Class I SAM-dependent methyltransferase

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein - conserved

Species:

Leishmania infantum

UniProt:

A4I374_LEIIN

TriTrypDb:

LINF_280005000

Length:

550

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4I374

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4I374

Function

Biological processes
Term	Name	Level	Count
GO:0006793	phosphorus metabolic process	3	3
GO:0006796	phosphate-containing compound metabolic process	4	3
GO:0008152	metabolic process	1	3
GO:0009987	cellular process	1	3
GO:0016310	phosphorylation	5	3
GO:0044237	cellular metabolic process	2	3

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	3
GO:0016301	kinase activity	4	3
GO:0016740	transferase activity	2	3
GO:0016772	transferase activity, transferring phosphorus-containing groups	3	3

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	113	117	PF00656	0.500
CLV_C14_Caspase3-7	41	45	PF00656	0.435
CLV_NRD_NRD_1	105	107	PF00675	0.382
CLV_NRD_NRD_1	141	143	PF00675	0.504
CLV_NRD_NRD_1	15	17	PF00675	0.564
CLV_NRD_NRD_1	2	4	PF00675	0.673
CLV_NRD_NRD_1	261	263	PF00675	0.421
CLV_NRD_NRD_1	293	295	PF00675	0.523
CLV_NRD_NRD_1	376	378	PF00675	0.394
CLV_NRD_NRD_1	410	412	PF00675	0.555
CLV_NRD_NRD_1	512	514	PF00675	0.602
CLV_NRD_NRD_1	545	547	PF00675	0.705
CLV_PCSK_KEX2_1	105	107	PF00082	0.382
CLV_PCSK_KEX2_1	141	143	PF00082	0.400
CLV_PCSK_KEX2_1	15	17	PF00082	0.558
CLV_PCSK_KEX2_1	2	4	PF00082	0.540
CLV_PCSK_KEX2_1	376	378	PF00082	0.394
CLV_PCSK_KEX2_1	410	412	PF00082	0.482
CLV_PCSK_KEX2_1	51	53	PF00082	0.509
CLV_PCSK_KEX2_1	544	546	PF00082	0.647
CLV_PCSK_PC1ET2_1	410	412	PF00082	0.482
CLV_PCSK_PC1ET2_1	51	53	PF00082	0.509
CLV_PCSK_PC7_1	101	107	PF00082	0.373
CLV_PCSK_PC7_1	540	546	PF00082	0.653
CLV_PCSK_SKI1_1	15	19	PF00082	0.509
CLV_PCSK_SKI1_1	181	185	PF00082	0.515
CLV_PCSK_SKI1_1	457	461	PF00082	0.539
CLV_PCSK_SKI1_1	540	544	PF00082	0.524
CLV_PCSK_SKI1_1	96	100	PF00082	0.480
DEG_APCC_DBOX_1	2	10	PF00400	0.633
DEG_APCC_DBOX_1	28	36	PF00400	0.435
DEG_APCC_DBOX_1	413	421	PF00400	0.364
DEG_Nend_UBRbox_1	1	4	PF02207	0.590
DOC_CKS1_1	384	389	PF01111	0.511
DOC_CYCLIN_RxL_1	10	23	PF00134	0.581
DOC_CYCLIN_RxL_1	222	233	PF00134	0.437
DOC_CYCLIN_yCln2_LP_2	179	185	PF00134	0.549
DOC_CYCLIN_yCln2_LP_2	190	196	PF00134	0.443
DOC_MAPK_gen_1	267	276	PF00069	0.454
DOC_MAPK_gen_1	294	303	PF00069	0.394
DOC_MAPK_gen_1	373	381	PF00069	0.396
DOC_MAPK_gen_1	410	419	PF00069	0.399
DOC_MAPK_gen_1	445	453	PF00069	0.623
DOC_MAPK_gen_1	457	465	PF00069	0.520
DOC_MAPK_MEF2A_6	201	210	PF00069	0.458
DOC_PP2B_LxvP_1	190	193	PF13499	0.495
DOC_PP4_FxxP_1	217	220	PF00568	0.410
DOC_PP4_FxxP_1	398	401	PF00568	0.511
DOC_PP4_FxxP_1	55	58	PF00568	0.349
DOC_SPAK_OSR1_1	377	381	PF12202	0.493
DOC_USP7_MATH_1	81	85	PF00917	0.495
DOC_USP7_UBL2_3	445	449	PF12436	0.582
DOC_WW_Pin1_4	265	270	PF00397	0.574
DOC_WW_Pin1_4	337	342	PF00397	0.528
DOC_WW_Pin1_4	383	388	PF00397	0.480
DOC_WW_Pin1_4	535	540	PF00397	0.478
LIG_14-3-3_CanoR_1	15	20	PF00244	0.520
LIG_14-3-3_CanoR_1	169	175	PF00244	0.453
LIG_14-3-3_CanoR_1	411	420	PF00244	0.423
LIG_14-3-3_CanoR_1	497	501	PF00244	0.575
LIG_14-3-3_CterR_2	545	550	PF00244	0.703
LIG_deltaCOP1_diTrp_1	107	114	PF00928	0.408
LIG_EVH1_2	198	202	PF00568	0.442
LIG_FHA_1	155	161	PF00498	0.467
LIG_FHA_1	394	400	PF00498	0.566
LIG_FHA_1	421	427	PF00498	0.537
LIG_FHA_1	88	94	PF00498	0.512
LIG_FHA_2	108	114	PF00498	0.493
LIG_LIR_Apic_2	363	367	PF02991	0.502
LIG_LIR_Apic_2	382	387	PF02991	0.419
LIG_LIR_Apic_2	396	401	PF02991	0.450
LIG_LIR_Gen_1	162	171	PF02991	0.352
LIG_LIR_Gen_1	333	343	PF02991	0.492
LIG_LIR_Gen_1	44	55	PF02991	0.395
LIG_LIR_Nem_3	107	111	PF02991	0.370
LIG_LIR_Nem_3	148	153	PF02991	0.394
LIG_LIR_Nem_3	162	167	PF02991	0.322
LIG_LIR_Nem_3	170	174	PF02991	0.353
LIG_LIR_Nem_3	280	285	PF02991	0.565
LIG_LIR_Nem_3	333	339	PF02991	0.494
LIG_LIR_Nem_3	44	50	PF02991	0.374
LIG_LIR_Nem_3	469	473	PF02991	0.477
LIG_LIR_Nem_3	501	507	PF02991	0.588
LIG_LIR_Nem_3	78	83	PF02991	0.417
LIG_LYPXL_yS_3	504	507	PF13949	0.581
LIG_LYPXL_yS_3	80	83	PF13949	0.432
LIG_Pex14_1	213	217	PF04695	0.385
LIG_PTB_Apo_2	124	131	PF02174	0.383
LIG_PTB_Apo_2	270	277	PF02174	0.553
LIG_REV1ctd_RIR_1	333	340	PF16727	0.509
LIG_SH2_CRK	194	198	PF00017	0.523
LIG_SH2_CRK	298	302	PF00017	0.393
LIG_SH2_CRK	384	388	PF00017	0.418
LIG_SH2_CRK	47	51	PF00017	0.491
LIG_SH2_NCK_1	384	388	PF00017	0.523
LIG_SH2_PTP2	164	167	PF00017	0.467
LIG_SH2_PTP2	34	37	PF00017	0.357
LIG_SH2_SRC	34	37	PF00017	0.489
LIG_SH2_STAP1	161	165	PF00017	0.330
LIG_SH2_STAP1	298	302	PF00017	0.393
LIG_SH2_STAP1	370	374	PF00017	0.421
LIG_SH2_STAT5	129	132	PF00017	0.405
LIG_SH2_STAT5	146	149	PF00017	0.308
LIG_SH2_STAT5	150	153	PF00017	0.339
LIG_SH2_STAT5	164	167	PF00017	0.334
LIG_SH2_STAT5	34	37	PF00017	0.377
LIG_SH2_STAT5	534	537	PF00017	0.582
LIG_SH3_3	179	185	PF00018	0.408
LIG_SH3_3	359	365	PF00018	0.421
LIG_SH3_3	499	505	PF00018	0.466
LIG_SUMO_SIM_anti_2	205	211	PF11976	0.480
LIG_TRAF2_1	305	308	PF00917	0.533
LIG_TYR_ITIM	192	197	PF00017	0.545
LIG_TYR_ITIM	32	37	PF00017	0.385
LIG_UBA3_1	207	211	PF00899	0.479
LIG_WRC_WIRS_1	168	173	PF05994	0.370
MOD_CDK_SPK_2	265	270	PF00069	0.574
MOD_CDK_SPK_2	535	540	PF00069	0.478
MOD_CDK_SPxK_1	383	389	PF00069	0.510
MOD_CK1_1	154	160	PF00069	0.447
MOD_CK1_1	170	176	PF00069	0.491
MOD_CK1_1	200	206	PF00069	0.484
MOD_CK1_1	272	278	PF00069	0.554
MOD_CK1_1	42	48	PF00069	0.449
MOD_CK2_1	169	175	PF00069	0.425
MOD_CK2_1	535	541	PF00069	0.536
MOD_GlcNHglycan	232	235	PF01048	0.398
MOD_GlcNHglycan	310	313	PF01048	0.594
MOD_GlcNHglycan	390	393	PF01048	0.588
MOD_GlcNHglycan	83	86	PF01048	0.496
MOD_GSK3_1	265	272	PF00069	0.581
MOD_GSK3_1	337	344	PF00069	0.436
MOD_GSK3_1	496	503	PF00069	0.545
MOD_N-GLC_1	119	124	PF02516	0.396
MOD_N-GLC_1	272	277	PF02516	0.554
MOD_NEK2_1	119	124	PF00069	0.393
MOD_NEK2_1	167	172	PF00069	0.364
MOD_NEK2_1	526	531	PF00069	0.532
MOD_PIKK_1	133	139	PF00454	0.382
MOD_PIKK_1	200	206	PF00454	0.536
MOD_PK_1	422	428	PF00069	0.490
MOD_PKA_1	15	21	PF00069	0.387
MOD_PKA_2	15	21	PF00069	0.535
MOD_PKA_2	388	394	PF00069	0.566
MOD_PKA_2	496	502	PF00069	0.585
MOD_Plk_1	119	125	PF00069	0.389
MOD_Plk_1	154	160	PF00069	0.364
MOD_Plk_1	21	27	PF00069	0.514
MOD_Plk_1	272	278	PF00069	0.555
MOD_Plk_2-3	107	113	PF00069	0.497
MOD_Plk_4	175	181	PF00069	0.461
MOD_Plk_4	42	48	PF00069	0.396
MOD_ProDKin_1	265	271	PF00069	0.566
MOD_ProDKin_1	337	343	PF00069	0.521
MOD_ProDKin_1	383	389	PF00069	0.487
MOD_ProDKin_1	535	541	PF00069	0.479
MOD_SUMO_rev_2	369	374	PF00179	0.406
MOD_SUMO_rev_2	469	475	PF00179	0.599
TRG_DiLeu_BaEn_1	155	160	PF01217	0.389
TRG_DiLeu_BaEn_1	163	168	PF01217	0.322
TRG_DiLeu_BaEn_1	175	180	PF01217	0.385
TRG_DiLeu_BaEn_1	205	210	PF01217	0.478
TRG_DiLeu_BaLyEn_6	473	478	PF01217	0.609
TRG_ENDOCYTIC_2	150	153	PF00928	0.370
TRG_ENDOCYTIC_2	164	167	PF00928	0.302
TRG_ENDOCYTIC_2	194	197	PF00928	0.512
TRG_ENDOCYTIC_2	298	301	PF00928	0.397
TRG_ENDOCYTIC_2	34	37	PF00928	0.381
TRG_ENDOCYTIC_2	47	50	PF00928	0.363
TRG_ENDOCYTIC_2	504	507	PF00928	0.581
TRG_ENDOCYTIC_2	80	83	PF00928	0.432
TRG_ER_diArg_1	1	3	PF00400	0.597
TRG_ER_diArg_1	104	106	PF00400	0.366
TRG_ER_diArg_1	140	142	PF00400	0.515
TRG_ER_diArg_1	15	17	PF00400	0.474
TRG_ER_diArg_1	254	257	PF00400	0.533
TRG_ER_diArg_1	376	378	PF00400	0.394
TRG_ER_diArg_1	543	546	PF00400	0.686
TRG_NLS_MonoExtC_3	293	299	PF00514	0.548
TRG_NLS_MonoExtC_3	409	414	PF00514	0.512
TRG_NLS_MonoExtN_4	407	414	PF00514	0.510
TRG_Pf-PMV_PEXEL_1	411	416	PF00026	0.445
TRG_Pf-PMV_PEXEL_1	479	483	PF00026	0.650

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I7B7	Leptomonas seymouri	75%	100%
A0A0S4IYT6	Bodo saltans	49%	90%
A0A1X0NV91	Trypanosomatidae	55%	99%
A0A3Q8IEE9	Leishmania donovani	100%	100%
A0A422NKU0	Trypanosoma rangeli	55%	99%
D0A7Q0	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	53%	99%
E9AIS9	Leishmania braziliensis	85%	100%
E9AZG2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	92%	100%
Q4Q8R9	Leishmania major	96%	100%
V5AS03	Trypanosoma cruzi	54%	99%