Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein - conserved

Species:

Leishmania infantum

UniProt:

A4I312_LEIIN

TriTrypDb:

LINF_270028800

Length:

376

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4I312

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4I312

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	2	4	PF00675	0.680
CLV_NRD_NRD_1	23	25	PF00675	0.624
CLV_NRD_NRD_1	346	348	PF00675	0.491
CLV_PCSK_KEX2_1	2	4	PF00082	0.680
CLV_PCSK_KEX2_1	346	348	PF00082	0.491
CLV_PCSK_SKI1_1	27	31	PF00082	0.558
DEG_COP1_1	238	246	PF00400	0.384
DEG_Nend_UBRbox_1	1	4	PF02207	0.663
DOC_CKS1_1	150	155	PF01111	0.436
DOC_CYCLIN_yClb5_NLxxxL_5	310	317	PF00134	0.370
DOC_CYCLIN_yCln2_LP_2	317	323	PF00134	0.486
DOC_MAPK_gen_1	235	243	PF00069	0.445
DOC_USP7_MATH_1	236	240	PF00917	0.531
DOC_WW_Pin1_4	149	154	PF00397	0.328
DOC_WW_Pin1_4	84	89	PF00397	0.398
LIG_14-3-3_CanoR_1	142	147	PF00244	0.337
LIG_14-3-3_CanoR_1	2	6	PF00244	0.645
LIG_14-3-3_CanoR_1	27	36	PF00244	0.626
LIG_Actin_WH2_2	59	75	PF00022	0.381
LIG_APCC_ABBA_1	16	21	PF00400	0.582
LIG_BIR_III_2	251	255	PF00653	0.340
LIG_BRCT_BRCA1_1	106	110	PF00533	0.412
LIG_BRCT_BRCA1_1	89	93	PF00533	0.446
LIG_DLG_GKlike_1	142	150	PF00625	0.377
LIG_FHA_1	150	156	PF00498	0.344
LIG_FHA_1	61	67	PF00498	0.499
LIG_FHA_1	84	90	PF00498	0.455
LIG_FHA_2	261	267	PF00498	0.475
LIG_LIR_Apic_2	101	106	PF02991	0.466
LIG_LIR_Gen_1	90	99	PF02991	0.320
LIG_LIR_Nem_3	148	154	PF02991	0.334
LIG_LIR_Nem_3	203	209	PF02991	0.318
LIG_LIR_Nem_3	266	270	PF02991	0.478
LIG_LIR_Nem_3	90	96	PF02991	0.317
LIG_MYND_1	244	248	PF01753	0.323
LIG_MYND_3	253	257	PF01753	0.386
LIG_Pex14_2	201	205	PF04695	0.457
LIG_Pex14_2	348	352	PF04695	0.464
LIG_REV1ctd_RIR_1	203	211	PF16727	0.447
LIG_REV1ctd_RIR_1	231	241	PF16727	0.421
LIG_REV1ctd_RIR_1	285	294	PF16727	0.496
LIG_REV1ctd_RIR_1	326	335	PF16727	0.363
LIG_SH2_CRK	103	107	PF00017	0.501
LIG_SH2_CRK	57	61	PF00017	0.495
LIG_SH2_NCK_1	103	107	PF00017	0.501
LIG_SH2_STAT5	151	154	PF00017	0.330
LIG_SH2_STAT5	157	160	PF00017	0.305
LIG_SH2_STAT5	186	189	PF00017	0.409
LIG_SH2_STAT5	242	245	PF00017	0.530
LIG_SH2_STAT5	344	347	PF00017	0.363
LIG_SH3_3	147	153	PF00018	0.457
LIG_SH3_3	74	80	PF00018	0.502
LIG_SUMO_SIM_par_1	335	341	PF11976	0.392
LIG_TRAF2_1	145	148	PF00917	0.386
MOD_CK1_1	149	155	PF00069	0.323
MOD_CK1_1	260	266	PF00069	0.415
MOD_CK1_1	87	93	PF00069	0.399
MOD_CK2_1	142	148	PF00069	0.373
MOD_CK2_1	260	266	PF00069	0.450
MOD_CK2_1	283	289	PF00069	0.384
MOD_GlcNHglycan	127	130	PF01048	0.442
MOD_GlcNHglycan	177	182	PF01048	0.493
MOD_GlcNHglycan	89	92	PF01048	0.449
MOD_GSK3_1	138	145	PF00069	0.375
MOD_GSK3_1	185	192	PF00069	0.419
MOD_GSK3_1	268	275	PF00069	0.418
MOD_GSK3_1	27	34	PF00069	0.613
MOD_GSK3_1	83	90	PF00069	0.338
MOD_N-GLC_1	257	262	PF02516	0.403
MOD_N-GLC_1	43	48	PF02516	0.393
MOD_NEK2_1	1	6	PF00069	0.638
MOD_NEK2_1	125	130	PF00069	0.403
MOD_NEK2_1	146	151	PF00069	0.375
MOD_NEK2_1	159	164	PF00069	0.320
MOD_NEK2_1	283	288	PF00069	0.462
MOD_NEK2_1	62	67	PF00069	0.558
MOD_NEK2_1	72	77	PF00069	0.439
MOD_PIKK_1	213	219	PF00454	0.464
MOD_PKA_1	38	44	PF00069	0.437
MOD_PKA_2	1	7	PF00069	0.651
MOD_PKA_2	19	25	PF00069	0.436
MOD_PKA_2	72	78	PF00069	0.457
MOD_Plk_1	146	152	PF00069	0.367
MOD_Plk_4	146	152	PF00069	0.460
MOD_Plk_4	242	248	PF00069	0.352
MOD_Plk_4	260	266	PF00069	0.356
MOD_Plk_4	31	37	PF00069	0.428
MOD_ProDKin_1	149	155	PF00069	0.326
MOD_ProDKin_1	84	90	PF00069	0.403
TRG_DiLeu_BaEn_1	366	371	PF01217	0.483
TRG_DiLeu_BaEn_2	120	126	PF01217	0.389
TRG_DiLeu_BaEn_4	178	184	PF01217	0.571
TRG_DiLeu_LyEn_5	366	371	PF01217	0.570
TRG_ENDOCYTIC_2	267	270	PF00928	0.474
TRG_ENDOCYTIC_2	57	60	PF00928	0.487
TRG_ER_diArg_1	1	3	PF00400	0.689
TRG_ER_diArg_1	345	347	PF00400	0.466
TRG_NLS_MonoCore_2	23	28	PF00514	0.590
TRG_Pf-PMV_PEXEL_1	369	374	PF00026	0.538

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I2W1	Leptomonas seymouri	74%	100%
A0A0S4ISK5	Bodo saltans	46%	100%
A0A1X0NRI0	Trypanosomatidae	54%	100%
A0A3Q8ICV5	Leishmania donovani	100%	100%
A4HFZ3	Leishmania braziliensis	89%	100%
C9ZJH9	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	58%	100%
E9ADJ6	Leishmania major	97%	100%
E9AZC2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	96%	100%
V5BNB6	Trypanosoma cruzi	60%	100%