Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein - conserved

Species:

Leishmania infantum

UniProt:

A4I2Z9_LEIIN

TriTrypDb:

LINF_270026200

Length:

672

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 4
NetGPI	no	yes: 0, no: 4

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0016020	membrane	2	3
GO:0110165	cellular anatomical entity	1	3

Expansion

Sequence features

A4I2Z9

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4I2Z9

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	516	520	PF00656	0.394
CLV_NRD_NRD_1	170	172	PF00675	0.571
CLV_NRD_NRD_1	265	267	PF00675	0.383
CLV_NRD_NRD_1	336	338	PF00675	0.398
CLV_NRD_NRD_1	366	368	PF00675	0.603
CLV_NRD_NRD_1	389	391	PF00675	0.580
CLV_NRD_NRD_1	428	430	PF00675	0.651
CLV_NRD_NRD_1	437	439	PF00675	0.657
CLV_NRD_NRD_1	482	484	PF00675	0.654
CLV_NRD_NRD_1	525	527	PF00675	0.573
CLV_NRD_NRD_1	571	573	PF00675	0.370
CLV_NRD_NRD_1	601	603	PF00675	0.596
CLV_NRD_NRD_1	613	615	PF00675	0.514
CLV_NRD_NRD_1	631	633	PF00675	0.412
CLV_PCSK_FUR_1	426	430	PF00082	0.635
CLV_PCSK_FUR_1	599	603	PF00082	0.481
CLV_PCSK_FUR_1	611	615	PF00082	0.408
CLV_PCSK_KEX2_1	170	172	PF00082	0.571
CLV_PCSK_KEX2_1	265	267	PF00082	0.383
CLV_PCSK_KEX2_1	336	338	PF00082	0.398
CLV_PCSK_KEX2_1	428	430	PF00082	0.651
CLV_PCSK_KEX2_1	437	439	PF00082	0.657
CLV_PCSK_KEX2_1	482	484	PF00082	0.654
CLV_PCSK_KEX2_1	525	527	PF00082	0.573
CLV_PCSK_KEX2_1	571	573	PF00082	0.370
CLV_PCSK_KEX2_1	601	603	PF00082	0.593
CLV_PCSK_KEX2_1	613	615	PF00082	0.495
CLV_PCSK_KEX2_1	631	633	PF00082	0.412
CLV_PCSK_KEX2_1	91	93	PF00082	0.573
CLV_PCSK_PC1ET2_1	91	93	PF00082	0.573
CLV_PCSK_SKI1_1	315	319	PF00082	0.500
CLV_PCSK_SKI1_1	476	480	PF00082	0.661
CLV_PCSK_SKI1_1	562	566	PF00082	0.448
DEG_APCC_DBOX_1	279	287	PF00400	0.564
DEG_APCC_DBOX_1	389	397	PF00400	0.370
DEG_APCC_DBOX_1	561	569	PF00400	0.339
DEG_MDM2_SWIB_1	566	574	PF02201	0.373
DEG_Nend_UBRbox_3	1	3	PF02207	0.684
DEG_SPOP_SBC_1	178	182	PF00917	0.363
DOC_CDC14_PxL_1	329	337	PF14671	0.339
DOC_CYCLIN_yCln2_LP_2	52	58	PF00134	0.623
DOC_MAPK_gen_1	140	149	PF00069	0.543
DOC_MAPK_gen_1	278	285	PF00069	0.572
DOC_MAPK_gen_1	515	523	PF00069	0.368
DOC_MAPK_MEF2A_6	143	151	PF00069	0.500
DOC_MAPK_MEF2A_6	53	62	PF00069	0.602
DOC_MAPK_MEF2A_6	544	553	PF00069	0.300
DOC_MAPK_RevD_3	469	483	PF00069	0.461
DOC_PP1_RVXF_1	560	567	PF00149	0.284
DOC_PP2B_LxvP_1	471	474	PF13499	0.474
DOC_PP4_FxxP_1	184	187	PF00568	0.471
DOC_PP4_FxxP_1	330	333	PF00568	0.339
DOC_USP7_MATH_1	18	22	PF00917	0.701
DOC_USP7_MATH_1	188	192	PF00917	0.439
DOC_USP7_MATH_1	225	229	PF00917	0.406
DOC_USP7_MATH_1	28	32	PF00917	0.643
DOC_USP7_MATH_1	410	414	PF00917	0.446
DOC_USP7_MATH_1	458	462	PF00917	0.467
DOC_USP7_MATH_1	472	476	PF00917	0.425
DOC_USP7_MATH_1	633	637	PF00917	0.690
DOC_USP7_MATH_1	9	13	PF00917	0.656
DOC_WW_Pin1_4	179	184	PF00397	0.455
DOC_WW_Pin1_4	21	26	PF00397	0.678
DOC_WW_Pin1_4	252	257	PF00397	0.412
DOC_WW_Pin1_4	37	42	PF00397	0.628
DOC_WW_Pin1_4	375	380	PF00397	0.437
DOC_WW_Pin1_4	438	443	PF00397	0.462
DOC_WW_Pin1_4	463	468	PF00397	0.478
DOC_WW_Pin1_4	626	631	PF00397	0.704
DOC_WW_Pin1_4	641	646	PF00397	0.605
LIG_14-3-3_CanoR_1	174	179	PF00244	0.414
LIG_14-3-3_CanoR_1	280	286	PF00244	0.566
LIG_14-3-3_CanoR_1	371	376	PF00244	0.456
LIG_14-3-3_CanoR_1	418	422	PF00244	0.460
LIG_14-3-3_CanoR_1	459	467	PF00244	0.461
LIG_14-3-3_CanoR_1	525	534	PF00244	0.320
LIG_14-3-3_CanoR_1	632	641	PF00244	0.708
LIG_14-3-3_CanoR_1	92	101	PF00244	0.311
LIG_Actin_RPEL_3	332	351	PF02755	0.311
LIG_ActinCP_TwfCPI_2	184	193	PF01115	0.470
LIG_APCC_ABBA_1	402	407	PF00400	0.375
LIG_APCC_ABBAyCdc20_2	518	524	PF00400	0.364
LIG_BRCT_BRCA1_1	180	184	PF00533	0.459
LIG_CtBP_PxDLS_1	114	118	PF00389	0.290
LIG_EH1_1	545	553	PF00400	0.300
LIG_eIF4E_1	141	147	PF01652	0.518
LIG_eIF4E_1	546	552	PF01652	0.339
LIG_eIF4E_1	72	78	PF01652	0.339
LIG_EVH1_1	42	46	PF00568	0.657
LIG_FHA_1	1	7	PF00498	0.662
LIG_FHA_1	302	308	PF00498	0.339
LIG_FHA_1	322	328	PF00498	0.199
LIG_FHA_1	384	390	PF00498	0.374
LIG_FHA_1	508	514	PF00498	0.392
LIG_FHA_1	543	549	PF00498	0.300
LIG_FHA_1	646	652	PF00498	0.663
LIG_FHA_1	77	83	PF00498	0.339
LIG_GBD_Chelix_1	117	125	PF00786	0.311
LIG_LIR_Apic_2	181	187	PF02991	0.465
LIG_LIR_Gen_1	116	126	PF02991	0.339
LIG_LIR_Gen_1	355	366	PF02991	0.419
LIG_LIR_Gen_1	420	427	PF02991	0.430
LIG_LIR_Gen_1	545	554	PF02991	0.300
LIG_LIR_Nem_3	116	122	PF02991	0.339
LIG_LIR_Nem_3	261	267	PF02991	0.568
LIG_LIR_Nem_3	338	344	PF02991	0.575
LIG_LIR_Nem_3	355	361	PF02991	0.220
LIG_LIR_Nem_3	420	424	PF02991	0.436
LIG_LIR_Nem_3	494	498	PF02991	0.414
LIG_LIR_Nem_3	500	504	PF02991	0.325
LIG_LIR_Nem_3	541	546	PF02991	0.354
LIG_PDZ_Class_1	667	672	PF00595	0.638
LIG_Pex14_2	566	570	PF04695	0.362
LIG_PTB_Apo_2	124	131	PF02174	0.339
LIG_REV1ctd_RIR_1	520	530	PF16727	0.380
LIG_RPA_C_Fungi	608	620	PF08784	0.547
LIG_SH2_CRK	358	362	PF00017	0.339
LIG_SH2_CRK	546	550	PF00017	0.339
LIG_SH2_PTP2	67	70	PF00017	0.332
LIG_SH2_PTP2	72	75	PF00017	0.311
LIG_SH2_SRC	394	397	PF00017	0.446
LIG_SH2_STAP1	134	138	PF00017	0.379
LIG_SH2_STAP1	358	362	PF00017	0.339
LIG_SH2_STAP1	381	385	PF00017	0.447
LIG_SH2_STAP1	394	398	PF00017	0.371
LIG_SH2_STAP1	546	550	PF00017	0.339
LIG_SH2_STAT3	603	606	PF00017	0.610
LIG_SH2_STAT5	163	166	PF00017	0.339
LIG_SH2_STAT5	301	304	PF00017	0.339
LIG_SH2_STAT5	329	332	PF00017	0.339
LIG_SH2_STAT5	385	388	PF00017	0.449
LIG_SH2_STAT5	491	494	PF00017	0.465
LIG_SH2_STAT5	501	504	PF00017	0.347
LIG_SH2_STAT5	658	661	PF00017	0.650
LIG_SH2_STAT5	67	70	PF00017	0.332
LIG_SH2_STAT5	72	75	PF00017	0.311
LIG_SH3_3	109	115	PF00018	0.443
LIG_SH3_3	184	190	PF00018	0.570
LIG_SH3_3	20	26	PF00018	0.566
LIG_SH3_3	216	222	PF00018	0.574
LIG_SH3_3	226	232	PF00018	0.427
LIG_SH3_3	250	256	PF00018	0.339
LIG_SH3_3	3	9	PF00018	0.575
LIG_SH3_3	38	44	PF00018	0.499
LIG_SH3_3	627	633	PF00018	0.600
LIG_SUMO_SIM_anti_2	79	86	PF11976	0.328
LIG_SUMO_SIM_par_1	315	321	PF11976	0.339
LIG_SUMO_SIM_par_1	350	355	PF11976	0.338
LIG_SUMO_SIM_par_1	54	59	PF11976	0.501
LIG_SUMO_SIM_par_1	552	559	PF11976	0.339
LIG_SUMO_SIM_par_1	74	81	PF11976	0.199
LIG_SUMO_SIM_par_1	83	89	PF11976	0.276
LIG_TRAF2_1	514	517	PF00917	0.498
LIG_TRAF2_1	604	607	PF00917	0.749
LIG_TRFH_1	329	333	PF08558	0.339
LIG_TYR_ITIM	327	332	PF00017	0.339
LIG_TYR_ITIM	419	424	PF00017	0.534
LIG_TYR_ITIM	70	75	PF00017	0.339
LIG_UBA3_1	56	65	PF00899	0.424
LIG_Vh1_VBS_1	62	80	PF01044	0.311
LIG_WRC_WIRS_1	259	264	PF05994	0.427
LIG_WRC_WIRS_1	322	327	PF05994	0.339
LIG_WRC_WIRS_1	87	92	PF05994	0.429
LIG_WW_2	43	46	PF00397	0.558
MOD_CDC14_SPxK_1	629	632	PF00782	0.631
MOD_CDK_SPK_2	626	631	PF00069	0.625
MOD_CDK_SPxK_1	626	632	PF00069	0.628
MOD_CDK_SPxxK_3	179	186	PF00069	0.537
MOD_CK1_1	177	183	PF00069	0.526
MOD_CK1_1	199	205	PF00069	0.538
MOD_CK1_1	21	27	PF00069	0.574
MOD_CK1_1	240	246	PF00069	0.306
MOD_CK1_1	252	258	PF00069	0.355
MOD_CK1_1	374	380	PF00069	0.536
MOD_CK1_1	462	468	PF00069	0.576
MOD_CK1_1	93	99	PF00069	0.440
MOD_CK2_1	208	214	PF00069	0.553
MOD_CK2_1	93	99	PF00069	0.440
MOD_CMANNOS	570	573	PF00535	0.439
MOD_GlcNHglycan	20	23	PF01048	0.637
MOD_GlcNHglycan	205	208	PF01048	0.556
MOD_GlcNHglycan	210	213	PF01048	0.520
MOD_GlcNHglycan	29	33	PF01048	0.559
MOD_GlcNHglycan	354	357	PF01048	0.339
MOD_GlcNHglycan	37	40	PF01048	0.486
MOD_GlcNHglycan	395	399	PF01048	0.460
MOD_GlcNHglycan	407	411	PF01048	0.427
MOD_GlcNHglycan	461	464	PF01048	0.566
MOD_GlcNHglycan	476	479	PF01048	0.481
MOD_GlcNHglycan	558	561	PF01048	0.339
MOD_GlcNHglycan	641	644	PF01048	0.625
MOD_GSK3_1	17	24	PF00069	0.618
MOD_GSK3_1	173	180	PF00069	0.494
MOD_GSK3_1	199	206	PF00069	0.586
MOD_GSK3_1	237	244	PF00069	0.337
MOD_GSK3_1	281	288	PF00069	0.425
MOD_GSK3_1	371	378	PF00069	0.553
MOD_GSK3_1	379	386	PF00069	0.407
MOD_GSK3_1	406	413	PF00069	0.519
MOD_GSK3_1	458	465	PF00069	0.574
MOD_GSK3_1	487	494	PF00069	0.447
MOD_GSK3_1	620	627	PF00069	0.593
MOD_GSK3_1	633	640	PF00069	0.549
MOD_GSK3_1	641	648	PF00069	0.538
MOD_GSK3_1	664	671	PF00069	0.538
MOD_GSK3_1	86	93	PF00069	0.458
MOD_N-GLC_1	485	490	PF02516	0.501
MOD_N-GLC_1	507	512	PF02516	0.450
MOD_NEK2_1	117	122	PF00069	0.339
MOD_NEK2_1	173	178	PF00069	0.428
MOD_NEK2_1	234	239	PF00069	0.339
MOD_NEK2_1	249	254	PF00069	0.235
MOD_NEK2_1	307	312	PF00069	0.436
MOD_NEK2_1	318	323	PF00069	0.263
MOD_NEK2_1	335	340	PF00069	0.352
MOD_NEK2_1	417	422	PF00069	0.549
MOD_NEK2_1	555	560	PF00069	0.339
MOD_NEK2_1	77	82	PF00069	0.334
MOD_NEK2_1	90	95	PF00069	0.399
MOD_NEK2_2	301	306	PF00069	0.339
MOD_NEK2_2	507	512	PF00069	0.450
MOD_NEK2_2	86	91	PF00069	0.389
MOD_PIKK_1	452	458	PF00454	0.533
MOD_PIKK_1	624	630	PF00454	0.622
MOD_PIKK_1	645	651	PF00454	0.599
MOD_PK_1	174	180	PF00069	0.451
MOD_PK_1	371	377	PF00069	0.558
MOD_PKA_2	173	179	PF00069	0.491
MOD_PKA_2	196	202	PF00069	0.579
MOD_PKA_2	281	287	PF00069	0.430
MOD_PKA_2	335	341	PF00069	0.470
MOD_PKA_2	417	423	PF00069	0.544
MOD_PKA_2	458	464	PF00069	0.565
MOD_PKA_2	93	99	PF00069	0.412
MOD_Plk_1	406	412	PF00069	0.513
MOD_Plk_1	507	513	PF00069	0.456
MOD_Plk_1	637	643	PF00069	0.603
MOD_Plk_4	174	180	PF00069	0.451
MOD_Plk_4	199	205	PF00069	0.586
MOD_Plk_4	225	231	PF00069	0.479
MOD_Plk_4	243	249	PF00069	0.230
MOD_Plk_4	281	287	PF00069	0.430
MOD_Plk_4	301	307	PF00069	0.199
MOD_Plk_4	400	406	PF00069	0.416
MOD_Plk_4	487	493	PF00069	0.472
MOD_Plk_4	78	84	PF00069	0.339
MOD_ProDKin_1	179	185	PF00069	0.561
MOD_ProDKin_1	21	27	PF00069	0.585
MOD_ProDKin_1	252	258	PF00069	0.405
MOD_ProDKin_1	37	43	PF00069	0.514
MOD_ProDKin_1	375	381	PF00069	0.530
MOD_ProDKin_1	438	444	PF00069	0.567
MOD_ProDKin_1	463	469	PF00069	0.591
MOD_ProDKin_1	626	632	PF00069	0.628
MOD_ProDKin_1	641	647	PF00069	0.485
TRG_DiLeu_BaEn_1	142	147	PF01217	0.360
TRG_DiLeu_BaLyEn_6	340	345	PF01217	0.437
TRG_DiLeu_BaLyEn_6	52	57	PF01217	0.513
TRG_ENDOCYTIC_2	163	166	PF00928	0.339
TRG_ENDOCYTIC_2	259	262	PF00928	0.413
TRG_ENDOCYTIC_2	329	332	PF00928	0.339
TRG_ENDOCYTIC_2	358	361	PF00928	0.339
TRG_ENDOCYTIC_2	421	424	PF00928	0.531
TRG_ENDOCYTIC_2	501	504	PF00928	0.417
TRG_ENDOCYTIC_2	546	549	PF00928	0.339
TRG_ENDOCYTIC_2	67	70	PF00928	0.339
TRG_ENDOCYTIC_2	72	75	PF00928	0.305
TRG_ER_diArg_1	264	266	PF00400	0.447
TRG_ER_diArg_1	279	282	PF00400	0.333
TRG_ER_diArg_1	335	337	PF00400	0.472
TRG_ER_diArg_1	426	429	PF00400	0.541
TRG_ER_diArg_1	436	438	PF00400	0.549
TRG_ER_diArg_1	481	483	PF00400	0.567
TRG_ER_diArg_1	525	527	PF00400	0.442
TRG_ER_diArg_1	570	572	PF00400	0.435
TRG_ER_diArg_1	599	602	PF00400	0.667
TRG_ER_diArg_1	611	614	PF00400	0.521
TRG_ER_diArg_1	630	632	PF00400	0.633
TRG_ER_diArg_1	92	95	PF00400	0.454
TRG_NES_CRM1_1	281	293	PF08389	0.410
TRG_NES_CRM1_1	59	71	PF08389	0.382

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A3S7X0W2	Leishmania donovani	99%	100%
E9ADH1	Leishmania major	90%	100%
E9AZ95	Leishmania mexicana (strain MHOM/GT/2001/U1103)	84%	100%