LeishMANIAdb
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Putative RNA-binding protein

Quick info Annotations Function or PPIs Localization Phosphorylation Abundance Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
Putative RNA-binding protein
Gene product:
RNA-binding protein - putative
Species:
Leishmania infantum
UniProt:
A4I2Y0_LEIIN
TriTrypDb:
LINF_270028100
Length:
449

Annotations

Annotations by Jardim et al.

Nucleic acid binding, RNA-binding

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) yes yes: 2
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 8
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 9
NetGPI no yes: 0, no: 9
Cellular components
Term Name Level Count
GO:0005737 cytoplasm 2 1
GO:0016604 nuclear body 2 1
GO:0016607 nuclear speck 3 1
GO:0110165 cellular anatomical entity 1 1

Phosphorylation

Amastigote: 159
Promastigote/Amastigote: 367, 377, 387, 397

Abundance

Amastigote (protein)
Source Evidence on protein Close homologs
Pescher et al. (upgregulation) no yes: 0
Promastigote and amastigote
Source Evidence on protein Close homologs
Lahav et al.
- mRNA
- Protein

Expansion

Sequence features

A4I2Y0
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4I2Y0

Function

Biological processes
Term Name Level Count
GO:0000375 RNA splicing, via transesterification reactions 8 1
GO:0000377 RNA splicing, via transesterification reactions with bulged adenosine as nucleophile 9 1
GO:0000398 mRNA splicing, via spliceosome 8 1
GO:0006139 nucleobase-containing compound metabolic process 3 1
GO:0006396 RNA processing 6 1
GO:0006397 mRNA processing 7 1
GO:0006725 cellular aromatic compound metabolic process 3 1
GO:0006807 nitrogen compound metabolic process 2 1
GO:0008152 metabolic process 1 1
GO:0008380 RNA splicing 7 1
GO:0009987 cellular process 1 1
GO:0016070 RNA metabolic process 5 1
GO:0016071 mRNA metabolic process 6 1
GO:0034641 cellular nitrogen compound metabolic process 3 1
GO:0043170 macromolecule metabolic process 3 1
GO:0044237 cellular metabolic process 2 1
GO:0044238 primary metabolic process 2 1
GO:0046483 heterocycle metabolic process 3 1
GO:0071704 organic substance metabolic process 2 1
GO:0090304 nucleic acid metabolic process 4 1
GO:1901360 organic cyclic compound metabolic process 3 1
Molecular functions
Term Name Level Count
GO:0003676 nucleic acid binding 3 10
GO:0003723 RNA binding 4 10
GO:0005488 binding 1 10
GO:0008270 zinc ion binding 6 10
GO:0043167 ion binding 2 10
GO:0043169 cation binding 3 10
GO:0046872 metal ion binding 4 10
GO:0046914 transition metal ion binding 5 10
GO:0097159 organic cyclic compound binding 2 10
GO:1901363 heterocyclic compound binding 2 10

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 218 222 PF00656 0.617
CLV_NRD_NRD_1 127 129 PF00675 0.590
CLV_NRD_NRD_1 219 221 PF00675 0.711
CLV_NRD_NRD_1 224 226 PF00675 0.756
CLV_NRD_NRD_1 237 239 PF00675 0.365
CLV_NRD_NRD_1 318 320 PF00675 0.442
CLV_NRD_NRD_1 339 341 PF00675 0.613
CLV_NRD_NRD_1 348 350 PF00675 0.589
CLV_NRD_NRD_1 363 365 PF00675 0.586
CLV_NRD_NRD_1 373 375 PF00675 0.480
CLV_NRD_NRD_1 383 385 PF00675 0.449
CLV_NRD_NRD_1 393 395 PF00675 0.418
CLV_NRD_NRD_1 405 407 PF00675 0.514
CLV_NRD_NRD_1 415 417 PF00675 0.610
CLV_NRD_NRD_1 427 429 PF00675 0.452
CLV_PCSK_FUR_1 344 348 PF00082 0.536
CLV_PCSK_FUR_1 357 361 PF00082 0.391
CLV_PCSK_FUR_1 370 374 PF00082 0.530
CLV_PCSK_FUR_1 380 384 PF00082 0.532
CLV_PCSK_FUR_1 390 394 PF00082 0.384
CLV_PCSK_FUR_1 400 404 PF00082 0.406
CLV_PCSK_FUR_1 425 429 PF00082 0.716
CLV_PCSK_KEX2_1 127 129 PF00082 0.544
CLV_PCSK_KEX2_1 219 221 PF00082 0.645
CLV_PCSK_KEX2_1 224 226 PF00082 0.696
CLV_PCSK_KEX2_1 237 239 PF00082 0.365
CLV_PCSK_KEX2_1 292 294 PF00082 0.342
CLV_PCSK_KEX2_1 318 320 PF00082 0.442
CLV_PCSK_KEX2_1 338 340 PF00082 0.629
CLV_PCSK_KEX2_1 344 346 PF00082 0.575
CLV_PCSK_KEX2_1 347 349 PF00082 0.583
CLV_PCSK_KEX2_1 359 361 PF00082 0.587
CLV_PCSK_KEX2_1 362 364 PF00082 0.619
CLV_PCSK_KEX2_1 372 374 PF00082 0.484
CLV_PCSK_KEX2_1 382 384 PF00082 0.447
CLV_PCSK_KEX2_1 392 394 PF00082 0.420
CLV_PCSK_KEX2_1 402 404 PF00082 0.468
CLV_PCSK_KEX2_1 405 407 PF00082 0.535
CLV_PCSK_KEX2_1 415 417 PF00082 0.621
CLV_PCSK_KEX2_1 425 427 PF00082 0.511
CLV_PCSK_KEX2_1 447 449 PF00082 0.630
CLV_PCSK_PC1ET2_1 292 294 PF00082 0.244
CLV_PCSK_PC7_1 220 226 PF00082 0.573
CLV_PCSK_PC7_1 340 346 PF00082 0.524
CLV_PCSK_PC7_1 357 363 PF00082 0.363
CLV_PCSK_PC7_1 400 406 PF00082 0.447
CLV_PCSK_PC7_1 411 417 PF00082 0.572
CLV_PCSK_PC7_1 421 427 PF00082 0.602
CLV_PCSK_PC7_1 443 449 PF00082 0.603
CLV_PCSK_SKI1_1 155 159 PF00082 0.243
CLV_PCSK_SKI1_1 188 192 PF00082 0.288
CLV_PCSK_SKI1_1 220 224 PF00082 0.557
CLV_PCSK_SKI1_1 255 259 PF00082 0.197
DEG_APCC_DBOX_1 150 158 PF00400 0.411
DOC_CYCLIN_RxL_1 185 193 PF00134 0.483
DOC_MAPK_gen_1 134 142 PF00069 0.417
DOC_MAPK_gen_1 237 244 PF00069 0.459
DOC_MAPK_gen_1 306 315 PF00069 0.604
DOC_MAPK_MEF2A_6 237 246 PF00069 0.443
DOC_MAPK_MEF2A_6 275 282 PF00069 0.483
DOC_PP2B_PxIxI_1 275 281 PF00149 0.444
DOC_PP4_FxxP_1 261 264 PF00568 0.483
DOC_PP4_FxxP_1 273 276 PF00568 0.483
DOC_PP4_FxxP_1 54 57 PF00568 0.483
DOC_USP7_MATH_1 114 118 PF00917 0.628
DOC_USP7_MATH_1 284 288 PF00917 0.445
DOC_WW_Pin1_4 156 161 PF00397 0.411
DOC_WW_Pin1_4 260 265 PF00397 0.444
DOC_WW_Pin1_4 409 414 PF00397 0.540
DOC_WW_Pin1_4 419 424 PF00397 0.536
DOC_WW_Pin1_4 429 434 PF00397 0.537
DOC_WW_Pin1_4 435 440 PF00397 0.529
DOC_WW_Pin1_4 441 446 PF00397 0.523
LIG_BIR_II_1 1 5 PF00653 0.501
LIG_FHA_1 3 9 PF00498 0.229
LIG_FHA_2 14 20 PF00498 0.402
LIG_FHA_2 179 185 PF00498 0.466
LIG_FHA_2 284 290 PF00498 0.498
LIG_LIR_Apic_2 270 276 PF02991 0.483
LIG_LIR_Apic_2 51 57 PF02991 0.444
LIG_LIR_Gen_1 166 175 PF02991 0.493
LIG_LIR_Gen_1 18 27 PF02991 0.413
LIG_LIR_Nem_3 166 170 PF02991 0.520
LIG_LIR_Nem_3 18 24 PF02991 0.413
LIG_MAD2 139 147 PF02301 0.350
LIG_NRP_CendR_1 447 449 PF00754 0.631
LIG_REV1ctd_RIR_1 21 30 PF16727 0.400
LIG_SH2_STAT5 180 183 PF00017 0.496
LIG_SH2_STAT5 7 10 PF00017 0.403
LIG_SH2_STAT5 78 81 PF00017 0.422
LIG_SH3_3 154 160 PF00018 0.411
LIG_SH3_3 200 206 PF00018 0.550
LIG_SH3_3 30 36 PF00018 0.483
LIG_TRAF2_1 181 184 PF00917 0.411
LIG_TRFH_1 167 171 PF08558 0.400
LIG_WW_3 207 211 PF00397 0.542
LIG_WW_3 412 416 PF00397 0.608
LIG_WW_3 422 426 PF00397 0.698
LIG_WW_3 432 436 PF00397 0.488
LIG_WW_3 438 442 PF00397 0.560
LIG_WW_3 444 448 PF00397 0.517
MOD_CDC14_SPxK_1 412 415 PF00782 0.537
MOD_CDC14_SPxK_1 422 425 PF00782 0.535
MOD_CDC14_SPxK_1 432 435 PF00782 0.535
MOD_CDC14_SPxK_1 438 441 PF00782 0.528
MOD_CDC14_SPxK_1 444 447 PF00782 0.502
MOD_CDK_SPxK_1 409 415 PF00069 0.534
MOD_CDK_SPxK_1 419 425 PF00069 0.537
MOD_CDK_SPxK_1 429 435 PF00069 0.538
MOD_CDK_SPxK_1 441 447 PF00069 0.525
MOD_CDK_SPxxK_3 409 416 PF00069 0.674
MOD_CDK_SPxxK_3 419 426 PF00069 0.607
MOD_CDK_SPxxK_3 441 448 PF00069 0.600
MOD_CK1_1 2 8 PF00069 0.461
MOD_CK1_1 233 239 PF00069 0.501
MOD_CK1_1 251 257 PF00069 0.523
MOD_CK1_1 334 340 PF00069 0.552
MOD_CK1_1 350 356 PF00069 0.371
MOD_CK1_1 62 68 PF00069 0.480
MOD_CK2_1 11 17 PF00069 0.486
MOD_CK2_1 178 184 PF00069 0.418
MOD_CK2_1 283 289 PF00069 0.473
MOD_DYRK1A_RPxSP_1 409 413 PF00069 0.537
MOD_DYRK1A_RPxSP_1 419 423 PF00069 0.536
MOD_DYRK1A_RPxSP_1 435 439 PF00069 0.536
MOD_DYRK1A_RPxSP_1 441 445 PF00069 0.545
MOD_GlcNHglycan 1 4 PF01048 0.521
MOD_GlcNHglycan 116 119 PF01048 0.650
MOD_GlcNHglycan 128 131 PF01048 0.696
MOD_GlcNHglycan 13 16 PF01048 0.288
MOD_GlcNHglycan 232 235 PF01048 0.614
MOD_GlcNHglycan 286 289 PF01048 0.233
MOD_GlcNHglycan 297 300 PF01048 0.192
MOD_GlcNHglycan 36 39 PF01048 0.226
MOD_GlcNHglycan 43 46 PF01048 0.345
MOD_GlcNHglycan 61 64 PF01048 0.157
MOD_GlcNHglycan 66 69 PF01048 0.480
MOD_GlcNHglycan 79 82 PF01048 0.482
MOD_GSK3_1 2 9 PF00069 0.463
MOD_GSK3_1 226 233 PF00069 0.654
MOD_GSK3_1 334 341 PF00069 0.563
MOD_GSK3_1 347 354 PF00069 0.586
MOD_GSK3_1 405 412 PF00069 0.526
MOD_GSK3_1 415 422 PF00069 0.612
MOD_GSK3_1 429 436 PF00069 0.602
MOD_GSK3_1 62 69 PF00069 0.483
MOD_GSK3_1 82 89 PF00069 0.374
MOD_N-GLC_1 226 231 PF02516 0.552
MOD_N-GLC_1 94 99 PF02516 0.495
MOD_NEK2_1 302 307 PF00069 0.453
MOD_PKA_1 338 344 PF00069 0.511
MOD_PKA_1 347 353 PF00069 0.481
MOD_PKA_1 362 368 PF00069 0.351
MOD_PKA_1 372 378 PF00069 0.518
MOD_PKA_1 382 388 PF00069 0.520
MOD_PKA_1 392 398 PF00069 0.398
MOD_PKA_1 405 411 PF00069 0.436
MOD_PKA_1 415 421 PF00069 0.606
MOD_PKA_1 427 433 PF00069 0.479
MOD_PKA_2 126 132 PF00069 0.581
MOD_PKA_2 133 139 PF00069 0.488
MOD_PKA_2 338 344 PF00069 0.601
MOD_PKA_2 347 353 PF00069 0.610
MOD_PKA_2 362 368 PF00069 0.351
MOD_PKA_2 372 378 PF00069 0.518
MOD_PKA_2 382 388 PF00069 0.520
MOD_PKA_2 392 398 PF00069 0.398
MOD_PKA_2 405 411 PF00069 0.436
MOD_PKA_2 415 421 PF00069 0.606
MOD_PKA_2 427 433 PF00069 0.479
MOD_PKB_1 345 353 PF00069 0.530
MOD_PKB_1 360 368 PF00069 0.358
MOD_PKB_1 370 378 PF00069 0.518
MOD_PKB_1 380 388 PF00069 0.525
MOD_PKB_1 390 398 PF00069 0.324
MOD_PKB_1 403 411 PF00069 0.418
MOD_PKB_1 425 433 PF00069 0.588
MOD_Plk_2-3 265 271 PF00069 0.331
MOD_Plk_4 141 147 PF00069 0.444
MOD_Plk_4 2 8 PF00069 0.461
MOD_ProDKin_1 156 162 PF00069 0.411
MOD_ProDKin_1 260 266 PF00069 0.444
MOD_ProDKin_1 409 415 PF00069 0.544
MOD_ProDKin_1 419 425 PF00069 0.537
MOD_ProDKin_1 429 435 PF00069 0.538
MOD_ProDKin_1 441 447 PF00069 0.525
MOD_SUMO_for_1 274 277 PF00179 0.483
TRG_DiLeu_BaLyEn_6 311 316 PF01217 0.461
TRG_ER_diArg_1 126 128 PF00400 0.577
TRG_ER_diArg_1 306 309 PF00400 0.459
TRG_ER_diArg_1 338 340 PF00400 0.663
TRG_ER_diArg_1 344 347 PF00400 0.596
TRG_ER_diArg_1 359 362 PF00400 0.505
TRG_ER_diArg_1 372 374 PF00400 0.480
TRG_ER_diArg_1 382 384 PF00400 0.483
TRG_ER_diArg_1 392 394 PF00400 0.384
TRG_ER_diArg_1 402 405 PF00400 0.459
TRG_ER_diArg_1 414 416 PF00400 0.614
TRG_ER_diArg_1 424 427 PF00400 0.655
TRG_ER_diArg_1 434 437 PF00400 0.453
TRG_ER_diArg_1 440 443 PF00400 0.554
TRG_ER_diArg_1 446 449 PF00400 0.561

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N1IMB5 Leptomonas seymouri 51% 100%
A0A1X0NSK5 Trypanosomatidae 30% 97%
A0A3R7LQ31 Trypanosoma rangeli 31% 100%
A0A3S7X0Y2 Leishmania donovani 99% 99%
A4HFY7 Leishmania braziliensis 81% 100%
C9ZJH0 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 29% 100%
E9ADJ0 Leishmania major 98% 100%
E9AZB6 Leishmania mexicana (strain MHOM/GT/2001/U1103) 94% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS