LeishMANIAdb
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Protein kinase domain-containing protein

Quick info Annotations Function or PPIs Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
Protein kinase domain-containing protein
Gene product:
protein kinase - putative
Species:
Leishmania infantum
UniProt:
A4I349_LEIIN
TriTrypDb:
LINF_270032900 *
Length:
564

Annotations

LeishMANIAdb annotations

A large and apprently artificial collection of diverse kinetoplastid protein kinases. None of them appear to be TM.

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 4
Forrest at al. (procyclic) no yes: 4
Silverman et al. no yes: 0
Pissara et al. yes yes: 21
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 5
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 10
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 22
NetGPI no yes: 0, no: 22
Cellular components
Term Name Level Count
GO:0005634 nucleus 5 1
GO:0005737 cytoplasm 2 2
GO:0043226 organelle 2 1
GO:0043227 membrane-bounded organelle 3 1
GO:0043229 intracellular organelle 3 1
GO:0043231 intracellular membrane-bounded organelle 4 1
GO:0110165 cellular anatomical entity 1 3
GO:0016020 membrane 2 1
GO:0031974 membrane-enclosed lumen 2 1
GO:0031981 nuclear lumen 5 1
GO:0032838 plasma membrane bounded cell projection cytoplasm 4 1
GO:0043233 organelle lumen 3 1
GO:0070013 intracellular organelle lumen 4 1
GO:0097014 ciliary plasm 5 1
GO:0099568 cytoplasmic region 3 1

Expansion

Sequence features

A4I349
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4I349

Function

Biological processes
Term Name Level Count
GO:0006468 protein phosphorylation 5 23
GO:0006793 phosphorus metabolic process 3 23
GO:0006796 phosphate-containing compound metabolic process 4 23
GO:0006807 nitrogen compound metabolic process 2 23
GO:0008152 metabolic process 1 23
GO:0009987 cellular process 1 23
GO:0016310 phosphorylation 5 23
GO:0019538 protein metabolic process 3 23
GO:0036211 protein modification process 4 23
GO:0043170 macromolecule metabolic process 3 23
GO:0043412 macromolecule modification 4 23
GO:0044237 cellular metabolic process 2 23
GO:0044238 primary metabolic process 2 23
GO:0071704 organic substance metabolic process 2 23
GO:1901564 organonitrogen compound metabolic process 3 23
GO:0007165 signal transduction 2 1
GO:0018105 peptidyl-serine phosphorylation 6 2
GO:0018193 peptidyl-amino acid modification 5 2
GO:0018209 peptidyl-serine modification 6 2
GO:0035556 intracellular signal transduction 3 1
GO:0046777 protein autophosphorylation 6 1
GO:0050789 regulation of biological process 2 1
GO:0050794 regulation of cellular process 3 1
GO:0065007 biological regulation 1 1
GO:0000281 mitotic cytokinesis 4 1
GO:0000910 cytokinesis 3 1
GO:0022402 cell cycle process 2 1
GO:0061640 cytoskeleton-dependent cytokinesis 4 1
GO:1903047 mitotic cell cycle process 3 1
Molecular functions
Term Name Level Count
GO:0000166 nucleotide binding 3 23
GO:0003824 catalytic activity 1 23
GO:0004672 protein kinase activity 3 23
GO:0005488 binding 1 23
GO:0005524 ATP binding 5 23
GO:0016301 kinase activity 4 23
GO:0016740 transferase activity 2 23
GO:0016772 transferase activity, transferring phosphorus-containing groups 3 23
GO:0016773 phosphotransferase activity, alcohol group as acceptor 4 23
GO:0017076 purine nucleotide binding 4 23
GO:0030554 adenyl nucleotide binding 5 23
GO:0032553 ribonucleotide binding 3 23
GO:0032555 purine ribonucleotide binding 4 23
GO:0032559 adenyl ribonucleotide binding 5 23
GO:0035639 purine ribonucleoside triphosphate binding 4 23
GO:0036094 small molecule binding 2 23
GO:0043167 ion binding 2 23
GO:0043168 anion binding 3 23
GO:0097159 organic cyclic compound binding 2 23
GO:0097367 carbohydrate derivative binding 2 23
GO:0140096 catalytic activity, acting on a protein 2 23
GO:1901265 nucleoside phosphate binding 3 23
GO:1901363 heterocyclic compound binding 2 23
GO:0004674 protein serine/threonine kinase activity 4 16
GO:0008270 zinc ion binding 6 1
GO:0043169 cation binding 3 1
GO:0046872 metal ion binding 4 1
GO:0046914 transition metal ion binding 5 1
GO:0004683 calmodulin-dependent protein kinase activity 5 1
GO:0005515 protein binding 2 1
GO:0005516 calmodulin binding 3 1
GO:0009931 calcium-dependent protein serine/threonine kinase activity 5 1
GO:0010857 calcium-dependent protein kinase activity 4 1

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_NRD_NRD_1 206 208 PF00675 0.342
CLV_NRD_NRD_1 440 442 PF00675 0.364
CLV_NRD_NRD_1 56 58 PF00675 0.264
CLV_NRD_NRD_1 562 564 PF00675 0.535
CLV_NRD_NRD_1 94 96 PF00675 0.216
CLV_PCSK_KEX2_1 408 410 PF00082 0.419
CLV_PCSK_KEX2_1 442 444 PF00082 0.337
CLV_PCSK_KEX2_1 549 551 PF00082 0.550
CLV_PCSK_KEX2_1 56 58 PF00082 0.380
CLV_PCSK_KEX2_1 562 564 PF00082 0.521
CLV_PCSK_KEX2_1 94 96 PF00082 0.216
CLV_PCSK_PC1ET2_1 408 410 PF00082 0.435
CLV_PCSK_PC1ET2_1 442 444 PF00082 0.337
CLV_PCSK_PC1ET2_1 549 551 PF00082 0.550
CLV_PCSK_PC1ET2_1 56 58 PF00082 0.380
CLV_PCSK_SKI1_1 128 132 PF00082 0.287
CLV_PCSK_SKI1_1 145 149 PF00082 0.399
CLV_PCSK_SKI1_1 309 313 PF00082 0.452
CLV_PCSK_SKI1_1 314 318 PF00082 0.527
CLV_PCSK_SKI1_1 490 494 PF00082 0.478
CLV_PCSK_SKI1_1 549 553 PF00082 0.552
DEG_APCC_DBOX_1 127 135 PF00400 0.338
DEG_APCC_DBOX_1 440 448 PF00400 0.346
DEG_SCF_FBW7_1 537 542 PF00400 0.553
DEG_SPOP_SBC_1 182 186 PF00917 0.338
DEG_SPOP_SBC_1 532 536 PF00917 0.552
DOC_CYCLIN_yCln2_LP_2 287 293 PF00134 0.252
DOC_MAPK_gen_1 145 154 PF00069 0.331
DOC_MAPK_gen_1 313 322 PF00069 0.487
DOC_MAPK_gen_1 43 53 PF00069 0.238
DOC_MAPK_gen_1 94 102 PF00069 0.274
DOC_MAPK_JIP1_4 148 154 PF00069 0.285
DOC_MAPK_JIP1_4 280 286 PF00069 0.229
DOC_MAPK_MEF2A_6 94 102 PF00069 0.285
DOC_MAPK_NFAT4_5 95 103 PF00069 0.301
DOC_SPAK_OSR1_1 95 99 PF12202 0.214
DOC_USP7_MATH_1 158 162 PF00917 0.359
DOC_USP7_MATH_1 427 431 PF00917 0.507
DOC_USP7_MATH_1 539 543 PF00917 0.714
DOC_USP7_MATH_1 545 549 PF00917 0.804
DOC_USP7_UBL2_3 313 317 PF12436 0.421
DOC_USP7_UBL2_3 52 56 PF12436 0.331
DOC_USP7_UBL2_3 540 544 PF12436 0.560
DOC_USP7_UBL2_3 58 62 PF12436 0.331
DOC_WW_Pin1_4 156 161 PF00397 0.274
DOC_WW_Pin1_4 187 192 PF00397 0.326
DOC_WW_Pin1_4 259 264 PF00397 0.302
DOC_WW_Pin1_4 333 338 PF00397 0.443
DOC_WW_Pin1_4 516 521 PF00397 0.634
DOC_WW_Pin1_4 533 538 PF00397 0.639
DOC_WW_Pin1_4 551 556 PF00397 0.538
LIG_14-3-3_CanoR_1 20 26 PF00244 0.315
LIG_14-3-3_CanoR_1 250 254 PF00244 0.404
LIG_14-3-3_CanoR_1 344 352 PF00244 0.465
LIG_14-3-3_CanoR_1 479 483 PF00244 0.573
LIG_14-3-3_CanoR_1 550 555 PF00244 0.524
LIG_14-3-3_CterR_2 562 564 PF00244 0.553
LIG_APCC_ABBA_1 413 418 PF00400 0.473
LIG_APCC_ABBAyCdc20_2 140 146 PF00400 0.227
LIG_deltaCOP1_diTrp_1 334 342 PF00928 0.478
LIG_EH1_1 96 104 PF00400 0.227
LIG_eIF4E_1 97 103 PF01652 0.237
LIG_FHA_1 222 228 PF00498 0.270
LIG_FHA_1 240 246 PF00498 0.222
LIG_FHA_1 324 330 PF00498 0.450
LIG_FHA_1 43 49 PF00498 0.299
LIG_FHA_1 66 72 PF00498 0.241
LIG_FHA_2 204 210 PF00498 0.255
LIG_FHA_2 262 268 PF00498 0.303
LIG_FHA_2 280 286 PF00498 0.412
LIG_LIR_Apic_2 190 196 PF02991 0.331
LIG_LIR_Apic_2 334 338 PF02991 0.496
LIG_LIR_Gen_1 224 233 PF02991 0.237
LIG_LIR_Gen_1 241 247 PF02991 0.318
LIG_LIR_Gen_1 255 265 PF02991 0.223
LIG_LIR_Gen_1 336 343 PF02991 0.515
LIG_LIR_Gen_1 346 353 PF02991 0.502
LIG_LIR_Gen_1 402 411 PF02991 0.353
LIG_LIR_Nem_3 224 228 PF02991 0.281
LIG_LIR_Nem_3 241 246 PF02991 0.287
LIG_LIR_Nem_3 255 261 PF02991 0.304
LIG_LIR_Nem_3 274 278 PF02991 0.222
LIG_LIR_Nem_3 336 342 PF02991 0.402
LIG_LIR_Nem_3 346 352 PF02991 0.393
LIG_LIR_Nem_3 402 406 PF02991 0.302
LIG_LIR_Nem_3 412 417 PF02991 0.356
LIG_LIR_Nem_3 481 486 PF02991 0.592
LIG_LIR_Nem_3 93 99 PF02991 0.380
LIG_LYPXL_S_1 413 417 PF13949 0.341
LIG_LYPXL_yS_3 414 417 PF13949 0.336
LIG_Pex14_1 335 339 PF04695 0.482
LIG_Pex14_2 239 243 PF04695 0.349
LIG_SH2_CRK 34 38 PF00017 0.278
LIG_SH2_NCK_1 275 279 PF00017 0.244
LIG_SH2_NCK_1 34 38 PF00017 0.237
LIG_SH2_PTP2 193 196 PF00017 0.271
LIG_SH2_PTP2 225 228 PF00017 0.305
LIG_SH2_PTP2 97 100 PF00017 0.418
LIG_SH2_SRC 181 184 PF00017 0.338
LIG_SH2_SRC 275 278 PF00017 0.222
LIG_SH2_STAP1 34 38 PF00017 0.237
LIG_SH2_STAP1 49 53 PF00017 0.338
LIG_SH2_STAT5 181 184 PF00017 0.298
LIG_SH2_STAT5 193 196 PF00017 0.321
LIG_SH2_STAT5 225 228 PF00017 0.312
LIG_SH2_STAT5 403 406 PF00017 0.321
LIG_SH2_STAT5 449 452 PF00017 0.301
LIG_SH2_STAT5 89 92 PF00017 0.321
LIG_SH2_STAT5 97 100 PF00017 0.330
LIG_SH3_3 275 281 PF00018 0.283
LIG_SH3_4 540 547 PF00018 0.535
LIG_SUMO_SIM_anti_2 282 288 PF11976 0.229
LIG_SUMO_SIM_anti_2 70 75 PF11976 0.279
LIG_SUMO_SIM_par_1 98 104 PF11976 0.373
LIG_TYR_ITIM 223 228 PF00017 0.351
LIG_TYR_ITIM 273 278 PF00017 0.222
LIG_UBA3_1 108 116 PF00899 0.311
MOD_CDK_SPK_2 535 540 PF00069 0.549
MOD_CDK_SPxK_1 556 562 PF00069 0.541
MOD_CDK_SPxxK_3 259 266 PF00069 0.278
MOD_CDK_SPxxK_3 533 540 PF00069 0.724
MOD_CDK_SPxxK_3 556 563 PF00069 0.523
MOD_CK1_1 121 127 PF00069 0.246
MOD_CK1_1 159 165 PF00069 0.250
MOD_CK1_1 166 172 PF00069 0.224
MOD_CK1_1 252 258 PF00069 0.281
MOD_CK1_1 304 310 PF00069 0.452
MOD_CK1_1 478 484 PF00069 0.518
MOD_CK1_1 519 525 PF00069 0.546
MOD_CK1_1 535 541 PF00069 0.558
MOD_CK1_1 543 549 PF00069 0.608
MOD_CK2_1 203 209 PF00069 0.254
MOD_CK2_1 235 241 PF00069 0.325
MOD_CK2_1 279 285 PF00069 0.246
MOD_CK2_1 496 502 PF00069 0.471
MOD_Cter_Amidation 406 409 PF01082 0.375
MOD_GlcNHglycan 103 106 PF01048 0.348
MOD_GlcNHglycan 131 134 PF01048 0.331
MOD_GlcNHglycan 228 231 PF01048 0.265
MOD_GSK3_1 1 8 PF00069 0.535
MOD_GSK3_1 156 163 PF00069 0.283
MOD_GSK3_1 183 190 PF00069 0.281
MOD_GSK3_1 235 242 PF00069 0.256
MOD_GSK3_1 245 252 PF00069 0.345
MOD_GSK3_1 257 264 PF00069 0.273
MOD_GSK3_1 343 350 PF00069 0.520
MOD_GSK3_1 363 370 PF00069 0.366
MOD_GSK3_1 486 493 PF00069 0.498
MOD_GSK3_1 519 526 PF00069 0.530
MOD_GSK3_1 531 538 PF00069 0.758
MOD_GSK3_1 539 546 PF00069 0.661
MOD_N-GLC_1 121 126 PF02516 0.222
MOD_N-GLC_1 166 171 PF02516 0.429
MOD_NEK2_1 1 6 PF00069 0.442
MOD_NEK2_1 245 250 PF00069 0.259
MOD_NEK2_1 323 328 PF00069 0.478
MOD_NEK2_1 475 480 PF00069 0.499
MOD_NEK2_1 486 491 PF00069 0.468
MOD_PIKK_1 323 329 PF00454 0.572
MOD_PIKK_1 354 360 PF00454 0.418
MOD_PKA_1 549 555 PF00069 0.527
MOD_PKA_2 249 255 PF00069 0.386
MOD_PKA_2 279 285 PF00069 0.255
MOD_PKA_2 343 349 PF00069 0.515
MOD_PKA_2 42 48 PF00069 0.264
MOD_PKA_2 478 484 PF00069 0.590
MOD_PKA_2 549 555 PF00069 0.526
MOD_Plk_1 121 127 PF00069 0.323
MOD_Plk_1 427 433 PF00069 0.418
MOD_Plk_4 121 127 PF00069 0.259
MOD_Plk_4 189 195 PF00069 0.269
MOD_Plk_4 325 331 PF00069 0.457
MOD_Plk_4 348 354 PF00069 0.333
MOD_Plk_4 478 484 PF00069 0.553
MOD_ProDKin_1 156 162 PF00069 0.274
MOD_ProDKin_1 187 193 PF00069 0.326
MOD_ProDKin_1 259 265 PF00069 0.302
MOD_ProDKin_1 333 339 PF00069 0.434
MOD_ProDKin_1 516 522 PF00069 0.638
MOD_ProDKin_1 533 539 PF00069 0.640
MOD_ProDKin_1 551 557 PF00069 0.538
MOD_SUMO_for_1 147 150 PF00179 0.331
MOD_SUMO_rev_2 357 364 PF00179 0.503
MOD_SUMO_rev_2 368 378 PF00179 0.447
TRG_DiLeu_BaEn_1 241 246 PF01217 0.222
TRG_DiLeu_BaEn_2 411 417 PF01217 0.469
TRG_ENDOCYTIC_2 225 228 PF00928 0.356
TRG_ENDOCYTIC_2 275 278 PF00928 0.224
TRG_ENDOCYTIC_2 34 37 PF00928 0.292
TRG_ENDOCYTIC_2 403 406 PF00928 0.305
TRG_ENDOCYTIC_2 414 417 PF00928 0.336
TRG_ENDOCYTIC_2 97 100 PF00928 0.348
TRG_ER_diArg_1 204 207 PF00400 0.386
TRG_ER_diArg_1 441 444 PF00400 0.343
TRG_ER_diArg_1 94 96 PF00400 0.214
TRG_NLS_MonoExtC_3 312 317 PF00514 0.388
TRG_NLS_MonoExtN_4 313 318 PF00514 0.403
TRG_Pf-PMV_PEXEL_1 145 150 PF00026 0.311

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N1PE80 Leptomonas seymouri 71% 100%
A0A0S4J7K4 Bodo saltans 60% 100%
A0A1X0NJV4 Trypanosomatidae 60% 100%
A0A1X0P1A2 Trypanosomatidae 60% 100%
A0A2I0BVG8 Plasmodium falciparum (isolate NF54) 28% 100%
A0A3Q8IDK8 Leishmania donovani 100% 100%
A0A3Q8IFK8 Leishmania donovani 27% 100%
A0A3Q8INQ4 Leishmania donovani 30% 100%
A0A3Q8IVR8 Leishmania donovani 26% 100%
A0A3S5H5G0 Leishmania donovani 28% 100%
A0A3S5H5U5 Leishmania donovani 23% 100%
A0A3S7WTN9 Leishmania donovani 25% 100%
A0A509AHB6 Plasmodium berghei (strain Anka) 28% 100%
A4H459 Leishmania braziliensis 29% 100%
A4H4S9 Leishmania braziliensis 25% 100%
A4H8C4 Leishmania braziliensis 26% 100%
A4HC27 Leishmania braziliensis 24% 100%
A4HCD7 Leishmania braziliensis 33% 100%
A4HED7 Leishmania braziliensis 29% 100%
A4HG27 Leishmania braziliensis 84% 100%
A4HJT5 Leishmania braziliensis 27% 100%
A4HJW2 Leishmania braziliensis 24% 100%
A4HNT2 Leishmania braziliensis 26% 100%
A4HP12 Leishmania braziliensis 27% 100%
A4HSE2 Leishmania infantum 28% 100%
A4HWP5 Leishmania infantum 25% 100%
A4I1T4 Leishmania infantum 30% 100%
A4I7A1 Leishmania infantum 27% 100%
A4IBT4 Leishmania infantum 27% 100%
A4ICR2 Leishmania infantum 26% 100%
C9ZN29 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 52% 100%
E9ACW7 Leishmania major 92% 100%
E9AG71 Leishmania infantum 23% 100%
E9AKB7 Leishmania mexicana (strain MHOM/GT/2001/U1103) 29% 100%
E9AKZ7 Leishmania mexicana (strain MHOM/GT/2001/U1103) 25% 100%
E9AQF3 Leishmania mexicana (strain MHOM/GT/2001/U1103) 25% 100%
E9AXW8 Leishmania mexicana (strain MHOM/GT/2001/U1103) 30% 100%
E9AZF6 Leishmania mexicana (strain MHOM/GT/2001/U1103) 95% 100%
E9B296 Leishmania mexicana (strain MHOM/GT/2001/U1103) 27% 100%
E9B6S4 Leishmania mexicana (strain MHOM/GT/2001/U1103) 28% 100%
P62343 Plasmodium falciparum (isolate K1 / Thailand) 28% 100%
P62344 Plasmodium falciparum (isolate 3D7) 28% 100%
Q4Q204 Leishmania major 26% 100%
Q4Q5W2 Leishmania major 28% 100%
Q4Q9K2 Leishmania major 31% 100%
Q4QF23 Leishmania major 25% 100%
Q4QIV8 Leishmania major 25% 100%
Q4QJJ0 Leishmania major 28% 100%
Q6C7U0 Yarrowia lipolytica (strain CLIB 122 / E 150) 27% 79%
Q7RAH3 Plasmodium yoelii yoelii 28% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS