Carbonic anhydrase-like protein

Quick info Annotations Localization Phosphorylation Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

carbonic anhydrase-like protein

Species:

Leishmania infantum

UniProt:

A4I3A0_LEIIN

TriTrypDb:

LINF_280007600

Length:

628

Annotations

LeishMANIAdb annotations

Carbonic anhydrase protein (luminal). Based on its distant eukaryotic relatives, it probably has a signal peptide on its N-terminus and a membrane anchor at the C-terminus

Annotations by Jardim et al.

Pentose Phosphate Pathway, Carbonic anhydrase-like

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 5

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 8

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	yes	yes: 6, no: 0
NetGPI	no	yes: 0, no: 6

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Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	4
GO:0110165	cellular anatomical entity	1	4

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Phosphorylation

Amastigote: 610

Expansion

Sequence features

A4I3A0

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4I3A0

Function

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Biological processes
Term	Name	Level	Count
GO:0006730	one-carbon metabolic process	3	1
GO:0008152	metabolic process	1	1
GO:0009987	cellular process	1	1
GO:0044237	cellular metabolic process	2	1
GO:0044281	small molecule metabolic process	2	1

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Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	7
GO:0004089	carbonate dehydratase activity	5	7
GO:0005488	binding	1	7
GO:0008270	zinc ion binding	6	7
GO:0016829	lyase activity	2	7
GO:0016835	carbon-oxygen lyase activity	3	7
GO:0016836	hydro-lyase activity	4	7
GO:0043167	ion binding	2	7
GO:0043169	cation binding	3	7
GO:0046872	metal ion binding	4	7

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Putative motif mimicry

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Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	282	286	PF00656	0.326
CLV_C14_Caspase3-7	316	320	PF00656	0.357
CLV_C14_Caspase3-7	527	531	PF00656	0.413
CLV_NRD_NRD_1	333	335	PF00675	0.608
CLV_NRD_NRD_1	592	594	PF00675	0.483
CLV_NRD_NRD_1	71	73	PF00675	0.499
CLV_PCSK_KEX2_1	220	222	PF00082	0.462
CLV_PCSK_KEX2_1	516	518	PF00082	0.674
CLV_PCSK_KEX2_1	592	594	PF00082	0.483
CLV_PCSK_KEX2_1	612	614	PF00082	0.460

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Homologs

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Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PBI8	Leptomonas seymouri	47%	100%
A0A3Q8IDR5	Leishmania donovani	99%	100%
A4HG87	Leishmania braziliensis	61%	99%
E9AZK8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	79%	98%
Q4Q8M3	Leishmania major	85%	100%

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