Lipase_3 domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein - conserved

Species:

Leishmania infantum

UniProt:

A4I2X7_LEIIN

TriTrypDb:

LINF_270027800

Length:

852

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 5
NetGPI	no	yes: 0, no: 5

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	4
GO:0110165	cellular anatomical entity	1	4

Expansion

Sequence features

A4I2X7

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4I2X7

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	250	254	PF00656	0.414
CLV_C14_Caspase3-7	34	38	PF00656	0.782
CLV_C14_Caspase3-7	461	465	PF00656	0.821
CLV_C14_Caspase3-7	814	818	PF00656	0.573
CLV_NRD_NRD_1	289	291	PF00675	0.702
CLV_NRD_NRD_1	355	357	PF00675	0.659
CLV_NRD_NRD_1	498	500	PF00675	0.621
CLV_NRD_NRD_1	603	605	PF00675	0.624
CLV_NRD_NRD_1	666	668	PF00675	0.626
CLV_NRD_NRD_1	711	713	PF00675	0.569
CLV_NRD_NRD_1	720	722	PF00675	0.546
CLV_PCSK_FUR_1	664	668	PF00082	0.628
CLV_PCSK_KEX2_1	289	291	PF00082	0.702
CLV_PCSK_KEX2_1	355	357	PF00082	0.659
CLV_PCSK_KEX2_1	498	500	PF00082	0.627
CLV_PCSK_KEX2_1	603	605	PF00082	0.624
CLV_PCSK_KEX2_1	666	668	PF00082	0.626
CLV_PCSK_KEX2_1	704	706	PF00082	0.533
CLV_PCSK_KEX2_1	710	712	PF00082	0.552
CLV_PCSK_KEX2_1	722	724	PF00082	0.401
CLV_PCSK_KEX2_1	93	95	PF00082	0.591
CLV_PCSK_PC1ET2_1	704	706	PF00082	0.533
CLV_PCSK_PC1ET2_1	710	712	PF00082	0.552
CLV_PCSK_PC1ET2_1	722	724	PF00082	0.401
CLV_PCSK_PC1ET2_1	93	95	PF00082	0.591
CLV_PCSK_PC7_1	89	95	PF00082	0.588
CLV_PCSK_SKI1_1	101	105	PF00082	0.622
CLV_PCSK_SKI1_1	480	484	PF00082	0.517
CLV_PCSK_SKI1_1	769	773	PF00082	0.657
CLV_PCSK_SKI1_1	799	803	PF00082	0.780
CLV_PCSK_SKI1_1	837	841	PF00082	0.692
DEG_APCC_DBOX_1	798	806	PF00400	0.582
DEG_SPOP_SBC_1	457	461	PF00917	0.801
DEG_SPOP_SBC_1	519	523	PF00917	0.738
DEG_SPOP_SBC_1	83	87	PF00917	0.692
DOC_CYCLIN_RxL_1	721	734	PF00134	0.750
DOC_MAPK_DCC_7	606	616	PF00069	0.710
DOC_MAPK_gen_1	166	175	PF00069	0.712
DOC_MAPK_gen_1	196	205	PF00069	0.708
DOC_MAPK_gen_1	319	329	PF00069	0.635
DOC_MAPK_gen_1	721	730	PF00069	0.753
DOC_MAPK_HePTP_8	205	217	PF00069	0.635
DOC_MAPK_MEF2A_6	135	143	PF00069	0.682
DOC_MAPK_MEF2A_6	208	217	PF00069	0.529
DOC_MAPK_MEF2A_6	322	331	PF00069	0.635
DOC_MAPK_RevD_3	79	94	PF00069	0.699
DOC_PP1_RVXF_1	724	731	PF00149	0.747
DOC_PP2B_LxvP_1	139	142	PF13499	0.784
DOC_PP2B_LxvP_1	582	585	PF13499	0.802
DOC_PP2B_LxvP_1	677	680	PF13499	0.713
DOC_PP4_FxxP_1	772	775	PF00568	0.496
DOC_SPAK_OSR1_1	208	212	PF12202	0.529
DOC_USP7_MATH_1	152	156	PF00917	0.783
DOC_USP7_MATH_1	320	324	PF00917	0.724
DOC_USP7_MATH_1	445	449	PF00917	0.704
DOC_USP7_MATH_1	494	498	PF00917	0.807
DOC_USP7_MATH_1	515	519	PF00917	0.754
DOC_USP7_MATH_1	67	71	PF00917	0.705
DOC_USP7_MATH_1	694	698	PF00917	0.711
DOC_USP7_MATH_1	72	76	PF00917	0.736
DOC_USP7_MATH_1	784	788	PF00917	0.555
DOC_USP7_MATH_1	809	813	PF00917	0.584
DOC_USP7_MATH_1	83	87	PF00917	0.642
DOC_USP7_UBL2_3	722	726	PF12436	0.741
DOC_WW_Pin1_4	563	568	PF00397	0.792
DOC_WW_Pin1_4	670	675	PF00397	0.746
DOC_WW_Pin1_4	788	793	PF00397	0.542
DOC_WW_Pin1_4	805	810	PF00397	0.427
DOC_WW_Pin1_4	831	836	PF00397	0.519
DOC_WW_Pin1_4	84	89	PF00397	0.800
LIG_14-3-3_CanoR_1	101	110	PF00244	0.814
LIG_14-3-3_CanoR_1	168	174	PF00244	0.720
LIG_14-3-3_CanoR_1	181	185	PF00244	0.583
LIG_14-3-3_CanoR_1	257	263	PF00244	0.482
LIG_14-3-3_CanoR_1	355	363	PF00244	0.494
LIG_14-3-3_CanoR_1	404	411	PF00244	0.733
LIG_14-3-3_CanoR_1	417	427	PF00244	0.605
LIG_14-3-3_CanoR_1	451	455	PF00244	0.802
LIG_14-3-3_CanoR_1	480	488	PF00244	0.766
LIG_14-3-3_CanoR_1	517	526	PF00244	0.738
LIG_14-3-3_CanoR_1	647	655	PF00244	0.812
LIG_14-3-3_CanoR_1	813	820	PF00244	0.499
LIG_14-3-3_CanoR_1	837	845	PF00244	0.491
LIG_APCC_ABBA_1	192	197	PF00400	0.713
LIG_APCC_ABBA_1	327	332	PF00400	0.467
LIG_BIR_III_4	443	447	PF00653	0.786
LIG_BRCT_BRCA1_1	283	287	PF00533	0.482
LIG_Clathr_ClatBox_1	328	332	PF01394	0.529
LIG_Clathr_ClatBox_1	829	833	PF01394	0.569
LIG_EH1_1	208	216	PF00400	0.529
LIG_FHA_1	229	235	PF00498	0.568
LIG_FHA_1	274	280	PF00498	0.355
LIG_FHA_1	295	301	PF00498	0.519
LIG_FHA_1	341	347	PF00498	0.393
LIG_FHA_1	349	355	PF00498	0.336
LIG_FHA_1	435	441	PF00498	0.764
LIG_FHA_1	458	464	PF00498	0.822
LIG_FHA_1	481	487	PF00498	0.757
LIG_FHA_1	751	757	PF00498	0.639
LIG_FHA_2	102	108	PF00498	0.711
LIG_FHA_2	143	149	PF00498	0.791
LIG_FHA_2	586	592	PF00498	0.802
LIG_FHA_2	739	745	PF00498	0.529
LIG_FHA_2	838	844	PF00498	0.594
LIG_Integrin_RGD_1	64	66	PF01839	0.527
LIG_LIR_Gen_1	197	206	PF02991	0.704
LIG_LIR_Gen_1	218	226	PF02991	0.525
LIG_LIR_Gen_1	230	240	PF02991	0.334
LIG_LIR_Gen_1	241	249	PF02991	0.365
LIG_LIR_Gen_1	268	275	PF02991	0.492
LIG_LIR_Nem_3	183	187	PF02991	0.682
LIG_LIR_Nem_3	190	195	PF02991	0.685
LIG_LIR_Nem_3	197	203	PF02991	0.601
LIG_LIR_Nem_3	218	222	PF02991	0.525
LIG_LIR_Nem_3	230	236	PF02991	0.318
LIG_LIR_Nem_3	240	245	PF02991	0.343
LIG_LIR_Nem_3	268	272	PF02991	0.489
LIG_LIR_Nem_3	580	584	PF02991	0.802
LIG_LIR_Nem_3	591	597	PF02991	0.711
LIG_LIR_Nem_3	761	767	PF02991	0.504
LIG_Pex14_2	287	291	PF04695	0.491
LIG_Pex14_2	727	731	PF04695	0.795
LIG_PTB_Apo_2	729	736	PF02174	0.760
LIG_PTB_Phospho_1	729	735	PF10480	0.762
LIG_REV1ctd_RIR_1	246	256	PF16727	0.495
LIG_REV1ctd_RIR_1	728	737	PF16727	0.802
LIG_SH2_CRK	200	204	PF00017	0.701
LIG_SH2_GRB2like	780	783	PF00017	0.505
LIG_SH2_NCK_1	200	204	PF00017	0.701
LIG_SH2_STAP1	350	354	PF00017	0.460
LIG_SH2_STAP1	735	739	PF00017	0.561
LIG_SH2_STAT3	195	198	PF00017	0.717
LIG_SH2_STAT5	350	353	PF00017	0.461
LIG_SH2_STAT5	379	382	PF00017	0.411
LIG_SH2_STAT5	399	402	PF00017	0.379
LIG_SH2_STAT5	427	430	PF00017	0.713
LIG_SH2_STAT5	739	742	PF00017	0.529
LIG_SH2_STAT5	804	807	PF00017	0.587
LIG_SH3_1	606	612	PF00018	0.707
LIG_SH3_3	172	178	PF00018	0.697
LIG_SH3_3	488	494	PF00018	0.845
LIG_SH3_3	523	529	PF00018	0.806
LIG_SH3_3	606	612	PF00018	0.707
LIG_SUMO_SIM_anti_2	826	834	PF11976	0.557
LIG_SUMO_SIM_par_1	212	218	PF11976	0.488
LIG_SUMO_SIM_par_1	342	348	PF11976	0.479
LIG_SxIP_EBH_1	151	165	PF03271	0.660
LIG_TRAF2_1	146	149	PF00917	0.792
LIG_TRAF2_1	787	790	PF00917	0.542
LIG_WRC_WIRS_1	216	221	PF05994	0.488
LIG_WRC_WIRS_1	764	769	PF05994	0.635
MOD_CDC14_SPxK_1	834	837	PF00782	0.601
MOD_CDK_SPK_2	84	89	PF00069	0.760
MOD_CDK_SPxK_1	831	837	PF00069	0.606
MOD_CK1_1	241	247	PF00069	0.485
MOD_CK1_1	261	267	PF00069	0.422
MOD_CK1_1	434	440	PF00069	0.584
MOD_CK1_1	47	53	PF00069	0.641
MOD_CK1_1	518	524	PF00069	0.673
MOD_CK1_1	610	616	PF00069	0.843
MOD_CK1_1	643	649	PF00069	0.700
MOD_CK1_1	697	703	PF00069	0.837
MOD_CK1_1	8	14	PF00069	0.764
MOD_CK1_1	808	814	PF00069	0.738
MOD_CK2_1	101	107	PF00069	0.644
MOD_CK2_1	142	148	PF00069	0.744
MOD_CK2_1	503	509	PF00069	0.650
MOD_CK2_1	595	601	PF00069	0.634
MOD_CK2_1	738	744	PF00069	0.529
MOD_CK2_1	784	790	PF00069	0.692
MOD_CMANNOS	266	269	PF00535	0.564
MOD_GlcNHglycan	101	104	PF01048	0.668
MOD_GlcNHglycan	109	113	PF01048	0.529
MOD_GlcNHglycan	119	122	PF01048	0.503
MOD_GlcNHglycan	154	157	PF01048	0.729
MOD_GlcNHglycan	2	5	PF01048	0.773
MOD_GlcNHglycan	21	24	PF01048	0.523
MOD_GlcNHglycan	263	266	PF01048	0.582
MOD_GlcNHglycan	283	286	PF01048	0.321
MOD_GlcNHglycan	322	325	PF01048	0.643
MOD_GlcNHglycan	420	423	PF01048	0.597
MOD_GlcNHglycan	480	483	PF01048	0.736
MOD_GlcNHglycan	544	547	PF01048	0.813
MOD_GlcNHglycan	649	652	PF01048	0.645
MOD_GlcNHglycan	686	689	PF01048	0.848
MOD_GlcNHglycan	7	10	PF01048	0.719
MOD_GlcNHglycan	847	850	PF01048	0.764
MOD_GlcNHglycan	90	93	PF01048	0.760
MOD_GSK3_1	101	108	PF00069	0.590
MOD_GSK3_1	17	24	PF00069	0.736
MOD_GSK3_1	228	235	PF00069	0.555
MOD_GSK3_1	33	40	PF00069	0.598
MOD_GSK3_1	431	438	PF00069	0.552
MOD_GSK3_1	445	452	PF00069	0.663
MOD_GSK3_1	466	473	PF00069	0.670
MOD_GSK3_1	474	481	PF00069	0.633
MOD_GSK3_1	515	522	PF00069	0.734
MOD_GSK3_1	555	562	PF00069	0.689
MOD_GSK3_1	595	602	PF00069	0.776
MOD_GSK3_1	633	640	PF00069	0.754
MOD_GSK3_1	643	650	PF00069	0.591
MOD_GSK3_1	675	682	PF00069	0.798
MOD_GSK3_1	694	701	PF00069	0.655
MOD_GSK3_1	734	741	PF00069	0.488
MOD_GSK3_1	784	791	PF00069	0.689
MOD_GSK3_1	805	812	PF00069	0.736
MOD_GSK3_1	821	828	PF00069	0.527
MOD_GSK3_1	833	840	PF00069	0.588
MOD_GSK3_1	84	91	PF00069	0.729
MOD_N-GLC_1	238	243	PF02516	0.567
MOD_N-GLC_1	273	278	PF02516	0.556
MOD_N-GLC_1	432	437	PF02516	0.654
MOD_N-GLC_1	465	470	PF02516	0.731
MOD_N-GLC_1	519	524	PF02516	0.670
MOD_N-GLC_1	633	638	PF02516	0.749
MOD_N-GLC_1	845	850	PF02516	0.762
MOD_NEK2_1	169	174	PF00069	0.674
MOD_NEK2_1	215	220	PF00069	0.525
MOD_NEK2_1	247	252	PF00069	0.577
MOD_NEK2_1	255	260	PF00069	0.536
MOD_NEK2_1	333	338	PF00069	0.378
MOD_NEK2_1	349	354	PF00069	0.472
MOD_NEK2_1	431	436	PF00069	0.528
MOD_NEK2_1	577	582	PF00069	0.788
MOD_OFUCOSY	353	358	PF10250	0.585
MOD_PIKK_1	458	464	PF00454	0.769
MOD_PIKK_1	774	780	PF00454	0.633
MOD_PK_1	470	476	PF00069	0.776
MOD_PKA_1	93	99	PF00069	0.750
MOD_PKA_2	105	111	PF00069	0.576
MOD_PKA_2	180	186	PF00069	0.665
MOD_PKA_2	318	324	PF00069	0.654
MOD_PKA_2	354	360	PF00069	0.595
MOD_PKA_2	403	409	PF00069	0.663
MOD_PKA_2	416	422	PF00069	0.487
MOD_PKA_2	450	456	PF00069	0.762
MOD_PKA_2	457	463	PF00069	0.801
MOD_PKA_2	466	472	PF00069	0.579
MOD_PKA_2	50	56	PF00069	0.646
MOD_PKA_2	88	94	PF00069	0.748
MOD_PKB_1	813	821	PF00069	0.657
MOD_Plk_1	108	114	PF00069	0.613
MOD_Plk_1	238	244	PF00069	0.559
MOD_Plk_1	519	525	PF00069	0.776
MOD_Plk_1	640	646	PF00069	0.830
MOD_Plk_1	65	71	PF00069	0.751
MOD_Plk_1	675	681	PF00069	0.805
MOD_Plk_1	695	701	PF00069	0.559
MOD_Plk_1	72	78	PF00069	0.643
MOD_Plk_1	825	831	PF00069	0.750
MOD_Plk_4	169	175	PF00069	0.675
MOD_Plk_4	238	244	PF00069	0.559
MOD_Plk_4	340	346	PF00069	0.467
MOD_Plk_4	395	401	PF00069	0.397
MOD_Plk_4	470	476	PF00069	0.651
MOD_Plk_4	577	583	PF00069	0.760
MOD_Plk_4	640	646	PF00069	0.830
MOD_Plk_4	825	831	PF00069	0.709
MOD_ProDKin_1	563	569	PF00069	0.748
MOD_ProDKin_1	670	676	PF00069	0.684
MOD_ProDKin_1	788	794	PF00069	0.686
MOD_ProDKin_1	805	811	PF00069	0.518
MOD_ProDKin_1	831	837	PF00069	0.647
MOD_ProDKin_1	84	90	PF00069	0.762
TRG_DiLeu_BaEn_1	744	749	PF01217	0.467
TRG_DiLeu_BaLyEn_6	139	144	PF01217	0.741
TRG_ENDOCYTIC_2	200	203	PF00928	0.629
TRG_ENDOCYTIC_2	764	767	PF00928	0.553
TRG_ER_diArg_1	165	168	PF00400	0.639
TRG_ER_diArg_1	288	290	PF00400	0.613
TRG_ER_diArg_1	354	356	PF00400	0.550
TRG_ER_diArg_1	415	418	PF00400	0.582
TRG_ER_diArg_1	603	605	PF00400	0.766
TRG_ER_diArg_1	664	667	PF00400	0.803
TRG_NLS_Bipartite_1	704	725	PF00514	0.652
TRG_Pf-PMV_PEXEL_1	705	709	PF00026	0.615

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A3Q8IQ50	Leishmania donovani	100%	100%
A4HFY4	Leishmania braziliensis	63%	96%
E9ADI7	Leishmania major	91%	100%
E9AZB3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	86%	100%