Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein - conserved

Species:

Leishmania infantum

UniProt:

A4I2W2_LEIIN

TriTrypDb:

LINF_270024000

Length:

688

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	10
GO:0110165	cellular anatomical entity	1	10

Expansion

Sequence features

A4I2W2

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4I2W2

Function

Biological processes
Term	Name	Level	Count
GO:0006810	transport	3	1
GO:0009987	cellular process	1	1
GO:0051179	localization	1	1
GO:0051234	establishment of localization	2	1
GO:0055085	transmembrane transport	2	1

Molecular functions
Term	Name	Level	Count
GO:0000166	nucleotide binding	3	11
GO:0005488	binding	1	11
GO:0005524	ATP binding	5	11
GO:0017076	purine nucleotide binding	4	11
GO:0030554	adenyl nucleotide binding	5	11
GO:0032553	ribonucleotide binding	3	11
GO:0032555	purine ribonucleotide binding	4	11
GO:0032559	adenyl ribonucleotide binding	5	11
GO:0035639	purine ribonucleoside triphosphate binding	4	11
GO:0036094	small molecule binding	2	11
GO:0043167	ion binding	2	11
GO:0043168	anion binding	3	11
GO:0097159	organic cyclic compound binding	2	11
GO:0097367	carbohydrate derivative binding	2	11
GO:1901265	nucleoside phosphate binding	3	11
GO:1901363	heterocyclic compound binding	2	11
GO:0005215	transporter activity	1	5
GO:0015399	primary active transmembrane transporter activity	4	5
GO:0022804	active transmembrane transporter activity	3	5
GO:0022857	transmembrane transporter activity	2	5
GO:0042626	ATPase-coupled transmembrane transporter activity	2	5
GO:0140657	ATP-dependent activity	1	5
GO:0140359	ABC-type transporter activity	3	4
GO:0003824	catalytic activity	1	1
GO:0016787	hydrolase activity	2	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	110	114	PF00656	0.453
CLV_C14_Caspase3-7	175	179	PF00656	0.433
CLV_C14_Caspase3-7	296	300	PF00656	0.450
CLV_NRD_NRD_1	168	170	PF00675	0.249
CLV_NRD_NRD_1	209	211	PF00675	0.266
CLV_NRD_NRD_1	233	235	PF00675	0.337
CLV_NRD_NRD_1	98	100	PF00675	0.355
CLV_PCSK_FUR_1	166	170	PF00082	0.348
CLV_PCSK_KEX2_1	168	170	PF00082	0.271
CLV_PCSK_KEX2_1	233	235	PF00082	0.335
CLV_PCSK_KEX2_1	97	99	PF00082	0.349
CLV_PCSK_SKI1_1	107	111	PF00082	0.310
CLV_PCSK_SKI1_1	136	140	PF00082	0.281
CLV_PCSK_SKI1_1	234	238	PF00082	0.276
CLV_PCSK_SKI1_1	377	381	PF00082	0.243
CLV_PCSK_SKI1_1	415	419	PF00082	0.239
DEG_APCC_DBOX_1	135	143	PF00400	0.438
DEG_APCC_DBOX_1	232	240	PF00400	0.532
DEG_APCC_DBOX_1	449	457	PF00400	0.235
DOC_AGCK_PIF_2	549	554	PF00069	0.427
DOC_CYCLIN_RxL_1	578	587	PF00134	0.223
DOC_CYCLIN_yCln2_LP_2	252	258	PF00134	0.498
DOC_MAPK_gen_1	233	239	PF00069	0.476
DOC_MAPK_gen_1	395	404	PF00069	0.542
DOC_MAPK_gen_1	482	489	PF00069	0.497
DOC_MAPK_MEF2A_6	233	241	PF00069	0.492
DOC_MAPK_MEF2A_6	450	457	PF00069	0.201
DOC_MAPK_MEF2A_6	482	489	PF00069	0.573
DOC_MAPK_MEF2A_6	499	507	PF00069	0.229
DOC_MAPK_MEF2A_6	521	529	PF00069	0.201
DOC_MAPK_NFAT4_5	234	242	PF00069	0.445
DOC_MAPK_NFAT4_5	450	458	PF00069	0.201
DOC_MAPK_RevD_3	87	100	PF00069	0.428
DOC_PP1_RVXF_1	396	402	PF00149	0.447
DOC_PP1_RVXF_1	502	508	PF00149	0.345
DOC_PP1_RVXF_1	579	586	PF00149	0.227
DOC_PP1_SILK_1	327	332	PF00149	0.524
DOC_PP1_SILK_1	586	591	PF00149	0.330
DOC_PP2B_LxvP_1	117	120	PF13499	0.487
DOC_PP2B_LxvP_1	330	333	PF13499	0.583
DOC_PP4_FxxP_1	630	633	PF00568	0.338
DOC_SPAK_OSR1_1	197	201	PF12202	0.441
DOC_USP7_MATH_1	13	17	PF00917	0.696
DOC_USP7_MATH_1	35	39	PF00917	0.719
DOC_USP7_MATH_1	523	527	PF00917	0.300
DOC_USP7_MATH_1	532	536	PF00917	0.212
DOC_USP7_MATH_1	633	637	PF00917	0.357
DOC_WW_Pin1_4	487	492	PF00397	0.467
DOC_WW_Pin1_4	5	10	PF00397	0.599
DOC_WW_Pin1_4	54	59	PF00397	0.708
LIG_14-3-3_CanoR_1	17	21	PF00244	0.662
LIG_14-3-3_CanoR_1	225	229	PF00244	0.563
LIG_14-3-3_CanoR_1	353	357	PF00244	0.449
LIG_14-3-3_CanoR_1	602	607	PF00244	0.375
LIG_14-3-3_CanoR_1	622	630	PF00244	0.290
LIG_Actin_WH2_2	576	592	PF00022	0.304
LIG_BIR_II_1	1	5	PF00653	0.637
LIG_BRCT_BRCA1_1	354	358	PF00533	0.527
LIG_BRCT_BRCA1_1	48	52	PF00533	0.685
LIG_CaM_IQ_9	261	277	PF13499	0.450
LIG_EH1_1	491	499	PF00400	0.472
LIG_FHA_1	160	166	PF00498	0.578
LIG_FHA_1	217	223	PF00498	0.477
LIG_FHA_1	346	352	PF00498	0.517
LIG_FHA_1	450	456	PF00498	0.230
LIG_FHA_1	528	534	PF00498	0.239
LIG_FHA_1	667	673	PF00498	0.321
LIG_FHA_2	108	114	PF00498	0.564
LIG_FHA_2	173	179	PF00498	0.447
LIG_FHA_2	183	189	PF00498	0.433
LIG_FHA_2	202	208	PF00498	0.384
LIG_FHA_2	291	297	PF00498	0.559
LIG_FHA_2	342	348	PF00498	0.504
LIG_FHA_2	383	389	PF00498	0.605
LIG_FHA_2	436	442	PF00498	0.408
LIG_FHA_2	60	66	PF00498	0.691
LIG_GBD_Chelix_1	416	424	PF00786	0.312
LIG_GBD_Chelix_1	426	434	PF00786	0.287
LIG_HP1_1	247	251	PF01393	0.447
LIG_IRF3_LxIS_1	481	488	PF10401	0.470
LIG_LIR_Apic_2	628	633	PF02991	0.338
LIG_LIR_Gen_1	185	193	PF02991	0.487
LIG_LIR_Gen_1	219	229	PF02991	0.446
LIG_LIR_Gen_1	293	303	PF02991	0.495
LIG_LIR_Gen_1	380	387	PF02991	0.483
LIG_LIR_Gen_1	452	461	PF02991	0.391
LIG_LIR_Gen_1	553	562	PF02991	0.410
LIG_LIR_Nem_3	185	190	PF02991	0.510
LIG_LIR_Nem_3	219	224	PF02991	0.484
LIG_LIR_Nem_3	257	261	PF02991	0.497
LIG_LIR_Nem_3	293	298	PF02991	0.486
LIG_LIR_Nem_3	380	386	PF02991	0.499
LIG_LIR_Nem_3	452	457	PF02991	0.400
LIG_LIR_Nem_3	553	557	PF02991	0.296
LIG_LIR_Nem_3	645	649	PF02991	0.251
LIG_LIR_Nem_3	81	87	PF02991	0.651
LIG_MYND_1	23	27	PF01753	0.601
LIG_NRBOX	452	458	PF00104	0.272
LIG_PCNA_yPIPBox_3	469	481	PF02747	0.434
LIG_Pex14_1	548	552	PF04695	0.494
LIG_PTB_Apo_2	186	193	PF02174	0.509
LIG_PTB_Apo_2	357	364	PF02174	0.473
LIG_PTB_Apo_2	556	563	PF02174	0.258
LIG_PTB_Phospho_1	357	363	PF10480	0.474
LIG_PTB_Phospho_1	556	562	PF10480	0.258
LIG_SH2_CRK	565	569	PF00017	0.256
LIG_SH2_CRK	593	597	PF00017	0.241
LIG_SH2_PTP2	486	489	PF00017	0.431
LIG_SH2_SRC	221	224	PF00017	0.443
LIG_SH2_STAP1	134	138	PF00017	0.535
LIG_SH2_STAT3	167	170	PF00017	0.543
LIG_SH2_STAT3	363	366	PF00017	0.482
LIG_SH2_STAT3	638	641	PF00017	0.283
LIG_SH2_STAT3	68	71	PF00017	0.584
LIG_SH2_STAT5	173	176	PF00017	0.530
LIG_SH2_STAT5	221	224	PF00017	0.562
LIG_SH2_STAT5	235	238	PF00017	0.478
LIG_SH2_STAT5	312	315	PF00017	0.541
LIG_SH2_STAT5	396	399	PF00017	0.484
LIG_SH2_STAT5	486	489	PF00017	0.433
LIG_SH2_STAT5	492	495	PF00017	0.404
LIG_SH2_STAT5	554	557	PF00017	0.287
LIG_SH2_STAT5	565	568	PF00017	0.181
LIG_SH2_STAT5	638	641	PF00017	0.250
LIG_SH2_STAT5	643	646	PF00017	0.240
LIG_SH3_2	23	28	PF14604	0.621
LIG_SH3_3	1	7	PF00018	0.743
LIG_SH3_3	17	23	PF00018	0.589
LIG_SH3_3	241	247	PF00018	0.436
LIG_SH3_3	497	503	PF00018	0.415
LIG_SH3_5	550	554	PF00018	0.461
LIG_SUMO_SIM_anti_2	246	254	PF11976	0.551
LIG_SUMO_SIM_anti_2	299	307	PF11976	0.443
LIG_SUMO_SIM_anti_2	335	342	PF11976	0.549
LIG_SUMO_SIM_anti_2	553	559	PF11976	0.386
LIG_SUMO_SIM_anti_2	657	663	PF11976	0.289
LIG_SUMO_SIM_par_1	246	254	PF11976	0.454
LIG_SUMO_SIM_par_1	347	352	PF11976	0.490
LIG_SUMO_SIM_par_1	433	439	PF11976	0.432
LIG_SUMO_SIM_par_1	523	528	PF11976	0.358
LIG_SUMO_SIM_par_1	572	578	PF11976	0.461
LIG_SUMO_SIM_par_1	659	665	PF11976	0.260
LIG_SxIP_EBH_1	572	581	PF03271	0.359
LIG_TRAF2_1	64	67	PF00917	0.765
LIG_TYR_ITIM	591	596	PF00017	0.401
LIG_TYR_ITSM	217	224	PF00017	0.341
LIG_UBA3_1	477	483	PF00899	0.270
LIG_WRC_WIRS_1	533	538	PF05994	0.335
LIG_WW_1	393	396	PF00397	0.480
LIG_WW_3	25	29	PF00397	0.550
LIG_WW_3	392	396	PF00397	0.332
MOD_CK1_1	129	135	PF00069	0.394
MOD_CK1_1	16	22	PF00069	0.604
MOD_CK1_1	257	263	PF00069	0.396
MOD_CK1_1	38	44	PF00069	0.762
MOD_CK1_1	46	52	PF00069	0.568
MOD_CK1_1	575	581	PF00069	0.362
MOD_CK1_1	610	616	PF00069	0.558
MOD_CK1_1	621	627	PF00069	0.519
MOD_CK1_1	636	642	PF00069	0.278
MOD_CK1_1	650	656	PF00069	0.359
MOD_CK1_1	680	686	PF00069	0.532
MOD_CK1_1	8	14	PF00069	0.697
MOD_CK2_1	182	188	PF00069	0.361
MOD_CK2_1	201	207	PF00069	0.220
MOD_CK2_1	38	44	PF00069	0.499
MOD_CK2_1	435	441	PF00069	0.406
MOD_CK2_1	610	616	PF00069	0.531
MOD_GlcNHglycan	10	13	PF01048	0.691
MOD_GlcNHglycan	279	282	PF01048	0.378
MOD_GlcNHglycan	285	288	PF01048	0.329
MOD_GlcNHglycan	37	40	PF01048	0.684
MOD_GlcNHglycan	569	572	PF01048	0.300
MOD_GlcNHglycan	609	612	PF01048	0.630
MOD_GlcNHglycan	618	621	PF01048	0.602
MOD_GlcNHglycan	627	630	PF01048	0.540
MOD_GlcNHglycan	633	636	PF01048	0.503
MOD_GlcNHglycan	679	682	PF01048	0.492
MOD_GSK3_1	107	114	PF00069	0.461
MOD_GSK3_1	125	132	PF00069	0.232
MOD_GSK3_1	279	286	PF00069	0.399
MOD_GSK3_1	299	306	PF00069	0.373
MOD_GSK3_1	341	348	PF00069	0.465
MOD_GSK3_1	382	389	PF00069	0.428
MOD_GSK3_1	523	530	PF00069	0.251
MOD_GSK3_1	612	619	PF00069	0.635
MOD_GSK3_1	621	628	PF00069	0.520
MOD_GSK3_1	650	657	PF00069	0.385
MOD_GSK3_1	662	669	PF00069	0.241
MOD_GSK3_1	672	679	PF00069	0.347
MOD_GSK3_1	680	687	PF00069	0.481
MOD_GSK3_1	74	81	PF00069	0.634
MOD_GSK3_1	8	15	PF00069	0.701
MOD_NEK2_1	130	135	PF00069	0.496
MOD_NEK2_1	182	187	PF00069	0.345
MOD_NEK2_1	191	196	PF00069	0.315
MOD_NEK2_1	349	354	PF00069	0.337
MOD_NEK2_1	358	363	PF00069	0.272
MOD_NEK2_1	43	48	PF00069	0.759
MOD_NEK2_1	455	460	PF00069	0.289
MOD_NEK2_1	485	490	PF00069	0.330
MOD_NEK2_1	493	498	PF00069	0.204
MOD_NEK2_1	527	532	PF00069	0.274
MOD_NEK2_1	572	577	PF00069	0.373
MOD_NEK2_1	662	667	PF00069	0.248
MOD_NEK2_1	672	677	PF00069	0.238
MOD_NEK2_1	74	79	PF00069	0.734
MOD_NEK2_2	633	638	PF00069	0.351
MOD_PIKK_1	107	113	PF00454	0.329
MOD_PIKK_1	191	197	PF00454	0.263
MOD_PIKK_1	67	73	PF00454	0.568
MOD_PKA_2	13	19	PF00069	0.609
MOD_PKA_2	224	230	PF00069	0.461
MOD_PKA_2	352	358	PF00069	0.412
MOD_PKA_2	449	455	PF00069	0.223
MOD_PKA_2	621	627	PF00069	0.599
MOD_PKB_1	105	113	PF00069	0.350
MOD_PKB_1	275	283	PF00069	0.319
MOD_PKB_1	375	383	PF00069	0.342
MOD_Plk_1	182	188	PF00069	0.290
MOD_Plk_1	43	49	PF00069	0.682
MOD_Plk_1	650	656	PF00069	0.440
MOD_Plk_1	87	93	PF00069	0.362
MOD_Plk_2-3	201	207	PF00069	0.351
MOD_Plk_4	16	22	PF00069	0.611
MOD_Plk_4	160	166	PF00069	0.387
MOD_Plk_4	182	188	PF00069	0.387
MOD_Plk_4	224	230	PF00069	0.477
MOD_Plk_4	254	260	PF00069	0.405
MOD_Plk_4	279	285	PF00069	0.427
MOD_Plk_4	299	305	PF00069	0.414
MOD_Plk_4	352	358	PF00069	0.449
MOD_Plk_4	38	44	PF00069	0.547
MOD_Plk_4	449	455	PF00069	0.263
MOD_Plk_4	462	468	PF00069	0.242
MOD_Plk_4	493	499	PF00069	0.266
MOD_Plk_4	584	590	PF00069	0.273
MOD_Plk_4	654	660	PF00069	0.232
MOD_Plk_4	680	686	PF00069	0.532
MOD_ProDKin_1	487	493	PF00069	0.328
MOD_ProDKin_1	5	11	PF00069	0.512
MOD_ProDKin_1	54	60	PF00069	0.665
MOD_SUMO_for_1	468	471	PF00179	0.342
TRG_DiLeu_BaEn_1	246	251	PF01217	0.308
TRG_ENDOCYTIC_2	221	224	PF00928	0.343
TRG_ENDOCYTIC_2	396	399	PF00928	0.407
TRG_ENDOCYTIC_2	486	489	PF00928	0.324
TRG_ENDOCYTIC_2	554	557	PF00928	0.309
TRG_ENDOCYTIC_2	565	568	PF00928	0.186
TRG_ENDOCYTIC_2	593	596	PF00928	0.291
TRG_ENDOCYTIC_2	643	646	PF00928	0.286
TRG_ENDOCYTIC_2	84	87	PF00928	0.364
TRG_ER_diArg_1	104	107	PF00400	0.500
TRG_ER_diArg_1	167	169	PF00400	0.372
TRG_ER_diArg_1	233	235	PF00400	0.312
TRG_ER_diArg_1	274	277	PF00400	0.378
TRG_ER_diArg_1	375	378	PF00400	0.426
TRG_ER_diArg_1	47	50	PF00400	0.750
TRG_ER_diArg_1	601	604	PF00400	0.363
TRG_ER_diArg_1	96	99	PF00400	0.471
TRG_Pf-PMV_PEXEL_1	365	369	PF00026	0.395
TRG_Pf-PMV_PEXEL_1	395	400	PF00026	0.306

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I194	Leptomonas seymouri	56%	83%
A0A0S4IZ09	Bodo saltans	35%	100%
A0A0S4KMF6	Bodo saltans	24%	85%
A0A1X0P4K0	Trypanosomatidae	33%	100%
A0A3Q8IDI3	Leishmania donovani	98%	100%
A0A3R7MIF6	Trypanosoma rangeli	32%	100%
A4HFU5	Leishmania braziliensis	77%	100%
D3ZCM3	Rattus norvegicus	22%	100%
E9ADE9	Leishmania major	91%	100%
P45843	Drosophila melanogaster	23%	100%
Q4GZT4	Bos taurus	21%	100%
Q91WA9	Mus musculus	21%	100%
Q99P81	Mus musculus	21%	100%
V5B0X3	Trypanosoma cruzi	35%	100%
V5BLN9	Trypanosoma cruzi	24%	99%