LeishMANIAdb
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NYD-SP28 domain-containing protein

Quick info Annotations Function or PPIs Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
NYD-SP28 domain-containing protein
Gene product:
dynein regulatory complex subunit - putative
Species:
Leishmania infantum
UniProt:
A4I378_LEIIN
TriTrypDb:
LINF_280005400
Length:
488

Annotations

Annotations by Jardim et al.

Structural Proteins, dynein regulatory complex subunit Uncharacterized

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 5
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 11
NetGPI no yes: 0, no: 11
Cellular components
Term Name Level Count
GO:0005858 axonemal dynein complex 4 12
GO:0005875 microtubule associated complex 2 12
GO:0030286 dynein complex 3 12
GO:0032991 protein-containing complex 1 12
GO:1902494 catalytic complex 2 12
GO:0005737 cytoplasm 2 1
GO:0005929 cilium 4 3
GO:0005930 axoneme 2 1
GO:0042995 cell projection 2 3
GO:0043226 organelle 2 3
GO:0043227 membrane-bounded organelle 3 3
GO:0110165 cellular anatomical entity 1 3
GO:0120025 plasma membrane bounded cell projection 3 3
GO:0031514 motile cilium 5 2

Expansion

Sequence features

A4I378
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4I378

Function

Biological processes
Term Name Level Count
GO:0009987 cellular process 1 12
GO:0016043 cellular component organization 3 12
GO:0022607 cellular component assembly 4 12
GO:0043933 protein-containing complex organization 4 12
GO:0065003 protein-containing complex assembly 5 12
GO:0070286 axonemal dynein complex assembly 6 12
GO:0071840 cellular component organization or biogenesis 2 12
GO:0001539 cilium or flagellum-dependent cell motility 3 1
GO:0003352 regulation of cilium movement 6 1
GO:0032886 regulation of microtubule-based process 4 1
GO:0048870 cell motility 2 1
GO:0050789 regulation of biological process 2 1
GO:0050794 regulation of cellular process 3 1
GO:0060285 cilium-dependent cell motility 4 1
GO:0060632 regulation of microtubule-based movement 5 1
GO:0065007 biological regulation 1 1
Could not find GO molecular_function term for this entry.

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 374 378 PF00656 0.637
CLV_NRD_NRD_1 239 241 PF00675 0.513
CLV_NRD_NRD_1 358 360 PF00675 0.623
CLV_NRD_NRD_1 62 64 PF00675 0.260
CLV_NRD_NRD_1 70 72 PF00675 0.256
CLV_NRD_NRD_1 8 10 PF00675 0.220
CLV_PCSK_KEX2_1 164 166 PF00082 0.466
CLV_PCSK_KEX2_1 318 320 PF00082 0.520
CLV_PCSK_KEX2_1 357 359 PF00082 0.500
CLV_PCSK_KEX2_1 62 64 PF00082 0.268
CLV_PCSK_KEX2_1 8 10 PF00082 0.233
CLV_PCSK_PC1ET2_1 164 166 PF00082 0.466
CLV_PCSK_PC1ET2_1 318 320 PF00082 0.520
CLV_PCSK_PC1ET2_1 357 359 PF00082 0.500
CLV_PCSK_SKI1_1 149 153 PF00082 0.433
CLV_PCSK_SKI1_1 258 262 PF00082 0.461
CLV_PCSK_SKI1_1 274 278 PF00082 0.408
CLV_PCSK_SKI1_1 282 286 PF00082 0.420
CLV_PCSK_SKI1_1 398 402 PF00082 0.387
CLV_PCSK_SKI1_1 410 414 PF00082 0.384
CLV_PCSK_SKI1_1 91 95 PF00082 0.230
CLV_Separin_Metazoa 59 63 PF03568 0.423
DEG_APCC_DBOX_1 148 156 PF00400 0.542
DEG_Nend_UBRbox_1 1 4 PF02207 0.471
DOC_ANK_TNKS_1 358 365 PF00023 0.441
DOC_CYCLIN_RxL_1 318 328 PF00134 0.395
DOC_CYCLIN_RxL_1 407 416 PF00134 0.512
DOC_CYCLIN_RxL_1 8 18 PF00134 0.521
DOC_MAPK_gen_1 318 329 PF00069 0.423
DOC_MAPK_gen_1 8 16 PF00069 0.431
DOC_SPAK_OSR1_1 391 395 PF12202 0.482
DOC_USP7_MATH_1 3 7 PF00917 0.537
DOC_USP7_MATH_1 362 366 PF00917 0.567
DOC_USP7_MATH_1 460 464 PF00917 0.658
DOC_USP7_MATH_1 93 97 PF00917 0.473
DOC_USP7_UBL2_3 283 287 PF12436 0.471
LIG_14-3-3_CanoR_1 439 445 PF00244 0.621
LIG_14-3-3_CanoR_1 62 66 PF00244 0.504
LIG_Actin_WH2_2 135 151 PF00022 0.519
LIG_Actin_WH2_2 178 195 PF00022 0.575
LIG_APCC_ABBA_1 105 110 PF00400 0.336
LIG_BIR_III_2 377 381 PF00653 0.574
LIG_deltaCOP1_diTrp_1 384 393 PF00928 0.424
LIG_deltaCOP1_diTrp_1 39 45 PF00928 0.430
LIG_FHA_1 110 116 PF00498 0.527
LIG_FHA_1 230 236 PF00498 0.540
LIG_FHA_1 441 447 PF00498 0.517
LIG_FHA_1 75 81 PF00498 0.486
LIG_FHA_2 174 180 PF00498 0.562
LIG_FHA_2 333 339 PF00498 0.425
LIG_FHA_2 76 82 PF00498 0.544
LIG_LIR_Gen_1 384 394 PF02991 0.519
LIG_LIR_Gen_1 39 46 PF02991 0.430
LIG_LIR_Nem_3 204 210 PF02991 0.443
LIG_LIR_Nem_3 384 389 PF02991 0.513
LIG_LIR_Nem_3 39 45 PF02991 0.430
LIG_PCNA_PIPBox_1 421 430 PF02747 0.418
LIG_PCNA_yPIPBox_3 11 24 PF02747 0.414
LIG_PCNA_yPIPBox_3 410 424 PF02747 0.411
LIG_SH2_NCK_1 132 136 PF00017 0.528
LIG_SH2_NCK_1 469 473 PF00017 0.649
LIG_SH2_STAT5 221 224 PF00017 0.575
LIG_SH2_STAT5 427 430 PF00017 0.415
LIG_SUMO_SIM_anti_2 57 62 PF11976 0.442
LIG_SUMO_SIM_par_1 441 447 PF11976 0.504
LIG_TRAF2_1 308 311 PF00917 0.548
LIG_UBA3_1 323 331 PF00899 0.406
MOD_CK1_1 248 254 PF00069 0.398
MOD_CK2_1 173 179 PF00069 0.561
MOD_CK2_1 332 338 PF00069 0.437
MOD_CK2_1 75 81 PF00069 0.507
MOD_GlcNHglycan 34 37 PF01048 0.328
MOD_GlcNHglycan 348 351 PF01048 0.603
MOD_GlcNHglycan 373 376 PF01048 0.671
MOD_GSK3_1 247 254 PF00069 0.441
MOD_GSK3_1 28 35 PF00069 0.438
MOD_GSK3_1 440 447 PF00069 0.566
MOD_GSK3_1 61 68 PF00069 0.504
MOD_N-GLC_1 306 311 PF02516 0.520
MOD_N-GLC_1 345 350 PF02516 0.552
MOD_NEK2_1 15 20 PF00069 0.516
MOD_NEK2_1 210 215 PF00069 0.412
MOD_NEK2_1 245 250 PF00069 0.407
MOD_NEK2_1 313 318 PF00069 0.457
MOD_NEK2_1 438 443 PF00069 0.505
MOD_NEK2_1 444 449 PF00069 0.498
MOD_NEK2_1 75 80 PF00069 0.473
MOD_PIKK_1 404 410 PF00454 0.399
MOD_PIKK_1 444 450 PF00454 0.563
MOD_PKA_2 438 444 PF00069 0.599
MOD_PKA_2 61 67 PF00069 0.504
MOD_Plk_1 274 280 PF00069 0.440
MOD_Plk_1 429 435 PF00069 0.465
MOD_Plk_1 461 467 PF00069 0.674
MOD_Plk_1 65 71 PF00069 0.501
MOD_Plk_1 81 87 PF00069 0.489
MOD_Plk_2-3 429 435 PF00069 0.497
MOD_Plk_2-3 81 87 PF00069 0.521
MOD_Plk_4 100 106 PF00069 0.543
MOD_Plk_4 440 446 PF00069 0.525
MOD_Plk_4 461 467 PF00069 0.586
MOD_Plk_4 75 81 PF00069 0.480
MOD_SUMO_rev_2 133 142 PF00179 0.483
TRG_DiLeu_BaEn_2 472 478 PF01217 0.592
TRG_DiLeu_BaEn_4 415 421 PF01217 0.395
TRG_DiLeu_BaLyEn_6 146 151 PF01217 0.512
TRG_DiLeu_BaLyEn_6 319 324 PF01217 0.520
TRG_ENDOCYTIC_2 207 210 PF00928 0.445
TRG_ENDOCYTIC_2 469 472 PF00928 0.548
TRG_ER_diArg_1 358 360 PF00400 0.620
TRG_ER_diArg_1 61 63 PF00400 0.442
TRG_ER_diArg_1 8 11 PF00400 0.429
TRG_NES_CRM1_1 422 435 PF08389 0.546
TRG_Pf-PMV_PEXEL_1 149 153 PF00026 0.463
TRG_Pf-PMV_PEXEL_1 164 168 PF00026 0.480
TRG_Pf-PMV_PEXEL_1 297 301 PF00026 0.527
TRG_Pf-PMV_PEXEL_1 410 414 PF00026 0.477
TRG_Pf-PMV_PEXEL_1 418 422 PF00026 0.468
TRG_Pf-PMV_PEXEL_1 44 48 PF00026 0.290
TRG_Pf-PMV_PEXEL_1 52 57 PF00026 0.303

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N1I5X5 Leptomonas seymouri 74% 95%
A0A0S4J2B0 Bodo saltans 49% 94%
A0A1X0NVC5 Trypanosomatidae 53% 96%
A0A3Q8IHV5 Leishmania donovani 100% 100%
A0A3R7MHP0 Trypanosoma rangeli 53% 96%
A4HG48 Leishmania braziliensis 81% 100%
A8JB22 Chlamydomonas reinhardtii 28% 85%
D0A7Q6 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 50% 96%
E9AZG6 Leishmania mexicana (strain MHOM/GT/2001/U1103) 93% 100%
Q2TA16 Bos taurus 30% 98%
Q4Q8R5 Leishmania major 95% 100%
Q4R7G7 Macaca fascicularis 29% 100%
Q5XIJ8 Rattus norvegicus 29% 97%
Q6DHI2 Danio rerio 26% 99%
Q8IXS2 Homo sapiens 30% 100%
Q8VHI7 Mus musculus 29% 99%
V5AS08 Trypanosoma cruzi 52% 95%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS