Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein - conserved

Species:

Leishmania infantum

UniProt:

A4I392_LEIIN

TriTrypDb:

LINF_280006800

Length:

517

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4I392

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4I392

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	266	270	PF00656	0.623
CLV_NRD_NRD_1	114	116	PF00675	0.572
CLV_NRD_NRD_1	122	124	PF00675	0.656
CLV_NRD_NRD_1	171	173	PF00675	0.837
CLV_NRD_NRD_1	228	230	PF00675	0.623
CLV_NRD_NRD_1	243	245	PF00675	0.622
CLV_NRD_NRD_1	247	249	PF00675	0.619
CLV_NRD_NRD_1	317	319	PF00675	0.658
CLV_NRD_NRD_1	346	348	PF00675	0.622
CLV_NRD_NRD_1	37	39	PF00675	0.594
CLV_PCSK_KEX2_1	114	116	PF00082	0.572
CLV_PCSK_KEX2_1	171	173	PF00082	0.837
CLV_PCSK_KEX2_1	228	230	PF00082	0.623
CLV_PCSK_KEX2_1	243	245	PF00082	0.622
CLV_PCSK_KEX2_1	317	319	PF00082	0.636
CLV_PCSK_KEX2_1	322	324	PF00082	0.586
CLV_PCSK_KEX2_1	346	348	PF00082	0.622
CLV_PCSK_KEX2_1	357	359	PF00082	0.619
CLV_PCSK_KEX2_1	37	39	PF00082	0.540
CLV_PCSK_KEX2_1	82	84	PF00082	0.536
CLV_PCSK_PC1ET2_1	322	324	PF00082	0.611
CLV_PCSK_PC1ET2_1	357	359	PF00082	0.720
CLV_PCSK_PC1ET2_1	82	84	PF00082	0.536
CLV_PCSK_PC7_1	318	324	PF00082	0.585
CLV_PCSK_PC7_1	78	84	PF00082	0.525
CLV_PCSK_SKI1_1	103	107	PF00082	0.490
CLV_PCSK_SKI1_1	133	137	PF00082	0.544
CLV_PCSK_SKI1_1	229	233	PF00082	0.600
CLV_PCSK_SKI1_1	244	248	PF00082	0.625
CLV_PCSK_SKI1_1	285	289	PF00082	0.653
CLV_PCSK_SKI1_1	317	321	PF00082	0.653
CLV_PCSK_SKI1_1	346	350	PF00082	0.719
CLV_PCSK_SKI1_1	511	515	PF00082	0.717
CLV_PCSK_SKI1_1	65	69	PF00082	0.571
CLV_PCSK_SKI1_1	82	86	PF00082	0.359
DEG_APCC_DBOX_1	233	241	PF00400	0.654
DEG_Nend_Nbox_1	1	3	PF02207	0.653
DEG_SCF_FBW7_1	230	236	PF00400	0.621
DEG_SPOP_SBC_1	143	147	PF00917	0.614
DOC_CKS1_1	230	235	PF01111	0.648
DOC_CYCLIN_yCln2_LP_2	302	305	PF00134	0.712
DOC_CYCLIN_yCln2_LP_2	386	392	PF00134	0.683
DOC_MAPK_gen_1	82	92	PF00069	0.435
DOC_MAPK_MEF2A_6	228	237	PF00069	0.666
DOC_MAPK_MEF2A_6	86	94	PF00069	0.433
DOC_PP2B_LxvP_1	176	179	PF13499	0.735
DOC_PP2B_LxvP_1	302	305	PF13499	0.712
DOC_PP2B_LxvP_1	386	389	PF13499	0.678
DOC_PP4_FxxP_1	432	435	PF00568	0.717
DOC_USP7_MATH_1	143	147	PF00917	0.590
DOC_USP7_MATH_1	204	208	PF00917	0.738
DOC_USP7_MATH_1	253	257	PF00917	0.637
DOC_USP7_MATH_1	444	448	PF00917	0.789
DOC_USP7_MATH_1	462	466	PF00917	0.574
DOC_USP7_MATH_2	279	285	PF00917	0.660
DOC_WW_Pin1_4	229	234	PF00397	0.650
DOC_WW_Pin1_4	288	293	PF00397	0.681
DOC_WW_Pin1_4	296	301	PF00397	0.724
DOC_WW_Pin1_4	427	432	PF00397	0.658
DOC_WW_Pin1_4	442	447	PF00397	0.774
DOC_WW_Pin1_4	450	455	PF00397	0.688
LIG_14-3-3_CanoR_1	114	118	PF00244	0.630
LIG_14-3-3_CanoR_1	234	238	PF00244	0.637
LIG_14-3-3_CanoR_1	37	42	PF00244	0.672
LIG_14-3-3_CanoR_1	492	496	PF00244	0.762
LIG_Actin_WH2_2	87	105	PF00022	0.495
LIG_BRCT_BRCA1_1	145	149	PF00533	0.595
LIG_BRCT_BRCA1_1	283	287	PF00533	0.659
LIG_BRCT_BRCA1_1	338	342	PF00533	0.608
LIG_BRCT_BRCA1_1	394	398	PF00533	0.724
LIG_BRCT_BRCA1_1	428	432	PF00533	0.702
LIG_BRCT_BRCA1_2	394	400	PF00533	0.727
LIG_DCNL_PONY_1	1	4	PF03556	0.646
LIG_EVH1_2	388	392	PF00568	0.703
LIG_FHA_1	230	236	PF00498	0.613
LIG_FHA_1	413	419	PF00498	0.713
LIG_FHA_1	51	57	PF00498	0.679
LIG_FHA_2	264	270	PF00498	0.783
LIG_FHA_2	376	382	PF00498	0.789
LIG_LIR_Apic_2	382	388	PF02991	0.667
LIG_LIR_Apic_2	429	435	PF02991	0.707
LIG_LIR_Gen_1	497	507	PF02991	0.668
LIG_LIR_Nem_3	284	290	PF02991	0.683
LIG_MYND_1	300	304	PF01753	0.710
LIG_MYND_1	431	435	PF01753	0.672
LIG_Pex14_2	149	153	PF04695	0.568
LIG_PTAP_UEV_1	445	450	PF05743	0.577
LIG_PTB_Apo_2	30	37	PF02174	0.619
LIG_SH2_CRK	15	19	PF00017	0.772
LIG_SH2_SRC	385	388	PF00017	0.600
LIG_SH2_SRC	457	460	PF00017	0.557
LIG_SH2_STAP1	457	461	PF00017	0.775
LIG_SH2_STAP1	95	99	PF00017	0.623
LIG_SH2_STAT3	41	44	PF00017	0.554
LIG_SH2_STAT3	479	482	PF00017	0.612
LIG_SH2_STAT5	385	388	PF00017	0.697
LIG_SH2_STAT5	55	58	PF00017	0.661
LIG_SH3_1	172	178	PF00018	0.674
LIG_SH3_2	239	244	PF14604	0.665
LIG_SH3_3	172	178	PF00018	0.674
LIG_SH3_3	198	204	PF00018	0.712
LIG_SH3_3	236	242	PF00018	0.721
LIG_SH3_3	294	300	PF00018	0.666
LIG_SH3_3	443	449	PF00018	0.737
LIG_SH3_3	470	476	PF00018	0.774
LIG_SUMO_SIM_par_1	414	419	PF11976	0.579
LIG_SUMO_SIM_par_1	503	510	PF11976	0.628
LIG_TRAF2_1	20	23	PF00917	0.701
LIG_TRAF2_1	506	509	PF00917	0.726
LIG_UBA3_1	106	111	PF00899	0.525
LIG_WW_1	454	457	PF00397	0.638
LIG_WW_3	240	244	PF00397	0.664
MOD_CDK_SPK_2	229	234	PF00069	0.648
MOD_CK1_1	129	135	PF00069	0.603
MOD_CK1_1	181	187	PF00069	0.781
MOD_CK1_1	199	205	PF00069	0.573
MOD_CK1_1	261	267	PF00069	0.656
MOD_CK1_1	296	302	PF00069	0.723
MOD_CK1_1	331	337	PF00069	0.618
MOD_CK1_1	375	381	PF00069	0.717
MOD_CK1_1	391	397	PF00069	0.716
MOD_CK1_1	414	420	PF00069	0.686
MOD_CK1_1	465	471	PF00069	0.615
MOD_CK1_1	494	500	PF00069	0.758
MOD_CK2_1	16	22	PF00069	0.702
MOD_CK2_1	503	509	PF00069	0.741
MOD_Cter_Amidation	169	172	PF01082	0.790
MOD_Cter_Amidation	226	229	PF01082	0.717
MOD_GlcNHglycan	146	149	PF01048	0.611
MOD_GlcNHglycan	260	263	PF01048	0.636
MOD_GlcNHglycan	266	269	PF01048	0.594
MOD_GlcNHglycan	351	354	PF01048	0.710
MOD_GlcNHglycan	407	410	PF01048	0.657
MOD_GlcNHglycan	446	449	PF01048	0.769
MOD_GSK3_1	113	120	PF00069	0.577
MOD_GSK3_1	125	132	PF00069	0.609
MOD_GSK3_1	133	140	PF00069	0.335
MOD_GSK3_1	177	184	PF00069	0.786
MOD_GSK3_1	229	236	PF00069	0.622
MOD_GSK3_1	253	260	PF00069	0.700
MOD_GSK3_1	333	340	PF00069	0.555
MOD_GSK3_1	342	349	PF00069	0.582
MOD_GSK3_1	368	375	PF00069	0.700
MOD_GSK3_1	388	395	PF00069	0.742
MOD_GSK3_1	412	419	PF00069	0.691
MOD_GSK3_1	461	468	PF00069	0.673
MOD_GSK3_1	474	481	PF00069	0.739
MOD_N-GLC_1	281	286	PF02516	0.687
MOD_NEK2_1	257	262	PF00069	0.730
MOD_NEK2_1	283	288	PF00069	0.649
MOD_NEK2_1	337	342	PF00069	0.602
MOD_NEK2_1	36	41	PF00069	0.563
MOD_NEK2_1	392	397	PF00069	0.717
MOD_NEK2_1	74	79	PF00069	0.520
MOD_NEK2_2	137	142	PF00069	0.553
MOD_NEK2_2	436	441	PF00069	0.802
MOD_PIKK_1	178	184	PF00454	0.840
MOD_PIKK_1	331	337	PF00454	0.489
MOD_PIKK_1	379	385	PF00454	0.609
MOD_PIKK_1	478	484	PF00454	0.653
MOD_PKA_1	346	352	PF00069	0.719
MOD_PKA_1	37	43	PF00069	0.502
MOD_PKA_2	113	119	PF00069	0.626
MOD_PKA_2	233	239	PF00069	0.648
MOD_PKA_2	346	352	PF00069	0.719
MOD_PKA_2	36	42	PF00069	0.674
MOD_PKA_2	491	497	PF00069	0.725
MOD_PKA_2	74	80	PF00069	0.530
MOD_Plk_1	125	131	PF00069	0.595
MOD_Plk_1	50	56	PF00069	0.638
MOD_Plk_4	137	143	PF00069	0.559
MOD_Plk_4	220	226	PF00069	0.625
MOD_Plk_4	253	259	PF00069	0.694
MOD_Plk_4	328	334	PF00069	0.591
MOD_Plk_4	337	343	PF00069	0.510
MOD_Plk_4	375	381	PF00069	0.794
MOD_Plk_4	494	500	PF00069	0.641
MOD_ProDKin_1	229	235	PF00069	0.650
MOD_ProDKin_1	288	294	PF00069	0.681
MOD_ProDKin_1	296	302	PF00069	0.727
MOD_ProDKin_1	427	433	PF00069	0.661
MOD_ProDKin_1	442	448	PF00069	0.773
MOD_ProDKin_1	450	456	PF00069	0.687
MOD_SUMO_for_1	109	112	PF00179	0.551
MOD_SUMO_for_1	404	407	PF00179	0.600
MOD_SUMO_for_1	56	59	PF00179	0.704
MOD_SUMO_rev_2	506	513	PF00179	0.632
TRG_DiLeu_BaEn_1	321	326	PF01217	0.628
TRG_DiLeu_BaEn_4	51	57	PF01217	0.679
TRG_DiLeu_BaLyEn_6	62	67	PF01217	0.645
TRG_ENDOCYTIC_2	15	18	PF00928	0.773
TRG_ER_diArg_1	113	115	PF00400	0.569
TRG_ER_diArg_1	228	230	PF00400	0.628
TRG_ER_diArg_1	242	244	PF00400	0.633
TRG_ER_diArg_1	317	319	PF00400	0.658
TRG_ER_diArg_1	36	38	PF00400	0.550
TRG_Pf-PMV_PEXEL_1	12	16	PF00026	0.720
TRG_Pf-PMV_PEXEL_1	323	328	PF00026	0.608
TRG_Pf-PMV_PEXEL_1	420	424	PF00026	0.607

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P724	Leptomonas seymouri	48%	71%
A0A3S7X148	Leishmania donovani	98%	100%
A4HG60	Leishmania braziliensis	60%	100%
E9AZI0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	82%	100%
Q4Q8Q1	Leishmania major	89%	100%