DNA-directed RNA polymerase III subunit RPC3

Quick info Annotations Localization Expansion Sequence features Structure Function Putative motif mimicry Download

Quick info

Protein:

Gene product:

hypothetical protein - conserved

Species:

Leishmania infantum

UniProt:

A4I334_LEIIN

TriTrypDb:

LINF_270033400

Length:

269

Annotations

Annotations by Jardim et al.

Uncharacterized Protein, Uncharacterized (Fragment)

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 1
NetGPI	no	yes: 0, no: 1

Cellular components
Term	Name	Level	Count
GO:0000428	DNA-directed RNA polymerase complex	4	2
GO:0005666	RNA polymerase III complex	4	2
GO:0030880	RNA polymerase complex	3	2
GO:0032991	protein-containing complex	1	2
GO:0055029	nuclear DNA-directed RNA polymerase complex	3	2
GO:0061695	transferase complex, transferring phosphorus-containing groups	4	2
GO:0140513	nuclear protein-containing complex	2	2
GO:0140535	intracellular protein-containing complex	2	2
GO:1902494	catalytic complex	2	2
GO:1990234	transferase complex	3	2

Expansion

Sequence features

A4I334

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4I334

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0003676	nucleic acid binding	3	2
GO:0003677	DNA binding	4	2
GO:0003697	single-stranded DNA binding	5	2
GO:0005488	binding	1	2
GO:0097159	organic cyclic compound binding	2	2
GO:1901363	heterocyclic compound binding	2	2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	61	65	PF00656	0.299
CLV_PCSK_SKI1_1	155	159	PF00082	0.260
CLV_PCSK_SKI1_1	174	178	PF00082	0.238
CLV_PCSK_SKI1_1	23	27	PF00082	0.359
DEG_SCF_FBW7_1	196	203	PF00400	0.303
DOC_MAPK_MEF2A_6	147	156	PF00069	0.262
DOC_MAPK_MEF2A_6	189	196	PF00069	0.282
DOC_PP1_RVXF_1	153	159	PF00149	0.259
DOC_WW_Pin1_4	196	201	PF00397	0.311
DOC_WW_Pin1_4	223	228	PF00397	0.412
DOC_WW_Pin1_4	258	263	PF00397	0.366
LIG_Actin_WH2_2	44	62	PF00022	0.272
LIG_eIF4E_1	148	154	PF01652	0.262
LIG_FHA_1	125	131	PF00498	0.263
LIG_FHA_1	197	203	PF00498	0.306
LIG_FHA_1	35	41	PF00498	0.291
LIG_FHA_1	88	94	PF00498	0.437
LIG_GBD_Chelix_1	43	51	PF00786	0.249
LIG_LIR_Apic_2	216	222	PF02991	0.282
LIG_LIR_Gen_1	208	215	PF02991	0.258
LIG_LIR_LC3C_4	127	131	PF02991	0.273
LIG_LIR_Nem_3	208	212	PF02991	0.263
LIG_PDZ_Class_2	264	269	PF00595	0.358
LIG_SH2_CRK	209	213	PF00017	0.262
LIG_SH2_STAP1	144	148	PF00017	0.268
LIG_SH3_3	153	159	PF00018	0.259
LIG_SH3_3	182	188	PF00018	0.266
LIG_SH3_3	244	250	PF00018	0.456
LIG_Sin3_3	158	165	PF02671	0.259
LIG_TYR_ITIM	207	212	PF00017	0.259
LIG_WW_3	186	190	PF00397	0.273
MOD_CK1_1	34	40	PF00069	0.296
MOD_GlcNHglycan	149	152	PF01048	0.260
MOD_GlcNHglycan	53	56	PF01048	0.299
MOD_GlcNHglycan	83	86	PF01048	0.390
MOD_GSK3_1	194	201	PF00069	0.302
MOD_GSK3_1	257	264	PF00069	0.355
MOD_GSK3_1	47	54	PF00069	0.264
MOD_GSK3_1	83	90	PF00069	0.410
MOD_N-GLC_1	257	262	PF02516	0.376
MOD_NEK2_1	256	261	PF00069	0.383
MOD_NEK2_1	31	36	PF00069	0.282
MOD_NEK2_1	51	56	PF00069	0.281
MOD_OFUCOSY	5	12	PF10250	0.411
MOD_PK_1	198	204	PF00069	0.302
MOD_PKA_2	81	87	PF00069	0.398
MOD_Plk_2-3	109	115	PF00069	0.389
MOD_ProDKin_1	196	202	PF00069	0.303
MOD_ProDKin_1	223	229	PF00069	0.418
MOD_ProDKin_1	258	264	PF00069	0.355
TRG_DiLeu_BaEn_1	216	221	PF01217	0.280
TRG_DiLeu_BaLyEn_6	130	135	PF01217	0.263
TRG_DiLeu_BaLyEn_6	156	161	PF01217	0.269
TRG_ENDOCYTIC_2	209	212	PF00928	0.259
TRG_Pf-PMV_PEXEL_1	49	53	PF00026	0.264