Tubulin-tyrosine ligase-like protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

tubulin-tyrosine ligase-like protein

Species:

Leishmania infantum

UniProt:

A4I351_LEIIN

TriTrypDb:

LINF_270033100

Length:

476

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005874	microtubule	6	1
GO:0005876	spindle microtubule	7	1
GO:0099080	supramolecular complex	2	1
GO:0099081	supramolecular polymer	3	1
GO:0099512	supramolecular fiber	4	1
GO:0099513	polymeric cytoskeletal fiber	5	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A4I351

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4I351

Function

Biological processes
Term	Name	Level	Count
GO:0006807	nitrogen compound metabolic process	2	12
GO:0008152	metabolic process	1	12
GO:0019538	protein metabolic process	3	12
GO:0036211	protein modification process	4	12
GO:0043170	macromolecule metabolic process	3	12
GO:0043412	macromolecule modification	4	12
GO:0044238	primary metabolic process	2	12
GO:0071704	organic substance metabolic process	2	12
GO:1901564	organonitrogen compound metabolic process	3	12
GO:0000226	microtubule cytoskeleton organization	3	1
GO:0006996	organelle organization	4	1
GO:0007010	cytoskeleton organization	5	1
GO:0007017	microtubule-based process	2	1
GO:0009987	cellular process	1	1
GO:0016043	cellular component organization	3	1
GO:0071840	cellular component organization or biogenesis	2	1

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	12
GO:0016874	ligase activity	2	12
GO:0004835	tubulin-tyrosine ligase activity	3	2
GO:0016879	ligase activity, forming carbon-nitrogen bonds	3	2
GO:0016881	acid-amino acid ligase activity	4	2
GO:0140096	catalytic activity, acting on a protein	2	2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	154	156	PF00675	0.293
CLV_NRD_NRD_1	222	224	PF00675	0.274
CLV_NRD_NRD_1	28	30	PF00675	0.708
CLV_NRD_NRD_1	432	434	PF00675	0.747
CLV_NRD_NRD_1	463	465	PF00675	0.581
CLV_NRD_NRD_1	65	67	PF00675	0.538
CLV_PCSK_KEX2_1	154	156	PF00082	0.266
CLV_PCSK_KEX2_1	431	433	PF00082	0.674
CLV_PCSK_KEX2_1	463	465	PF00082	0.534
CLV_PCSK_KEX2_1	65	67	PF00082	0.544
CLV_PCSK_SKI1_1	154	158	PF00082	0.251
CLV_PCSK_SKI1_1	182	186	PF00082	0.291
CLV_PCSK_SKI1_1	2	6	PF00082	0.594
CLV_PCSK_SKI1_1	215	219	PF00082	0.278
CLV_PCSK_SKI1_1	315	319	PF00082	0.280
CLV_PCSK_SKI1_1	320	324	PF00082	0.271
CLV_PCSK_SKI1_1	369	373	PF00082	0.478
CLV_PCSK_SKI1_1	379	383	PF00082	0.457
CLV_PCSK_SKI1_1	94	98	PF00082	0.488
DEG_APCC_DBOX_1	154	162	PF00400	0.537
DEG_APCC_DBOX_1	319	327	PF00400	0.491
DEG_SPOP_SBC_1	3	7	PF00917	0.525
DEG_SPOP_SBC_1	421	425	PF00917	0.548
DOC_CKS1_1	370	375	PF01111	0.444
DOC_CYCLIN_RxL_1	309	321	PF00134	0.543
DOC_CYCLIN_yCln2_LP_2	233	239	PF00134	0.451
DOC_MAPK_gen_1	180	187	PF00069	0.493
DOC_MAPK_gen_1	223	229	PF00069	0.453
DOC_PP4_FxxP_1	370	373	PF00568	0.451
DOC_PP4_FxxP_1	83	86	PF00568	0.376
DOC_SPAK_OSR1_1	82	86	PF12202	0.371
DOC_USP7_MATH_1	18	22	PF00917	0.607
DOC_USP7_MATH_1	200	204	PF00917	0.547
DOC_USP7_MATH_1	3	7	PF00917	0.619
DOC_USP7_MATH_1	31	35	PF00917	0.675
DOC_USP7_MATH_1	396	400	PF00917	0.717
DOC_USP7_MATH_1	422	426	PF00917	0.597
DOC_USP7_MATH_1	96	100	PF00917	0.406
DOC_WW_Pin1_4	21	26	PF00397	0.597
DOC_WW_Pin1_4	232	237	PF00397	0.451
DOC_WW_Pin1_4	360	365	PF00397	0.443
DOC_WW_Pin1_4	369	374	PF00397	0.364
DOC_WW_Pin1_4	417	422	PF00397	0.748
DOC_WW_Pin1_4	439	444	PF00397	0.660
DOC_WW_Pin1_4	7	12	PF00397	0.623
LIG_14-3-3_CanoR_1	115	119	PF00244	0.457
LIG_14-3-3_CanoR_1	188	196	PF00244	0.538
LIG_14-3-3_CanoR_1	2	11	PF00244	0.488
LIG_14-3-3_CanoR_1	248	253	PF00244	0.449
LIG_14-3-3_CanoR_1	431	438	PF00244	0.717
LIG_14-3-3_CanoR_1	65	72	PF00244	0.452
LIG_APCC_ABBA_1	49	54	PF00400	0.354
LIG_BIR_III_2	466	470	PF00653	0.484
LIG_BRCT_BRCA1_1	434	438	PF00533	0.626
LIG_BRCT_BRCA1_1	45	49	PF00533	0.486
LIG_BRCT_BRCA1_1	97	101	PF00533	0.494
LIG_Clathr_ClatBox_1	89	93	PF01394	0.444
LIG_CSL_BTD_1	287	290	PF09270	0.475
LIG_deltaCOP1_diTrp_1	130	136	PF00928	0.486
LIG_eIF4E_1	212	218	PF01652	0.451
LIG_eIF4E_1	337	343	PF01652	0.475
LIG_FHA_1	102	108	PF00498	0.444
LIG_FHA_1	306	312	PF00498	0.526
LIG_FHA_1	370	376	PF00498	0.406
LIG_FHA_1	46	52	PF00498	0.468
LIG_FHA_2	247	253	PF00498	0.526
LIG_FHA_2	400	406	PF00498	0.740
LIG_GBD_Chelix_1	318	326	PF00786	0.343
LIG_Integrin_isoDGR_2	221	223	PF01839	0.300
LIG_Integrin_RGD_1	464	466	PF01839	0.491
LIG_LIR_Apic_2	368	373	PF02991	0.394
LIG_LIR_Apic_2	81	86	PF02991	0.366
LIG_LIR_Gen_1	50	59	PF02991	0.357
LIG_LIR_Nem_3	104	109	PF02991	0.446
LIG_LIR_Nem_3	235	240	PF02991	0.452
LIG_LIR_Nem_3	334	340	PF02991	0.450
LIG_LIR_Nem_3	455	461	PF02991	0.502
LIG_LIR_Nem_3	46	52	PF02991	0.377
LIG_PCNA_PIPBox_1	126	135	PF02747	0.500
LIG_Pex14_1	106	110	PF04695	0.338
LIG_Pex14_2	458	462	PF04695	0.381
LIG_SH2_CRK	242	246	PF00017	0.472
LIG_SH2_CRK	345	349	PF00017	0.451
LIG_SH2_CRK	87	91	PF00017	0.376
LIG_SH2_NCK_1	242	246	PF00017	0.537
LIG_SH2_SRC	141	144	PF00017	0.525
LIG_SH2_STAP1	237	241	PF00017	0.451
LIG_SH2_STAP1	345	349	PF00017	0.451
LIG_SH2_STAP1	52	56	PF00017	0.388
LIG_SH2_STAT3	207	210	PF00017	0.511
LIG_SH2_STAT5	109	112	PF00017	0.450
LIG_SH2_STAT5	207	210	PF00017	0.462
LIG_SH2_STAT5	212	215	PF00017	0.438
LIG_SH2_STAT5	242	245	PF00017	0.498
LIG_SH2_STAT5	295	298	PF00017	0.462
LIG_SH2_STAT5	42	45	PF00017	0.465
LIG_SH2_STAT5	87	90	PF00017	0.520
LIG_SH3_3	210	216	PF00018	0.451
LIG_SUMO_SIM_par_1	214	220	PF11976	0.537
LIG_TYR_ITIM	85	90	PF00017	0.353
MOD_CDK_SPxxK_3	369	376	PF00069	0.450
MOD_CK1_1	20	26	PF00069	0.690
MOD_CK1_1	235	241	PF00069	0.472
MOD_CK1_1	246	252	PF00069	0.420
MOD_CK1_1	257	263	PF00069	0.462
MOD_CK1_1	294	300	PF00069	0.500
MOD_CK1_1	38	44	PF00069	0.287
MOD_CK1_1	399	405	PF00069	0.737
MOD_CK1_1	412	418	PF00069	0.606
MOD_CK1_1	420	426	PF00069	0.730
MOD_CK1_1	439	445	PF00069	0.607
MOD_CK1_1	47	53	PF00069	0.362
MOD_CK2_1	246	252	PF00069	0.553
MOD_CK2_1	374	380	PF00069	0.524
MOD_CK2_1	399	405	PF00069	0.709
MOD_CK2_1	47	53	PF00069	0.389
MOD_CMANNOS	133	136	PF00535	0.337
MOD_Cter_Amidation	221	224	PF01082	0.262
MOD_Cter_Amidation	429	432	PF01082	0.661
MOD_GlcNHglycan	176	179	PF01048	0.252
MOD_GlcNHglycan	189	192	PF01048	0.226
MOD_GlcNHglycan	33	36	PF01048	0.682
MOD_GlcNHglycan	37	40	PF01048	0.498
MOD_GlcNHglycan	415	418	PF01048	0.708
MOD_GlcNHglycan	438	441	PF01048	0.713
MOD_GSK3_1	110	117	PF00069	0.447
MOD_GSK3_1	17	24	PF00069	0.472
MOD_GSK3_1	291	298	PF00069	0.567
MOD_GSK3_1	3	10	PF00069	0.663
MOD_GSK3_1	31	38	PF00069	0.611
MOD_GSK3_1	387	394	PF00069	0.691
MOD_GSK3_1	396	403	PF00069	0.660
MOD_GSK3_1	405	412	PF00069	0.634
MOD_GSK3_1	413	420	PF00069	0.711
MOD_GSK3_1	43	50	PF00069	0.525
MOD_GSK3_1	432	439	PF00069	0.488
MOD_GSK3_1	67	74	PF00069	0.448
MOD_N-GLC_1	360	365	PF02516	0.251
MOD_N-GLC_1	409	414	PF02516	0.666
MOD_N-GLC_2	268	270	PF02516	0.251
MOD_N-GLC_2	426	428	PF02516	0.521
MOD_NEK2_1	101	106	PF00069	0.353
MOD_NEK2_1	110	115	PF00069	0.384
MOD_NEK2_1	187	192	PF00069	0.497
MOD_NEK2_1	217	222	PF00069	0.566
MOD_NEK2_1	305	310	PF00069	0.538
MOD_NEK2_1	318	323	PF00069	0.532
MOD_NEK2_1	374	379	PF00069	0.469
MOD_NEK2_1	4	9	PF00069	0.612
MOD_NEK2_1	43	48	PF00069	0.386
MOD_NEK2_1	95	100	PF00069	0.440
MOD_NEK2_2	202	207	PF00069	0.431
MOD_PIKK_1	240	246	PF00454	0.511
MOD_PKA_1	431	437	PF00069	0.630
MOD_PKA_1	65	71	PF00069	0.488
MOD_PKA_2	114	120	PF00069	0.445
MOD_PKA_2	187	193	PF00069	0.557
MOD_PKA_2	431	437	PF00069	0.723
MOD_PKA_2	65	71	PF00069	0.433
MOD_Plk_4	235	241	PF00069	0.480
MOD_Plk_4	291	297	PF00069	0.541
MOD_Plk_4	38	44	PF00069	0.409
MOD_Plk_4	85	91	PF00069	0.368
MOD_Plk_4	96	102	PF00069	0.390
MOD_ProDKin_1	21	27	PF00069	0.598
MOD_ProDKin_1	232	238	PF00069	0.451
MOD_ProDKin_1	360	366	PF00069	0.443
MOD_ProDKin_1	369	375	PF00069	0.358
MOD_ProDKin_1	417	423	PF00069	0.746
MOD_ProDKin_1	439	445	PF00069	0.658
MOD_ProDKin_1	7	13	PF00069	0.624
TRG_DiLeu_BaEn_1	153	158	PF01217	0.537
TRG_DiLeu_BaEn_1	456	461	PF01217	0.528
TRG_DiLeu_BaEn_2	453	459	PF01217	0.556
TRG_DiLeu_BaLyEn_6	213	218	PF01217	0.451
TRG_DiLeu_BaLyEn_6	353	358	PF01217	0.553
TRG_ENDOCYTIC_2	242	245	PF00928	0.472
TRG_ENDOCYTIC_2	337	340	PF00928	0.455
TRG_ENDOCYTIC_2	345	348	PF00928	0.444
TRG_ENDOCYTIC_2	52	55	PF00928	0.354
TRG_ENDOCYTIC_2	87	90	PF00928	0.351
TRG_ER_diArg_1	431	433	PF00400	0.674
TRG_ER_diArg_1	462	464	PF00400	0.435
TRG_ER_diArg_1	64	66	PF00400	0.557
TRG_Pf-PMV_PEXEL_1	135	139	PF00026	0.329
TRG_Pf-PMV_PEXEL_1	155	159	PF00026	0.324
TRG_Pf-PMV_PEXEL_1	57	61	PF00026	0.452

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P402	Leptomonas seymouri	23%	100%
A0A0N1I1A1	Leptomonas seymouri	65%	100%
A0A0S4ISF0	Bodo saltans	25%	84%
A0A0S4J6I6	Bodo saltans	41%	100%
A0A1X0NFL2	Trypanosomatidae	51%	100%
A0A1X0NRN8	Trypanosomatidae	33%	96%
A0A1X0P6A0	Trypanosomatidae	25%	71%
A0A3Q8IDP1	Leishmania donovani	100%	89%
A0A422N932	Trypanosoma rangeli	24%	100%
A0A422NE52	Trypanosoma rangeli	49%	100%
A0A422P136	Trypanosoma rangeli	26%	72%
A4H9E1	Leishmania braziliensis	23%	100%
A4HG29	Leishmania braziliensis	79%	100%
A4Q9E4	Mus musculus	27%	88%
C9ZJM2	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	53%	100%
E9ACW9	Leishmania major	94%	100%
E9ARH4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	22%	100%
E9AZF8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	94%	100%
P38160	Sus scrofa	35%	100%
P38584	Bos taurus	34%	100%
P38585	Mus musculus	34%	100%
Q23SI8	Tetrahymena thermophila (strain SB210)	25%	100%
Q8NG68	Homo sapiens	35%	100%
Q9QXJ0	Rattus norvegicus	34%	100%
V5B4U2	Trypanosoma cruzi	23%	86%
V5D711	Trypanosoma cruzi	51%	100%