LeishMANIAdb
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Pre-mRNA-processing factor 19

Quick info Annotations Function or PPIs Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
Pre-mRNA-processing factor 19
Gene product:
WD-repeat protein
Species:
Leishmania infantum
UniProt:
A4I350_LEIIN
TriTrypDb:
LINF_270033000
Length:
513

Annotations

Annotations by Jardim et al.

Protein modification, Uncharacterized

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 10
NetGPI no yes: 0, no: 10
Cellular components
Term Name Level Count
GO:0000974 Prp19 complex 2 11
GO:0005681 spliceosomal complex 3 11
GO:0005840 ribosome 5 6
GO:0032991 protein-containing complex 1 11
GO:0043226 organelle 2 6
GO:0043228 non-membrane-bounded organelle 3 6
GO:0043229 intracellular organelle 3 6
GO:0043232 intracellular non-membrane-bounded organelle 4 6
GO:0110165 cellular anatomical entity 1 6
GO:0140513 nuclear protein-containing complex 2 11
GO:1990904 ribonucleoprotein complex 2 11
GO:0005654 nucleoplasm 2 1
GO:0005684 U2-type spliceosomal complex 4 1
GO:0005730 nucleolus 5 1
GO:0005737 cytoplasm 2 1
GO:0071006 U2-type catalytic step 1 spliceosome 4 1
GO:0071012 catalytic step 1 spliceosome 3 1
GO:1902494 catalytic complex 2 1

Expansion

Sequence features

A4I350
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4I350

Function

Biological processes
Term Name Level Count
GO:0000209 protein polyubiquitination 8 11
GO:0000375 RNA splicing, via transesterification reactions 8 11
GO:0000377 RNA splicing, via transesterification reactions with bulged adenosine as nucleophile 9 11
GO:0000398 mRNA splicing, via spliceosome 8 11
GO:0006139 nucleobase-containing compound metabolic process 3 11
GO:0006259 DNA metabolic process 4 11
GO:0006281 DNA repair 5 11
GO:0006396 RNA processing 6 11
GO:0006397 mRNA processing 7 11
GO:0006725 cellular aromatic compound metabolic process 3 11
GO:0006807 nitrogen compound metabolic process 2 11
GO:0006950 response to stress 2 11
GO:0006974 DNA damage response 4 11
GO:0008152 metabolic process 1 11
GO:0008380 RNA splicing 7 11
GO:0009987 cellular process 1 11
GO:0016070 RNA metabolic process 5 11
GO:0016071 mRNA metabolic process 6 11
GO:0016567 protein ubiquitination 7 11
GO:0019538 protein metabolic process 3 11
GO:0032446 protein modification by small protein conjugation 6 11
GO:0033554 cellular response to stress 3 11
GO:0034641 cellular nitrogen compound metabolic process 3 11
GO:0036211 protein modification process 4 11
GO:0043170 macromolecule metabolic process 3 11
GO:0043412 macromolecule modification 4 11
GO:0044237 cellular metabolic process 2 11
GO:0044238 primary metabolic process 2 11
GO:0044260 obsolete cellular macromolecule metabolic process 3 11
GO:0046483 heterocycle metabolic process 3 11
GO:0050896 response to stimulus 1 11
GO:0051716 cellular response to stimulus 2 11
GO:0070534 protein K63-linked ubiquitination 9 11
GO:0070647 protein modification by small protein conjugation or removal 5 11
GO:0071704 organic substance metabolic process 2 11
GO:0090304 nucleic acid metabolic process 4 11
GO:1901360 organic cyclic compound metabolic process 3 11
GO:1901564 organonitrogen compound metabolic process 3 11
Molecular functions
Term Name Level Count
GO:0003824 catalytic activity 1 11
GO:0004842 ubiquitin-protein transferase activity 4 11
GO:0016740 transferase activity 2 11
GO:0019787 ubiquitin-like protein transferase activity 3 11
GO:0061630 ubiquitin protein ligase activity 5 11
GO:0061659 ubiquitin-like protein ligase activity 4 11
GO:0140096 catalytic activity, acting on a protein 2 11
GO:0016746 acyltransferase activity 3 1

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_NRD_NRD_1 156 158 PF00675 0.465
CLV_NRD_NRD_1 168 170 PF00675 0.414
CLV_NRD_NRD_1 171 173 PF00675 0.442
CLV_NRD_NRD_1 46 48 PF00675 0.475
CLV_PCSK_KEX2_1 156 158 PF00082 0.474
CLV_PCSK_SKI1_1 418 422 PF00082 0.480
DEG_APCC_DBOX_1 417 425 PF00400 0.557
DEG_Nend_Nbox_1 1 3 PF02207 0.559
DEG_SPOP_SBC_1 193 197 PF00917 0.495
DOC_ANK_TNKS_1 234 241 PF00023 0.458
DOC_ANK_TNKS_1 438 445 PF00023 0.503
DOC_MAPK_DCC_7 418 426 PF00069 0.562
DOC_MAPK_HePTP_8 6 18 PF00069 0.517
DOC_MAPK_MEF2A_6 9 18 PF00069 0.513
DOC_USP7_MATH_1 14 18 PF00917 0.388
DOC_USP7_MATH_1 175 179 PF00917 0.630
DOC_USP7_MATH_1 181 185 PF00917 0.533
DOC_USP7_MATH_1 194 198 PF00917 0.524
DOC_USP7_MATH_1 200 204 PF00917 0.601
DOC_USP7_MATH_1 215 219 PF00917 0.615
DOC_USP7_MATH_1 351 355 PF00917 0.360
DOC_USP7_MATH_1 59 63 PF00917 0.636
DOC_WW_Pin1_4 179 184 PF00397 0.633
DOC_WW_Pin1_4 234 239 PF00397 0.564
LIG_14-3-3_CanoR_1 275 284 PF00244 0.432
LIG_14-3-3_CanoR_1 3 11 PF00244 0.576
LIG_14-3-3_CanoR_1 461 469 PF00244 0.576
LIG_14-3-3_CanoR_1 96 106 PF00244 0.524
LIG_Actin_WH2_2 116 133 PF00022 0.527
LIG_Actin_WH2_2 465 480 PF00022 0.573
LIG_BIR_III_2 432 436 PF00653 0.493
LIG_BRCT_BRCA1_1 219 223 PF00533 0.554
LIG_BRCT_BRCA1_1 392 396 PF00533 0.470
LIG_FHA_1 10 16 PF00498 0.523
LIG_FHA_1 249 255 PF00498 0.495
LIG_FHA_1 271 277 PF00498 0.380
LIG_FHA_1 330 336 PF00498 0.508
LIG_FHA_1 472 478 PF00498 0.527
LIG_FHA_1 490 496 PF00498 0.497
LIG_FHA_2 317 323 PF00498 0.502
LIG_FHA_2 343 349 PF00498 0.497
LIG_FHA_2 465 471 PF00498 0.551
LIG_FHA_2 74 80 PF00498 0.521
LIG_LIR_LC3C_4 446 449 PF02991 0.492
LIG_LIR_Nem_3 84 88 PF02991 0.468
LIG_Rb_LxCxE_1 339 354 PF01857 0.508
LIG_RPA_C_Fungi 201 213 PF08784 0.494
LIG_SH2_CRK 352 356 PF00017 0.372
LIG_SH2_NCK_1 506 510 PF00017 0.494
LIG_SH2_STAP1 352 356 PF00017 0.464
LIG_SH2_STAP1 506 510 PF00017 0.500
LIG_SH2_STAT5 32 35 PF00017 0.439
LIG_SH3_3 145 151 PF00018 0.531
LIG_SH3_3 417 423 PF00018 0.463
LIG_SH3_3 8 14 PF00018 0.434
LIG_SUMO_SIM_par_1 14 20 PF11976 0.507
LIG_SUMO_SIM_par_1 315 322 PF11976 0.484
LIG_SUMO_SIM_par_1 332 341 PF11976 0.515
LIG_TRAF2_1 137 140 PF00917 0.675
MOD_CK1_1 17 23 PF00069 0.402
MOD_CK1_1 196 202 PF00069 0.690
MOD_CK1_1 204 210 PF00069 0.501
MOD_CK1_1 225 231 PF00069 0.482
MOD_CK1_1 300 306 PF00069 0.446
MOD_CK1_1 463 469 PF00069 0.606
MOD_CK1_1 62 68 PF00069 0.583
MOD_CK1_1 73 79 PF00069 0.283
MOD_CK2_1 24 30 PF00069 0.403
MOD_CK2_1 264 270 PF00069 0.466
MOD_CK2_1 318 324 PF00069 0.447
MOD_CK2_1 342 348 PF00069 0.489
MOD_CK2_1 464 470 PF00069 0.619
MOD_CK2_1 73 79 PF00069 0.381
MOD_GlcNHglycan 177 180 PF01048 0.574
MOD_GlcNHglycan 19 22 PF01048 0.424
MOD_GlcNHglycan 198 201 PF01048 0.685
MOD_GlcNHglycan 203 206 PF01048 0.599
MOD_GlcNHglycan 219 222 PF01048 0.358
MOD_GlcNHglycan 224 227 PF01048 0.503
MOD_GlcNHglycan 266 269 PF01048 0.386
MOD_GlcNHglycan 293 296 PF01048 0.475
MOD_GlcNHglycan 324 327 PF01048 0.523
MOD_GlcNHglycan 340 343 PF01048 0.388
MOD_GlcNHglycan 392 395 PF01048 0.362
MOD_GlcNHglycan 396 399 PF01048 0.351
MOD_GlcNHglycan 429 432 PF01048 0.462
MOD_GlcNHglycan 462 465 PF01048 0.575
MOD_GlcNHglycan 479 482 PF01048 0.481
MOD_GlcNHglycan 489 492 PF01048 0.531
MOD_GlcNHglycan 65 68 PF01048 0.592
MOD_GSK3_1 175 182 PF00069 0.597
MOD_GSK3_1 192 199 PF00069 0.534
MOD_GSK3_1 200 207 PF00069 0.595
MOD_GSK3_1 282 289 PF00069 0.520
MOD_GSK3_1 318 325 PF00069 0.425
MOD_GSK3_1 329 336 PF00069 0.416
MOD_GSK3_1 338 345 PF00069 0.279
MOD_GSK3_1 382 389 PF00069 0.495
MOD_GSK3_1 390 397 PF00069 0.345
MOD_GSK3_1 460 467 PF00069 0.520
MOD_GSK3_1 485 492 PF00069 0.445
MOD_GSK3_1 59 66 PF00069 0.602
MOD_N-GLC_1 4 9 PF02516 0.575
MOD_NEK2_1 24 29 PF00069 0.493
MOD_NEK2_1 337 342 PF00069 0.548
MOD_NEK2_1 462 467 PF00069 0.554
MOD_NEK2_1 477 482 PF00069 0.544
MOD_NEK2_1 505 510 PF00069 0.477
MOD_NEK2_2 14 19 PF00069 0.508
MOD_PIKK_1 181 187 PF00454 0.533
MOD_PIKK_1 256 262 PF00454 0.481
MOD_PIKK_1 297 303 PF00454 0.475
MOD_PIKK_1 4 10 PF00454 0.499
MOD_PIKK_1 97 103 PF00454 0.402
MOD_PKA_2 121 127 PF00069 0.433
MOD_PKA_2 382 388 PF00069 0.562
MOD_PKA_2 460 466 PF00069 0.522
MOD_Plk_1 24 30 PF00069 0.403
MOD_Plk_1 270 276 PF00069 0.393
MOD_Plk_1 59 65 PF00069 0.615
MOD_Plk_2-3 239 245 PF00069 0.483
MOD_Plk_4 282 288 PF00069 0.556
MOD_Plk_4 374 380 PF00069 0.482
MOD_Plk_4 73 79 PF00069 0.421
MOD_ProDKin_1 179 185 PF00069 0.627
MOD_ProDKin_1 234 240 PF00069 0.574
TRG_ENDOCYTIC_2 352 355 PF00928 0.376
TRG_ER_diArg_1 155 157 PF00400 0.521
TRG_NLS_Bipartite_1 156 173 PF00514 0.518
TRG_NLS_MonoExtC_3 168 173 PF00514 0.526
TRG_NLS_MonoExtN_4 166 173 PF00514 0.520
TRG_Pf-PMV_PEXEL_1 26 30 PF00026 0.369

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N1IMA9 Leptomonas seymouri 64% 100%
A0A0S4J7B3 Bodo saltans 35% 100%
A0A1X0NFA4 Trypanosomatidae 35% 100%
A0A3Q8IGJ0 Leishmania donovani 100% 100%
A0A3R7NBE4 Trypanosoma rangeli 35% 100%
A4HG28 Leishmania braziliensis 83% 100%
C9ZJM1 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 31% 100%
E9ACW8 Leishmania major 98% 100%
E9AZF7 Leishmania mexicana (strain MHOM/GT/2001/U1103) 96% 100%
O22785 Arabidopsis thaliana 28% 98%
Q08E38 Bos taurus 30% 100%
Q10051 Caenorhabditis elegans 28% 100%
Q5ZMA2 Gallus gallus 30% 100%
Q94BR4 Arabidopsis thaliana 26% 98%
Q99KP6 Mus musculus 29% 100%
Q9AV81 Oryza sativa subsp. japonica 26% 97%
Q9JMJ4 Rattus norvegicus 29% 100%
Q9UMS4 Homo sapiens 30% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2024 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS