Nuclear RNA export factor 1

Quick info Annotations Localization Abundance Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein - conserved

Species:

Leishmania infantum

UniProt:

A4I2W0_LEIIN

TriTrypDb:

LINF_270023800

Length:

538

Annotations

Annotations by Jardim et al.

Uncharacterized Protein, Uncharacterized

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	yes	yes: 25

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 8

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 21
NetGPI	no	yes: 0, no: 21

Show entries

Cellular components
Term	Name	Level	Count
GO:0005634	nucleus	5	4
GO:0005643	nuclear pore	3	1
GO:0005737	cytoplasm	2	1
GO:0005929	cilium	4	22
GO:0032991	protein-containing complex	1	1
GO:0042995	cell projection	2	22
GO:0043226	organelle	2	22
GO:0043227	membrane-bounded organelle	3	22
GO:0043229	intracellular organelle	3	4
GO:0043231	intracellular membrane-bounded organelle	4	4

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Abundance

Amastigote (protein)


Source	Evidence on protein	Close homologs
Pescher et al. (upgregulation)	no	yes: 0

Promastigote and amastigote


Source	Evidence on protein	Close homologs
Lahav et al. - mRNA - Protein

Expansion

Sequence features

A4I2W0

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4I2W0

Function

Show entries

Biological processes
Term	Name	Level	Count
GO:0006405	RNA export from nucleus	5	2
GO:0006406	mRNA export from nucleus	6	2
GO:0006810	transport	3	4
GO:0006913	nucleocytoplasmic transport	5	2
GO:0009987	cellular process	1	2
GO:0015931	nucleobase-containing compound transport	5	4
GO:0016973	poly(A)+ mRNA export from nucleus	7	2
GO:0046907	intracellular transport	3	2
GO:0050657	nucleic acid transport	6	4
GO:0050658	RNA transport	4	4

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Show entries

Molecular functions
Term	Name	Level	Count
GO:0003676	nucleic acid binding	3	2
GO:0003723	RNA binding	4	2
GO:0005488	binding	1	11
GO:0043167	ion binding	2	10
GO:0043169	cation binding	3	10
GO:0046872	metal ion binding	4	10
GO:0097159	organic cyclic compound binding	2	2
GO:1901363	heterocyclic compound binding	2	2

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Putative motif mimicry

Show entries


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	483	485	PF00675	0.451
CLV_PCSK_KEX2_1	118	120	PF00082	0.546
CLV_PCSK_KEX2_1	192	194	PF00082	0.431
CLV_PCSK_KEX2_1	482	484	PF00082	0.463
CLV_PCSK_KEX2_1	533	535	PF00082	0.543
CLV_PCSK_PC1ET2_1	118	120	PF00082	0.546
CLV_PCSK_PC1ET2_1	192	194	PF00082	0.471
CLV_PCSK_PC1ET2_1	533	535	PF00082	0.409
CLV_PCSK_SKI1_1	154	158	PF00082	0.417
CLV_PCSK_SKI1_1	170	174	PF00082	0.373

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Homologs

Show entries


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P8E9	Leptomonas seymouri	24%	86%
A0A0N0P8S6	Leptomonas seymouri	74%	100%
A0A0S4IRU5	Bodo saltans	27%	100%
A0A0S4IW66	Bodo saltans	28%	100%
A0A1X0P4A3	Trypanosomatidae	45%	100%
A0A1X0P4L1	Trypanosomatidae	26%	92%
A0A3R7NID6	Trypanosoma rangeli	26%	92%
A0A3S7X0T0	Leishmania donovani	100%	100%
A0A3S7X0T8	Leishmania donovani	26%	87%
A4HFU3	Leishmania braziliensis	87%	100%

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