PrgI family protein

Quick info Annotations Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

PrgI family protein

Gene product:

hypothetical protein - conserved

Species:

Leishmania infantum

UniProt:

A4I2X9_LEIIN

TriTrypDb:

LINF_270028000

Length:

148

Annotations

LeishMANIAdb annotations

Relatively conserved in Kinetoplastids but not seen beyond.

Annotations by Jardim et al.

Tricarboxylic acid cycle, Succinate dehydrogenase (SDH8)

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	9
GO:0110165	cellular anatomical entity	1	9

Expansion

Sequence features

A4I2X9

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4I2X9

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	111	113	PF00675	0.340
CLV_NRD_NRD_1	26	28	PF00675	0.410
CLV_NRD_NRD_1	43	45	PF00675	0.277
CLV_NRD_NRD_1	68	70	PF00675	0.596
CLV_PCSK_FUR_1	40	44	PF00082	0.387
CLV_PCSK_KEX2_1	111	113	PF00082	0.340
CLV_PCSK_KEX2_1	26	28	PF00082	0.418
CLV_PCSK_KEX2_1	42	44	PF00082	0.294
CLV_PCSK_KEX2_1	67	69	PF00082	0.590
CLV_PCSK_SKI1_1	44	48	PF00082	0.304
DEG_Nend_UBRbox_3	1	3	PF02207	0.751
DOC_CYCLIN_RxL_1	40	51	PF00134	0.569
DOC_MAPK_gen_1	40	48	PF00069	0.569
DOC_MAPK_gen_1	67	76	PF00069	0.381
DOC_PP1_RVXF_1	109	116	PF00149	0.541
DOC_PP1_RVXF_1	42	49	PF00149	0.564
DOC_USP7_MATH_1	3	7	PF00917	0.686
DOC_USP7_UBL2_3	117	121	PF12436	0.553
LIG_14-3-3_CanoR_1	132	138	PF00244	0.671
LIG_14-3-3_CanoR_1	43	49	PF00244	0.467
LIG_14-3-3_CanoR_1	67	73	PF00244	0.434
LIG_FHA_1	45	51	PF00498	0.496
LIG_FHA_1	54	60	PF00498	0.336
LIG_FHA_1	69	75	PF00498	0.343
LIG_LIR_Gen_1	124	131	PF02991	0.597
LIG_LIR_Gen_1	71	79	PF02991	0.296
LIG_LIR_Gen_1	80	89	PF02991	0.342
LIG_LIR_Nem_3	124	128	PF02991	0.598
LIG_LIR_Nem_3	61	65	PF02991	0.349
LIG_LIR_Nem_3	71	76	PF02991	0.241
LIG_LIR_Nem_3	77	82	PF02991	0.231
LIG_Pex14_1	133	137	PF04695	0.579
LIG_Pex14_1	35	39	PF04695	0.601
LIG_SH2_CRK	125	129	PF00017	0.611
LIG_SH2_GRB2like	98	101	PF00017	0.587
LIG_SH2_NCK_1	125	129	PF00017	0.611
LIG_SH2_NCK_1	98	102	PF00017	0.619
LIG_SH2_SRC	98	101	PF00017	0.587
LIG_SH2_STAP1	98	102	PF00017	0.582
LIG_SH2_STAT5	63	66	PF00017	0.412
LIG_SH2_STAT5	72	75	PF00017	0.273
LIG_TYR_ITIM	96	101	PF00017	0.403
LIG_WRC_WIRS_1	76	81	PF05994	0.330
MOD_CK1_1	53	59	PF00069	0.390
MOD_CK1_1	77	83	PF00069	0.376
MOD_GlcNHglycan	52	55	PF01048	0.390
MOD_GlcNHglycan	79	82	PF01048	0.410
MOD_GSK3_1	44	51	PF00069	0.483
MOD_GSK3_1	54	61	PF00069	0.317
MOD_N-GLC_1	3	8	PF02516	0.533
MOD_NEK2_1	48	53	PF00069	0.357
MOD_NEK2_1	58	63	PF00069	0.348
MOD_NEK2_1	75	80	PF00069	0.249
MOD_PIKK_1	123	129	PF00454	0.568
MOD_PKA_1	68	74	PF00069	0.383
MOD_PKA_2	68	74	PF00069	0.401
MOD_PKB_1	42	50	PF00069	0.541
MOD_Plk_1	105	111	PF00069	0.528
MOD_Plk_1	123	129	PF00069	0.568
MOD_Plk_4	105	111	PF00069	0.536
MOD_Plk_4	54	60	PF00069	0.330
MOD_Plk_4	68	74	PF00069	0.334
TRG_ENDOCYTIC_2	125	128	PF00928	0.583
TRG_ENDOCYTIC_2	63	66	PF00928	0.464
TRG_ENDOCYTIC_2	72	75	PF00928	0.304
TRG_ENDOCYTIC_2	98	101	PF00928	0.530
TRG_ER_diArg_1	110	112	PF00400	0.535
TRG_ER_diArg_1	25	27	PF00400	0.619
TRG_ER_diArg_1	39	42	PF00400	0.482
TRG_ER_diArg_1	66	69	PF00400	0.431
TRG_ER_diLys_1	145	148	PF00400	0.705

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PDZ2	Leptomonas seymouri	82%	100%
A0A0S4IJ67	Bodo saltans	52%	100%
A0A1X0NST1	Trypanosomatidae	74%	100%
A0A3S5IQM8	Trypanosoma rangeli	67%	100%
A0A3S7X0X5	Leishmania donovani	100%	100%
A4HFY6	Leishmania braziliensis	89%	100%
C9ZJG9	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	63%	98%
E9ADI9	Leishmania major	95%	100%
E9AZB5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	95%	100%