Protein kinase domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

protein kinase - putative

Species:

Leishmania infantum

UniProt:

A4I347_LEIIN

TriTrypDb:

LINF_270032800

Length:

125

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 1
NetGPI	no	yes: 0, no: 1

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4I347

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4I347

Function

Biological processes
Term	Name	Level	Count
GO:0006468	protein phosphorylation	5	2
GO:0006793	phosphorus metabolic process	3	2
GO:0006796	phosphate-containing compound metabolic process	4	2
GO:0006807	nitrogen compound metabolic process	2	2
GO:0008152	metabolic process	1	2
GO:0009987	cellular process	1	2
GO:0016310	phosphorylation	5	2
GO:0019538	protein metabolic process	3	2
GO:0036211	protein modification process	4	2
GO:0043170	macromolecule metabolic process	3	2
GO:0043412	macromolecule modification	4	2
GO:0044237	cellular metabolic process	2	2
GO:0044238	primary metabolic process	2	2
GO:0071704	organic substance metabolic process	2	2
GO:1901564	organonitrogen compound metabolic process	3	2

Molecular functions
Term	Name	Level	Count
GO:0000166	nucleotide binding	3	2
GO:0003824	catalytic activity	1	2
GO:0004672	protein kinase activity	3	2
GO:0005488	binding	1	2
GO:0005524	ATP binding	5	2
GO:0016301	kinase activity	4	2
GO:0016740	transferase activity	2	2
GO:0016772	transferase activity, transferring phosphorus-containing groups	3	2
GO:0016773	phosphotransferase activity, alcohol group as acceptor	4	2
GO:0017076	purine nucleotide binding	4	2
GO:0030554	adenyl nucleotide binding	5	2
GO:0032553	ribonucleotide binding	3	2
GO:0032555	purine ribonucleotide binding	4	2
GO:0032559	adenyl ribonucleotide binding	5	2
GO:0035639	purine ribonucleoside triphosphate binding	4	2
GO:0036094	small molecule binding	2	2
GO:0043167	ion binding	2	2
GO:0043168	anion binding	3	2
GO:0097159	organic cyclic compound binding	2	2
GO:0097367	carbohydrate derivative binding	2	2
GO:0140096	catalytic activity, acting on a protein	2	2
GO:1901265	nucleoside phosphate binding	3	2
GO:1901363	heterocyclic compound binding	2	2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	47	49	PF00675	0.199
CLV_PCSK_KEX2_1	33	35	PF00082	0.199
CLV_PCSK_KEX2_1	47	49	PF00082	0.199
CLV_PCSK_PC1ET2_1	33	35	PF00082	0.199
CLV_PCSK_SKI1_1	113	117	PF00082	0.199
CLV_PCSK_SKI1_1	34	38	PF00082	0.199
DEG_APCC_DBOX_1	112	120	PF00400	0.199
DOC_CDC14_PxL_1	62	70	PF14671	0.199
DOC_MAPK_gen_1	47	53	PF00069	0.199
DOC_MAPK_MEF2A_6	70	78	PF00069	0.199
DOC_USP7_MATH_1	43	47	PF00917	0.199
DOC_USP7_UBL2_3	33	37	PF12436	0.199
LIG_14-3-3_CanoR_1	96	103	PF00244	0.199
LIG_APCC_ABBA_1	72	77	PF00400	0.199
LIG_BIR_II_1	1	5	PF00653	0.290
LIG_BRCT_BRCA1_1	10	14	PF00533	0.282
LIG_GBD_Chelix_1	111	119	PF00786	0.199
LIG_KLC1_Yacidic_2	73	77	PF13176	0.199
LIG_LIR_Gen_1	10	20	PF02991	0.286
LIG_LIR_Gen_1	73	83	PF02991	0.199
LIG_LIR_Gen_1	92	102	PF02991	0.199
LIG_LIR_Nem_3	10	15	PF02991	0.282
LIG_LIR_Nem_3	73	78	PF02991	0.199
LIG_LIR_Nem_3	92	97	PF02991	0.199
LIG_SH2_CRK	12	16	PF00017	0.283
LIG_SH2_CRK	94	98	PF00017	0.199
LIG_SH2_PTP2	75	78	PF00017	0.199
LIG_SH2_SRC	75	78	PF00017	0.199
LIG_SH2_STAP1	12	16	PF00017	0.283
LIG_SH2_STAT5	75	78	PF00017	0.199
LIG_SH3_1	60	66	PF00018	0.199
LIG_SH3_3	60	66	PF00018	0.199
LIG_SUMO_SIM_anti_2	117	123	PF11976	0.199
LIG_SUMO_SIM_anti_2	79	86	PF11976	0.199
LIG_TRAF2_1	52	55	PF00917	0.199
MOD_GSK3_1	23	30	PF00069	0.199
MOD_GSK3_1	54	61	PF00069	0.199
MOD_NEK2_1	58	63	PF00069	0.199
MOD_PKA_2	23	29	PF00069	0.199
MOD_PKA_2	79	85	PF00069	0.199
MOD_PKA_2	95	101	PF00069	0.199
MOD_Plk_4	79	85	PF00069	0.199
MOD_Plk_4	89	95	PF00069	0.199
TRG_DiLeu_BaEn_2	9	15	PF01217	0.278
TRG_ENDOCYTIC_2	12	15	PF00928	0.279
TRG_ENDOCYTIC_2	75	78	PF00928	0.199
TRG_ENDOCYTIC_2	94	97	PF00928	0.199
TRG_NES_CRM1_1	67	79	PF08389	0.199

Homologs


Protein	Taxonomy	Sequence identity	Coverage
D0N4E2	PHYIT	32%	31%
P15735	HUMAN	30%	31%
P31325	RAT	28%	31%
P49071	DROME	32%	35%
Q16644	HUMAN	33%	33%
Q2KJ16	BOVIN	30%	31%
Q3SYZ2	BOVIN	34%	33%
Q3UMW7	MOUSE	34%	33%
Q54SJ5	DICDI	27%	40%
Q66H84	RAT	34%	33%
Q8GVC7	PHYIN	32%	31%
Q965G5	CAEEL	33%	34%
Q9DB30	MOUSE	29%	31%