Histone H2B

Quick info Annotations Localization Abundance Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Histone H2B

Gene product:

histone H2B variant

Species:

Leishmania infantum

UniProt:

A4I394_LEIIN

TriTrypDb:

LINF_280007000

Length:

142

Annotations

Annotations by Jardim et al.

Histone/chromosome structure, Histone H2B

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	yes	yes: 25

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	yes	yes: 16

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0000786	nucleosome	3	12
GO:0005634	nucleus	5	12
GO:0032991	protein-containing complex	1	12
GO:0032993	protein-DNA complex	2	12
GO:0043226	organelle	2	12
GO:0043227	membrane-bounded organelle	3	12
GO:0043229	intracellular organelle	3	12
GO:0043231	intracellular membrane-bounded organelle	4	12
GO:0044815	DNA packaging complex	2	12
GO:0110165	cellular anatomical entity	1	12

Abundance

Amastigote (protein)


Source	Evidence on protein	Close homologs
Pescher et al. (upgregulation)	no	yes: 0

Promastigote and amastigote


Source	Evidence on protein	Close homologs
Lahav et al. - mRNA - Protein

Expansion

Sequence features

A4I394

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4I394

Function

Biological processes
Term	Name	Level	Count
GO:0006325	chromatin organization	4	1
GO:0006334	nucleosome assembly	7	1
GO:0006338	chromatin remodeling	5	1
GO:0009987	cellular process	1	1
GO:0016043	cellular component organization	3	1
GO:0022607	cellular component assembly	4	1
GO:0034728	nucleosome organization	6	1
GO:0043933	protein-containing complex organization	4	1
GO:0065003	protein-containing complex assembly	5	1
GO:0065004	protein-DNA complex assembly	6	1
GO:0071824	protein-DNA complex subunit organization	5	1
GO:0071840	cellular component organization or biogenesis	2	1

Molecular functions
Term	Name	Level	Count
GO:0003676	nucleic acid binding	3	12
GO:0003677	DNA binding	4	12
GO:0005198	structural molecule activity	1	12
GO:0005488	binding	1	12
GO:0005515	protein binding	2	12
GO:0030527	structural constituent of chromatin	2	12
GO:0046982	protein heterodimerization activity	4	12
GO:0046983	protein dimerization activity	3	12
GO:0097159	organic cyclic compound binding	2	12
GO:1901363	heterocyclic compound binding	2	12

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	35	37	PF00675	0.224
CLV_NRD_NRD_1	54	56	PF00675	0.269
CLV_PCSK_KEX2_1	20	22	PF00082	0.227
CLV_PCSK_KEX2_1	34	36	PF00082	0.208
CLV_PCSK_KEX2_1	40	42	PF00082	0.170
CLV_PCSK_KEX2_1	54	56	PF00082	0.225
CLV_PCSK_KEX2_1	58	60	PF00082	0.124
CLV_PCSK_KEX2_1	8	10	PF00082	0.550
CLV_PCSK_PC1ET2_1	20	22	PF00082	0.227
CLV_PCSK_PC1ET2_1	34	36	PF00082	0.277
CLV_PCSK_PC1ET2_1	40	42	PF00082	0.219
CLV_PCSK_PC1ET2_1	58	60	PF00082	0.121
CLV_PCSK_PC1ET2_1	8	10	PF00082	0.550
CLV_PCSK_PC7_1	36	42	PF00082	0.293
CLV_PCSK_PC7_1	54	60	PF00082	0.103
CLV_PCSK_SKI1_1	107	111	PF00082	0.274
CLV_PCSK_SKI1_1	54	58	PF00082	0.291
CLV_PCSK_SKI1_1	95	99	PF00082	0.190
DOC_CYCLIN_yCln2_LP_2	109	112	PF00134	0.343
DOC_MAPK_gen_1	5	13	PF00069	0.585
DOC_PP2B_LxvP_1	108	111	PF13499	0.339
DOC_USP7_UBL2_3	124	128	PF12436	0.357
DOC_USP7_UBL2_3	16	20	PF12436	0.390
LIG_14-3-3_CanoR_1	68	74	PF00244	0.400
LIG_14-3-3_CanoR_1	80	88	PF00244	0.395
LIG_CtBP_PxDLS_1	111	115	PF00389	0.345
LIG_FHA_1	121	127	PF00498	0.360
LIG_FHA_1	81	87	PF00498	0.474
LIG_FHA_2	96	102	PF00498	0.401
LIG_LIR_Gen_1	75	86	PF02991	0.414
LIG_LIR_Nem_3	42	48	PF02991	0.480
LIG_LIR_Nem_3	75	81	PF02991	0.390
LIG_REV1ctd_RIR_1	54	63	PF16727	0.493
LIG_SH2_STAT5	48	51	PF00017	0.400
LIG_WRC_WIRS_1	70	75	PF05994	0.390
MOD_CK1_1	120	126	PF00069	0.349
MOD_CK2_1	129	135	PF00069	0.401
MOD_CK2_1	69	75	PF00069	0.390
MOD_CK2_1	95	101	PF00069	0.421
MOD_Cter_Amidation	18	21	PF01082	0.192
MOD_Cter_Amidation	6	9	PF01082	0.539
MOD_GlcNHglycan	104	107	PF01048	0.190
MOD_GlcNHglycan	21	24	PF01048	0.252
MOD_GlcNHglycan	28	31	PF01048	0.187
MOD_N-GLC_1	129	134	PF02516	0.366
MOD_PIKK_1	39	45	PF00454	0.405
MOD_PKA_1	58	64	PF00069	0.400
MOD_PKA_2	58	64	PF00069	0.400
MOD_Plk_4	69	75	PF00069	0.419
TRG_DiLeu_BaLyEn_6	104	109	PF01217	0.390
TRG_ER_diArg_1	53	55	PF00400	0.468
TRG_NLS_Bipartite_1	20	38	PF00514	0.392

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PD10	Leptomonas seymouri	94%	100%
A0A0S4IT56	Bodo saltans	62%	97%
A0A1X0NWS2	Trypanosomatidae	75%	99%
A0A381MG06	Leishmania infantum	45%	100%
A0A3R7NJN4	Trypanosoma rangeli	42%	100%
A0A3S5H748	Leishmania donovani	45%	100%
A0A3S5H7I6	Leishmania donovani	100%	100%
A0A3S7WUK6	Leishmania donovani	43%	100%
A0A422N4F4	Trypanosoma rangeli	74%	100%
A0A422NDW8	Trypanosoma rangeli	42%	100%
A1CJ09	Aspergillus clavatus (strain ATCC 1007 / CBS 513.65 / DSM 816 / NCTC 3887 / NRRL 1 / QM 1276 / 107)	46%	100%
A1D8G9	Neosartorya fischeri (strain ATCC 1020 / DSM 3700 / CBS 544.65 / FGSC A1164 / JCM 1740 / NRRL 181 / WB 181)	41%	100%
A2QY49	Aspergillus niger (strain CBS 513.88 / FGSC A1513)	45%	100%
A2WKP3	Oryza sativa subsp. indica	40%	93%
A2WKP5	Oryza sativa subsp. indica	40%	93%
A2WKS3	Oryza sativa subsp. indica	40%	93%
A2WKT4	Oryza sativa subsp. indica	43%	92%
A2XF66	Oryza sativa subsp. indica	43%	93%
A3AGM4	Oryza sativa subsp. japonica	43%	93%
A3LXE6	Scheffersomyces stipitis (strain ATCC 58785 / CBS 6054 / NBRC 10063 / NRRL Y-11545)	41%	100%
A3LZZ1	Scheffersomyces stipitis (strain ATCC 58785 / CBS 6054 / NBRC 10063 / NRRL Y-11545)	41%	100%
A4H5W2	Leishmania braziliensis	47%	100%
A4H9W0	Leishmania braziliensis	41%	78%
A4H9W1	Leishmania braziliensis	42%	78%
A4H9W2	Leishmania braziliensis	45%	100%
A4HG62	Leishmania braziliensis	96%	100%
A4HU57	Leishmania infantum	40%	100%
A4HXJ9	Leishmania infantum	43%	100%
A4HY42	Leishmania infantum	41%	100%
A5DBG5	Meyerozyma guilliermondii (strain ATCC 6260 / CBS 566 / DSM 6381 / JCM 1539 / NBRC 10279 / NRRL Y-324)	40%	100%
A5DJJ1	Meyerozyma guilliermondii (strain ATCC 6260 / CBS 566 / DSM 6381 / JCM 1539 / NBRC 10279 / NRRL Y-324)	40%	100%
A5DWF0	Lodderomyces elongisporus (strain ATCC 11503 / CBS 2605 / JCM 1781 / NBRC 1676 / NRRL YB-4239)	40%	100%
D0A4I4	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	41%	100%
D0A4I8	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	42%	100%
D0A7S0	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	76%	86%
E9AMY6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	42%	99%
E9AR94	Leishmania mexicana (strain MHOM/GT/2001/U1103)	42%	100%
E9ARV5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	41%	100%
E9AZI2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	98%	100%
L7I1W3	Magnaporthe oryzae (strain Y34)	41%	100%
O22582	Gossypium hirsutum	43%	97%
O23629	Arabidopsis thaliana	42%	95%
O49118	Capsicum annuum	37%	98%
O60814	Homo sapiens	43%	100%
O65818	Solanum lycopersicum	41%	100%
O65821	Solanum lycopersicum	38%	100%
O97484	Euplotes crassus	48%	100%
P02281	Xenopus laevis	44%	100%
P02287	Psammechinus miliaris	43%	100%
P02288	Psammechinus miliaris	45%	100%
P02289	Strongylocentrotus purpuratus	44%	100%
P02293	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	44%	100%
P02294	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	44%	100%
P04255	Caenorhabditis elegans	48%	100%
P04913	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	46%	100%
P06899	Homo sapiens	43%	100%
P06900	Xenopus laevis	44%	100%
P07794	Psammechinus miliaris	44%	100%
P07795	Psammechinus miliaris	45%	100%
P08993	Tetrahymena thermophila (strain SB210)	43%	100%
P08994	Tetrahymena thermophila (strain SB210)	41%	100%
P0C1H4	Gallus gallus	43%	100%
P0C1H5	Gallus gallus	43%	100%
P0CO02	Cryptococcus neoformans var. neoformans serotype D (strain JEC21 / ATCC MYA-565)	45%	100%
P0CO03	Cryptococcus neoformans var. neoformans serotype D (strain B-3501A)	45%	100%
P0CT13	Magnaporthe oryzae (strain 70-15 / ATCC MYA-4617 / FGSC 8958)	41%	100%
P10853	Mus musculus	44%	100%
P10854	Mus musculus	45%	100%
P16868	Volvox carteri	43%	92%
P23527	Homo sapiens	44%	100%
P23754	Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)	45%	100%
P27893	Leishmania enriettii	43%	100%
P33778	Homo sapiens	44%	100%
P35067	Acropora formosa	42%	100%
P35068	Tigriopus californicus	48%	100%
P35069	Tigriopus californicus	48%	100%
P37210	Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)	43%	100%
P40283	Arabidopsis thaliana	43%	95%
P40284	Entamoeba invadens	36%	100%
P48557	Holothuria tubulosa	43%	100%
P48989	Candida albicans (strain SC5314 / ATCC MYA-2876)	44%	100%
P50565	Chlamydomonas reinhardtii	42%	93%
P57053	Homo sapiens	42%	100%
P58876	Homo sapiens	45%	100%
P62807	Homo sapiens	44%	100%
P62808	Bos taurus	44%	100%
P69069	Oncorhynchus mykiss	43%	100%
P69070	Salmo trutta	43%	100%
P70696	Mus musculus	44%	100%
P78567	Agaricus bisporus	40%	99%
P93354	Nicotiana tabacum	43%	97%
Q00715	Rattus norvegicus	42%	100%
Q00729	Rattus norvegicus	44%	100%
Q0CBD1	Aspergillus terreus (strain NIH 2624 / FGSC A1156)	47%	100%
Q0U1A0	Phaeosphaeria nodorum (strain SN15 / ATCC MYA-4574 / FGSC 10173)	42%	100%
Q16778	Homo sapiens	44%	100%
Q1E5N0	Coccidioides immitis (strain RS)	45%	100%
Q27484	Caenorhabditis elegans	47%	100%
Q27750	Psammechinus miliaris	42%	99%
Q27876	Caenorhabditis elegans	48%	100%
Q27894	Caenorhabditis elegans	48%	100%
Q2HH38	Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)	44%	100%
Q2M2T1	Bos taurus	43%	100%
Q2PFX4	Macaca fascicularis	44%	100%
Q2U5A9	Aspergillus oryzae (strain ATCC 42149 / RIB 40)	47%	100%
Q32L48	Bos taurus	44%	100%
Q41575	Triticum aestivum	38%	100%
Q4HTT2	Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)	39%	100%
Q4JHM7	Leishmania donovani	40%	100%
Q4PEF8	Ustilago maydis (strain 521 / FGSC 9021)	41%	100%
Q4Q8P9	Leishmania major	98%	100%
Q4QDL6	Leishmania major	42%	100%
Q4QHP1	Leishmania major	42%	100%
Q4WWC5	Neosartorya fumigata (strain ATCC MYA-4609 / Af293 / CBS 101355 / FGSC A1100)	41%	100%
Q54LP8	Dictyostelium discoideum	40%	92%
Q59VP1	Candida albicans (strain SC5314 / ATCC MYA-2876)	43%	100%
Q5BJA5	Danio rerio	44%	100%
Q5QNW6	Homo sapiens	44%	100%
Q5R893	Pongo abelii	44%	100%
Q5RCP8	Pongo abelii	44%	100%
Q64475	Mus musculus	44%	100%
Q64478	Mus musculus	44%	100%
Q64524	Mus musculus	44%	100%
Q64525	Mus musculus	44%	100%
Q6BKW7	Debaryomyces hansenii (strain ATCC 36239 / CBS 767 / BCRC 21394 / JCM 1990 / NBRC 0083 / IGC 2968)	40%	100%
Q6BRG2	Debaryomyces hansenii (strain ATCC 36239 / CBS 767 / BCRC 21394 / JCM 1990 / NBRC 0083 / IGC 2968)	42%	100%
Q6C4I7	Yarrowia lipolytica (strain CLIB 122 / E 150)	38%	100%
Q6CK60	Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37)	42%	100%
Q6CMV8	Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37)	42%	100%
Q6FM30	Candida glabrata (strain ATCC 2001 / CBS 138 / JCM 3761 / NBRC 0622 / NRRL Y-65)	44%	100%
Q6FWM8	Candida glabrata (strain ATCC 2001 / CBS 138 / JCM 3761 / NBRC 0622 / NRRL Y-65)	44%	100%
Q6PC60	Danio rerio	43%	100%
Q6ZWY9	Mus musculus	44%	100%
Q74ZL5	Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056)	42%	100%
Q75VN4	Zhangixalus schlegelii	44%	100%
Q7M400	Tetrahymena pyriformis	43%	100%
Q7Z2G1	Homo sapiens	39%	81%
Q7Z9J4	Ajellomyces capsulatus	43%	100%
Q875B7	Podospora anserina	42%	100%
Q8CGP1	Mus musculus	43%	100%
Q8CGP2	Mus musculus	44%	100%
Q8J1F8	Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056)	42%	100%
Q8J1K2	Rosellinia necatrix	44%	100%
Q93079	Homo sapiens	44%	100%
Q94JE1	Oryza sativa subsp. japonica	43%	92%
Q94JJ4	Oryza sativa subsp. japonica	40%	93%
Q94JJ7	Oryza sativa subsp. japonica	40%	93%
Q96A08	Homo sapiens	44%	100%
Q99285	Pisum sativum	43%	100%
Q99877	Homo sapiens	44%	100%
Q99879	Homo sapiens	44%	100%
Q99880	Homo sapiens	44%	100%
Q9FFC0	Arabidopsis thaliana	42%	98%
Q9LGI2	Oryza sativa subsp. japonica	40%	93%
Q9LQQ4	Arabidopsis thaliana	42%	96%
Q9LZT0	Arabidopsis thaliana	42%	98%
Q9MBF7	Lilium longiflorum	27%	90%
Q9PSW9	Gallus gallus	43%	100%
Q9SF55	Arabidopsis thaliana	39%	100%
Q9SI96	Arabidopsis thaliana	41%	94%
Q9U8C0	Leishmania major	41%	100%
Q9ZUS0	Arabidopsis thaliana	39%	100%
V5D812	Trypanosoma cruzi	74%	99%