LeishMANIAdb
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Uncharacterized protein

Quick info Annotations Function or PPIs Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
Uncharacterized protein
Gene product:
XRN 5'-3' exonuclease N-terminus - putative
Species:
Leishmania infantum
UniProt:
A4I352_LEIIN
TriTrypDb:
LINF_270015700
Length:
570

Annotations

Annotations by Jardim et al.

Nucleic acid binding, Uncharacterized

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 14
NetGPI no yes: 0, no: 14
Cellular components
Term Name Level Count
GO:0005634 nucleus 5 1
GO:0005737 cytoplasm 2 1
GO:0043226 organelle 2 1
GO:0043227 membrane-bounded organelle 3 1
GO:0043229 intracellular organelle 3 1
GO:0043231 intracellular membrane-bounded organelle 4 1
GO:0110165 cellular anatomical entity 1 1

Expansion

Sequence features

A4I352
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4I352

Function

Biological processes
Term Name Level Count
GO:0000956 nuclear-transcribed mRNA catabolic process 7 1
GO:0006139 nucleobase-containing compound metabolic process 3 1
GO:0006401 RNA catabolic process 5 1
GO:0006402 mRNA catabolic process 6 1
GO:0006725 cellular aromatic compound metabolic process 3 1
GO:0006807 nitrogen compound metabolic process 2 1
GO:0008152 metabolic process 1 1
GO:0009056 catabolic process 2 1
GO:0009057 macromolecule catabolic process 4 1
GO:0009892 negative regulation of metabolic process 4 1
GO:0009987 cellular process 1 1
GO:0010468 regulation of gene expression 5 1
GO:0010605 negative regulation of macromolecule metabolic process 5 1
GO:0010629 negative regulation of gene expression 6 1
GO:0016070 RNA metabolic process 5 1
GO:0016071 mRNA metabolic process 6 1
GO:0019222 regulation of metabolic process 3 1
GO:0019439 aromatic compound catabolic process 4 1
GO:0034641 cellular nitrogen compound metabolic process 3 1
GO:0034655 nucleobase-containing compound catabolic process 4 1
GO:0043170 macromolecule metabolic process 3 1
GO:0044237 cellular metabolic process 2 1
GO:0044238 primary metabolic process 2 1
GO:0044248 cellular catabolic process 3 1
GO:0044260 obsolete cellular macromolecule metabolic process 3 1
GO:0044265 obsolete cellular macromolecule catabolic process 4 1
GO:0044270 cellular nitrogen compound catabolic process 4 1
GO:0046483 heterocycle metabolic process 3 1
GO:0046700 heterocycle catabolic process 4 1
GO:0048519 negative regulation of biological process 3 1
GO:0050789 regulation of biological process 2 1
GO:0060255 regulation of macromolecule metabolic process 4 1
GO:0065007 biological regulation 1 1
GO:0071704 organic substance metabolic process 2 1
GO:0090304 nucleic acid metabolic process 4 1
GO:1901360 organic cyclic compound metabolic process 3 1
GO:1901361 organic cyclic compound catabolic process 4 1
GO:1901575 organic substance catabolic process 3 1
Molecular functions
Term Name Level Count
GO:0003676 nucleic acid binding 3 15
GO:0003824 catalytic activity 1 15
GO:0004518 nuclease activity 4 15
GO:0004527 exonuclease activity 5 15
GO:0005488 binding 1 15
GO:0016787 hydrolase activity 2 15
GO:0016788 hydrolase activity, acting on ester bonds 3 15
GO:0097159 organic cyclic compound binding 2 15
GO:1901363 heterocyclic compound binding 2 15
GO:0003723 RNA binding 4 1
GO:0004532 RNA exonuclease activity 5 1
GO:0004534 5'-3' RNA exonuclease activity 7 1
GO:0004540 RNA nuclease activity 4 1
GO:0008409 5'-3' exonuclease activity 6 1
GO:0016796 exonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 5'-phosphomonoesters 6 1
GO:0016896 RNA exonuclease activity, producing 5'-phosphomonoesters 6 1
GO:0140098 catalytic activity, acting on RNA 3 1
GO:0140640 catalytic activity, acting on a nucleic acid 2 1

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 202 206 PF00656 0.571
CLV_C14_Caspase3-7 435 439 PF00656 0.635
CLV_MEL_PAP_1 465 471 PF00089 0.502
CLV_NRD_NRD_1 166 168 PF00675 0.332
CLV_NRD_NRD_1 196 198 PF00675 0.348
CLV_NRD_NRD_1 301 303 PF00675 0.384
CLV_NRD_NRD_1 314 316 PF00675 0.376
CLV_NRD_NRD_1 351 353 PF00675 0.593
CLV_NRD_NRD_1 420 422 PF00675 0.510
CLV_NRD_NRD_1 518 520 PF00675 0.573
CLV_NRD_NRD_1 544 546 PF00675 0.716
CLV_NRD_NRD_1 98 100 PF00675 0.265
CLV_PCSK_FUR_1 349 353 PF00082 0.623
CLV_PCSK_KEX2_1 196 198 PF00082 0.340
CLV_PCSK_KEX2_1 301 303 PF00082 0.356
CLV_PCSK_KEX2_1 314 316 PF00082 0.396
CLV_PCSK_KEX2_1 351 353 PF00082 0.609
CLV_PCSK_KEX2_1 518 520 PF00082 0.576
CLV_PCSK_KEX2_1 556 558 PF00082 0.757
CLV_PCSK_KEX2_1 98 100 PF00082 0.263
CLV_PCSK_PC1ET2_1 351 353 PF00082 0.589
CLV_PCSK_PC1ET2_1 556 558 PF00082 0.697
CLV_PCSK_SKI1_1 108 112 PF00082 0.322
CLV_PCSK_SKI1_1 314 318 PF00082 0.487
CLV_PCSK_SKI1_1 331 335 PF00082 0.256
CLV_PCSK_SKI1_1 34 38 PF00082 0.361
CLV_PCSK_SKI1_1 356 360 PF00082 0.569
CLV_PCSK_SKI1_1 60 64 PF00082 0.231
DEG_APCC_DBOX_1 33 41 PF00400 0.571
DEG_APCC_DBOX_1 75 83 PF00400 0.555
DOC_CYCLIN_yCln2_LP_2 238 244 PF00134 0.481
DOC_MAPK_gen_1 301 308 PF00069 0.392
DOC_MAPK_gen_1 466 473 PF00069 0.487
DOC_MAPK_gen_1 72 81 PF00069 0.522
DOC_MAPK_gen_1 96 104 PF00069 0.500
DOC_MAPK_MEF2A_6 274 282 PF00069 0.334
DOC_PP1_RVXF_1 272 278 PF00149 0.338
DOC_PP2B_LxvP_1 345 348 PF13499 0.569
DOC_SPAK_OSR1_1 468 472 PF12202 0.304
DOC_USP7_MATH_1 112 116 PF00917 0.523
DOC_USP7_MATH_1 204 208 PF00917 0.571
DOC_WW_Pin1_4 124 129 PF00397 0.567
DOC_WW_Pin1_4 444 449 PF00397 0.546
LIG_14-3-3_CanoR_1 352 359 PF00244 0.580
LIG_14-3-3_CanoR_1 466 472 PF00244 0.402
LIG_14-3-3_CanoR_1 487 497 PF00244 0.545
LIG_14-3-3_CanoR_1 512 520 PF00244 0.496
LIG_14-3-3_CanoR_1 52 59 PF00244 0.549
LIG_14-3-3_CanoR_1 60 69 PF00244 0.493
LIG_14-3-3_CanoR_1 98 103 PF00244 0.498
LIG_AP2alpha_2 240 242 PF02296 0.508
LIG_APCC_ABBA_1 139 144 PF00400 0.541
LIG_APCC_ABBA_1 397 402 PF00400 0.595
LIG_BRCT_BRCA1_1 385 389 PF00533 0.494
LIG_eIF4E_1 171 177 PF01652 0.571
LIG_eIF4E_1 233 239 PF01652 0.483
LIG_eIF4E_1 312 318 PF01652 0.450
LIG_FHA_1 159 165 PF00498 0.537
LIG_FHA_1 340 346 PF00498 0.570
LIG_FHA_1 353 359 PF00498 0.413
LIG_FHA_1 372 378 PF00498 0.457
LIG_FHA_1 444 450 PF00498 0.636
LIG_FHA_1 496 502 PF00498 0.462
LIG_FHA_1 508 514 PF00498 0.449
LIG_FHA_1 76 82 PF00498 0.479
LIG_FHA_2 200 206 PF00498 0.571
LIG_FHA_2 235 241 PF00498 0.427
LIG_FHA_2 479 485 PF00498 0.544
LIG_FHA_2 504 510 PF00498 0.475
LIG_FHA_2 512 518 PF00498 0.417
LIG_FHA_2 92 98 PF00498 0.561
LIG_LIR_Apic_2 14 20 PF02991 0.488
LIG_LIR_Gen_1 172 178 PF02991 0.562
LIG_LIR_Gen_1 234 244 PF02991 0.383
LIG_LIR_Gen_1 276 283 PF02991 0.322
LIG_LIR_Nem_3 172 176 PF02991 0.542
LIG_LIR_Nem_3 234 239 PF02991 0.337
LIG_LIR_Nem_3 276 282 PF02991 0.322
LIG_LIR_Nem_3 286 292 PF02991 0.350
LIG_LIR_Nem_3 394 398 PF02991 0.498
LIG_Rb_LxCxE_1 151 172 PF01857 0.571
LIG_SH2_CRK 17 21 PF00017 0.561
LIG_SH2_CRK 83 87 PF00017 0.553
LIG_SH2_NCK_1 236 240 PF00017 0.492
LIG_SH2_SRC 9 12 PF00017 0.525
LIG_SH2_STAT3 163 166 PF00017 0.516
LIG_SH2_STAT5 130 133 PF00017 0.545
LIG_SH2_STAT5 159 162 PF00017 0.557
LIG_SH2_STAT5 163 166 PF00017 0.551
LIG_SH2_STAT5 236 239 PF00017 0.374
LIG_SH2_STAT5 312 315 PF00017 0.470
LIG_SH2_STAT5 387 390 PF00017 0.448
LIG_SH2_STAT5 9 12 PF00017 0.488
LIG_SH3_3 101 107 PF00018 0.535
LIG_SH3_3 226 232 PF00018 0.522
LIG_SH3_3 257 263 PF00018 0.567
LIG_SH3_3 442 448 PF00018 0.658
LIG_SH3_3 449 455 PF00018 0.417
LIG_SH3_3 47 53 PF00018 0.552
LIG_SUMO_SIM_anti_2 220 227 PF11976 0.493
LIG_SUMO_SIM_anti_2 77 84 PF11976 0.497
LIG_SUMO_SIM_par_1 77 84 PF11976 0.513
LIG_TRAF2_1 155 158 PF00917 0.554
LIG_TYR_ITAM 286 306 PF00017 0.511
LIG_TYR_ITIM 81 86 PF00017 0.571
LIG_WW_2 263 266 PF00397 0.566
LIG_WW_3 105 109 PF00397 0.571
MOD_CK1_1 116 122 PF00069 0.508
MOD_CK1_1 234 240 PF00069 0.453
MOD_CK1_1 245 251 PF00069 0.461
MOD_CK1_1 339 345 PF00069 0.586
MOD_CK1_1 383 389 PF00069 0.452
MOD_CK1_1 406 412 PF00069 0.518
MOD_CK1_1 507 513 PF00069 0.541
MOD_CK2_1 245 251 PF00069 0.438
MOD_CK2_1 5 11 PF00069 0.577
MOD_CK2_1 511 517 PF00069 0.430
MOD_CK2_1 91 97 PF00069 0.561
MOD_Cter_Amidation 553 556 PF01082 0.476
MOD_GlcNHglycan 118 121 PF01048 0.305
MOD_GlcNHglycan 178 181 PF01048 0.298
MOD_GlcNHglycan 191 194 PF01048 0.244
MOD_GlcNHglycan 283 286 PF01048 0.396
MOD_GlcNHglycan 318 321 PF01048 0.501
MOD_GlcNHglycan 336 339 PF01048 0.609
MOD_GlcNHglycan 524 527 PF01048 0.615
MOD_GSK3_1 108 115 PF00069 0.544
MOD_GSK3_1 116 123 PF00069 0.520
MOD_GSK3_1 124 131 PF00069 0.507
MOD_GSK3_1 467 474 PF00069 0.482
MOD_GSK3_1 48 55 PF00069 0.503
MOD_GSK3_1 486 493 PF00069 0.483
MOD_GSK3_1 503 510 PF00069 0.416
MOD_GSK3_1 518 525 PF00069 0.544
MOD_LATS_1 415 421 PF00433 0.573
MOD_N-GLC_1 120 125 PF02516 0.363
MOD_N-GLC_1 218 223 PF02516 0.277
MOD_N-GLC_1 558 563 PF02516 0.749
MOD_NEK2_1 176 181 PF00069 0.520
MOD_NEK2_1 242 247 PF00069 0.496
MOD_NEK2_1 334 339 PF00069 0.533
MOD_NEK2_1 488 493 PF00069 0.417
MOD_NEK2_2 120 125 PF00069 0.571
MOD_NEK2_2 380 385 PF00069 0.495
MOD_PIKK_1 206 212 PF00454 0.488
MOD_PIKK_1 254 260 PF00454 0.498
MOD_PIKK_1 339 345 PF00454 0.660
MOD_PIKK_1 371 377 PF00454 0.440
MOD_PIKK_1 478 484 PF00454 0.508
MOD_PIKK_1 91 97 PF00454 0.498
MOD_PKA_1 351 357 PF00069 0.603
MOD_PKA_1 518 524 PF00069 0.616
MOD_PKA_1 98 104 PF00069 0.489
MOD_PKA_2 351 357 PF00069 0.580
MOD_PKA_2 467 473 PF00069 0.388
MOD_PKA_2 477 483 PF00069 0.412
MOD_PKA_2 486 492 PF00069 0.486
MOD_PKA_2 51 57 PF00069 0.559
MOD_PKA_2 511 517 PF00069 0.544
MOD_PKA_2 518 524 PF00069 0.589
MOD_PKA_2 75 81 PF00069 0.531
MOD_PKA_2 98 104 PF00069 0.498
MOD_Plk_1 120 126 PF00069 0.516
MOD_Plk_1 242 248 PF00069 0.472
MOD_Plk_4 159 165 PF00069 0.565
MOD_Plk_4 212 218 PF00069 0.539
MOD_Plk_4 231 237 PF00069 0.220
MOD_Plk_4 245 251 PF00069 0.423
MOD_Plk_4 75 81 PF00069 0.494
MOD_ProDKin_1 124 130 PF00069 0.567
MOD_ProDKin_1 444 450 PF00069 0.529
MOD_SUMO_rev_2 183 192 PF00179 0.469
TRG_DiLeu_BaEn_1 372 377 PF01217 0.494
TRG_ENDOCYTIC_2 235 238 PF00928 0.364
TRG_ENDOCYTIC_2 289 292 PF00928 0.372
TRG_ENDOCYTIC_2 303 306 PF00928 0.317
TRG_ENDOCYTIC_2 395 398 PF00928 0.551
TRG_ENDOCYTIC_2 83 86 PF00928 0.553
TRG_ER_diArg_1 195 197 PF00400 0.561
TRG_ER_diArg_1 300 302 PF00400 0.385
TRG_ER_diArg_1 313 315 PF00400 0.387
TRG_ER_diArg_1 465 468 PF00400 0.407
TRG_ER_diArg_1 518 520 PF00400 0.574
TRG_ER_diArg_1 73 76 PF00400 0.566
TRG_NLS_Bipartite_1 545 559 PF00514 0.462
TRG_NLS_MonoExtN_4 348 355 PF00514 0.595
TRG_Pf-PMV_PEXEL_1 196 201 PF00026 0.355
TRG_Pf-PMV_PEXEL_1 34 39 PF00026 0.361

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N1I835 Leptomonas seymouri 63% 97%
A0A0S4ILZ5 Bodo saltans 33% 97%
A0A0S4JAK8 Bodo saltans 28% 99%
A0A1X0P557 Trypanosomatidae 40% 100%
A0A3R7RG04 Trypanosoma rangeli 28% 69%
A0A3S7X0L0 Leishmania donovani 99% 100%
A0A422N1U3 Trypanosoma rangeli 42% 100%
A4HFL7 Leishmania braziliensis 80% 100%
D0A5U8 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 38% 100%
E9AD71 Leishmania major 93% 100%
E9AYZ6 Leishmania mexicana (strain MHOM/GT/2001/U1103) 90% 100%
V5AT41 Trypanosoma cruzi 38% 100%
V5BDQ7 Trypanosoma cruzi 30% 93%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS