LeishMANIAdb
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Putative TPR-repeat protein

Quick info Annotations Function or PPIs Localization Phosphorylation Abundance Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:
Putative TPR-repeat protein
Gene product:
TPR-repeat protein - putative
Species:
Leishmania infantum
UniProt:
A4I340_LEIIN
TriTrypDb:
LINF_270032100
Length:
488

Annotations

Annotations by Jardim et al.

Metal Binding, TPR-repeat

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. yes yes: 10
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 11
NetGPI no yes: 0, no: 11
Cellular components
Term Name Level Count
GO:0032991 protein-containing complex 1 1
GO:0101031 protein folding chaperone complex 3 1
GO:0140535 intracellular protein-containing complex 2 1

Phosphorylation

Amastigote: 4

Abundance

Amastigote (protein)
Source Evidence on protein Close homologs
Pescher et al. (upgregulation) no yes: 0
Promastigote and amastigote
Source Evidence on protein Close homologs
Lahav et al.
- mRNA
- Protein

Expansion

Sequence features

A4I340
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4I340

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 234 238 PF00656 0.638
CLV_NRD_NRD_1 167 169 PF00675 0.281
CLV_NRD_NRD_1 171 173 PF00675 0.281
CLV_NRD_NRD_1 271 273 PF00675 0.535
CLV_NRD_NRD_1 276 278 PF00675 0.534
CLV_NRD_NRD_1 300 302 PF00675 0.641
CLV_NRD_NRD_1 380 382 PF00675 0.297
CLV_NRD_NRD_1 39 41 PF00675 0.575
CLV_NRD_NRD_1 482 484 PF00675 0.465
CLV_PCSK_FUR_1 298 302 PF00082 0.605
CLV_PCSK_KEX2_1 167 169 PF00082 0.281
CLV_PCSK_KEX2_1 212 214 PF00082 0.574
CLV_PCSK_KEX2_1 229 231 PF00082 0.370
CLV_PCSK_KEX2_1 271 273 PF00082 0.539
CLV_PCSK_KEX2_1 297 299 PF00082 0.602
CLV_PCSK_KEX2_1 300 302 PF00082 0.604
CLV_PCSK_KEX2_1 380 382 PF00082 0.297
CLV_PCSK_PC1ET2_1 212 214 PF00082 0.574
CLV_PCSK_PC1ET2_1 229 231 PF00082 0.370
CLV_PCSK_PC1ET2_1 297 299 PF00082 0.593
CLV_PCSK_SKI1_1 149 153 PF00082 0.450
CLV_PCSK_SKI1_1 483 487 PF00082 0.424
DEG_APCC_DBOX_1 16 24 PF00400 0.570
DEG_APCC_DBOX_1 171 179 PF00400 0.289
DEG_APCC_DBOX_1 181 189 PF00400 0.268
DEG_Nend_UBRbox_2 1 3 PF02207 0.561
DEG_SPOP_SBC_1 344 348 PF00917 0.741
DEG_SPOP_SBC_1 349 353 PF00917 0.749
DOC_CKS1_1 369 374 PF01111 0.513
DOC_CKS1_1 471 476 PF01111 0.513
DOC_MAPK_gen_1 227 233 PF00069 0.604
DOC_MAPK_gen_1 297 307 PF00069 0.578
DOC_MAPK_MEF2A_6 444 452 PF00069 0.456
DOC_USP7_MATH_1 214 218 PF00917 0.568
DOC_USP7_MATH_1 248 252 PF00917 0.682
DOC_USP7_MATH_1 325 329 PF00917 0.631
DOC_USP7_MATH_1 344 348 PF00917 0.687
DOC_USP7_MATH_1 365 369 PF00917 0.637
DOC_USP7_MATH_1 76 80 PF00917 0.630
DOC_USP7_UBL2_3 173 177 PF12436 0.367
DOC_USP7_UBL2_3 37 41 PF12436 0.568
DOC_WW_Pin1_4 311 316 PF00397 0.711
DOC_WW_Pin1_4 321 326 PF00397 0.630
DOC_WW_Pin1_4 332 337 PF00397 0.574
DOC_WW_Pin1_4 339 344 PF00397 0.629
DOC_WW_Pin1_4 345 350 PF00397 0.714
DOC_WW_Pin1_4 368 373 PF00397 0.436
DOC_WW_Pin1_4 410 415 PF00397 0.440
DOC_WW_Pin1_4 470 475 PF00397 0.500
LIG_APCC_ABBA_1 448 453 PF00400 0.409
LIG_FHA_1 113 119 PF00498 0.445
LIG_FHA_1 124 130 PF00498 0.449
LIG_FHA_1 150 156 PF00498 0.447
LIG_FHA_1 204 210 PF00498 0.399
LIG_FHA_1 333 339 PF00498 0.664
LIG_FHA_1 428 434 PF00498 0.503
LIG_FHA_2 143 149 PF00498 0.509
LIG_FHA_2 255 261 PF00498 0.636
LIG_LIR_Gen_1 374 382 PF02991 0.430
LIG_LIR_Gen_1 393 401 PF02991 0.411
LIG_LIR_Nem_3 374 378 PF02991 0.430
LIG_LIR_Nem_3 379 385 PF02991 0.428
LIG_LIR_Nem_3 393 398 PF02991 0.411
LIG_PCNA_PIPBox_1 388 397 PF02747 0.534
LIG_Pex14_2 378 382 PF04695 0.440
LIG_SH2_GRB2like 131 134 PF00017 0.406
LIG_SH2_NCK_1 161 165 PF00017 0.390
LIG_SH2_PTP2 395 398 PF00017 0.413
LIG_SH2_STAP1 131 135 PF00017 0.406
LIG_SH2_STAP1 161 165 PF00017 0.390
LIG_SH2_STAT5 114 117 PF00017 0.447
LIG_SH2_STAT5 138 141 PF00017 0.383
LIG_SH2_STAT5 395 398 PF00017 0.430
LIG_SH3_1 468 474 PF00018 0.572
LIG_SH3_2 471 476 PF14604 0.591
LIG_SH3_3 333 339 PF00018 0.698
LIG_SH3_3 383 389 PF00018 0.527
LIG_SH3_3 39 45 PF00018 0.621
LIG_SH3_3 468 474 PF00018 0.572
LIG_SUMO_SIM_anti_2 303 312 PF11976 0.674
LIG_SUMO_SIM_anti_2 462 469 PF11976 0.435
LIG_TRAF2_1 198 201 PF00917 0.512
LIG_TRAF2_1 232 235 PF00917 0.401
LIG_TRAF2_1 256 259 PF00917 0.636
LIG_TRAF2_1 279 282 PF00917 0.614
LIG_TRAF2_1 315 318 PF00917 0.750
LIG_UBA3_1 416 425 PF00899 0.429
LIG_WRC_WIRS_1 424 429 PF05994 0.515
LIG_WW_2 336 339 PF00397 0.493
MOD_CDK_SPK_2 368 373 PF00069 0.469
MOD_CDK_SPxK_1 470 476 PF00069 0.503
MOD_CK1_1 124 130 PF00069 0.449
MOD_CK1_1 217 223 PF00069 0.636
MOD_CK1_1 324 330 PF00069 0.645
MOD_CK1_1 347 353 PF00069 0.642
MOD_CK1_1 368 374 PF00069 0.461
MOD_CK1_1 410 416 PF00069 0.485
MOD_CK2_1 1 7 PF00069 0.609
MOD_CK2_1 142 148 PF00069 0.441
MOD_CK2_1 285 291 PF00069 0.518
MOD_CK2_1 311 317 PF00069 0.734
MOD_CK2_1 371 377 PF00069 0.283
MOD_CK2_1 440 446 PF00069 0.479
MOD_CK2_1 58 64 PF00069 0.522
MOD_GlcNHglycan 103 106 PF01048 0.521
MOD_GlcNHglycan 123 126 PF01048 0.332
MOD_GlcNHglycan 195 199 PF01048 0.409
MOD_GlcNHglycan 250 253 PF01048 0.701
MOD_GlcNHglycan 327 330 PF01048 0.636
MOD_GlcNHglycan 352 355 PF01048 0.692
MOD_GlcNHglycan 46 49 PF01048 0.691
MOD_GlcNHglycan 468 471 PF01048 0.509
MOD_GlcNHglycan 78 81 PF01048 0.571
MOD_GSK3_1 214 221 PF00069 0.609
MOD_GSK3_1 250 257 PF00069 0.590
MOD_GSK3_1 321 328 PF00069 0.634
MOD_GSK3_1 339 346 PF00069 0.657
MOD_GSK3_1 349 356 PF00069 0.632
MOD_GSK3_1 367 374 PF00069 0.496
MOD_GSK3_1 423 430 PF00069 0.493
MOD_GSK3_1 466 473 PF00069 0.386
MOD_N-GLC_1 410 415 PF02516 0.240
MOD_N-GLC_1 427 432 PF02516 0.240
MOD_NEK2_1 1 6 PF00069 0.613
MOD_NEK2_1 101 106 PF00069 0.478
MOD_NEK2_1 250 255 PF00069 0.521
MOD_NEK2_1 407 412 PF00069 0.477
MOD_NEK2_1 427 432 PF00069 0.298
MOD_NEK2_1 466 471 PF00069 0.442
MOD_PIKK_1 214 220 PF00454 0.559
MOD_PIKK_1 250 256 PF00454 0.511
MOD_PIKK_1 285 291 PF00454 0.524
MOD_PKA_2 55 61 PF00069 0.535
MOD_Plk_1 1 7 PF00069 0.609
MOD_Plk_2-3 235 241 PF00069 0.686
MOD_ProDKin_1 311 317 PF00069 0.712
MOD_ProDKin_1 321 327 PF00069 0.630
MOD_ProDKin_1 332 338 PF00069 0.573
MOD_ProDKin_1 339 345 PF00069 0.633
MOD_ProDKin_1 368 374 PF00069 0.433
MOD_ProDKin_1 410 416 PF00069 0.440
MOD_ProDKin_1 470 476 PF00069 0.503
MOD_SUMO_rev_2 13 23 PF00179 0.474
MOD_SUMO_rev_2 311 321 PF00179 0.701
MOD_SUMO_rev_2 477 485 PF00179 0.521
TRG_DiLeu_BaLyEn_6 394 399 PF01217 0.451
TRG_ENDOCYTIC_2 138 141 PF00928 0.405
TRG_ENDOCYTIC_2 395 398 PF00928 0.409
TRG_ER_diArg_1 166 168 PF00400 0.281
TRG_ER_diArg_1 270 272 PF00400 0.588
TRG_ER_diArg_1 298 301 PF00400 0.585
TRG_ER_diArg_1 358 361 PF00400 0.698
TRG_ER_diArg_1 380 382 PF00400 0.515
TRG_ER_diLys_1 484 488 PF00400 0.529
TRG_NLS_Bipartite_1 212 232 PF00514 0.616
TRG_NLS_MonoCore_2 226 231 PF00514 0.602
TRG_NLS_MonoExtC_3 296 301 PF00514 0.572
TRG_NLS_MonoExtN_4 227 232 PF00514 0.554
TRG_Pf-PMV_PEXEL_1 383 387 PF00026 0.251

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N1PF88 Leptomonas seymouri 62% 99%
A0A0S4J9Z5 Bodo saltans 40% 100%
A0A1X0NH58 Trypanosomatidae 39% 100%
A0A3Q8IHU4 Leishmania donovani 99% 100%
A0A3R7KY85 Trypanosoma rangeli 38% 100%
A4HG19 Leishmania braziliensis 83% 100%
C9ZJL2 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 42% 100%
E9ACV9 Leishmania major 94% 100%
E9AZE8 Leishmania mexicana (strain MHOM/GT/2001/U1103) 88% 100%
Q28IV3 Xenopus tropicalis 25% 74%
Q68FQ7 Rattus norvegicus 26% 74%
Q6NU95 Xenopus laevis 26% 74%
Q9D706 Mus musculus 25% 74%
V5AR46 Trypanosoma cruzi 39% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS