LeishMANIAdb
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Uncharacterized protein

Quick info Annotations Function or PPIs Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
Uncharacterized protein
Gene product:
Rab-GTPase-TBC domain containing protein - putative
Species:
Leishmania infantum
UniProt:
A4I306_LEIIN
TriTrypDb:
LINF_270027000
Length:
1024

Annotations

Annotations by Jardim et al.

Uncharacterized Protein, Uncharacterized

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 6
NetGPI no yes: 0, no: 6
Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4I306
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4I306

Function

Biological processes
Term Name Level Count
GO:0043085 positive regulation of catalytic activity 4 1
GO:0043087 regulation of GTPase activity 5 1
GO:0043547 positive regulation of GTPase activity 6 1
GO:0044093 positive regulation of molecular function 3 1
GO:0050790 regulation of catalytic activity 3 1
GO:0051336 regulation of hydrolase activity 4 1
GO:0051345 positive regulation of hydrolase activity 5 1
GO:0065007 biological regulation 1 1
GO:0065009 regulation of molecular function 2 1
GO:0090630 activation of GTPase activity 7 1
Molecular functions
Term Name Level Count
GO:0005096 GTPase activator activity 4 1
GO:0008047 enzyme activator activity 3 1
GO:0030234 enzyme regulator activity 2 1
GO:0030695 GTPase regulator activity 4 1
GO:0060589 nucleoside-triphosphatase regulator activity 3 1
GO:0098772 molecular function regulator activity 1 1
GO:0140677 molecular function activator activity 2 1

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 218 222 PF00656 0.689
CLV_C14_Caspase3-7 796 800 PF00656 0.347
CLV_C14_Caspase3-7 934 938 PF00656 0.611
CLV_NRD_NRD_1 1017 1019 PF00675 0.419
CLV_NRD_NRD_1 122 124 PF00675 0.536
CLV_NRD_NRD_1 135 137 PF00675 0.527
CLV_NRD_NRD_1 24 26 PF00675 0.648
CLV_NRD_NRD_1 272 274 PF00675 0.661
CLV_NRD_NRD_1 40 42 PF00675 0.511
CLV_NRD_NRD_1 428 430 PF00675 0.423
CLV_NRD_NRD_1 431 433 PF00675 0.412
CLV_NRD_NRD_1 611 613 PF00675 0.615
CLV_NRD_NRD_1 773 775 PF00675 0.304
CLV_PCSK_FUR_1 22 26 PF00082 0.610
CLV_PCSK_FUR_1 429 433 PF00082 0.415
CLV_PCSK_KEX2_1 122 124 PF00082 0.536
CLV_PCSK_KEX2_1 135 137 PF00082 0.527
CLV_PCSK_KEX2_1 24 26 PF00082 0.648
CLV_PCSK_KEX2_1 272 274 PF00082 0.661
CLV_PCSK_KEX2_1 40 42 PF00082 0.511
CLV_PCSK_KEX2_1 430 432 PF00082 0.409
CLV_PCSK_KEX2_1 611 613 PF00082 0.572
CLV_PCSK_KEX2_1 773 775 PF00082 0.304
CLV_PCSK_PC1ET2_1 430 432 PF00082 0.409
CLV_PCSK_PC7_1 118 124 PF00082 0.513
CLV_PCSK_SKI1_1 40 44 PF00082 0.507
CLV_PCSK_SKI1_1 400 404 PF00082 0.389
CLV_PCSK_SKI1_1 520 524 PF00082 0.369
CLV_PCSK_SKI1_1 549 553 PF00082 0.338
CLV_Separin_Metazoa 54 58 PF03568 0.633
DEG_APCC_DBOX_1 519 527 PF00400 0.369
DEG_Nend_UBRbox_2 1 3 PF02207 0.581
DEG_SCF_TRCP1_1 372 378 PF00400 0.516
DEG_SPOP_SBC_1 195 199 PF00917 0.566
DEG_SPOP_SBC_1 506 510 PF00917 0.555
DEG_SPOP_SBC_1 845 849 PF00917 0.696
DOC_ANK_TNKS_1 15 22 PF00023 0.578
DOC_ANK_TNKS_1 23 30 PF00023 0.597
DOC_CDC14_PxL_1 149 157 PF14671 0.549
DOC_CKS1_1 180 185 PF01111 0.611
DOC_CKS1_1 257 262 PF01111 0.637
DOC_CKS1_1 686 691 PF01111 0.621
DOC_CKS1_1 695 700 PF01111 0.461
DOC_CYCLIN_RxL_1 37 47 PF00134 0.509
DOC_CYCLIN_RxL_1 546 555 PF00134 0.344
DOC_CYCLIN_RxL_1 749 759 PF00134 0.304
DOC_CYCLIN_yClb5_NLxxxL_5 880 886 PF00134 0.432
DOC_CYCLIN_yCln2_LP_2 686 692 PF00134 0.621
DOC_CYCLIN_yCln2_LP_2 813 819 PF00134 0.369
DOC_CYCLIN_yCln2_LP_2 959 965 PF00134 0.446
DOC_MAPK_DCC_7 811 819 PF00069 0.369
DOC_MAPK_gen_1 294 302 PF00069 0.543
DOC_MAPK_gen_1 653 663 PF00069 0.537
DOC_MAPK_MEF2A_6 245 254 PF00069 0.586
DOC_MAPK_MEF2A_6 344 351 PF00069 0.608
DOC_MAPK_MEF2A_6 656 663 PF00069 0.489
DOC_MAPK_MEF2A_6 811 819 PF00069 0.304
DOC_MAPK_NFAT4_5 656 664 PF00069 0.489
DOC_PP1_RVXF_1 142 148 PF00149 0.469
DOC_PP1_RVXF_1 390 397 PF00149 0.477
DOC_PP1_RVXF_1 403 410 PF00149 0.287
DOC_PP1_SILK_1 766 771 PF00149 0.304
DOC_PP2B_LxvP_1 528 531 PF13499 0.304
DOC_PP2B_LxvP_1 813 816 PF13499 0.369
DOC_PP2B_LxvP_1 896 899 PF13499 0.551
DOC_PP4_FxxP_1 181 184 PF00568 0.623
DOC_USP7_MATH_1 195 199 PF00917 0.592
DOC_USP7_MATH_1 239 243 PF00917 0.662
DOC_USP7_MATH_1 285 289 PF00917 0.645
DOC_USP7_MATH_1 31 35 PF00917 0.550
DOC_USP7_MATH_1 310 314 PF00917 0.590
DOC_USP7_MATH_1 332 336 PF00917 0.634
DOC_USP7_MATH_1 345 349 PF00917 0.539
DOC_USP7_MATH_1 352 356 PF00917 0.565
DOC_USP7_MATH_1 511 515 PF00917 0.463
DOC_USP7_MATH_1 540 544 PF00917 0.304
DOC_USP7_MATH_1 587 591 PF00917 0.482
DOC_USP7_MATH_1 80 84 PF00917 0.578
DOC_USP7_MATH_1 840 844 PF00917 0.662
DOC_USP7_MATH_1 857 861 PF00917 0.536
DOC_USP7_MATH_1 900 904 PF00917 0.564
DOC_USP7_MATH_1 931 935 PF00917 0.662
DOC_USP7_MATH_1 939 943 PF00917 0.781
DOC_WW_Pin1_4 179 184 PF00397 0.583
DOC_WW_Pin1_4 190 195 PF00397 0.582
DOC_WW_Pin1_4 256 261 PF00397 0.653
DOC_WW_Pin1_4 266 271 PF00397 0.586
DOC_WW_Pin1_4 450 455 PF00397 0.557
DOC_WW_Pin1_4 513 518 PF00397 0.293
DOC_WW_Pin1_4 532 537 PF00397 0.304
DOC_WW_Pin1_4 679 684 PF00397 0.590
DOC_WW_Pin1_4 685 690 PF00397 0.605
DOC_WW_Pin1_4 694 699 PF00397 0.477
DOC_WW_Pin1_4 706 711 PF00397 0.531
DOC_WW_Pin1_4 720 725 PF00397 0.432
LIG_14-3-3_CanoR_1 144 148 PF00244 0.571
LIG_14-3-3_CanoR_1 234 244 PF00244 0.666
LIG_14-3-3_CanoR_1 272 276 PF00244 0.609
LIG_14-3-3_CanoR_1 296 301 PF00244 0.620
LIG_14-3-3_CanoR_1 330 340 PF00244 0.612
LIG_14-3-3_CanoR_1 410 417 PF00244 0.370
LIG_14-3-3_CanoR_1 439 448 PF00244 0.520
LIG_14-3-3_CanoR_1 660 670 PF00244 0.535
LIG_14-3-3_CanoR_1 672 676 PF00244 0.562
LIG_14-3-3_CanoR_1 701 710 PF00244 0.545
LIG_14-3-3_CanoR_1 73 79 PF00244 0.597
LIG_14-3-3_CanoR_1 752 757 PF00244 0.304
LIG_14-3-3_CanoR_1 995 1000 PF00244 0.483
LIG_Actin_WH2_2 141 158 PF00022 0.602
LIG_BRCT_BRCA1_1 177 181 PF00533 0.616
LIG_BRCT_BRCA1_1 186 190 PF00533 0.576
LIG_BRCT_BRCA1_1 534 538 PF00533 0.304
LIG_DLG_GKlike_1 296 303 PF00625 0.621
LIG_FHA_1 167 173 PF00498 0.621
LIG_FHA_1 295 301 PF00498 0.678
LIG_FHA_1 336 342 PF00498 0.590
LIG_FHA_1 376 382 PF00498 0.469
LIG_FHA_1 507 513 PF00498 0.584
LIG_FHA_1 653 659 PF00498 0.519
LIG_FHA_1 74 80 PF00498 0.543
LIG_FHA_1 846 852 PF00498 0.524
LIG_FHA_1 891 897 PF00498 0.566
LIG_FHA_2 257 263 PF00498 0.640
LIG_FHA_2 319 325 PF00498 0.659
LIG_FHA_2 738 744 PF00498 0.284
LIG_FHA_2 794 800 PF00498 0.347
LIG_FHA_2 921 927 PF00498 0.613
LIG_LIR_Apic_2 178 184 PF02991 0.619
LIG_LIR_Gen_1 799 810 PF02991 0.304
LIG_LIR_Gen_1 823 830 PF02991 0.304
LIG_LIR_Nem_3 799 805 PF02991 0.304
LIG_LIR_Nem_3 823 828 PF02991 0.304
LIG_LIR_Nem_3 964 970 PF02991 0.418
LIG_LYPXL_SIV_4 31 39 PF13949 0.527
LIG_NRBOX 144 150 PF00104 0.532
LIG_NRBOX 38 44 PF00104 0.567
LIG_NRBOX 804 810 PF00104 0.304
LIG_OCRL_FandH_1 801 813 PF00620 0.304
LIG_Pex14_2 574 578 PF04695 0.369
LIG_Pex14_2 963 967 PF04695 0.383
LIG_SH2_NCK_1 415 419 PF00017 0.399
LIG_SH2_SRC 415 418 PF00017 0.387
LIG_SH2_STAP1 168 172 PF00017 0.572
LIG_SH2_STAP1 437 441 PF00017 0.416
LIG_SH2_STAP1 518 522 PF00017 0.369
LIG_SH2_STAT3 437 440 PF00017 0.414
LIG_SH2_STAT3 738 741 PF00017 0.430
LIG_SH2_STAT5 1014 1017 PF00017 0.365
LIG_SH2_STAT5 168 171 PF00017 0.581
LIG_SH2_STAT5 243 246 PF00017 0.610
LIG_SH2_STAT5 437 440 PF00017 0.414
LIG_SH2_STAT5 441 444 PF00017 0.436
LIG_SH2_STAT5 563 566 PF00017 0.304
LIG_SH2_STAT5 69 72 PF00017 0.545
LIG_SH2_STAT5 711 714 PF00017 0.489
LIG_SH2_STAT5 738 741 PF00017 0.430
LIG_SH2_STAT5 825 828 PF00017 0.304
LIG_SH3_3 154 160 PF00018 0.537
LIG_SH3_3 170 176 PF00018 0.588
LIG_SH3_3 177 183 PF00018 0.714
LIG_SH3_3 189 195 PF00018 0.522
LIG_SH3_3 760 766 PF00018 0.477
LIG_SUMO_SIM_anti_2 713 723 PF11976 0.487
LIG_SUMO_SIM_par_1 446 453 PF11976 0.513
LIG_TRAF2_1 139 142 PF00917 0.573
LIG_TRAF2_1 259 262 PF00917 0.570
LIG_TRAF2_1 82 85 PF00917 0.665
LIG_TRAF2_1 863 866 PF00917 0.467
LIG_TRAF2_1 923 926 PF00917 0.614
LIG_TRAF2_1 973 976 PF00917 0.473
LIG_WW_3 269 273 PF00397 0.630
MOD_CDK_SPxK_1 266 272 PF00069 0.695
MOD_CDK_SPxxK_3 266 273 PF00069 0.640
MOD_CDK_SPxxK_3 513 520 PF00069 0.304
MOD_CDK_SPxxK_3 694 701 PF00069 0.578
MOD_CK1_1 114 120 PF00069 0.650
MOD_CK1_1 143 149 PF00069 0.525
MOD_CK1_1 212 218 PF00069 0.669
MOD_CK1_1 317 323 PF00069 0.630
MOD_CK1_1 335 341 PF00069 0.495
MOD_CK1_1 443 449 PF00069 0.480
MOD_CK1_1 453 459 PF00069 0.555
MOD_CK1_1 507 513 PF00069 0.549
MOD_CK1_1 664 670 PF00069 0.584
MOD_CK1_1 674 680 PF00069 0.650
MOD_CK1_1 681 687 PF00069 0.503
MOD_CK1_1 737 743 PF00069 0.385
MOD_CK1_1 860 866 PF00069 0.522
MOD_CK1_1 890 896 PF00069 0.687
MOD_CK1_1 920 926 PF00069 0.593
MOD_CK1_1 942 948 PF00069 0.766
MOD_CK2_1 256 262 PF00069 0.574
MOD_CK2_1 310 316 PF00069 0.629
MOD_CK2_1 318 324 PF00069 0.613
MOD_CK2_1 381 387 PF00069 0.488
MOD_CK2_1 446 452 PF00069 0.574
MOD_CK2_1 513 519 PF00069 0.304
MOD_CK2_1 737 743 PF00069 0.343
MOD_CK2_1 860 866 PF00069 0.522
MOD_CK2_1 920 926 PF00069 0.577
MOD_CK2_1 943 949 PF00069 0.577
MOD_GlcNHglycan 198 201 PF01048 0.709
MOD_GlcNHglycan 211 214 PF01048 0.568
MOD_GlcNHglycan 287 290 PF01048 0.611
MOD_GlcNHglycan 33 36 PF01048 0.552
MOD_GlcNHglycan 354 357 PF01048 0.614
MOD_GlcNHglycan 372 375 PF01048 0.393
MOD_GlcNHglycan 442 445 PF01048 0.436
MOD_GlcNHglycan 502 505 PF01048 0.716
MOD_GlcNHglycan 509 512 PF01048 0.611
MOD_GlcNHglycan 589 592 PF01048 0.460
MOD_GlcNHglycan 613 616 PF01048 0.662
MOD_GlcNHglycan 623 626 PF01048 0.730
MOD_GlcNHglycan 639 642 PF01048 0.665
MOD_GlcNHglycan 666 669 PF01048 0.556
MOD_GlcNHglycan 842 845 PF01048 0.647
MOD_GlcNHglycan 860 863 PF01048 0.549
MOD_GlcNHglycan 902 905 PF01048 0.541
MOD_GlcNHglycan 928 931 PF01048 0.612
MOD_GlcNHglycan 933 936 PF01048 0.608
MOD_GlcNHglycan 941 944 PF01048 0.649
MOD_GlcNHglycan 971 974 PF01048 0.551
MOD_GSK3_1 112 119 PF00069 0.732
MOD_GSK3_1 171 178 PF00069 0.632
MOD_GSK3_1 186 193 PF00069 0.561
MOD_GSK3_1 205 212 PF00069 0.518
MOD_GSK3_1 235 242 PF00069 0.632
MOD_GSK3_1 27 34 PF00069 0.573
MOD_GSK3_1 277 284 PF00069 0.680
MOD_GSK3_1 301 308 PF00069 0.638
MOD_GSK3_1 310 317 PF00069 0.555
MOD_GSK3_1 331 338 PF00069 0.781
MOD_GSK3_1 446 453 PF00069 0.536
MOD_GSK3_1 500 507 PF00069 0.713
MOD_GSK3_1 597 604 PF00069 0.506
MOD_GSK3_1 662 669 PF00069 0.668
MOD_GSK3_1 670 677 PF00069 0.546
MOD_GSK3_1 681 688 PF00069 0.479
MOD_GSK3_1 690 697 PF00069 0.522
MOD_GSK3_1 706 713 PF00069 0.390
MOD_GSK3_1 836 843 PF00069 0.599
MOD_GSK3_1 847 854 PF00069 0.571
MOD_GSK3_1 887 894 PF00069 0.595
MOD_GSK3_1 939 946 PF00069 0.617
MOD_N-GLC_1 184 189 PF02516 0.591
MOD_N-GLC_1 306 311 PF02516 0.609
MOD_N-GLC_1 888 893 PF02516 0.550
MOD_NEK2_1 302 307 PF00069 0.615
MOD_NEK2_1 318 323 PF00069 0.539
MOD_NEK2_1 375 380 PF00069 0.496
MOD_NEK2_1 463 468 PF00069 0.528
MOD_NEK2_1 500 505 PF00069 0.606
MOD_NEK2_1 552 557 PF00069 0.304
MOD_NEK2_1 661 666 PF00069 0.512
MOD_NEK2_1 851 856 PF00069 0.495
MOD_NEK2_1 887 892 PF00069 0.524
MOD_PIKK_1 116 122 PF00454 0.465
MOD_PIKK_1 205 211 PF00454 0.630
MOD_PIKK_1 552 558 PF00454 0.304
MOD_PIKK_1 737 743 PF00454 0.343
MOD_PIKK_1 888 894 PF00454 0.558
MOD_PIKK_1 99 105 PF00454 0.697
MOD_PKA_1 611 617 PF00069 0.571
MOD_PKA_2 124 130 PF00069 0.507
MOD_PKA_2 143 149 PF00069 0.665
MOD_PKA_2 224 230 PF00069 0.599
MOD_PKA_2 271 277 PF00069 0.648
MOD_PKA_2 295 301 PF00069 0.562
MOD_PKA_2 335 341 PF00069 0.619
MOD_PKA_2 587 593 PF00069 0.496
MOD_PKA_2 597 603 PF00069 0.519
MOD_PKA_2 610 616 PF00069 0.598
MOD_PKA_2 671 677 PF00069 0.642
MOD_PKA_2 700 706 PF00069 0.529
MOD_PKA_2 72 78 PF00069 0.618
MOD_PKA_2 920 926 PF00069 0.571
MOD_PKB_1 993 1001 PF00069 0.449
MOD_Plk_2-3 623 629 PF00069 0.706
MOD_Plk_4 124 130 PF00069 0.546
MOD_Plk_4 143 149 PF00069 0.454
MOD_Plk_4 239 245 PF00069 0.616
MOD_Plk_4 314 320 PF00069 0.599
MOD_Plk_4 443 449 PF00069 0.480
MOD_Plk_4 456 462 PF00069 0.570
MOD_Plk_4 734 740 PF00069 0.434
MOD_Plk_4 743 749 PF00069 0.262
MOD_Plk_4 752 758 PF00069 0.214
MOD_Plk_4 782 788 PF00069 0.335
MOD_Plk_4 793 799 PF00069 0.484
MOD_Plk_4 910 916 PF00069 0.565
MOD_ProDKin_1 179 185 PF00069 0.585
MOD_ProDKin_1 190 196 PF00069 0.583
MOD_ProDKin_1 256 262 PF00069 0.653
MOD_ProDKin_1 266 272 PF00069 0.588
MOD_ProDKin_1 450 456 PF00069 0.558
MOD_ProDKin_1 513 519 PF00069 0.293
MOD_ProDKin_1 532 538 PF00069 0.304
MOD_ProDKin_1 679 685 PF00069 0.589
MOD_ProDKin_1 694 700 PF00069 0.558
MOD_ProDKin_1 706 712 PF00069 0.521
MOD_ProDKin_1 720 726 PF00069 0.429
MOD_SUMO_for_1 973 976 PF00179 0.473
MOD_SUMO_rev_2 105 115 PF00179 0.683
MOD_SUMO_rev_2 630 639 PF00179 0.620
TRG_DiLeu_BaEn_4 261 267 PF01217 0.669
TRG_DiLeu_BaLyEn_6 150 155 PF01217 0.548
TRG_DiLeu_BaLyEn_6 38 43 PF01217 0.564
TRG_DiLeu_BaLyEn_6 407 412 PF01217 0.343
TRG_DiLeu_BaLyEn_6 657 662 PF01217 0.505
TRG_DiLeu_BaLyEn_6 813 818 PF01217 0.369
TRG_ENDOCYTIC_2 575 578 PF00928 0.304
TRG_ENDOCYTIC_2 825 828 PF00928 0.304
TRG_ER_diArg_1 135 137 PF00400 0.506
TRG_ER_diArg_1 22 25 PF00400 0.650
TRG_ER_diArg_1 271 273 PF00400 0.697
TRG_ER_diArg_1 39 41 PF00400 0.514
TRG_ER_diArg_1 429 432 PF00400 0.417
TRG_ER_diArg_1 772 774 PF00400 0.308
TRG_NLS_MonoCore_2 428 433 PF00514 0.418
TRG_NLS_MonoExtC_3 429 435 PF00514 0.405
TRG_NLS_MonoExtN_4 429 434 PF00514 0.405
TRG_Pf-PMV_PEXEL_1 273 277 PF00026 0.551
TRG_Pf-PMV_PEXEL_1 410 414 PF00026 0.364
TRG_Pf-PMV_PEXEL_1 520 524 PF00026 0.303

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N1PE32 Leptomonas seymouri 41% 96%
A0A3Q8ICU1 Leishmania donovani 99% 100%
A4HFX6 Leishmania braziliensis 70% 100%
E9ADH9 Leishmania major 89% 100%
E9AZA3 Leishmania mexicana (strain MHOM/GT/2001/U1103) 88% 99%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS