Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein - conserved

Species:

Leishmania infantum

UniProt:

A4I386_LEIIN

TriTrypDb:

LINF_280006200

Length:

182

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 15
NetGPI	no	yes: 0, no: 15

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	14
GO:0110165	cellular anatomical entity	1	14

Expansion

Sequence features

A4I386

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4I386

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	173	175	PF00675	0.445
CLV_PCSK_KEX2_1	173	175	PF00082	0.487
DOC_CKS1_1	34	39	PF01111	0.313
DOC_MAPK_gen_1	76	86	PF00069	0.480
DOC_MAPK_MEF2A_6	79	88	PF00069	0.490
DOC_USP7_MATH_1	156	160	PF00917	0.669
DOC_WW_Pin1_4	33	38	PF00397	0.412
LIG_14-3-3_CanoR_1	111	115	PF00244	0.261
LIG_14-3-3_CanoR_1	173	179	PF00244	0.696
LIG_14-3-3_CanoR_1	5	9	PF00244	0.588
LIG_Actin_WH2_2	95	113	PF00022	0.410
LIG_EH1_1	15	23	PF00400	0.371
LIG_FHA_1	122	128	PF00498	0.402
LIG_FHA_1	162	168	PF00498	0.629
LIG_FHA_1	72	78	PF00498	0.578
LIG_GBD_Chelix_1	85	93	PF00786	0.449
LIG_LIR_Gen_1	100	110	PF02991	0.369
LIG_LIR_Gen_1	132	142	PF02991	0.389
LIG_LIR_Gen_1	42	50	PF02991	0.318
LIG_LIR_Nem_3	100	106	PF02991	0.308
LIG_LIR_Nem_3	132	137	PF02991	0.391
LIG_LIR_Nem_3	23	27	PF02991	0.393
LIG_LIR_Nem_3	42	47	PF02991	0.331
LIG_NRBOX	76	82	PF00104	0.597
LIG_PCNA_PIPBox_1	138	147	PF02747	0.620
LIG_PDZ_Class_3	177	182	PF00595	0.649
LIG_Pex14_2	131	135	PF04695	0.388
LIG_Pex14_2	144	148	PF04695	0.667
LIG_SH2_CRK	137	141	PF00017	0.550
LIG_SH2_CRK	15	19	PF00017	0.444
LIG_SH2_STAP1	65	69	PF00017	0.547
LIG_SH2_STAT5	27	30	PF00017	0.409
LIG_SH2_STAT5	44	47	PF00017	0.139
LIG_SH3_3	3	9	PF00018	0.473
LIG_SUMO_SIM_par_1	17	23	PF11976	0.376
LIG_SUMO_SIM_par_1	94	100	PF11976	0.365
LIG_TYR_ITIM	13	18	PF00017	0.442
LIG_WRC_WIRS_1	103	108	PF05994	0.443
LIG_WRC_WIRS_1	21	26	PF05994	0.459
MOD_CDK_SPK_2	33	38	PF00069	0.272
MOD_GSK3_1	110	117	PF00069	0.341
MOD_NEK2_1	114	119	PF00069	0.317
MOD_NEK2_1	121	126	PF00069	0.318
MOD_NEK2_1	4	9	PF00069	0.547
MOD_NEK2_1	63	68	PF00069	0.480
MOD_NEK2_1	88	93	PF00069	0.412
MOD_PIKK_1	172	178	PF00454	0.695
MOD_PKA_2	110	116	PF00069	0.263
MOD_PKA_2	172	178	PF00069	0.550
MOD_PKA_2	4	10	PF00069	0.583
MOD_Plk_4	114	120	PF00069	0.311
MOD_Plk_4	130	136	PF00069	0.403
MOD_ProDKin_1	33	39	PF00069	0.412
TRG_DiLeu_BaEn_2	98	104	PF01217	0.443
TRG_DiLeu_BaLyEn_6	76	81	PF01217	0.574
TRG_ENDOCYTIC_2	137	140	PF00928	0.434
TRG_ENDOCYTIC_2	15	18	PF00928	0.447
TRG_ENDOCYTIC_2	27	30	PF00928	0.506
TRG_ENDOCYTIC_2	44	47	PF00928	0.239
TRG_ER_diArg_1	172	174	PF00400	0.686
TRG_Pf-PMV_PEXEL_1	153	157	PF00026	0.492
TRG_Pf-PMV_PEXEL_1	38	42	PF00026	0.532

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1ILT5	Leptomonas seymouri	59%	100%
A0A0N1PC80	Leptomonas seymouri	24%	99%
A0A0S4IY98	Bodo saltans	35%	100%
A0A0S4KLI9	Bodo saltans	24%	76%
A0A1X0NX01	Trypanosomatidae	39%	99%
A0A1X0NXC4	Trypanosomatidae	29%	100%
A0A3Q8IQ96	Leishmania donovani	99%	100%
A0A3R7JVT6	Trypanosoma rangeli	37%	99%
A4HBK6	Leishmania braziliensis	27%	100%
A4HG55	Leishmania braziliensis	70%	100%
E9AZH4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	87%	100%
Q4Q8Q7	Leishmania major	90%	100%
V5B3X7	Trypanosoma cruzi	26%	73%
V5BC06	Trypanosoma cruzi	30%	99%