Protein kinase-like protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

protein kinase-like protein

Species:

Leishmania infantum

UniProt:

A4I302_LEIIN

TriTrypDb:

LINF_270026500

Length:

955

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 8
NetGPI	no	yes: 0, no: 8

Cellular components
Term	Name	Level	Count
GO:0005634	nucleus	5	1
GO:0016592	mediator complex	3	1
GO:0032991	protein-containing complex	1	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1
GO:0110165	cellular anatomical entity	1	1
GO:0140513	nuclear protein-containing complex	2	1

Expansion

Sequence features

A4I302

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4I302

Function

Biological processes
Term	Name	Level	Count
GO:0006468	protein phosphorylation	5	9
GO:0006793	phosphorus metabolic process	3	9
GO:0006796	phosphate-containing compound metabolic process	4	9
GO:0006807	nitrogen compound metabolic process	2	9
GO:0008152	metabolic process	1	9
GO:0009987	cellular process	1	9
GO:0016310	phosphorylation	5	9
GO:0019538	protein metabolic process	3	9
GO:0036211	protein modification process	4	9
GO:0043170	macromolecule metabolic process	3	9
GO:0043412	macromolecule modification	4	9
GO:0044237	cellular metabolic process	2	9
GO:0044238	primary metabolic process	2	9
GO:0071704	organic substance metabolic process	2	9
GO:1901564	organonitrogen compound metabolic process	3	9
GO:0000086	G2/M transition of mitotic cell cycle	5	1
GO:0000365	mRNA trans splicing, via spliceosome	9	1
GO:0000375	RNA splicing, via transesterification reactions	8	1
GO:0000377	RNA splicing, via transesterification reactions with bulged adenosine as nucleophile	9	1
GO:0000398	mRNA splicing, via spliceosome	8	1
GO:0006139	nucleobase-containing compound metabolic process	3	1
GO:0006396	RNA processing	6	1
GO:0006397	mRNA processing	7	1
GO:0006725	cellular aromatic compound metabolic process	3	1
GO:0008380	RNA splicing	7	1
GO:0016070	RNA metabolic process	5	1
GO:0016071	mRNA metabolic process	6	1
GO:0022402	cell cycle process	2	1
GO:0034641	cellular nitrogen compound metabolic process	3	1
GO:0044770	cell cycle phase transition	3	1
GO:0044772	mitotic cell cycle phase transition	4	1
GO:0044839	cell cycle G2/M phase transition	4	1
GO:0045291	mRNA trans splicing, SL addition	10	1
GO:0046483	heterocycle metabolic process	3	1
GO:0090304	nucleic acid metabolic process	4	1
GO:1901360	organic cyclic compound metabolic process	3	1
GO:1903047	mitotic cell cycle process	3	1

Molecular functions
Term	Name	Level	Count
GO:0000166	nucleotide binding	3	9
GO:0003824	catalytic activity	1	9
GO:0004672	protein kinase activity	3	9
GO:0005488	binding	1	9
GO:0005524	ATP binding	5	9
GO:0016301	kinase activity	4	9
GO:0016740	transferase activity	2	9
GO:0016772	transferase activity, transferring phosphorus-containing groups	3	9
GO:0016773	phosphotransferase activity, alcohol group as acceptor	4	9
GO:0017076	purine nucleotide binding	4	9
GO:0030554	adenyl nucleotide binding	5	9
GO:0032553	ribonucleotide binding	3	9
GO:0032555	purine ribonucleotide binding	4	9
GO:0032559	adenyl ribonucleotide binding	5	9
GO:0035639	purine ribonucleoside triphosphate binding	4	9
GO:0036094	small molecule binding	2	9
GO:0043167	ion binding	2	9
GO:0043168	anion binding	3	9
GO:0097159	organic cyclic compound binding	2	9
GO:0097367	carbohydrate derivative binding	2	9
GO:0140096	catalytic activity, acting on a protein	2	9
GO:1901265	nucleoside phosphate binding	3	9
GO:1901363	heterocyclic compound binding	2	9
GO:0004674	protein serine/threonine kinase activity	4	1
GO:0004693	cyclin-dependent protein serine/threonine kinase activity	5	1
GO:0008353	RNA polymerase II CTD heptapeptide repeat kinase activity	5	1
GO:0097472	cyclin-dependent protein kinase activity	4	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	49	53	PF00656	0.629
CLV_C14_Caspase3-7	88	92	PF00656	0.624
CLV_C14_Caspase3-7	900	904	PF00656	0.734
CLV_C14_Caspase3-7	932	936	PF00656	0.646
CLV_NRD_NRD_1	10	12	PF00675	0.465
CLV_NRD_NRD_1	377	379	PF00675	0.695
CLV_NRD_NRD_1	424	426	PF00675	0.611
CLV_NRD_NRD_1	509	511	PF00675	0.475
CLV_NRD_NRD_1	649	651	PF00675	0.385
CLV_NRD_NRD_1	747	749	PF00675	0.400
CLV_NRD_NRD_1	799	801	PF00675	0.684
CLV_NRD_NRD_1	921	923	PF00675	0.735
CLV_PCSK_KEX2_1	377	379	PF00082	0.735
CLV_PCSK_KEX2_1	424	426	PF00082	0.611
CLV_PCSK_KEX2_1	509	511	PF00082	0.532
CLV_PCSK_KEX2_1	649	651	PF00082	0.385
CLV_PCSK_KEX2_1	746	748	PF00082	0.385
CLV_PCSK_KEX2_1	799	801	PF00082	0.684
CLV_PCSK_KEX2_1	921	923	PF00082	0.735
CLV_PCSK_SKI1_1	193	197	PF00082	0.541
CLV_PCSK_SKI1_1	286	290	PF00082	0.437
CLV_PCSK_SKI1_1	328	332	PF00082	0.419
CLV_PCSK_SKI1_1	440	444	PF00082	0.617
CLV_PCSK_SKI1_1	458	462	PF00082	0.530
CLV_PCSK_SKI1_1	491	495	PF00082	0.456
CLV_PCSK_SKI1_1	510	514	PF00082	0.374
CLV_PCSK_SKI1_1	577	581	PF00082	0.291
CLV_PCSK_SKI1_1	650	654	PF00082	0.385
CLV_PCSK_SKI1_1	878	882	PF00082	0.574
CLV_Separin_Metazoa	771	775	PF03568	0.445
DEG_Nend_UBRbox_3	1	3	PF02207	0.593
DEG_SPOP_SBC_1	388	392	PF00917	0.656
DEG_SPOP_SBC_1	396	400	PF00917	0.633
DEG_SPOP_SBC_1	61	65	PF00917	0.677
DEG_SPOP_SBC_1	819	823	PF00917	0.622
DOC_CDC14_PxL_1	617	625	PF14671	0.291
DOC_CYCLIN_RxL_1	647	657	PF00134	0.385
DOC_CYCLIN_yCln2_LP_2	648	654	PF00134	0.385
DOC_MAPK_gen_1	577	586	PF00069	0.291
DOC_MAPK_MEF2A_6	348	356	PF00069	0.396
DOC_MAPK_MEF2A_6	489	497	PF00069	0.487
DOC_MAPK_MEF2A_6	94	101	PF00069	0.516
DOC_MAPK_RevD_3	634	650	PF00069	0.385
DOC_PP1_RVXF_1	562	569	PF00149	0.385
DOC_PP2B_LxvP_1	669	672	PF13499	0.367
DOC_PP2B_LxvP_1	97	100	PF13499	0.571
DOC_PP4_FxxP_1	79	82	PF00568	0.572
DOC_USP7_MATH_1	127	131	PF00917	0.745
DOC_USP7_MATH_1	144	148	PF00917	0.742
DOC_USP7_MATH_1	160	164	PF00917	0.498
DOC_USP7_MATH_1	209	213	PF00917	0.575
DOC_USP7_MATH_1	228	232	PF00917	0.566
DOC_USP7_MATH_1	311	315	PF00917	0.660
DOC_USP7_MATH_1	388	392	PF00917	0.664
DOC_USP7_MATH_1	396	400	PF00917	0.727
DOC_USP7_MATH_1	46	50	PF00917	0.689
DOC_USP7_MATH_1	547	551	PF00917	0.467
DOC_USP7_MATH_1	788	792	PF00917	0.729
DOC_USP7_MATH_1	80	84	PF00917	0.662
DOC_USP7_MATH_1	850	854	PF00917	0.774
DOC_USP7_MATH_1	864	868	PF00917	0.595
DOC_USP7_MATH_1	874	878	PF00917	0.700
DOC_USP7_UBL2_3	328	332	PF12436	0.421
DOC_WW_Pin1_4	370	375	PF00397	0.629
DOC_WW_Pin1_4	378	383	PF00397	0.707
DOC_WW_Pin1_4	384	389	PF00397	0.712
DOC_WW_Pin1_4	392	397	PF00397	0.539
DOC_WW_Pin1_4	403	408	PF00397	0.526
DOC_WW_Pin1_4	536	541	PF00397	0.545
DOC_WW_Pin1_4	607	612	PF00397	0.385
DOC_WW_Pin1_4	78	83	PF00397	0.574
DOC_WW_Pin1_4	860	865	PF00397	0.662
DOC_WW_Pin1_4	866	871	PF00397	0.646
LIG_14-3-3_CanoR_1	233	240	PF00244	0.625
LIG_14-3-3_CanoR_1	275	283	PF00244	0.475
LIG_14-3-3_CanoR_1	286	293	PF00244	0.340
LIG_14-3-3_CanoR_1	509	518	PF00244	0.580
LIG_14-3-3_CanoR_1	695	705	PF00244	0.418
LIG_14-3-3_CanoR_1	825	833	PF00244	0.760
LIG_14-3-3_CanoR_1	921	928	PF00244	0.610
LIG_BIR_III_4	149	153	PF00653	0.582
LIG_Clathr_ClatBox_1	367	371	PF01394	0.531
LIG_deltaCOP1_diTrp_1	635	643	PF00928	0.367
LIG_EVH1_2	75	79	PF00568	0.664
LIG_FHA_1	120	126	PF00498	0.761
LIG_FHA_1	140	146	PF00498	0.728
LIG_FHA_1	153	159	PF00498	0.536
LIG_FHA_1	30	36	PF00498	0.684
LIG_FHA_1	322	328	PF00498	0.408
LIG_FHA_1	476	482	PF00498	0.692
LIG_FHA_1	579	585	PF00498	0.303
LIG_FHA_1	608	614	PF00498	0.291
LIG_FHA_1	697	703	PF00498	0.367
LIG_FHA_1	936	942	PF00498	0.585
LIG_FHA_2	149	155	PF00498	0.648
LIG_FHA_2	287	293	PF00498	0.452
LIG_FHA_2	427	433	PF00498	0.620
LIG_FHA_2	463	469	PF00498	0.750
LIG_FHA_2	511	517	PF00498	0.569
LIG_LIR_Apic_2	615	621	PF02991	0.291
LIG_LIR_Gen_1	492	502	PF02991	0.354
LIG_LIR_Gen_1	557	568	PF02991	0.385
LIG_LIR_Gen_1	588	599	PF02991	0.385
LIG_LIR_Nem_3	498	502	PF02991	0.331
LIG_LIR_Nem_3	557	563	PF02991	0.385
LIG_LIR_Nem_3	588	594	PF02991	0.385
LIG_LIR_Nem_3	622	628	PF02991	0.367
LIG_LIR_Nem_3	674	680	PF02991	0.315
LIG_NRBOX	109	115	PF00104	0.522
LIG_Pex14_2	643	647	PF04695	0.367
LIG_REV1ctd_RIR_1	757	763	PF16727	0.319
LIG_SH2_CRK	270	274	PF00017	0.407
LIG_SH2_CRK	281	285	PF00017	0.328
LIG_SH2_CRK	560	564	PF00017	0.367
LIG_SH2_CRK	681	685	PF00017	0.385
LIG_SH2_NCK_1	270	274	PF00017	0.462
LIG_SH2_NCK_1	511	515	PF00017	0.506
LIG_SH2_PTP2	591	594	PF00017	0.385
LIG_SH2_STAP1	511	515	PF00017	0.616
LIG_SH2_STAP1	630	634	PF00017	0.291
LIG_SH2_STAT3	293	296	PF00017	0.518
LIG_SH2_STAT5	270	273	PF00017	0.369
LIG_SH2_STAT5	345	348	PF00017	0.403
LIG_SH2_STAT5	499	502	PF00017	0.408
LIG_SH2_STAT5	535	538	PF00017	0.452
LIG_SH2_STAT5	551	554	PF00017	0.427
LIG_SH2_STAT5	591	594	PF00017	0.357
LIG_SH3_2	202	207	PF14604	0.619
LIG_SH3_3	199	205	PF00018	0.600
LIG_SH3_3	302	308	PF00018	0.736
LIG_SH3_3	337	343	PF00018	0.465
LIG_SH3_3	67	73	PF00018	0.669
LIG_SH3_3	763	769	PF00018	0.445
LIG_SH3_CIN85_PxpxPR_1	372	377	PF14604	0.673
LIG_SUMO_SIM_anti_2	349	354	PF11976	0.466
LIG_SUMO_SIM_anti_2	366	371	PF11976	0.343
LIG_SUMO_SIM_anti_2	612	618	PF11976	0.385
LIG_SUMO_SIM_anti_2	731	739	PF11976	0.388
LIG_SUMO_SIM_par_1	366	371	PF11976	0.434
LIG_SUMO_SIM_par_1	661	667	PF11976	0.385
LIG_TRAF2_1	672	675	PF00917	0.363
LIG_TYR_ITIM	533	538	PF00017	0.521
LIG_TYR_ITIM	558	563	PF00017	0.367
LIG_UBA3_1	6	12	PF00899	0.554
MOD_CDC14_SPxK_1	381	384	PF00782	0.631
MOD_CDK_SPK_2	536	541	PF00069	0.545
MOD_CDK_SPxK_1	378	384	PF00069	0.631
MOD_CDK_SPxxK_3	370	377	PF00069	0.646
MOD_CK1_1	120	126	PF00069	0.665
MOD_CK1_1	159	165	PF00069	0.792
MOD_CK1_1	212	218	PF00069	0.656
MOD_CK1_1	235	241	PF00069	0.577
MOD_CK1_1	310	316	PF00069	0.698
MOD_CK1_1	387	393	PF00069	0.769
MOD_CK1_1	395	401	PF00069	0.596
MOD_CK1_1	403	409	PF00069	0.513
MOD_CK1_1	65	71	PF00069	0.610
MOD_CK1_1	656	662	PF00069	0.385
MOD_CK1_1	805	811	PF00069	0.659
MOD_CK1_1	81	87	PF00069	0.513
MOD_CK1_1	813	819	PF00069	0.658
MOD_CK1_1	827	833	PF00069	0.595
MOD_CK1_1	853	859	PF00069	0.635
MOD_CK1_1	869	875	PF00069	0.513
MOD_CK2_1	173	179	PF00069	0.713
MOD_CK2_1	2	8	PF00069	0.567
MOD_CK2_1	388	394	PF00069	0.685
MOD_CK2_1	425	431	PF00069	0.654
MOD_CK2_1	462	468	PF00069	0.582
MOD_CK2_1	510	516	PF00069	0.557
MOD_CK2_1	747	753	PF00069	0.325
MOD_CK2_1	840	846	PF00069	0.631
MOD_CK2_1	851	857	PF00069	0.622
MOD_CK2_1	931	937	PF00069	0.612
MOD_GlcNHglycan	129	132	PF01048	0.728
MOD_GlcNHglycan	157	161	PF01048	0.801
MOD_GlcNHglycan	162	165	PF01048	0.675
MOD_GlcNHglycan	174	178	PF01048	0.612
MOD_GlcNHglycan	235	238	PF01048	0.657
MOD_GlcNHglycan	255	259	PF01048	0.400
MOD_GlcNHglycan	309	312	PF01048	0.651
MOD_GlcNHglycan	313	316	PF01048	0.661
MOD_GlcNHglycan	48	51	PF01048	0.711
MOD_GlcNHglycan	529	532	PF01048	0.659
MOD_GlcNHglycan	731	734	PF01048	0.340
MOD_GlcNHglycan	749	752	PF01048	0.206
MOD_GlcNHglycan	790	793	PF01048	0.797
MOD_GlcNHglycan	827	830	PF01048	0.729
MOD_GlcNHglycan	83	86	PF01048	0.675
MOD_GlcNHglycan	842	845	PF01048	0.737
MOD_GlcNHglycan	853	856	PF01048	0.774
MOD_GlcNHglycan	866	869	PF01048	0.649
MOD_GlcNHglycan	898	902	PF01048	0.691
MOD_GSK3_1	117	124	PF00069	0.504
MOD_GSK3_1	144	151	PF00069	0.615
MOD_GSK3_1	152	159	PF00069	0.638
MOD_GSK3_1	173	180	PF00069	0.526
MOD_GSK3_1	212	219	PF00069	0.675
MOD_GSK3_1	228	235	PF00069	0.631
MOD_GSK3_1	303	310	PF00069	0.679
MOD_GSK3_1	378	385	PF00069	0.661
MOD_GSK3_1	386	393	PF00069	0.665
MOD_GSK3_1	394	401	PF00069	0.704
MOD_GSK3_1	426	433	PF00069	0.575
MOD_GSK3_1	458	465	PF00069	0.681
MOD_GSK3_1	523	530	PF00069	0.710
MOD_GSK3_1	61	68	PF00069	0.680
MOD_GSK3_1	685	692	PF00069	0.338
MOD_GSK3_1	697	704	PF00069	0.408
MOD_GSK3_1	820	827	PF00069	0.782
MOD_GSK3_1	853	860	PF00069	0.685
MOD_GSK3_1	876	883	PF00069	0.736
MOD_GSK3_1	893	900	PF00069	0.617
MOD_GSK3_1	917	924	PF00069	0.683
MOD_GSK3_1	931	938	PF00069	0.716
MOD_LATS_1	919	925	PF00433	0.690
MOD_N-GLC_1	29	34	PF02516	0.665
MOD_N-GLC_1	696	701	PF02516	0.454
MOD_NEK2_1	335	340	PF00069	0.529
MOD_NEK2_1	569	574	PF00069	0.412
MOD_NEK2_1	579	584	PF00069	0.281
MOD_NEK2_1	689	694	PF00069	0.319
MOD_NEK2_1	736	741	PF00069	0.367
MOD_NEK2_2	228	233	PF00069	0.650
MOD_NEK2_2	876	881	PF00069	0.549
MOD_OFUCOSY	98	103	PF10250	0.548
MOD_PIKK_1	177	183	PF00454	0.647
MOD_PIKK_1	274	280	PF00454	0.494
MOD_PIKK_1	335	341	PF00454	0.517
MOD_PIKK_1	458	464	PF00454	0.687
MOD_PIKK_1	805	811	PF00454	0.691
MOD_PK_1	554	560	PF00069	0.385
MOD_PKA_1	747	753	PF00069	0.385
MOD_PKA_1	921	927	PF00069	0.695
MOD_PKA_2	172	178	PF00069	0.649
MOD_PKA_2	232	238	PF00069	0.628
MOD_PKA_2	274	280	PF00069	0.476
MOD_PKA_2	303	309	PF00069	0.766
MOD_PKA_2	426	432	PF00069	0.599
MOD_PKA_2	697	703	PF00069	0.385
MOD_PKA_2	747	753	PF00069	0.291
MOD_PKA_2	805	811	PF00069	0.642
MOD_PKA_2	824	830	PF00069	0.492
MOD_PKA_2	920	926	PF00069	0.713
MOD_Plk_1	156	162	PF00069	0.596
MOD_Plk_1	335	341	PF00069	0.576
MOD_Plk_1	673	679	PF00069	0.291
MOD_Plk_1	845	851	PF00069	0.627
MOD_Plk_2-3	931	937	PF00069	0.612
MOD_Plk_4	179	185	PF00069	0.483
MOD_Plk_4	2	8	PF00069	0.567
MOD_Plk_4	235	241	PF00069	0.565
MOD_Plk_4	503	509	PF00069	0.388
MOD_Plk_4	547	553	PF00069	0.566
MOD_Plk_4	554	560	PF00069	0.405
MOD_Plk_4	609	615	PF00069	0.300
MOD_Plk_4	62	68	PF00069	0.598
MOD_Plk_4	685	691	PF00069	0.328
MOD_Plk_4	701	707	PF00069	0.341
MOD_Plk_4	736	742	PF00069	0.447
MOD_ProDKin_1	370	376	PF00069	0.637
MOD_ProDKin_1	378	384	PF00069	0.709
MOD_ProDKin_1	392	398	PF00069	0.539
MOD_ProDKin_1	403	409	PF00069	0.604
MOD_ProDKin_1	536	542	PF00069	0.537
MOD_ProDKin_1	607	613	PF00069	0.385
MOD_ProDKin_1	78	84	PF00069	0.576
MOD_ProDKin_1	860	866	PF00069	0.663
MOD_SUMO_for_1	760	763	PF00179	0.438
MOD_SUMO_rev_2	520	527	PF00179	0.626
MOD_SUMO_rev_2	572	582	PF00179	0.468
TRG_DiLeu_BaEn_1	349	354	PF01217	0.394
TRG_DiLeu_BaEn_4	911	917	PF01217	0.633
TRG_ENDOCYTIC_2	270	273	PF00928	0.385
TRG_ENDOCYTIC_2	281	284	PF00928	0.352
TRG_ENDOCYTIC_2	535	538	PF00928	0.448
TRG_ENDOCYTIC_2	560	563	PF00928	0.385
TRG_ENDOCYTIC_2	591	594	PF00928	0.385
TRG_ER_diArg_1	190	193	PF00400	0.668
TRG_ER_diArg_1	302	305	PF00400	0.629
TRG_ER_diArg_1	376	378	PF00400	0.772
TRG_ER_diArg_1	423	425	PF00400	0.601
TRG_ER_diArg_1	508	510	PF00400	0.506
TRG_ER_diArg_1	648	650	PF00400	0.385
TRG_ER_diArg_1	745	748	PF00400	0.385
TRG_NLS_Bipartite_1	424	444	PF00514	0.599
TRG_NLS_MonoExtC_3	10	16	PF00514	0.551
TRG_NLS_MonoExtC_3	439	445	PF00514	0.621
TRG_NLS_MonoExtN_4	9	15	PF00514	0.554
TRG_Pf-PMV_PEXEL_1	573	578	PF00026	0.291
TRG_Pf-PMV_PEXEL_1	946	951	PF00026	0.737

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I6G8	Leptomonas seymouri	49%	100%
A0A3R7KFZ3	Trypanosoma rangeli	38%	100%
A0A3S5H7I2	Leishmania donovani	99%	100%
A4HFW9	Leishmania braziliensis	77%	100%
C9ZJF3	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	35%	100%
E9ADH4	Leishmania major	92%	100%
E9AZ98	Leishmania mexicana (strain MHOM/GT/2001/U1103)	88%	100%