_4 454 460 PF00069 0.584
MOD_Plk_4 536 542 PF00069 0.524
MOD_ProDKin_1 265 271 PF00069 0.310
MOD_ProDKin_1 369 375 PF00069 0.692
MOD_ProDKin_1 388 394 PF00069 0.814
MOD_ProDKin_1 44 50 PF00069 0.561
MOD_ProDKin_1 482 488 PF00069 0.665
MOD_ProDKin_1 71 77 PF00069 0.310
TRG_DiLeu_BaLyEn_6 304 309 PF01217 0.345
TRG_ENDOCYTIC_2 57 60 PF00928 0.408
TRG_ER_diArg_1 591 593 PF00400 0.604
TRG_NLS_MonoExtC_3 514 520 PF00514 0.577
TRG_NLS_MonoExtN_4 513 519 PF00514 0.565
TRG_Pf-PMV_PEXEL_1 111 115 PF00026 0.283
TRG_Pf-PMV_PEXEL_1 128 132 PF00026 0.198
TRG_Pf-PMV_PEXEL_1 164 169 PF00026 0.310

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N1PBI8 Leptomonas seymouri 47% 100%
A0A3Q8IDR5 Leishmania donovani 99% 100%
A4HG87 Leishmania braziliensis 61% 99%
E9AZK8 Leishmania mexicana (strain MHOM/GT/2001/U1103) 79% 98%
Q4Q8M3 Leishmania major 85% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS