LeishMANIAdb
  • Home
  • Browse
  • Manual
  • FAQ
  • Download

Vacuolar iron transporter 1

Quick info Annotations Function or PPIs Localization Abundance Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
Vacuolar iron transporter 1
Gene product:
Vacuolar iron transporter 1 - putative
Species:
Leishmania infantum
UniProt:
A4I355_LEIIN
TriTrypDb:
LINF_270007000
Length:
289

Annotations

Annotations by Jardim et al.

Acidocalcisome, Vacuolar iron transporter 1

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. yes yes: 18
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 11
NetGPI no yes: 0, no: 11
Cellular components
Term Name Level Count
GO:0016020 membrane 2 12
GO:0110165 cellular anatomical entity 1 12
GO:0005737 cytoplasm 2 1
GO:0020022 acidocalcisome 5 1
GO:0043226 organelle 2 1
GO:0043227 membrane-bounded organelle 3 1
GO:0043229 intracellular organelle 3 1
GO:0043231 intracellular membrane-bounded organelle 4 1

Abundance

Amastigote (protein)
Source Evidence on protein Close homologs
Pescher et al. (upgregulation) no yes: 0
Promastigote and amastigote
Source Evidence on protein Close homologs
Lahav et al.
- mRNA
- Protein

Expansion

Sequence features

A4I355
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4I355

Function

Biological processes
Term Name Level Count
GO:0006873 intracellular monoatomic ion homeostasis 4 12
GO:0006875 obsolete intracellular metal ion homeostasis 6 12
GO:0009987 cellular process 1 12
GO:0019725 cellular homeostasis 2 12
GO:0030003 intracellular monoatomic cation homeostasis 5 12
GO:0030026 intracellular manganese ion homeostasis 8 12
GO:0042592 homeostatic process 3 12
GO:0046916 obsolete intracellular transition metal ion homeostasis 7 12
GO:0048878 chemical homeostasis 4 12
GO:0050801 monoatomic ion homeostasis 5 12
GO:0055065 obsolete metal ion homeostasis 7 12
GO:0055071 manganese ion homeostasis 9 12
GO:0055076 obsolete transition metal ion homeostasis 8 12
GO:0055080 monoatomic cation homeostasis 6 12
GO:0055082 intracellular chemical homeostasis 3 12
GO:0065007 biological regulation 1 12
GO:0065008 regulation of biological quality 2 12
GO:0098771 inorganic ion homeostasis 6 12
GO:0006880 intracellular sequestering of iron ion 4 1
GO:0051179 localization 1 1
GO:0051235 maintenance of location 2 1
GO:0051238 sequestering of metal ion 3 1
GO:0051651 maintenance of location in cell 2 1
GO:0097577 sequestering of iron ion 3 1
Molecular functions
Term Name Level Count
GO:0005215 transporter activity 1 12
GO:0005384 manganese ion transmembrane transporter activity 7 12
GO:0008324 monoatomic cation transmembrane transporter activity 4 12
GO:0015075 monoatomic ion transmembrane transporter activity 3 12
GO:0015318 inorganic molecular entity transmembrane transporter activity 3 12
GO:0022857 transmembrane transporter activity 2 12
GO:0022890 inorganic cation transmembrane transporter activity 4 12
GO:0046873 metal ion transmembrane transporter activity 5 12
GO:0046915 transition metal ion transmembrane transporter activity 6 12
GO:0005381 iron ion transmembrane transporter activity 7 1

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_NRD_NRD_1 122 124 PF00675 0.229
CLV_NRD_NRD_1 36 38 PF00675 0.401
CLV_PCSK_KEX2_1 121 123 PF00082 0.228
CLV_PCSK_KEX2_1 36 38 PF00082 0.396
CLV_PCSK_SKI1_1 24 28 PF00082 0.328
DOC_CDC14_PxL_1 202 210 PF14671 0.331
DOC_CYCLIN_RxL_1 143 152 PF00134 0.530
DOC_CYCLIN_RxL_1 54 65 PF00134 0.494
DOC_MAPK_gen_1 162 170 PF00069 0.444
DOC_MAPK_gen_1 189 196 PF00069 0.439
DOC_MAPK_MEF2A_6 162 170 PF00069 0.456
DOC_MAPK_MEF2A_6 240 248 PF00069 0.549
DOC_PP1_RVXF_1 144 151 PF00149 0.530
DOC_PP1_RVXF_1 55 62 PF00149 0.444
DOC_USP7_MATH_1 283 287 PF00917 0.431
DOC_USP7_MATH_1 77 81 PF00917 0.297
DOC_USP7_UBL2_3 14 18 PF12436 0.613
DOC_WD40_RPTOR_TOS_1 132 138 PF00400 0.456
LIG_BIR_II_1 1 5 PF00653 0.632
LIG_BIR_III_4 184 188 PF00653 0.522
LIG_BRCT_BRCA1_1 197 201 PF00533 0.405
LIG_BRCT_BRCA1_1 231 235 PF00533 0.413
LIG_BRCT_BRCA1_1 57 61 PF00533 0.440
LIG_Clathr_ClatBox_1 179 183 PF01394 0.530
LIG_deltaCOP1_diTrp_1 124 132 PF00928 0.456
LIG_EH1_1 153 161 PF00400 0.494
LIG_FHA_1 282 288 PF00498 0.472
LIG_FHA_1 68 74 PF00498 0.341
LIG_FHA_1 84 90 PF00498 0.214
LIG_FHA_2 276 282 PF00498 0.279
LIG_LIR_Gen_1 169 178 PF02991 0.490
LIG_LIR_Gen_1 198 207 PF02991 0.312
LIG_LIR_Gen_1 219 228 PF02991 0.366
LIG_LIR_Gen_1 69 78 PF02991 0.297
LIG_LIR_Nem_3 169 173 PF02991 0.511
LIG_LIR_Nem_3 198 202 PF02991 0.308
LIG_LIR_Nem_3 219 223 PF02991 0.327
LIG_LIR_Nem_3 58 64 PF02991 0.286
LIG_LIR_Nem_3 69 74 PF02991 0.290
LIG_PDZ_Class_2 284 289 PF00595 0.494
LIG_Pex14_2 100 104 PF04695 0.290
LIG_Pex14_2 223 227 PF04695 0.405
LIG_SH2_SRC 210 213 PF00017 0.331
LIG_SH2_STAT5 107 110 PF00017 0.450
LIG_SH2_STAT5 210 213 PF00017 0.294
LIG_SH2_STAT5 242 245 PF00017 0.469
LIG_SH2_STAT5 55 58 PF00017 0.495
LIG_SUMO_SIM_par_1 178 184 PF11976 0.448
LIG_UBA3_1 207 214 PF00899 0.354
LIG_WRC_WIRS_1 196 201 PF05994 0.297
LIG_WRC_WIRS_1 264 269 PF05994 0.331
LIG_WRC_WIRS_1 68 73 PF05994 0.297
MOD_CK1_1 2 8 PF00069 0.664
MOD_CK2_1 32 38 PF00069 0.548
MOD_CK2_1 48 54 PF00069 0.591
MOD_CK2_1 7 13 PF00069 0.711
MOD_GlcNHglycan 108 111 PF01048 0.241
MOD_GlcNHglycan 250 253 PF01048 0.256
MOD_GlcNHglycan 261 264 PF01048 0.280
MOD_GlcNHglycan 50 53 PF01048 0.421
MOD_GlcNHglycan 79 82 PF01048 0.538
MOD_GlcNHglycan 9 12 PF01048 0.423
MOD_GSK3_1 222 229 PF00069 0.417
MOD_GSK3_1 244 251 PF00069 0.473
MOD_GSK3_1 259 266 PF00069 0.220
MOD_N-GLC_1 48 53 PF02516 0.489
MOD_N-GLC_1 7 12 PF02516 0.505
MOD_NEK2_1 1 6 PF00069 0.733
MOD_NEK2_1 195 200 PF00069 0.297
MOD_NEK2_1 201 206 PF00069 0.297
MOD_NEK2_1 222 227 PF00069 0.312
MOD_NEK2_1 235 240 PF00069 0.312
MOD_NEK2_1 248 253 PF00069 0.375
MOD_NEK2_1 275 280 PF00069 0.386
MOD_NEK2_1 7 12 PF00069 0.654
MOD_NEK2_1 90 95 PF00069 0.289
MOD_Plk_1 128 134 PF00069 0.505
MOD_Plk_1 2 8 PF00069 0.675
MOD_Plk_4 152 158 PF00069 0.456
MOD_Plk_4 195 201 PF00069 0.333
MOD_Plk_4 229 235 PF00069 0.373
MOD_Plk_4 263 269 PF00069 0.360
MOD_Plk_4 55 61 PF00069 0.444
MOD_Plk_4 83 89 PF00069 0.257
MOD_SUMO_rev_2 161 167 PF00179 0.458
TRG_DiLeu_BaEn_1 174 179 PF01217 0.469
TRG_DiLeu_BaLyEn_6 203 208 PF01217 0.331
TRG_ER_diArg_1 121 123 PF00400 0.439

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N1PCC2 Leptomonas seymouri 78% 99%
A0A0S4J3A7 Bodo saltans 58% 100%
A0A1X0NM64 Trypanosomatidae 69% 100%
A0A3Q8IE64 Leishmania donovani 100% 100%
A0A3R7MYU7 Trypanosoma rangeli 64% 100%
A4HFD9 Leishmania braziliensis 86% 100%
C9ZKW1 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 67% 100%
E9ACZ8 Leishmania major 98% 100%
E9AYS3 Leishmania mexicana (strain MHOM/GT/2001/U1103) 95% 100%
P0DO17 Eucalyptus grandis 27% 100%
Q6ERE5 Oryza sativa subsp. japonica 28% 100%
Q6MWE5 Oryza sativa subsp. japonica 27% 100%
Q9P6J2 Schizosaccharomyces pombe (strain 972 / ATCC 24843) 24% 100%
Q9ZUA5 Arabidopsis thaliana 28% 100%
V5BKT4 Trypanosoma cruzi 69% 100%

Download

Download
LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS