LeishMANIAdb
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BAR domain-containing protein

Quick info Annotations Function or PPIs Localization Phosphorylation Abundance Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:
BAR domain-containing protein
Gene product:
hypothetical protein - conserved
Species:
Leishmania infantum
UniProt:
A4I2W4_LEIIN
TriTrypDb:
LINF_270024200
Length:
339

Annotations

Annotations by Jardim et al.

Uncharacterized Protein, Uncharacterized

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) yes yes: 6
Forrest at al. (procyclic) yes yes: 6
Silverman et al. no yes: 0
Pissara et al. yes yes: 24
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 5
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. yes yes: 10
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 16
NetGPI no yes: 0, no: 16
Cellular components
Term Name Level Count
GO:0005737 cytoplasm 2 1
GO:0005886 plasma membrane 3 1
GO:0016020 membrane 2 1
GO:0031090 organelle membrane 3 1
GO:0031253 cell projection membrane 4 1
GO:0060170 ciliary membrane 5 1
GO:0098588 bounding membrane of organelle 4 1
GO:0098590 plasma membrane region 3 1
GO:0110165 cellular anatomical entity 1 1

Phosphorylation

Promastigote: 260, 265
Promastigote/Amastigote: 266, 269, 275

Abundance

Amastigote (protein)
Source Evidence on protein Close homologs
Pescher et al. (upgregulation) no yes: 0
Promastigote and amastigote
Source Evidence on protein Close homologs
Lahav et al.
- mRNA
- Protein

Expansion

Sequence features

A4I2W4
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4I2W4

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 74 78 PF00656 0.478
CLV_NRD_NRD_1 246 248 PF00675 0.520
CLV_NRD_NRD_1 249 251 PF00675 0.535
CLV_NRD_NRD_1 68 70 PF00675 0.401
CLV_PCSK_KEX2_1 160 162 PF00082 0.528
CLV_PCSK_KEX2_1 246 248 PF00082 0.520
CLV_PCSK_PC1ET2_1 160 162 PF00082 0.465
CLV_PCSK_SKI1_1 111 115 PF00082 0.412
CLV_PCSK_SKI1_1 172 176 PF00082 0.487
CLV_PCSK_SKI1_1 187 191 PF00082 0.458
CLV_PCSK_SKI1_1 27 31 PF00082 0.434
CLV_PCSK_SKI1_1 80 84 PF00082 0.435
DEG_ODPH_VHL_1 301 314 PF01847 0.509
DOC_MAPK_gen_1 111 122 PF00069 0.503
DOC_PP1_RVXF_1 113 120 PF00149 0.264
DOC_PP2B_LxvP_1 301 304 PF13499 0.578
DOC_USP7_MATH_1 113 117 PF00917 0.422
DOC_USP7_MATH_1 150 154 PF00917 0.540
DOC_USP7_MATH_1 35 39 PF00917 0.327
DOC_USP7_UBL2_3 107 111 PF12436 0.416
DOC_USP7_UBL2_3 139 143 PF12436 0.549
DOC_USP7_UBL2_3 156 160 PF12436 0.436
DOC_USP7_UBL2_3 234 238 PF12436 0.416
LIG_Actin_WH2_2 96 113 PF00022 0.345
LIG_BRCT_BRCA1_1 115 119 PF00533 0.280
LIG_BRCT_BRCA1_1 223 227 PF00533 0.509
LIG_BRCT_BRCA1_1 254 258 PF00533 0.635
LIG_CaM_IQ_9 179 194 PF13499 0.348
LIG_EH_1 255 259 PF12763 0.506
LIG_FHA_1 15 21 PF00498 0.468
LIG_FHA_1 184 190 PF00498 0.498
LIG_FHA_1 97 103 PF00498 0.416
LIG_FHA_2 215 221 PF00498 0.638
LIG_FHA_2 258 264 PF00498 0.639
LIG_FHA_2 311 317 PF00498 0.568
LIG_FHA_2 46 52 PF00498 0.389
LIG_LIR_Gen_1 116 127 PF02991 0.434
LIG_LIR_Gen_1 48 57 PF02991 0.362
LIG_LIR_Nem_3 116 122 PF02991 0.440
LIG_LIR_Nem_3 126 130 PF02991 0.515
LIG_LIR_Nem_3 48 53 PF02991 0.349
LIG_SH2_CRK 127 131 PF00017 0.404
LIG_SH2_CRK 43 47 PF00017 0.407
LIG_SH2_CRK 57 61 PF00017 0.367
LIG_SH2_GRB2like 318 321 PF00017 0.553
LIG_SH2_GRB2like 43 46 PF00017 0.332
LIG_SH2_STAP1 318 322 PF00017 0.522
LIG_SH2_STAT5 197 200 PF00017 0.430
LIG_SH2_STAT5 21 24 PF00017 0.409
LIG_SH3_3 65 71 PF00018 0.443
LIG_SH3_3 99 105 PF00018 0.403
LIG_SUMO_SIM_anti_2 99 104 PF11976 0.342
LIG_SUMO_SIM_par_1 98 104 PF11976 0.340
LIG_WRC_WIRS_1 88 93 PF05994 0.416
MOD_CK1_1 266 272 PF00069 0.597
MOD_CK2_1 310 316 PF00069 0.647
MOD_GlcNHglycan 291 294 PF01048 0.722
MOD_GlcNHglycan 33 36 PF01048 0.467
MOD_GSK3_1 150 157 PF00069 0.538
MOD_GSK3_1 164 171 PF00069 0.419
MOD_GSK3_1 262 269 PF00069 0.568
MOD_GSK3_1 283 290 PF00069 0.550
MOD_GSK3_1 3 10 PF00069 0.443
MOD_GSK3_1 31 38 PF00069 0.450
MOD_N-GLC_1 266 271 PF02516 0.661
MOD_NEK2_1 148 153 PF00069 0.538
MOD_NEK2_1 182 187 PF00069 0.498
MOD_NEK2_1 190 195 PF00069 0.411
MOD_NEK2_1 198 203 PF00069 0.402
MOD_NEK2_1 3 8 PF00069 0.452
MOD_NEK2_1 36 41 PF00069 0.334
MOD_NEK2_2 113 118 PF00069 0.342
MOD_PKA_1 283 289 PF00069 0.564
MOD_Plk_1 137 143 PF00069 0.463
MOD_Plk_1 208 214 PF00069 0.391
MOD_Plk_1 310 316 PF00069 0.594
MOD_Plk_2-3 310 316 PF00069 0.568
MOD_Plk_4 185 191 PF00069 0.419
MOD_Plk_4 283 289 PF00069 0.536
MOD_SUMO_rev_2 104 113 PF00179 0.479
TRG_ENDOCYTIC_2 127 130 PF00928 0.454
TRG_ENDOCYTIC_2 43 46 PF00928 0.417
TRG_ENDOCYTIC_2 57 60 PF00928 0.470
TRG_NLS_MonoExtC_3 142 147 PF00514 0.651
TRG_Pf-PMV_PEXEL_1 18 23 PF00026 0.353
TRG_Pf-PMV_PEXEL_1 80 84 PF00026 0.429

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N1PG41 Leptomonas seymouri 57% 100%
A0A1X0NY72 Trypanosomatidae 25% 92%
A0A3Q8IKU7 Leishmania donovani 26% 100%
A0A3S5H792 Leishmania donovani 24% 100%
A0A3S5H7I1 Leishmania donovani 100% 100%
A4HBK0 Leishmania braziliensis 21% 100%
A4HFU7 Leishmania braziliensis 74% 100%
A4HZL5 Leishmania infantum 24% 100%
A4HZL6 Leishmania infantum 27% 100%
E9ADF0 Leishmania major 93% 100%
E9AUW8 Leishmania mexicana (strain MHOM/GT/2001/U1103) 24% 100%
E9AUW9 Leishmania mexicana (strain MHOM/GT/2001/U1103) 25% 100%
E9AZ74 Leishmania mexicana (strain MHOM/GT/2001/U1103) 90% 100%
Q4QCL3 Leishmania major 22% 100%
Q4QCL4 Leishmania major 27% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS