LeishMANIAdb
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PrgI family protein

Quick info Annotations Function or PPIs Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:
PrgI family protein
Gene product:
hypothetical protein - conserved
Species:
Leishmania infantum
UniProt:
A4I2X9_LEIIN
TriTrypDb:
LINF_270028000
Length:
148

Annotations

LeishMANIAdb annotations

Relatively conserved in Kinetoplastids but not seen beyond.

Annotations by Jardim et al.

Tricarboxylic acid cycle, Succinate dehydrogenase (SDH8)

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 10
NetGPI no yes: 0, no: 10
Cellular components
TermNameLevelCount
GO:0016020 membrane 2 9
GO:0110165 cellular anatomical entity 1 9
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Expansion

Sequence features

A4I2X9
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4I2X9

Putative motif mimicry

LeishmaniaFromToDomain/MotifScore
CLV_NRD_NRD_1 111 113 PF00675 0.340
CLV_NRD_NRD_1 26 28 PF00675 0.410
CLV_NRD_NRD_1 43 45 PF00675 0.277
CLV_NRD_NRD_1 68 70 PF00675 0.596
CLV_PCSK_FUR_1 40 44 PF00082 0.387
CLV_PCSK_KEX2_1 111 113 PF00082 0.340
CLV_PCSK_KEX2_1 26 28 PF00082 0.418
CLV_PCSK_KEX2_1 42 44 PF00082 0.294
CLV_PCSK_KEX2_1 67 69 PF00082 0.590
CLV_PCSK_SKI1_1 44 48 PF00082 0.304
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Homologs

ProteinTaxonomySequence identityCoverage
A0A0N1PDZ2 Leptomonas seymouri 82% 100%
A0A0S4IJ67 Bodo saltans 52% 100%
A0A1X0NST1 Trypanosomatidae 74% 100%
A0A3S5IQM8 Trypanosoma rangeli 67% 100%
A0A3S7X0X5 Leishmania donovani 100% 100%
A4HFY6 Leishmania braziliensis 89% 100%
C9ZJG9 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 63% 98%
E9ADI9 Leishmania major 95% 100%
E9AZB5 Leishmania mexicana (strain MHOM/GT/2001/U1103) 95% 100%
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Download

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS