Putative RNA binding protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

RNA binding protein - putative

Species:

Leishmania infantum

UniProt:

A4I389_LEIIN

TriTrypDb:

LINF_280006500

Length:

196

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 8
NetGPI	no	yes: 0, no: 8

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4I389

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4I389

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0003676	nucleic acid binding	3	9
GO:0005488	binding	1	9
GO:0097159	organic cyclic compound binding	2	9
GO:1901363	heterocyclic compound binding	2	9
GO:0003723	RNA binding	4	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	47	51	PF00656	0.741
CLV_NRD_NRD_1	11	13	PF00675	0.512
CLV_NRD_NRD_1	17	19	PF00675	0.505
CLV_NRD_NRD_1	190	192	PF00675	0.573
CLV_NRD_NRD_1	6	8	PF00675	0.549
CLV_NRD_NRD_1	78	80	PF00675	0.502
CLV_PCSK_KEX2_1	10	12	PF00082	0.532
CLV_PCSK_KEX2_1	17	19	PF00082	0.507
CLV_PCSK_KEX2_1	189	191	PF00082	0.577
CLV_PCSK_KEX2_1	82	84	PF00082	0.449
CLV_PCSK_PC1ET2_1	82	84	PF00082	0.548
CLV_PCSK_PC7_1	7	13	PF00082	0.563
CLV_PCSK_SKI1_1	85	89	PF00082	0.422
CLV_PCSK_SKI1_1	99	103	PF00082	0.579
DEG_COP1_1	53	62	PF00400	0.582
DOC_CYCLIN_RxL_1	11	24	PF00134	0.517
DOC_MAPK_gen_1	79	89	PF00069	0.455
DOC_MAPK_MEF2A_6	142	150	PF00069	0.438
LIG_14-3-3_CanoR_1	83	88	PF00244	0.429
LIG_FHA_1	124	130	PF00498	0.580
LIG_FHA_1	84	90	PF00498	0.411
LIG_FHA_2	105	111	PF00498	0.511
LIG_FHA_2	4	10	PF00498	0.608
LIG_FHA_2	45	51	PF00498	0.682
LIG_RPA_C_Fungi	40	52	PF08784	0.520
LIG_SH2_STAP1	118	122	PF00017	0.583
LIG_SH2_STAT3	118	121	PF00017	0.631
LIG_SH2_STAT5	147	150	PF00017	0.493
LIG_SH3_3	54	60	PF00018	0.678
LIG_SUMO_SIM_par_1	106	112	PF11976	0.517
MOD_CK1_1	28	34	PF00069	0.576
MOD_CK1_1	94	100	PF00069	0.497
MOD_CK2_1	3	9	PF00069	0.570
MOD_GlcNHglycan	93	96	PF01048	0.512
MOD_GSK3_1	21	28	PF00069	0.553
MOD_N-GLC_1	28	33	PF02516	0.502
MOD_NEK2_1	104	109	PF00069	0.459
MOD_NEK2_1	146	151	PF00069	0.433
MOD_NEK2_1	21	26	PF00069	0.598
MOD_PKA_2	44	50	PF00069	0.712
MOD_PKB_1	10	18	PF00069	0.595
MOD_Plk_4	104	110	PF00069	0.450
MOD_Plk_4	71	77	PF00069	0.547
MOD_SUMO_rev_2	55	64	PF00179	0.671
TRG_DiLeu_BaEn_4	130	136	PF01217	0.546
TRG_ENDOCYTIC_2	147	150	PF00928	0.496
TRG_ER_diArg_1	10	12	PF00400	0.528
TRG_ER_diArg_1	17	19	PF00400	0.514
TRG_ER_diArg_1	188	191	PF00400	0.568
TRG_Pf-PMV_PEXEL_1	17	22	PF00026	0.569

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A3Q8IEM8	Leishmania donovani	99%	100%
A0A422N4H9	Trypanosoma rangeli	42%	70%
A4HG57	Leishmania braziliensis	77%	100%
D0A7R5	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	40%	67%
E9AZH7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	92%	100%
Q4Q8Q4	Leishmania major	91%	100%
V5BGL1	Trypanosoma cruzi	45%	70%