LeishMANIAdb
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Putative vesicle-associated membrane protein (Vamp)

Quick info Annotations Function or PPIs Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
Putative vesicle-associated membrane protein (Vamp)
Gene product:
vesicle-associated membrane protein
Species:
Leishmania infantum
UniProt:
A4I337_LEIIN
TriTrypDb:
LINF_270031700
Length:
220

Annotations

LeishMANIAdb annotations

Homologous to animal VAMP7 proteins. Likely involved in vesicular transport.. Localization: Vesicular (by homology)

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 11
NetGPI no yes: 0, no: 11
Cellular components
Term Name Level Count
GO:0016020 membrane 2 12
GO:0110165 cellular anatomical entity 1 12
GO:0000331 contractile vacuole 6 1
GO:0005773 vacuole 5 1
GO:0005886 plasma membrane 3 1
GO:0020016 ciliary pocket 2 1
GO:0020022 acidocalcisome 5 1
GO:0031410 cytoplasmic vesicle 6 1
GO:0031982 vesicle 4 1
GO:0043226 organelle 2 1
GO:0043227 membrane-bounded organelle 3 1
GO:0043229 intracellular organelle 3 1
GO:0043231 intracellular membrane-bounded organelle 4 1
GO:0097708 intracellular vesicle 5 1

Expansion

Sequence features

A4I337
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4I337

Function

Biological processes
Term Name Level Count
GO:0006810 transport 3 11
GO:0016192 vesicle-mediated transport 4 11
GO:0051179 localization 1 11
GO:0051234 establishment of localization 2 11
GO:0006950 response to stress 2 1
GO:0006970 response to osmotic stress 3 1
GO:0009628 response to abiotic stimulus 2 1
GO:0009987 cellular process 1 1
GO:0016043 cellular component organization 3 1
GO:0033554 cellular response to stress 3 1
GO:0042221 response to chemical 2 1
GO:0050896 response to stimulus 1 1
GO:0051716 cellular response to stimulus 2 1
GO:0061024 membrane organization 4 1
GO:0061025 membrane fusion 5 1
GO:0062197 cellular response to chemical stress 4 1
GO:0070887 cellular response to chemical stimulus 3 1
GO:0071214 cellular response to abiotic stimulus 3 1
GO:0071470 cellular response to osmotic stress 4 1
GO:0071840 cellular component organization or biogenesis 2 1
GO:0104004 cellular response to environmental stimulus 3 1
Could not find GO molecular_function term for this entry.

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_NRD_NRD_1 117 119 PF00675 0.391
CLV_PCSK_SKI1_1 180 184 PF00082 0.253
CLV_PCSK_SKI1_1 72 76 PF00082 0.267
CLV_PCSK_SKI1_1 82 86 PF00082 0.267
CLV_Separin_Metazoa 166 170 PF03568 0.533
DEG_SPOP_SBC_1 2 6 PF00917 0.502
DEG_SPOP_SBC_1 62 66 PF00917 0.514
DOC_MAPK_HePTP_8 187 199 PF00069 0.491
DOC_MAPK_MEF2A_6 190 199 PF00069 0.463
DOC_MAPK_RevD_3 204 219 PF00069 0.323
DOC_PP1_RVXF_1 70 76 PF00149 0.518
DOC_USP7_MATH_1 16 20 PF00917 0.585
DOC_USP7_MATH_1 2 6 PF00917 0.563
DOC_USP7_MATH_1 40 44 PF00917 0.533
DOC_USP7_UBL2_3 82 86 PF12436 0.514
DOC_WW_Pin1_4 100 105 PF00397 0.481
DOC_WW_Pin1_4 121 126 PF00397 0.607
DOC_WW_Pin1_4 18 23 PF00397 0.570
LIG_14-3-3_CanoR_1 118 122 PF00244 0.508
LIG_Clathr_ClatBox_1 7 11 PF01394 0.587
LIG_EH1_1 188 196 PF00400 0.514
LIG_FHA_1 138 144 PF00498 0.516
LIG_FHA_1 207 213 PF00498 0.434
LIG_FHA_2 118 124 PF00498 0.576
LIG_FHA_2 158 164 PF00498 0.542
LIG_Integrin_RGD_1 154 156 PF01839 0.342
LIG_LIR_Gen_1 49 59 PF02991 0.487
LIG_LIR_Nem_3 49 54 PF02991 0.487
LIG_MYND_1 22 26 PF01753 0.493
LIG_PCNA_yPIPBox_3 71 82 PF02747 0.493
LIG_Pex14_2 85 89 PF04695 0.456
LIG_SH2_GRB2like 69 72 PF00017 0.497
LIG_SH2_STAP1 69 73 PF00017 0.542
LIG_TRAF2_1 124 127 PF00917 0.643
LIG_UBA3_1 78 86 PF00899 0.540
LIG_WRC_WIRS_1 207 212 PF05994 0.344
MOD_CK1_1 117 123 PF00069 0.587
MOD_CK2_1 117 123 PF00069 0.549
MOD_CK2_1 147 153 PF00069 0.533
MOD_GlcNHglycan 65 68 PF01048 0.270
MOD_GSK3_1 109 116 PF00069 0.559
MOD_GSK3_1 117 124 PF00069 0.592
MOD_GSK3_1 16 23 PF00069 0.596
MOD_GSK3_1 174 181 PF00069 0.477
MOD_N-GLC_1 121 126 PF02516 0.437
MOD_N-GLC_1 137 142 PF02516 0.357
MOD_NEK2_1 110 115 PF00069 0.524
MOD_NEK2_1 206 211 PF00069 0.362
MOD_NEK2_1 85 90 PF00069 0.450
MOD_PKA_2 117 123 PF00069 0.509
MOD_Plk_1 16 22 PF00069 0.616
MOD_Plk_4 147 153 PF00069 0.520
MOD_Plk_4 3 9 PF00069 0.482
MOD_ProDKin_1 100 106 PF00069 0.481
MOD_ProDKin_1 121 127 PF00069 0.615
MOD_ProDKin_1 18 24 PF00069 0.567
MOD_SUMO_rev_2 123 130 PF00179 0.564
TRG_NES_CRM1_1 45 58 PF08389 0.561

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N1I418 Leptomonas seymouri 27% 100%
A0A0N1IMB1 Leptomonas seymouri 73% 100%
A0A0S4IUW0 Bodo saltans 27% 100%
A0A0S4JCC4 Bodo saltans 48% 94%
A0A0S4JL59 Bodo saltans 23% 98%
A0A0S4JYF9 Bodo saltans 29% 100%
A0A1X0NF95 Trypanosomatidae 54% 99%
A0A1X0NQE9 Trypanosomatidae 26% 100%
A0A1X0NYJ8 Trypanosomatidae 24% 88%
A0A3S7WQ28 Leishmania donovani 27% 100%
A0A3S7X115 Leishmania donovani 100% 100%
A0A422N7W7 Trypanosoma rangeli 27% 100%
A0A422NDY3 Trypanosoma rangeli 53% 99%
A4H570 Leishmania braziliensis 25% 95%
A4HG15 Leishmania braziliensis 78% 100%
A4HTF3 Leishmania infantum 27% 95%
C9ZJK9 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 39% 100%
C9ZPM9 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 27% 100%
E9ACV5 Leishmania major 93% 100%
E9AM81 Leishmania mexicana (strain MHOM/GT/2001/U1103) 27% 95%
E9AZE4 Leishmania mexicana (strain MHOM/GT/2001/U1103) 88% 100%
O23429 Arabidopsis thaliana 24% 99%
O48850 Arabidopsis thaliana 27% 77%
O49377 Arabidopsis thaliana 28% 100%
P22214 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) 22% 100%
P47192 Arabidopsis thaliana 27% 100%
P51809 Homo sapiens 28% 100%
P70280 Mus musculus 28% 100%
Q17QI5 Bos taurus 28% 100%
Q4QIG6 Leishmania major 28% 95%
Q54NW7 Dictyostelium discoideum 23% 100%
Q5RF94 Pongo abelii 28% 100%
Q5ZL74 Gallus gallus 27% 100%
Q6C537 Yarrowia lipolytica (strain CLIB 122 / E 150) 23% 100%
Q6C880 Yarrowia lipolytica (strain CLIB 122 / E 150) 20% 100%
Q6CJA0 Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37) 21% 100%
Q86AQ7 Dictyostelium discoideum 24% 85%
Q9FMR5 Arabidopsis thaliana 25% 100%
Q9JHW5 Rattus norvegicus 27% 100%
Q9LFP1 Arabidopsis thaliana 26% 100%
Q9M376 Arabidopsis thaliana 22% 92%
Q9MAS5 Arabidopsis thaliana 25% 100%
Q9SIQ9 Arabidopsis thaliana 29% 100%
Q9Y7L0 Schizosaccharomyces pombe (strain 972 / ATCC 24843) 24% 100%
Q9ZTW3 Arabidopsis thaliana 25% 100%
V5BFM1 Trypanosoma cruzi 51% 99%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS