LeishMANIAdb
  • Home
  • Browse
  • Manual
  • FAQ
  • Download

TPR_REGION domain-containing protein

Quick info Annotations Function or PPIs Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:
TPR_REGION domain-containing protein
Gene product:
hypothetical protein - conserved
Species:
Leishmania infantum
UniProt:
A4I377_LEIIN
TriTrypDb:
LINF_280005300
Length:
902

Annotations

Annotations by Jardim et al.

Uncharacterized Protein, Uncharacterized

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 11
NetGPI no yes: 0, no: 11
Cellular components
Term Name Level Count
GO:0005737 cytoplasm 2 1
GO:0110165 cellular anatomical entity 1 1

Expansion

Sequence features

A4I377
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4I377

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 795 799 PF00656 0.445
CLV_NRD_NRD_1 194 196 PF00675 0.610
CLV_NRD_NRD_1 263 265 PF00675 0.524
CLV_NRD_NRD_1 317 319 PF00675 0.392
CLV_NRD_NRD_1 354 356 PF00675 0.446
CLV_NRD_NRD_1 371 373 PF00675 0.327
CLV_NRD_NRD_1 453 455 PF00675 0.481
CLV_NRD_NRD_1 488 490 PF00675 0.411
CLV_NRD_NRD_1 607 609 PF00675 0.374
CLV_NRD_NRD_1 760 762 PF00675 0.511
CLV_NRD_NRD_1 897 899 PF00675 0.569
CLV_PCSK_KEX2_1 114 116 PF00082 0.607
CLV_PCSK_KEX2_1 263 265 PF00082 0.534
CLV_PCSK_KEX2_1 354 356 PF00082 0.442
CLV_PCSK_KEX2_1 488 490 PF00082 0.394
CLV_PCSK_KEX2_1 52 54 PF00082 0.571
CLV_PCSK_KEX2_1 760 762 PF00082 0.494
CLV_PCSK_KEX2_1 897 899 PF00082 0.557
CLV_PCSK_PC1ET2_1 114 116 PF00082 0.607
CLV_PCSK_PC1ET2_1 52 54 PF00082 0.559
CLV_PCSK_PC1ET2_1 897 899 PF00082 0.557
CLV_PCSK_PC7_1 350 356 PF00082 0.584
CLV_PCSK_PC7_1 484 490 PF00082 0.461
CLV_PCSK_SKI1_1 159 163 PF00082 0.562
CLV_PCSK_SKI1_1 17 21 PF00082 0.431
CLV_PCSK_SKI1_1 195 199 PF00082 0.584
CLV_PCSK_SKI1_1 263 267 PF00082 0.581
CLV_PCSK_SKI1_1 302 306 PF00082 0.508
CLV_PCSK_SKI1_1 355 359 PF00082 0.393
CLV_PCSK_SKI1_1 402 406 PF00082 0.492
CLV_PCSK_SKI1_1 422 426 PF00082 0.403
CLV_PCSK_SKI1_1 463 467 PF00082 0.444
CLV_PCSK_SKI1_1 489 493 PF00082 0.442
CLV_PCSK_SKI1_1 573 577 PF00082 0.545
CLV_PCSK_SKI1_1 608 612 PF00082 0.361
CLV_PCSK_SKI1_1 701 705 PF00082 0.453
CLV_PCSK_SKI1_1 760 764 PF00082 0.529
CLV_PCSK_SKI1_1 805 809 PF00082 0.340
CLV_Separin_Metazoa 586 590 PF03568 0.519
DEG_APCC_DBOX_1 354 362 PF00400 0.512
DEG_APCC_DBOX_1 401 409 PF00400 0.372
DEG_APCC_DBOX_1 488 496 PF00400 0.437
DEG_APCC_DBOX_1 607 615 PF00400 0.363
DEG_APCC_DBOX_1 655 663 PF00400 0.463
DEG_SCF_FBW7_1 177 184 PF00400 0.504
DEG_SCF_FBW7_2 145 152 PF00400 0.577
DOC_CKS1_1 178 183 PF01111 0.504
DOC_CKS1_1 73 78 PF01111 0.644
DOC_CYCLIN_RxL_1 14 22 PF00134 0.418
DOC_CYCLIN_RxL_1 299 309 PF00134 0.405
DOC_CYCLIN_RxL_1 350 362 PF00134 0.445
DOC_CYCLIN_RxL_1 484 496 PF00134 0.527
DOC_CYCLIN_RxL_1 698 708 PF00134 0.500
DOC_MAPK_gen_1 114 123 PF00069 0.672
DOC_MAPK_gen_1 195 205 PF00069 0.547
DOC_MAPK_gen_1 372 378 PF00069 0.497
DOC_MAPK_gen_1 396 405 PF00069 0.488
DOC_MAPK_gen_1 91 98 PF00069 0.589
DOC_MAPK_MEF2A_6 114 123 PF00069 0.653
DOC_MAPK_MEF2A_6 195 203 PF00069 0.548
DOC_MAPK_MEF2A_6 91 98 PF00069 0.541
DOC_PP1_RVXF_1 15 21 PF00149 0.431
DOC_PP1_RVXF_1 285 291 PF00149 0.547
DOC_PP1_RVXF_1 640 647 PF00149 0.489
DOC_PP2B_LxvP_1 121 124 PF13499 0.707
DOC_PP4_MxPP_1 1 4 PF00568 0.646
DOC_USP7_MATH_1 181 185 PF00917 0.672
DOC_USP7_MATH_1 221 225 PF00917 0.646
DOC_USP7_MATH_1 306 310 PF00917 0.519
DOC_USP7_MATH_1 325 329 PF00917 0.321
DOC_USP7_MATH_1 424 428 PF00917 0.522
DOC_USP7_MATH_1 459 463 PF00917 0.416
DOC_USP7_MATH_1 678 682 PF00917 0.618
DOC_USP7_MATH_1 727 731 PF00917 0.543
DOC_USP7_UBL2_3 893 897 PF12436 0.419
DOC_WD40_RPTOR_TOS_1 237 243 PF00400 0.381
DOC_WW_Pin1_4 103 108 PF00397 0.750
DOC_WW_Pin1_4 143 148 PF00397 0.621
DOC_WW_Pin1_4 177 182 PF00397 0.713
DOC_WW_Pin1_4 189 194 PF00397 0.662
DOC_WW_Pin1_4 676 681 PF00397 0.510
DOC_WW_Pin1_4 72 77 PF00397 0.638
LIG_14-3-3_CanoR_1 263 268 PF00244 0.577
LIG_14-3-3_CanoR_1 283 287 PF00244 0.423
LIG_14-3-3_CanoR_1 326 332 PF00244 0.443
LIG_14-3-3_CanoR_1 463 471 PF00244 0.501
LIG_14-3-3_CanoR_1 488 492 PF00244 0.497
LIG_14-3-3_CanoR_1 493 501 PF00244 0.524
LIG_14-3-3_CanoR_1 573 578 PF00244 0.396
LIG_14-3-3_CanoR_1 663 669 PF00244 0.508
LIG_Actin_WH2_2 574 591 PF00022 0.457
LIG_Actin_WH2_2 637 655 PF00022 0.502
LIG_APCC_ABBA_1 853 858 PF00400 0.418
LIG_CtBP_PxDLS_1 124 128 PF00389 0.606
LIG_deltaCOP1_diTrp_1 848 856 PF00928 0.470
LIG_FHA_1 178 184 PF00498 0.705
LIG_FHA_1 283 289 PF00498 0.602
LIG_FHA_1 380 386 PF00498 0.435
LIG_FHA_1 516 522 PF00498 0.497
LIG_FHA_1 525 531 PF00498 0.508
LIG_FHA_1 582 588 PF00498 0.446
LIG_FHA_1 686 692 PF00498 0.533
LIG_FHA_1 789 795 PF00498 0.419
LIG_FHA_1 799 805 PF00498 0.292
LIG_FHA_1 850 856 PF00498 0.369
LIG_FHA_1 871 877 PF00498 0.442
LIG_FHA_1 883 889 PF00498 0.349
LIG_FHA_2 103 109 PF00498 0.623
LIG_FHA_2 111 117 PF00498 0.617
LIG_FHA_2 131 137 PF00498 0.615
LIG_FHA_2 146 152 PF00498 0.564
LIG_FHA_2 213 219 PF00498 0.570
LIG_FHA_2 390 396 PF00498 0.431
LIG_FHA_2 747 753 PF00498 0.359
LIG_FHA_2 790 796 PF00498 0.418
LIG_IRF3_LxIS_1 837 842 PF10401 0.452
LIG_LIR_Gen_1 503 511 PF02991 0.365
LIG_LIR_Gen_1 666 677 PF02991 0.563
LIG_LIR_Gen_1 752 762 PF02991 0.379
LIG_LIR_Nem_3 386 391 PF02991 0.421
LIG_LIR_Nem_3 503 509 PF02991 0.363
LIG_LIR_Nem_3 553 558 PF02991 0.476
LIG_LIR_Nem_3 666 672 PF02991 0.449
LIG_PCNA_yPIPBox_3 165 178 PF02747 0.458
LIG_PCNA_yPIPBox_3 556 568 PF02747 0.381
LIG_Pex14_2 384 388 PF04695 0.491
LIG_SH2_STAP1 39 43 PF00017 0.476
LIG_SH2_STAP1 506 510 PF00017 0.359
LIG_SH2_STAP1 685 689 PF00017 0.473
LIG_SH2_STAP1 754 758 PF00017 0.277
LIG_SH2_STAT3 39 42 PF00017 0.477
LIG_SH2_STAT5 802 805 PF00017 0.472
LIG_SH3_2 73 78 PF14604 0.686
LIG_SH3_2 99 104 PF14604 0.624
LIG_SH3_3 137 143 PF00018 0.600
LIG_SH3_3 175 181 PF00018 0.580
LIG_SH3_3 2 8 PF00018 0.686
LIG_SH3_3 70 76 PF00018 0.685
LIG_SH3_3 741 747 PF00018 0.467
LIG_SH3_3 827 833 PF00018 0.436
LIG_SH3_3 96 102 PF00018 0.610
LIG_Sin3_3 475 482 PF02671 0.367
LIG_SUMO_SIM_anti_2 439 444 PF11976 0.482
LIG_SUMO_SIM_anti_2 730 736 PF11976 0.381
LIG_SUMO_SIM_par_1 435 441 PF11976 0.559
LIG_SUMO_SIM_par_1 94 100 PF11976 0.638
LIG_TRAF2_1 149 152 PF00917 0.697
LIG_TRAF2_1 392 395 PF00917 0.376
LIG_TRAF2_1 583 586 PF00917 0.548
LIG_WRC_WIRS_1 127 132 PF05994 0.503
LIG_WRC_WIRS_1 314 319 PF05994 0.390
MOD_CDC14_SPxK_1 192 195 PF00782 0.552
MOD_CDK_SPxK_1 103 109 PF00069 0.527
MOD_CDK_SPxK_1 189 195 PF00069 0.555
MOD_CDK_SPxK_1 72 78 PF00069 0.565
MOD_CDK_SPxxK_3 189 196 PF00069 0.553
MOD_CDK_SPxxK_3 676 683 PF00069 0.481
MOD_CK1_1 126 132 PF00069 0.599
MOD_CK1_1 138 144 PF00069 0.604
MOD_CK1_1 341 347 PF00069 0.587
MOD_CK1_1 379 385 PF00069 0.454
MOD_CK1_1 670 676 PF00069 0.621
MOD_CK1_1 679 685 PF00069 0.568
MOD_CK1_1 696 702 PF00069 0.380
MOD_CK1_1 730 736 PF00069 0.406
MOD_CK1_1 774 780 PF00069 0.482
MOD_CK1_1 842 848 PF00069 0.410
MOD_CK1_1 862 868 PF00069 0.379
MOD_CK1_1 870 876 PF00069 0.459
MOD_CK2_1 102 108 PF00069 0.686
MOD_CK2_1 110 116 PF00069 0.680
MOD_CK2_1 130 136 PF00069 0.612
MOD_CK2_1 145 151 PF00069 0.578
MOD_CK2_1 32 38 PF00069 0.635
MOD_CK2_1 389 395 PF00069 0.466
MOD_CK2_1 430 436 PF00069 0.509
MOD_CK2_1 461 467 PF00069 0.444
MOD_CK2_1 626 632 PF00069 0.438
MOD_CK2_1 789 795 PF00069 0.488
MOD_DYRK1A_RPxSP_1 72 76 PF00069 0.523
MOD_GlcNHglycan 140 143 PF01048 0.668
MOD_GlcNHglycan 183 186 PF01048 0.528
MOD_GlcNHglycan 21 24 PF01048 0.389
MOD_GlcNHglycan 223 226 PF01048 0.653
MOD_GlcNHglycan 308 311 PF01048 0.505
MOD_GlcNHglycan 327 330 PF01048 0.307
MOD_GlcNHglycan 343 346 PF01048 0.406
MOD_GlcNHglycan 378 381 PF01048 0.433
MOD_GlcNHglycan 432 435 PF01048 0.529
MOD_GlcNHglycan 467 470 PF01048 0.570
MOD_GlcNHglycan 480 483 PF01048 0.543
MOD_GlcNHglycan 694 698 PF01048 0.514
MOD_GlcNHglycan 728 732 PF01048 0.412
MOD_GlcNHglycan 80 83 PF01048 0.742
MOD_GlcNHglycan 844 847 PF01048 0.419
MOD_GlcNHglycan 864 867 PF01048 0.253
MOD_GlcNHglycan 9 12 PF01048 0.532
MOD_GSK3_1 110 117 PF00069 0.701
MOD_GSK3_1 126 133 PF00069 0.627
MOD_GSK3_1 177 184 PF00069 0.645
MOD_GSK3_1 231 238 PF00069 0.485
MOD_GSK3_1 282 289 PF00069 0.508
MOD_GSK3_1 334 341 PF00069 0.507
MOD_GSK3_1 379 386 PF00069 0.408
MOD_GSK3_1 426 433 PF00069 0.561
MOD_GSK3_1 459 466 PF00069 0.392
MOD_GSK3_1 483 490 PF00069 0.511
MOD_GSK3_1 626 633 PF00069 0.361
MOD_GSK3_1 764 771 PF00069 0.377
MOD_GSK3_1 835 842 PF00069 0.397
MOD_LATS_1 571 577 PF00433 0.396
MOD_N-GLC_1 515 520 PF02516 0.414
MOD_N-GLC_1 630 635 PF02516 0.564
MOD_N-GLC_1 764 769 PF02516 0.334
MOD_N-GLC_1 798 803 PF02516 0.390
MOD_NEK2_1 130 135 PF00069 0.663
MOD_NEK2_1 19 24 PF00069 0.442
MOD_NEK2_1 282 287 PF00069 0.584
MOD_NEK2_1 32 37 PF00069 0.550
MOD_NEK2_1 376 381 PF00069 0.405
MOD_NEK2_1 443 448 PF00069 0.433
MOD_NEK2_1 465 470 PF00069 0.515
MOD_NEK2_1 626 631 PF00069 0.427
MOD_NEK2_1 788 793 PF00069 0.510
MOD_NEK2_1 839 844 PF00069 0.413
MOD_NEK2_1 859 864 PF00069 0.315
MOD_NEK2_2 313 318 PF00069 0.369
MOD_NEK2_2 849 854 PF00069 0.420
MOD_PIKK_1 443 449 PF00454 0.553
MOD_PIKK_1 870 876 PF00454 0.389
MOD_PKA_1 114 120 PF00069 0.498
MOD_PKA_1 263 269 PF00069 0.663
MOD_PKA_2 114 120 PF00069 0.595
MOD_PKA_2 263 269 PF00069 0.545
MOD_PKA_2 282 288 PF00069 0.428
MOD_PKA_2 325 331 PF00069 0.531
MOD_PKA_2 443 449 PF00069 0.475
MOD_PKA_2 483 489 PF00069 0.515
MOD_PKA_2 662 668 PF00069 0.521
MOD_PKA_2 670 676 PF00069 0.595
MOD_Plk_1 135 141 PF00069 0.734
MOD_Plk_1 292 298 PF00069 0.557
MOD_Plk_1 438 444 PF00069 0.441
MOD_Plk_1 501 507 PF00069 0.416
MOD_Plk_1 630 636 PF00069 0.372
MOD_Plk_1 764 770 PF00069 0.424
MOD_Plk_1 789 795 PF00069 0.491
MOD_Plk_1 798 804 PF00069 0.438
MOD_Plk_1 85 91 PF00069 0.644
MOD_Plk_2-3 790 796 PF00069 0.382
MOD_Plk_4 438 444 PF00069 0.412
MOD_Plk_4 501 507 PF00069 0.416
MOD_Plk_4 687 693 PF00069 0.638
MOD_Plk_4 720 726 PF00069 0.487
MOD_Plk_4 730 736 PF00069 0.357
MOD_Plk_4 768 774 PF00069 0.343
MOD_Plk_4 777 783 PF00069 0.349
MOD_Plk_4 798 804 PF00069 0.346
MOD_Plk_4 867 873 PF00069 0.486
MOD_ProDKin_1 103 109 PF00069 0.753
MOD_ProDKin_1 143 149 PF00069 0.622
MOD_ProDKin_1 177 183 PF00069 0.714
MOD_ProDKin_1 189 195 PF00069 0.663
MOD_ProDKin_1 676 682 PF00069 0.507
MOD_ProDKin_1 72 78 PF00069 0.642
MOD_SUMO_for_1 725 728 PF00179 0.441
MOD_SUMO_for_1 889 892 PF00179 0.465
MOD_SUMO_rev_2 151 161 PF00179 0.631
TRG_DiLeu_BaEn_4 260 266 PF01217 0.507
TRG_DiLeu_BaEn_4 394 400 PF01217 0.424
TRG_DiLeu_BaEn_4 418 424 PF01217 0.476
TRG_DiLeu_BaLyEn_6 91 96 PF01217 0.553
TRG_ENDOCYTIC_2 506 509 PF00928 0.361
TRG_ENDOCYTIC_2 754 757 PF00928 0.339
TRG_ER_diArg_1 263 265 PF00400 0.616
TRG_ER_diArg_1 353 355 PF00400 0.458
TRG_ER_diArg_1 487 489 PF00400 0.414
TRG_ER_diArg_1 760 762 PF00400 0.431
TRG_ER_diLys_1 897 902 PF00400 0.477
TRG_NES_CRM1_1 694 708 PF08389 0.510
TRG_NLS_MonoCore_2 896 901 PF00514 0.506
TRG_NLS_MonoExtC_3 194 199 PF00514 0.683
TRG_NLS_MonoExtC_3 896 901 PF00514 0.506
TRG_NLS_MonoExtN_4 193 199 PF00514 0.657
TRG_NLS_MonoExtN_4 897 902 PF00514 0.526
TRG_Pf-PMV_PEXEL_1 299 303 PF00026 0.495
TRG_Pf-PMV_PEXEL_1 355 359 PF00026 0.447
TRG_Pf-PMV_PEXEL_1 463 467 PF00026 0.479
TRG_Pf-PMV_PEXEL_1 489 494 PF00026 0.472
TRG_Pf-PMV_PEXEL_1 528 533 PF00026 0.409

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N1PF72 Leptomonas seymouri 59% 98%
A0A0S4J1J7 Bodo saltans 29% 85%
A0A1X0NWQ3 Trypanosomatidae 35% 96%
A0A3Q8ICX2 Leishmania donovani 99% 100%
A0A3R7LZ16 Trypanosoma rangeli 36% 95%
A4HG47 Leishmania braziliensis 74% 100%
D0A7Q3 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 34% 95%
E9AZG5 Leishmania mexicana (strain MHOM/GT/2001/U1103) 89% 100%
Q4Q8R6 Leishmania major 91% 100%
V5BBZ0 Trypanosoma cruzi 36% 95%

Download

Download
LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS