Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein - conserved

Species:

Leishmania infantum

UniProt:

A4I368_LEIIN

TriTrypDb:

LINF_270022000

Length:

743

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4I368

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4I368

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	352	356	PF00656	0.705
CLV_C14_Caspase3-7	458	462	PF00656	0.712
CLV_MEL_PAP_1	116	122	PF00089	0.587
CLV_NRD_NRD_1	332	334	PF00675	0.740
CLV_NRD_NRD_1	339	341	PF00675	0.745
CLV_NRD_NRD_1	342	344	PF00675	0.739
CLV_NRD_NRD_1	578	580	PF00675	0.683
CLV_NRD_NRD_1	676	678	PF00675	0.529
CLV_PCSK_FUR_1	329	333	PF00082	0.822
CLV_PCSK_FUR_1	340	344	PF00082	0.559
CLV_PCSK_KEX2_1	331	333	PF00082	0.727
CLV_PCSK_KEX2_1	338	340	PF00082	0.732
CLV_PCSK_KEX2_1	342	344	PF00082	0.716
CLV_PCSK_KEX2_1	676	678	PF00082	0.529
CLV_PCSK_KEX2_1	713	715	PF00082	0.577
CLV_PCSK_PC1ET2_1	338	340	PF00082	0.768
CLV_PCSK_PC1ET2_1	342	344	PF00082	0.778
CLV_PCSK_PC1ET2_1	713	715	PF00082	0.577
CLV_PCSK_PC7_1	340	346	PF00082	0.677
CLV_PCSK_SKI1_1	152	156	PF00082	0.488
CLV_PCSK_SKI1_1	33	37	PF00082	0.495
CLV_PCSK_SKI1_1	45	49	PF00082	0.462
CLV_PCSK_SKI1_1	530	534	PF00082	0.452
CLV_PCSK_SKI1_1	592	596	PF00082	0.537
CLV_PCSK_SKI1_1	612	616	PF00082	0.371
CLV_PCSK_SKI1_1	690	694	PF00082	0.477
CLV_PCSK_SKI1_1	724	728	PF00082	0.617
CLV_PCSK_SKI1_1	74	78	PF00082	0.437
DEG_APCC_DBOX_1	634	642	PF00400	0.600
DEG_APCC_DBOX_1	689	697	PF00400	0.471
DEG_APCC_DBOX_1	723	731	PF00400	0.612
DEG_APCC_DBOX_1	73	81	PF00400	0.460
DEG_ODPH_VHL_1	128	140	PF01847	0.482
DEG_SPOP_SBC_1	370	374	PF00917	0.707
DOC_CKS1_1	432	437	PF01111	0.502
DOC_CKS1_1	552	557	PF01111	0.585
DOC_CYCLIN_yCln2_LP_2	150	156	PF00134	0.494
DOC_CYCLIN_yCln2_LP_2	290	296	PF00134	0.609
DOC_CYCLIN_yCln2_LP_2	449	455	PF00134	0.645
DOC_CYCLIN_yCln2_LP_2	643	649	PF00134	0.601
DOC_MAPK_gen_1	132	140	PF00069	0.465
DOC_MAPK_gen_1	303	310	PF00069	0.624
DOC_MAPK_gen_1	527	537	PF00069	0.455
DOC_MAPK_MEF2A_6	530	539	PF00069	0.496
DOC_MAPK_MEF2A_6	650	658	PF00069	0.452
DOC_PP1_RVXF_1	31	37	PF00149	0.475
DOC_PP2B_LxvP_1	127	130	PF13499	0.463
DOC_PP4_MxPP_1	193	196	PF00568	0.532
DOC_USP7_MATH_1	189	193	PF00917	0.554
DOC_USP7_MATH_1	203	207	PF00917	0.492
DOC_USP7_MATH_1	3	7	PF00917	0.558
DOC_USP7_MATH_1	369	373	PF00917	0.797
DOC_USP7_MATH_1	393	397	PF00917	0.698
DOC_USP7_MATH_1	454	458	PF00917	0.695
DOC_USP7_MATH_1	548	552	PF00917	0.496
DOC_USP7_MATH_1	614	618	PF00917	0.524
DOC_USP7_MATH_1	684	688	PF00917	0.527
DOC_USP7_MATH_2	518	524	PF00917	0.510
DOC_USP7_UBL2_3	338	342	PF12436	0.747
DOC_WW_Pin1_4	17	22	PF00397	0.491
DOC_WW_Pin1_4	218	223	PF00397	0.588
DOC_WW_Pin1_4	23	28	PF00397	0.504
DOC_WW_Pin1_4	243	248	PF00397	0.608
DOC_WW_Pin1_4	260	265	PF00397	0.422
DOC_WW_Pin1_4	379	384	PF00397	0.754
DOC_WW_Pin1_4	414	419	PF00397	0.559
DOC_WW_Pin1_4	431	436	PF00397	0.504
DOC_WW_Pin1_4	514	519	PF00397	0.540
DOC_WW_Pin1_4	551	556	PF00397	0.588
DOC_WW_Pin1_4	661	666	PF00397	0.569
LIG_14-3-3_CanoR_1	119	128	PF00244	0.470
LIG_14-3-3_CanoR_1	132	141	PF00244	0.485
LIG_14-3-3_CanoR_1	19	29	PF00244	0.555
LIG_14-3-3_CanoR_1	270	278	PF00244	0.512
LIG_14-3-3_CanoR_1	45	51	PF00244	0.467
LIG_14-3-3_CanoR_1	596	601	PF00244	0.550
LIG_14-3-3_CanoR_1	612	621	PF00244	0.338
LIG_14-3-3_CanoR_1	645	654	PF00244	0.576
LIG_Actin_WH2_2	399	417	PF00022	0.559
LIG_EH1_1	648	656	PF00400	0.465
LIG_eIF4E_1	29	35	PF01652	0.480
LIG_EVH1_2	183	187	PF00568	0.542
LIG_FHA_1	122	128	PF00498	0.465
LIG_FHA_1	196	202	PF00498	0.691
LIG_FHA_1	248	254	PF00498	0.499
LIG_FHA_1	261	267	PF00498	0.495
LIG_FHA_1	279	285	PF00498	0.609
LIG_FHA_1	397	403	PF00498	0.680
LIG_FHA_1	63	69	PF00498	0.488
LIG_FHA_1	684	690	PF00498	0.495
LIG_FHA_2	134	140	PF00498	0.486
LIG_FHA_2	295	301	PF00498	0.578
LIG_FHA_2	350	356	PF00498	0.679
LIG_FHA_2	515	521	PF00498	0.526
LIG_FHA_2	554	560	PF00498	0.494
LIG_FHA_2	613	619	PF00498	0.539
LIG_FHA_2	7	13	PF00498	0.495
LIG_LIR_Gen_1	298	309	PF02991	0.588
LIG_LIR_Gen_1	556	566	PF02991	0.557
LIG_LIR_Gen_1	9	17	PF02991	0.478
LIG_LIR_Nem_3	298	304	PF02991	0.578
LIG_LIR_Nem_3	556	561	PF02991	0.349
LIG_LIR_Nem_3	71	76	PF02991	0.462
LIG_LIR_Nem_3	9	13	PF02991	0.483
LIG_NRBOX	252	258	PF00104	0.483
LIG_SH2_CRK	64	68	PF00017	0.489
LIG_SH2_CRK	698	702	PF00017	0.512
LIG_SH2_CRK	73	77	PF00017	0.454
LIG_SH2_STAP1	674	678	PF00017	0.509
LIG_SH2_STAT3	63	66	PF00017	0.492
LIG_SH2_STAT3	694	697	PF00017	0.470
LIG_SH2_STAT5	252	255	PF00017	0.478
LIG_SH2_STAT5	64	67	PF00017	0.501
LIG_SH2_STAT5	694	697	PF00017	0.470
LIG_SH2_STAT5	8	11	PF00017	0.486
LIG_SH3_3	34	40	PF00018	0.503
LIG_SH3_3	348	354	PF00018	0.737
LIG_SH3_3	380	386	PF00018	0.747
LIG_SH3_3	450	456	PF00018	0.617
LIG_SUMO_SIM_anti_2	136	142	PF11976	0.485
LIG_SUMO_SIM_par_1	46	51	PF11976	0.446
LIG_SUMO_SIM_par_1	639	644	PF11976	0.637
LIG_TRAF2_1	325	328	PF00917	0.618
LIG_UBA3_1	424	431	PF00899	0.488
LIG_UBA3_1	726	734	PF00899	0.521
MOD_CDK_SPxxK_3	260	267	PF00069	0.504
MOD_CK1_1	115	121	PF00069	0.495
MOD_CK1_1	20	26	PF00069	0.541
MOD_CK1_1	251	257	PF00069	0.475
MOD_CK1_1	288	294	PF00069	0.599
MOD_CK1_1	349	355	PF00069	0.777
MOD_CK1_1	372	378	PF00069	0.789
MOD_CK1_1	387	393	PF00069	0.578
MOD_CK1_1	396	402	PF00069	0.548
MOD_CK1_1	417	423	PF00069	0.514
MOD_CK1_1	470	476	PF00069	0.560
MOD_CK1_1	551	557	PF00069	0.480
MOD_CK1_1	588	594	PF00069	0.663
MOD_CK1_1	6	12	PF00069	0.516
MOD_CK1_1	604	610	PF00069	0.518
MOD_CK2_1	294	300	PF00069	0.691
MOD_CK2_1	491	497	PF00069	0.384
MOD_CK2_1	514	520	PF00069	0.542
MOD_CK2_1	553	559	PF00069	0.495
MOD_CK2_1	612	618	PF00069	0.536
MOD_GlcNHglycan	164	167	PF01048	0.492
MOD_GlcNHglycan	205	208	PF01048	0.605
MOD_GlcNHglycan	313	316	PF01048	0.738
MOD_GlcNHglycan	322	325	PF01048	0.717
MOD_GlcNHglycan	335	338	PF01048	0.684
MOD_GlcNHglycan	348	351	PF01048	0.662
MOD_GlcNHglycan	457	460	PF01048	0.790
MOD_GlcNHglycan	469	472	PF01048	0.553
MOD_GlcNHglycan	5	8	PF01048	0.654
MOD_GlcNHglycan	510	513	PF01048	0.590
MOD_GlcNHglycan	548	551	PF01048	0.470
MOD_GlcNHglycan	603	606	PF01048	0.522
MOD_GSK3_1	111	118	PF00069	0.523
MOD_GSK3_1	195	202	PF00069	0.581
MOD_GSK3_1	226	233	PF00069	0.483
MOD_GSK3_1	243	250	PF00069	0.509
MOD_GSK3_1	256	263	PF00069	0.473
MOD_GSK3_1	309	316	PF00069	0.636
MOD_GSK3_1	345	352	PF00069	0.747
MOD_GSK3_1	369	376	PF00069	0.784
MOD_GSK3_1	396	403	PF00069	0.625
MOD_GSK3_1	581	588	PF00069	0.753
MOD_GSK3_1	604	611	PF00069	0.542
MOD_GSK3_1	626	633	PF00069	0.587
MOD_LATS_1	83	89	PF00433	0.611
MOD_N-GLC_1	377	382	PF02516	0.713
MOD_N-GLC_1	491	496	PF02516	0.374
MOD_N-GLC_1	678	683	PF02516	0.617
MOD_N-GLC_2	657	659	PF02516	0.448
MOD_NEK2_1	248	253	PF00069	0.478
MOD_NEK2_1	256	261	PF00069	0.503
MOD_NEK2_1	309	314	PF00069	0.594
MOD_NEK2_1	377	382	PF00069	0.744
MOD_NEK2_1	441	446	PF00069	0.527
MOD_NEK2_1	467	472	PF00069	0.600
MOD_NEK2_1	508	513	PF00069	0.570
MOD_NEK2_1	521	526	PF00069	0.491
MOD_NEK2_1	595	600	PF00069	0.424
MOD_NEK2_2	189	194	PF00069	0.606
MOD_PIKK_1	20	26	PF00454	0.531
MOD_PIKK_1	393	399	PF00454	0.558
MOD_PIKK_1	62	68	PF00454	0.483
MOD_PIKK_1	626	632	PF00454	0.696
MOD_PIKK_1	684	690	PF00454	0.519
MOD_PK_1	596	602	PF00069	0.542
MOD_PKA_1	338	344	PF00069	0.641
MOD_PKA_2	118	124	PF00069	0.479
MOD_PKA_2	269	275	PF00069	0.510
MOD_PKA_2	338	344	PF00069	0.641
MOD_PKA_2	508	514	PF00069	0.463
MOD_PKA_2	578	584	PF00069	0.572
MOD_PKA_2	595	601	PF00069	0.539
MOD_PKB_1	331	339	PF00069	0.815
MOD_PKB_1	343	351	PF00069	0.535
MOD_Plk_1	299	305	PF00069	0.677
MOD_Plk_1	377	383	PF00069	0.713
MOD_Plk_2-3	732	738	PF00069	0.485
MOD_Plk_4	226	232	PF00069	0.500
MOD_Plk_4	248	254	PF00069	0.585
MOD_Plk_4	521	527	PF00069	0.496
MOD_Plk_4	548	554	PF00069	0.566
MOD_Plk_4	604	610	PF00069	0.422
MOD_Plk_4	650	656	PF00069	0.452
MOD_ProDKin_1	17	23	PF00069	0.499
MOD_ProDKin_1	218	224	PF00069	0.581
MOD_ProDKin_1	243	249	PF00069	0.601
MOD_ProDKin_1	260	266	PF00069	0.422
MOD_ProDKin_1	379	385	PF00069	0.752
MOD_ProDKin_1	414	420	PF00069	0.553
MOD_ProDKin_1	431	437	PF00069	0.502
MOD_ProDKin_1	514	520	PF00069	0.542
MOD_ProDKin_1	551	557	PF00069	0.582
MOD_ProDKin_1	661	667	PF00069	0.564
MOD_SUMO_for_1	712	715	PF00179	0.517
MOD_SUMO_rev_2	259	268	PF00179	0.524
TRG_DiLeu_BaLyEn_6	123	128	PF01217	0.464
TRG_DiLeu_BaLyEn_6	181	186	PF01217	0.613
TRG_DiLeu_BaLyEn_6	30	35	PF01217	0.475
TRG_DiLeu_BaLyEn_6	537	542	PF01217	0.470
TRG_DiLeu_BaLyEn_6	725	730	PF01217	0.607
TRG_ENDOCYTIC_2	73	76	PF00928	0.457
TRG_ER_diArg_1	329	332	PF00400	0.815
TRG_ER_diArg_1	572	575	PF00400	0.479
TRG_ER_diArg_1	676	678	PF00400	0.529
TRG_NLS_MonoExtC_3	337	342	PF00514	0.763
TRG_Pf-PMV_PEXEL_1	527	531	PF00026	0.561
TRG_Pf-PMV_PEXEL_1	540	544	PF00026	0.393
TRG_Pf-PMV_PEXEL_1	728	732	PF00026	0.628

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P5D1	Leptomonas seymouri	64%	100%
A0A3S7X0R8	Leishmania donovani	100%	100%
A4HFT0	Leishmania braziliensis	81%	100%
E9ADD1	Leishmania major	94%	100%
E9AZ56	Leishmania mexicana (strain MHOM/GT/2001/U1103)	91%	100%