LeishMANIAdb
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Uncharacterized protein

Quick info Annotations Function or PPIs Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
Uncharacterized protein
Gene product:
hypothetical protein - conserved
Species:
Leishmania infantum
UniProt:
A4I356_LEIIN
TriTrypDb:
LINF_270006900
Length:
372

Annotations

LeishMANIAdb annotations

A Zn-finger protein with a TM segment on the C-terminus (2 paralogous lineages in Kinetoplastids: A4HSS9_LEIINvs. A4I356_LEIIN). Unlikely to be GPI-anchored due to reverse topology. Weakly similar to NLRC3/NOD3 intracellular immune receptor.

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 1, no: 14
NetGPI no yes: 0, no: 15
Cellular components
Term Name Level Count
GO:0005929 cilium 4 16
GO:0042995 cell projection 2 16
GO:0043226 organelle 2 16
GO:0043227 membrane-bounded organelle 3 16
GO:0110165 cellular anatomical entity 1 16
GO:0120025 plasma membrane bounded cell projection 3 16
GO:0005737 cytoplasm 2 2
GO:0016020 membrane 2 10
GO:0005741 mitochondrial outer membrane 5 1
GO:0019867 outer membrane 3 1
GO:0031090 organelle membrane 3 1
GO:0031966 mitochondrial membrane 4 1
GO:0031968 organelle outer membrane 4 1
GO:0098588 bounding membrane of organelle 4 1

Expansion

Sequence features

A4I356
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4I356

Function

Could not find GO biological_process term for this entry.
Molecular functions
Term Name Level Count
GO:0005488 binding 1 15
GO:0043167 ion binding 2 15
GO:0043169 cation binding 3 15
GO:0046872 metal ion binding 4 15
GO:0003676 nucleic acid binding 3 6
GO:0003723 RNA binding 4 6
GO:0097159 organic cyclic compound binding 2 6
GO:1901363 heterocyclic compound binding 2 6
GO:0003729 mRNA binding 5 5

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_NRD_NRD_1 313 315 PF00675 0.691
CLV_NRD_NRD_1 363 365 PF00675 0.535
CLV_PCSK_FUR_1 311 315 PF00082 0.640
CLV_PCSK_KEX2_1 302 304 PF00082 0.755
CLV_PCSK_KEX2_1 311 313 PF00082 0.675
CLV_PCSK_KEX2_1 363 365 PF00082 0.511
CLV_PCSK_PC1ET2_1 302 304 PF00082 0.778
CLV_PCSK_SKI1_1 82 86 PF00082 0.568
DEG_Nend_UBRbox_2 1 3 PF02207 0.530
DOC_MAPK_gen_1 136 144 PF00069 0.311
DOC_USP7_MATH_1 126 130 PF00917 0.298
DOC_USP7_MATH_1 153 157 PF00917 0.300
DOC_USP7_MATH_1 367 371 PF00917 0.626
DOC_WW_Pin1_4 144 149 PF00397 0.302
DOC_WW_Pin1_4 301 306 PF00397 0.631
DOC_WW_Pin1_4 317 322 PF00397 0.498
DOC_WW_Pin1_4 336 341 PF00397 0.503
LIG_14-3-3_CterR_2 368 372 PF00244 0.630
LIG_Actin_WH2_2 103 120 PF00022 0.302
LIG_Actin_WH2_2 153 170 PF00022 0.344
LIG_APCC_ABBA_1 84 89 PF00400 0.318
LIG_BRCT_BRCA1_1 102 106 PF00533 0.282
LIG_BRCT_BRCA1_1 270 274 PF00533 0.460
LIG_BRCT_BRCA1_1 90 94 PF00533 0.317
LIG_eIF4E_1 233 239 PF01652 0.356
LIG_FHA_1 167 173 PF00498 0.272
LIG_FHA_1 302 308 PF00498 0.462
LIG_FHA_2 11 17 PF00498 0.332
LIG_FHA_2 145 151 PF00498 0.310
LIG_IBAR_NPY_1 164 166 PF08397 0.276
LIG_LIR_Apic_2 293 297 PF02991 0.468
LIG_LIR_Gen_1 59 69 PF02991 0.416
LIG_LIR_Nem_3 336 341 PF02991 0.502
LIG_LIR_Nem_3 59 64 PF02991 0.406
LIG_LIR_Nem_3 66 72 PF02991 0.403
LIG_LIR_Nem_3 88 93 PF02991 0.359
LIG_MLH1_MIPbox_1 90 94 PF16413 0.406
LIG_Pex14_2 90 94 PF04695 0.312
LIG_SH2_CRK 61 65 PF00017 0.332
LIG_SH2_GRB2like 61 64 PF00017 0.394
LIG_SH2_PTP2 141 144 PF00017 0.310
LIG_SH2_STAP1 100 104 PF00017 0.285
LIG_SH2_STAP1 250 254 PF00017 0.371
LIG_SH2_STAT5 141 144 PF00017 0.310
LIG_SH2_STAT5 166 169 PF00017 0.270
LIG_SH2_STAT5 233 236 PF00017 0.314
LIG_SH2_STAT5 53 56 PF00017 0.345
LIG_SH2_STAT5 61 64 PF00017 0.346
LIG_SH3_3 204 210 PF00018 0.482
LIG_SH3_3 282 288 PF00018 0.416
LIG_SUMO_SIM_par_1 168 175 PF11976 0.285
LIG_TYR_ITIM 139 144 PF00017 0.363
LIG_WW_3 284 288 PF00397 0.606
MOD_CDK_SPK_2 301 306 PF00069 0.608
MOD_CK1_1 38 44 PF00069 0.490
MOD_CK1_1 59 65 PF00069 0.394
MOD_CK2_1 10 16 PF00069 0.479
MOD_CK2_1 126 132 PF00069 0.360
MOD_CK2_1 144 150 PF00069 0.362
MOD_CK2_1 191 197 PF00069 0.412
MOD_GlcNHglycan 18 21 PF01048 0.547
MOD_GlcNHglycan 256 259 PF01048 0.546
MOD_GlcNHglycan 266 269 PF01048 0.492
MOD_GlcNHglycan 342 345 PF01048 0.504
MOD_GlcNHglycan 35 38 PF01048 0.379
MOD_GlcNHglycan 88 93 PF01048 0.432
MOD_GSK3_1 12 19 PF00069 0.499
MOD_GSK3_1 250 257 PF00069 0.495
MOD_GSK3_1 264 271 PF00069 0.528
MOD_GSK3_1 286 293 PF00069 0.708
MOD_GSK3_1 336 343 PF00069 0.717
MOD_GSK3_1 52 59 PF00069 0.475
MOD_N-GLC_1 108 113 PF02516 0.357
MOD_N-GLC_1 120 125 PF02516 0.379
MOD_N-GLC_1 191 196 PF02516 0.380
MOD_N-GLC_1 59 64 PF02516 0.555
MOD_N-GLC_2 63 65 PF02516 0.333
MOD_NEK2_1 134 139 PF00069 0.340
MOD_NEK2_1 191 196 PF00069 0.503
MOD_NEK2_1 254 259 PF00069 0.490
MOD_NEK2_1 80 85 PF00069 0.327
MOD_PKA_2 286 292 PF00069 0.708
MOD_Plk_1 108 114 PF00069 0.356
MOD_Plk_1 172 178 PF00069 0.412
MOD_Plk_1 203 209 PF00069 0.459
MOD_Plk_1 262 268 PF00069 0.604
MOD_Plk_1 73 79 PF00069 0.400
MOD_Plk_4 172 178 PF00069 0.411
MOD_Plk_4 203 209 PF00069 0.459
MOD_ProDKin_1 144 150 PF00069 0.362
MOD_ProDKin_1 301 307 PF00069 0.812
MOD_ProDKin_1 317 323 PF00069 0.634
MOD_ProDKin_1 336 342 PF00069 0.635
MOD_SUMO_rev_2 298 304 PF00179 0.815
TRG_DiLeu_BaLyEn_6 337 342 PF01217 0.680
TRG_ENDOCYTIC_2 141 144 PF00928 0.367
TRG_ENDOCYTIC_2 61 64 PF00928 0.504
TRG_ENDOCYTIC_2 87 90 PF00928 0.511
TRG_ER_diArg_1 135 138 PF00400 0.444
TRG_ER_diArg_1 311 314 PF00400 0.683
TRG_ER_diArg_1 4 7 PF00400 0.489
TRG_Pf-PMV_PEXEL_1 12 16 PF00026 0.462
TRG_Pf-PMV_PEXEL_1 28 33 PF00026 0.357

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N0P4T9 Leptomonas seymouri 76% 100%
A0A1X0NNG2 Trypanosomatidae 49% 100%
A0A3R7NQS8 Trypanosoma rangeli 56% 100%
A0A3S5H5P9 Leishmania donovani 22% 93%
A0A3S7X0C2 Leishmania donovani 99% 100%
A4H4K3 Leishmania braziliensis 21% 99%
A4HFD8 Leishmania braziliensis 84% 98%
A4HSS9 Leishmania infantum 22% 93%
C9ZKV9 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 50% 100%
E9ACZ7 Leishmania major 93% 98%
E9AKR6 Leishmania mexicana (strain MHOM/GT/2001/U1103) 21% 99%
E9AYS2 Leishmania mexicana (strain MHOM/GT/2001/U1103) 93% 100%
Q4QJ41 Leishmania major 22% 93%
V5DCE2 Trypanosoma cruzi 56% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS