LeishMANIAdb
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TM1586_NiRdase domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:
TM1586_NiRdase domain-containing protein
Gene product:
hypothetical protein - conserved
Species:
Leishmania infantum
UniProt:
A4I375_LEIIN
TriTrypDb:
LINF_280005100
Length:
133

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 9
NetGPI no yes: 0, no: 9
Cellular components
Term Name Level Count
GO:0005741 mitochondrial outer membrane 5 1
GO:0016020 membrane 2 1
GO:0019867 outer membrane 3 1
GO:0031090 organelle membrane 3 1
GO:0031966 mitochondrial membrane 4 1
GO:0031968 organelle outer membrane 4 1
GO:0098588 bounding membrane of organelle 4 1
GO:0110165 cellular anatomical entity 1 1

Expansion

Sequence features

A4I375
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4I375

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_NRD_NRD_1 11 13 PF00675 0.405
CLV_NRD_NRD_1 120 122 PF00675 0.678
CLV_NRD_NRD_1 72 74 PF00675 0.432
CLV_PCSK_FUR_1 9 13 PF00082 0.459
CLV_PCSK_KEX2_1 11 13 PF00082 0.405
CLV_PCSK_KEX2_1 119 121 PF00082 0.669
CLV_PCSK_PC1ET2_1 119 121 PF00082 0.620
CLV_PCSK_SKI1_1 116 120 PF00082 0.495
CLV_PCSK_SKI1_1 51 55 PF00082 0.473
DEG_Nend_UBRbox_2 1 3 PF02207 0.407
DOC_CYCLIN_RxL_1 96 106 PF00134 0.495
DOC_MAPK_DCC_7 54 63 PF00069 0.411
DOC_PP1_RVXF_1 97 104 PF00149 0.408
DOC_PP2B_LxvP_1 22 25 PF13499 0.520
DOC_USP7_MATH_1 25 29 PF00917 0.515
LIG_14-3-3_CanoR_1 120 124 PF00244 0.613
LIG_14-3-3_CanoR_1 41 46 PF00244 0.463
LIG_FHA_1 42 48 PF00498 0.445
LIG_LIR_Gen_1 5 13 PF02991 0.396
LIG_LIR_Nem_3 17 23 PF02991 0.412
LIG_LIR_Nem_3 5 10 PF02991 0.391
LIG_LIR_Nem_3 87 92 PF02991 0.516
LIG_PCNA_PIPBox_1 1 10 PF02747 0.392
LIG_Pex14_1 98 102 PF04695 0.372
LIG_PTB_Apo_2 83 90 PF02174 0.490
LIG_SH2_CRK 20 24 PF00017 0.471
LIG_SH2_SRC 57 60 PF00017 0.452
LIG_SH2_STAT5 102 105 PF00017 0.375
LIG_SH2_STAT5 57 60 PF00017 0.435
LIG_SUMO_SIM_par_1 43 49 PF11976 0.339
MOD_GlcNHglycan 86 89 PF01048 0.505
MOD_NEK2_1 84 89 PF00069 0.549
MOD_PKA_1 119 125 PF00069 0.645
MOD_PKA_2 119 125 PF00069 0.603
MOD_Plk_4 41 47 PF00069 0.481
MOD_SUMO_rev_2 100 109 PF00179 0.537
TRG_DiLeu_BaEn_1 18 23 PF01217 0.508
TRG_DiLeu_BaEn_4 5 11 PF01217 0.413
TRG_ENDOCYTIC_2 20 23 PF00928 0.414
TRG_ER_diArg_1 8 11 PF00400 0.385
TRG_NLS_MonoExtN_4 116 123 PF00514 0.632

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N0P725 Leptomonas seymouri 83% 100%
A0A0S4J1U2 Bodo saltans 58% 100%
A0A1X0NVA8 Trypanosomatidae 78% 100%
A0A3S7X152 Leishmania donovani 100% 100%
A4HG45 Leishmania braziliensis 86% 100%
D0A7Q1 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 72% 100%
E9AZG3 Leishmania mexicana (strain MHOM/GT/2001/U1103) 96% 100%
Q4Q8R8 Leishmania major 95% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS