LeishMANIAdb
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Obg-like ATPase 1

Quick info Annotations Function or PPIs Localization Abundance Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
Obg-like ATPase 1
Gene product:
GTP binding protein - putative
Species:
Leishmania infantum
UniProt:
A4I330_LEIIN
TriTrypDb:
LINF_270030700
Length:
392

Annotations

Annotations by Jardim et al.

ATPases, Obg-like ATPase 1

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) yes yes: 6
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. yes yes: 16
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 11
NetGPI no yes: 0, no: 11
Cellular components
Term Name Level Count
GO:0005737 cytoplasm 2 12
GO:0110165 cellular anatomical entity 1 12

Abundance

Amastigote (protein)
Source Evidence on protein Close homologs
Pescher et al. (upgregulation) no yes: 0
Promastigote and amastigote
Source Evidence on protein Close homologs
Lahav et al.
- mRNA
- Protein

Expansion

Sequence features

A4I330
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4I330

Function

Could not find GO biological_process term for this entry.
Molecular functions
Term Name Level Count
GO:0000166 nucleotide binding 3 12
GO:0003824 catalytic activity 1 12
GO:0005488 binding 1 12
GO:0005524 ATP binding 5 12
GO:0005525 GTP binding 5 12
GO:0016462 pyrophosphatase activity 5 12
GO:0016787 hydrolase activity 2 12
GO:0016817 hydrolase activity, acting on acid anhydrides 3 12
GO:0016818 hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides 4 12
GO:0016887 ATP hydrolysis activity 7 12
GO:0017076 purine nucleotide binding 4 12
GO:0017111 ribonucleoside triphosphate phosphatase activity 6 12
GO:0019001 guanyl nucleotide binding 5 12
GO:0030554 adenyl nucleotide binding 5 12
GO:0032553 ribonucleotide binding 3 12
GO:0032555 purine ribonucleotide binding 4 12
GO:0032559 adenyl ribonucleotide binding 5 12
GO:0032561 guanyl ribonucleotide binding 5 12
GO:0035639 purine ribonucleoside triphosphate binding 4 12
GO:0036094 small molecule binding 2 12
GO:0043021 ribonucleoprotein complex binding 3 12
GO:0043022 ribosome binding 4 12
GO:0043023 ribosomal large subunit binding 4 12
GO:0043167 ion binding 2 12
GO:0043168 anion binding 3 12
GO:0044877 protein-containing complex binding 2 12
GO:0097159 organic cyclic compound binding 2 12
GO:0097367 carbohydrate derivative binding 2 12
GO:1901265 nucleoside phosphate binding 3 12
GO:1901363 heterocyclic compound binding 2 12

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 373 377 PF00656 0.260
CLV_PCSK_SKI1_1 12 16 PF00082 0.441
CLV_PCSK_SKI1_1 190 194 PF00082 0.405
CLV_PCSK_SKI1_1 240 244 PF00082 0.463
CLV_PCSK_SKI1_1 291 295 PF00082 0.314
DOC_MAPK_HePTP_8 15 27 PF00069 0.332
DOC_MAPK_MEF2A_6 18 27 PF00069 0.337
DOC_PP1_RVXF_1 205 212 PF00149 0.342
DOC_USP7_UBL2_3 240 244 PF12436 0.337
DOC_USP7_UBL2_3 388 392 PF12436 0.473
DOC_USP7_UBL2_3 4 8 PF12436 0.585
DOC_WW_Pin1_4 165 170 PF00397 0.360
DOC_WW_Pin1_4 269 274 PF00397 0.396
LIG_APCC_ABBA_1 124 129 PF00400 0.412
LIG_BRCT_BRCA1_1 35 39 PF00533 0.400
LIG_deltaCOP1_diTrp_1 346 350 PF00928 0.379
LIG_EH1_1 296 304 PF00400 0.310
LIG_eIF4E_1 297 303 PF01652 0.247
LIG_FHA_1 11 17 PF00498 0.427
LIG_FHA_1 166 172 PF00498 0.327
LIG_FHA_1 212 218 PF00498 0.305
LIG_FHA_1 264 270 PF00498 0.480
LIG_FHA_1 59 65 PF00498 0.405
LIG_FHA_2 131 137 PF00498 0.400
LIG_FHA_2 331 337 PF00498 0.304
LIG_FXI_DFP_1 347 351 PF00024 0.315
LIG_LIR_Gen_1 146 157 PF02991 0.263
LIG_LIR_Gen_1 265 276 PF02991 0.380
LIG_LIR_Gen_1 295 305 PF02991 0.267
LIG_LIR_Gen_1 346 353 PF02991 0.252
LIG_LIR_Gen_1 36 47 PF02991 0.400
LIG_LIR_Gen_1 68 77 PF02991 0.400
LIG_LIR_Nem_3 146 152 PF02991 0.266
LIG_LIR_Nem_3 295 300 PF02991 0.280
LIG_LIR_Nem_3 346 350 PF02991 0.252
LIG_LIR_Nem_3 36 42 PF02991 0.400
LIG_LIR_Nem_3 378 384 PF02991 0.260
LIG_LIR_Nem_3 68 74 PF02991 0.400
LIG_REV1ctd_RIR_1 379 387 PF16727 0.260
LIG_SH2_CRK 297 301 PF00017 0.282
LIG_SH2_NCK_1 297 301 PF00017 0.402
LIG_SH2_STAT3 234 237 PF00017 0.467
LIG_SH2_STAT3 372 375 PF00017 0.260
LIG_SH2_STAT5 279 282 PF00017 0.420
LIG_SH2_STAT5 305 308 PF00017 0.260
LIG_SH3_3 25 31 PF00018 0.400
LIG_SH3_3 253 259 PF00018 0.383
LIG_SUMO_SIM_anti_2 144 151 PF11976 0.293
LIG_TYR_ITSM 293 300 PF00017 0.317
LIG_UBA3_1 148 155 PF00899 0.291
LIG_UBA3_1 38 45 PF00899 0.360
MOD_CK1_1 112 118 PF00069 0.466
MOD_CK2_1 130 136 PF00069 0.400
MOD_CK2_1 269 275 PF00069 0.396
MOD_CK2_1 330 336 PF00069 0.244
MOD_CK2_1 98 104 PF00069 0.400
MOD_Cter_Amidation 389 392 PF01082 0.479
MOD_GlcNHglycan 260 263 PF01048 0.312
MOD_GSK3_1 109 116 PF00069 0.485
MOD_N-GLC_1 227 232 PF02516 0.309
MOD_NEK2_1 130 135 PF00069 0.483
MOD_NEK2_1 175 180 PF00069 0.409
MOD_NEK2_1 211 216 PF00069 0.351
MOD_NEK2_1 264 269 PF00069 0.426
MOD_NEK2_2 34 39 PF00069 0.409
MOD_PIKK_1 284 290 PF00454 0.333
MOD_PK_1 79 85 PF00069 0.412
MOD_PKA_2 319 325 PF00069 0.244
MOD_Plk_1 130 136 PF00069 0.400
MOD_Plk_1 264 270 PF00069 0.444
MOD_Plk_4 10 16 PF00069 0.504
MOD_Plk_4 264 270 PF00069 0.419
MOD_Plk_4 295 301 PF00069 0.333
MOD_Plk_4 34 40 PF00069 0.407
MOD_Plk_4 79 85 PF00069 0.412
MOD_ProDKin_1 165 171 PF00069 0.358
MOD_ProDKin_1 269 275 PF00069 0.396
MOD_SUMO_rev_2 194 199 PF00179 0.470
MOD_SUMO_rev_2 275 285 PF00179 0.445
MOD_SUMO_rev_2 7 14 PF00179 0.645
TRG_ENDOCYTIC_2 297 300 PF00928 0.278
TRG_ER_diArg_1 235 238 PF00400 0.372
TRG_NES_CRM1_1 138 151 PF08389 0.304

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N1PD45 Leptomonas seymouri 32% 100%
A0A0N1PG70 Leptomonas seymouri 90% 100%
A0A0S4JQA1 Bodo saltans 80% 100%
A0A0S4JQX4 Bodo saltans 32% 100%
A0A1X0NR20 Trypanosomatidae 81% 99%
A0A1X0NSW3 Trypanosomatidae 34% 100%
A0A3R7MAR4 Trypanosoma rangeli 79% 99%
A0A3R7MNI8 Trypanosoma rangeli 35% 100%
A0A3S7X0V3 Leishmania donovani 35% 100%
A0A3S7X112 Leishmania donovani 100% 100%
A0JPJ7 Rattus norvegicus 54% 99%
A4HFV7 Leishmania braziliensis 34% 99%
A4HG11 Leishmania braziliensis 95% 100%
A4I2Y9 Leishmania infantum 35% 100%
B1AJA2 Ureaplasma parvum serovar 3 (strain ATCC 27815 / 27 / NCTC 11736) 26% 90%
B8BBN7 Oryza sativa subsp. indica 55% 99%
C9ZJD5 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 33% 100%
C9ZJK3 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 77% 99%
E9ACV1 Leishmania major 97% 100%
E9ADG1 Leishmania major 34% 98%
E9AZ85 Leishmania mexicana (strain MHOM/GT/2001/U1103) 34% 98%
E9AZE0 Leishmania mexicana (strain MHOM/GT/2001/U1103) 98% 100%
O13998 Schizosaccharomyces pombe (strain 972 / ATCC 24843) 48% 100%
O14078 Schizosaccharomyces pombe (strain 972 / ATCC 24843) 43% 96%
P0ABU2 Escherichia coli (strain K12) 41% 100%
P0ABU3 Escherichia coli O157:H7 41% 100%
P0ABU4 Shigella flexneri 41% 100%
P37518 Bacillus subtilis (strain 168) 40% 100%
P38219 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) 49% 99%
P38746 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) 40% 97%
P44681 Haemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd) 41% 100%
P47270 Mycoplasma genitalium (strain ATCC 33530 / DSM 19775 / NCTC 10195 / G37) 39% 100%
P57288 Buchnera aphidicola subsp. Acyrthosiphon pisum (strain APS) 38% 100%
P75088 Mycoplasma pneumoniae (strain ATCC 29342 / M129 / Subtype 1) 38% 100%
P91917 Caenorhabditis elegans 56% 99%
Q2HJ33 Bos taurus 54% 99%
Q4AAV4 Mesomycoplasma hyopneumoniae (strain J / ATCC 25934 / NCTC 10110) 25% 94%
Q58728 Methanocaldococcus jannaschii (strain ATCC 43067 / DSM 2661 / JAL-1 / JCM 10045 / NBRC 100440) 26% 100%
Q5R821 Pongo abelii 54% 99%
Q5ZM25 Gallus gallus 55% 99%
Q602A7 Mesomycoplasma hyopneumoniae (strain 232) 25% 94%
Q66JG0 Xenopus tropicalis 53% 99%
Q6Z1J6 Oryza sativa subsp. japonica 56% 99%
Q7VMI2 Haemophilus ducreyi (strain 35000HP / ATCC 700724) 41% 100%
Q7ZU42 Danio rerio 55% 99%
Q7ZWM6 Xenopus laevis 54% 99%
Q89AR6 Buchnera aphidicola subsp. Baizongia pistaciae (strain Bp) 37% 100%
Q8K9V2 Buchnera aphidicola subsp. Schizaphis graminum (strain Sg) 38% 100%
Q8SWU7 Drosophila melanogaster 53% 99%
Q9CP90 Pasteurella multocida (strain Pm70) 41% 100%
Q9CZ30 Mus musculus 54% 99%
Q9NTK5 Homo sapiens 54% 99%
Q9PQ29 Ureaplasma parvum serovar 3 (strain ATCC 700970) 26% 90%
Q9SA73 Arabidopsis thaliana 55% 99%
V5AYP1 Trypanosoma cruzi 34% 91%
V5B8C6 Trypanosoma cruzi 80% 99%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS