LeishMANIAdb
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Nuclear RNA export factor 1

Quick info Annotations Function or PPIs Localization Abundance Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
Nuclear RNA export factor 1
Gene product:
hypothetical protein - conserved
Species:
Leishmania infantum
UniProt:
A4I2W0_LEIIN
TriTrypDb:
LINF_270023800
Length:
538

Annotations

Annotations by Jardim et al.

Uncharacterized Protein, Uncharacterized

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. yes yes: 25
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 8
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 21
NetGPI no yes: 0, no: 21
Cellular components
Term Name Level Count
GO:0005929 cilium 4 22
GO:0042995 cell projection 2 22
GO:0043226 organelle 2 22
GO:0043227 membrane-bounded organelle 3 22
GO:0110165 cellular anatomical entity 1 22
GO:0120025 plasma membrane bounded cell projection 3 22
GO:0005634 nucleus 5 4
GO:0043229 intracellular organelle 3 4
GO:0043231 intracellular membrane-bounded organelle 4 4
GO:0005643 nuclear pore 3 1
GO:0005737 cytoplasm 2 1
GO:0032991 protein-containing complex 1 1
GO:0140513 nuclear protein-containing complex 2 1

Abundance

Amastigote (protein)
Source Evidence on protein Close homologs
Pescher et al. (upgregulation) no yes: 0
Promastigote and amastigote
Source Evidence on protein Close homologs
Lahav et al.
- mRNA
- Protein

Expansion

Sequence features

A4I2W0
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4I2W0

Function

Biological processes
Term Name Level Count
GO:0006810 transport 3 4
GO:0015931 nucleobase-containing compound transport 5 4
GO:0050657 nucleic acid transport 6 4
GO:0050658 RNA transport 4 4
GO:0051028 mRNA transport 5 4
GO:0051179 localization 1 4
GO:0051234 establishment of localization 2 4
GO:0051236 establishment of RNA localization 3 4
GO:0071702 organic substance transport 4 4
GO:0071705 nitrogen compound transport 4 4
GO:0006405 RNA export from nucleus 5 2
GO:0006406 mRNA export from nucleus 6 2
GO:0006913 nucleocytoplasmic transport 5 2
GO:0009987 cellular process 1 2
GO:0016973 poly(A)+ mRNA export from nucleus 7 2
GO:0046907 intracellular transport 3 2
GO:0051168 nuclear export 6 2
GO:0051169 nuclear transport 4 2
GO:0051641 cellular localization 2 2
GO:0051649 establishment of localization in cell 3 2
Molecular functions
Term Name Level Count
GO:0005488 binding 1 11
GO:0043167 ion binding 2 10
GO:0043169 cation binding 3 10
GO:0046872 metal ion binding 4 10
GO:0003676 nucleic acid binding 3 2
GO:0003723 RNA binding 4 2
GO:0097159 organic cyclic compound binding 2 2
GO:1901363 heterocyclic compound binding 2 2

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_NRD_NRD_1 483 485 PF00675 0.451
CLV_PCSK_KEX2_1 118 120 PF00082 0.546
CLV_PCSK_KEX2_1 192 194 PF00082 0.431
CLV_PCSK_KEX2_1 482 484 PF00082 0.463
CLV_PCSK_KEX2_1 533 535 PF00082 0.543
CLV_PCSK_PC1ET2_1 118 120 PF00082 0.546
CLV_PCSK_PC1ET2_1 192 194 PF00082 0.471
CLV_PCSK_PC1ET2_1 533 535 PF00082 0.409
CLV_PCSK_SKI1_1 154 158 PF00082 0.417
CLV_PCSK_SKI1_1 170 174 PF00082 0.373
CLV_PCSK_SKI1_1 234 238 PF00082 0.541
CLV_PCSK_SKI1_1 430 434 PF00082 0.366
CLV_PCSK_SKI1_1 533 537 PF00082 0.555
CLV_PCSK_SKI1_1 80 84 PF00082 0.411
CLV_Separin_Metazoa 133 137 PF03568 0.476
DOC_CYCLIN_RxL_1 138 152 PF00134 0.481
DOC_CYCLIN_RxL_1 154 161 PF00134 0.479
DOC_CYCLIN_RxL_1 77 84 PF00134 0.510
DOC_CYCLIN_yClb1_LxF_4 182 188 PF00134 0.472
DOC_CYCLIN_yCln2_LP_2 403 409 PF00134 0.391
DOC_MAPK_DCC_7 216 226 PF00069 0.547
DOC_MAPK_gen_1 136 145 PF00069 0.415
DOC_MAPK_MEF2A_6 219 226 PF00069 0.444
DOC_MAPK_MEF2A_6 364 372 PF00069 0.508
DOC_MAPK_MEF2A_6 508 516 PF00069 0.546
DOC_MAPK_MEF2A_6 80 87 PF00069 0.490
DOC_MAPK_NFAT4_5 80 88 PF00069 0.494
DOC_PP2B_LxvP_1 237 240 PF13499 0.532
DOC_PP2B_LxvP_1 515 518 PF13499 0.533
DOC_USP7_MATH_1 11 15 PF00917 0.466
DOC_USP7_MATH_1 242 246 PF00917 0.534
DOC_USP7_MATH_1 320 324 PF00917 0.572
DOC_USP7_MATH_1 335 339 PF00917 0.501
DOC_USP7_MATH_1 500 504 PF00917 0.508
DOC_USP7_MATH_1 524 528 PF00917 0.533
DOC_USP7_MATH_2 349 355 PF00917 0.377
DOC_WW_Pin1_4 107 112 PF00397 0.493
DOC_WW_Pin1_4 461 466 PF00397 0.515
DOC_WW_Pin1_4 471 476 PF00397 0.540
LIG_14-3-3_CanoR_1 326 334 PF00244 0.478
LIG_14-3-3_CanoR_1 430 435 PF00244 0.344
LIG_Actin_WH2_2 311 328 PF00022 0.442
LIG_APCC_ABBAyCdc20_2 456 462 PF00400 0.620
LIG_BIR_II_1 1 5 PF00653 0.548
LIG_BRCT_BRCA1_1 123 127 PF00533 0.374
LIG_BRCT_BRCA1_1 327 331 PF00533 0.413
LIG_BRCT_BRCA1_1 424 428 PF00533 0.404
LIG_BRCT_BRCA1_1 466 470 PF00533 0.547
LIG_BRCT_BRCA1_1 83 87 PF00533 0.451
LIG_BRCT_BRCA1_1 91 95 PF00533 0.446
LIG_BRCT_BRCA1_2 123 129 PF00533 0.390
LIG_BRCT_BRCA1_2 83 89 PF00533 0.493
LIG_FHA_1 305 311 PF00498 0.461
LIG_FHA_1 429 435 PF00498 0.314
LIG_FHA_1 488 494 PF00498 0.448
LIG_FHA_2 424 430 PF00498 0.432
LIG_FHA_2 499 505 PF00498 0.502
LIG_IRF3_LxIS_1 283 289 PF10401 0.489
LIG_LIR_Gen_1 121 130 PF02991 0.390
LIG_LIR_Gen_1 262 272 PF02991 0.490
LIG_LIR_Gen_1 281 288 PF02991 0.523
LIG_LIR_Gen_1 88 98 PF02991 0.501
LIG_LIR_Nem_3 121 125 PF02991 0.395
LIG_LIR_Nem_3 269 275 PF02991 0.457
LIG_LIR_Nem_3 281 286 PF02991 0.501
LIG_LIR_Nem_3 328 334 PF02991 0.461
LIG_LIR_Nem_3 88 94 PF02991 0.498
LIG_LRP6_Inhibitor_1 148 154 PF00058 0.357
LIG_MLH1_MIPbox_1 424 428 PF16413 0.444
LIG_MYND_1 111 115 PF01753 0.449
LIG_NRBOX 155 161 PF00104 0.348
LIG_NRBOX 196 202 PF00104 0.377
LIG_NRBOX 81 87 PF00104 0.363
LIG_PCNA_PIPBox_1 252 261 PF02747 0.474
LIG_PDZ_Class_2 533 538 PF00595 0.317
LIG_Pex14_2 372 376 PF04695 0.548
LIG_PTB_Apo_2 370 377 PF02174 0.537
LIG_REV1ctd_RIR_1 425 434 PF16727 0.379
LIG_SH2_CRK 122 126 PF00017 0.488
LIG_SH2_CRK 194 198 PF00017 0.474
LIG_SH2_CRK 272 276 PF00017 0.437
LIG_SH2_CRK 91 95 PF00017 0.492
LIG_SH2_NCK_1 122 126 PF00017 0.488
LIG_SH2_NCK_1 272 276 PF00017 0.344
LIG_SH2_NCK_1 91 95 PF00017 0.474
LIG_SH2_SRC 277 280 PF00017 0.344
LIG_SH2_STAP1 213 217 PF00017 0.391
LIG_SH2_STAP1 91 95 PF00017 0.515
LIG_SH2_STAT3 258 261 PF00017 0.505
LIG_SH2_STAT3 279 282 PF00017 0.509
LIG_SH2_STAT5 258 261 PF00017 0.440
LIG_SH2_STAT5 277 280 PF00017 0.416
LIG_SH2_STAT5 402 405 PF00017 0.518
LIG_SH3_3 403 409 PF00018 0.391
LIG_SH3_3 411 417 PF00018 0.563
LIG_SH3_3 462 468 PF00018 0.615
LIG_SUMO_SIM_anti_2 199 204 PF11976 0.432
LIG_SUMO_SIM_par_1 429 435 PF11976 0.448
LIG_TRAF2_1 503 506 PF00917 0.419
LIG_TYR_ITIM 120 125 PF00017 0.486
LIG_UBA3_1 82 89 PF00899 0.387
LIG_WRC_WIRS_1 424 429 PF05994 0.482
MOD_CDK_SPxK_1 471 477 PF00069 0.589
MOD_CK1_1 186 192 PF00069 0.436
MOD_CK1_1 266 272 PF00069 0.499
MOD_CK1_1 281 287 PF00069 0.437
MOD_CK1_1 338 344 PF00069 0.521
MOD_CK1_1 69 75 PF00069 0.607
MOD_CK2_1 473 479 PF00069 0.422
MOD_CK2_1 499 505 PF00069 0.528
MOD_CK2_1 524 530 PF00069 0.501
MOD_Cter_Amidation 5 8 PF01082 0.577
MOD_GlcNHglycan 15 18 PF01048 0.605
MOD_GlcNHglycan 175 178 PF01048 0.359
MOD_GlcNHglycan 188 191 PF01048 0.325
MOD_GlcNHglycan 244 247 PF01048 0.594
MOD_GlcNHglycan 283 286 PF01048 0.419
MOD_GlcNHglycan 301 304 PF01048 0.394
MOD_GlcNHglycan 337 340 PF01048 0.573
MOD_GlcNHglycan 35 38 PF01048 0.750
MOD_GlcNHglycan 63 66 PF01048 0.624
MOD_GlcNHglycan 68 71 PF01048 0.649
MOD_GSK3_1 211 218 PF00069 0.538
MOD_GSK3_1 242 249 PF00069 0.560
MOD_GSK3_1 259 266 PF00069 0.393
MOD_GSK3_1 320 327 PF00069 0.502
MOD_GSK3_1 408 415 PF00069 0.499
MOD_GSK3_1 428 435 PF00069 0.366
MOD_GSK3_1 437 444 PF00069 0.371
MOD_GSK3_1 59 66 PF00069 0.693
MOD_N-GLC_1 102 107 PF02516 0.425
MOD_N-GLC_1 178 183 PF02516 0.522
MOD_N-GLC_1 498 503 PF02516 0.528
MOD_N-GLC_1 59 64 PF02516 0.713
MOD_N-GLC_1 66 71 PF02516 0.694
MOD_N-GLC_2 358 360 PF02516 0.296
MOD_NEK2_1 102 107 PF00069 0.419
MOD_NEK2_1 259 264 PF00069 0.429
MOD_NEK2_1 278 283 PF00069 0.442
MOD_NEK2_1 286 291 PF00069 0.382
MOD_NEK2_1 381 386 PF00069 0.493
MOD_NEK2_1 423 428 PF00069 0.353
MOD_NEK2_1 87 92 PF00069 0.380
MOD_NEK2_2 392 397 PF00069 0.335
MOD_PIKK_1 246 252 PF00454 0.482
MOD_PIKK_1 278 284 PF00454 0.530
MOD_PIKK_1 325 331 PF00454 0.525
MOD_PIKK_1 408 414 PF00454 0.502
MOD_PIKK_1 89 95 PF00454 0.492
MOD_PK_1 178 184 PF00069 0.327
MOD_PKA_2 215 221 PF00069 0.496
MOD_PKA_2 325 331 PF00069 0.552
MOD_Plk_1 149 155 PF00069 0.416
MOD_Plk_1 178 184 PF00069 0.457
MOD_Plk_1 259 265 PF00069 0.492
MOD_Plk_1 362 368 PF00069 0.502
MOD_Plk_1 381 387 PF00069 0.317
MOD_Plk_1 428 434 PF00069 0.370
MOD_Plk_1 87 93 PF00069 0.510
MOD_Plk_4 183 189 PF00069 0.448
MOD_Plk_4 251 257 PF00069 0.467
MOD_Plk_4 259 265 PF00069 0.367
MOD_Plk_4 423 429 PF00069 0.416
MOD_Plk_4 507 513 PF00069 0.484
MOD_Plk_4 81 87 PF00069 0.382
MOD_ProDKin_1 107 113 PF00069 0.486
MOD_ProDKin_1 461 467 PF00069 0.515
MOD_ProDKin_1 471 477 PF00069 0.534
MOD_SUMO_rev_2 502 510 PF00179 0.544
TRG_DiLeu_BaEn_1 97 102 PF01217 0.557
TRG_ENDOCYTIC_2 122 125 PF00928 0.485
TRG_ENDOCYTIC_2 194 197 PF00928 0.403
TRG_ENDOCYTIC_2 272 275 PF00928 0.441
TRG_ENDOCYTIC_2 91 94 PF00928 0.519
TRG_ER_diArg_1 142 145 PF00400 0.494
TRG_ER_diArg_1 481 484 PF00400 0.465
TRG_Pf-PMV_PEXEL_1 129 133 PF00026 0.465
TRG_Pf-PMV_PEXEL_1 144 149 PF00026 0.451
TRG_Pf-PMV_PEXEL_1 332 337 PF00026 0.498

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N0P8E9 Leptomonas seymouri 24% 86%
A0A0N0P8S6 Leptomonas seymouri 74% 100%
A0A0S4IRU5 Bodo saltans 27% 100%
A0A0S4IW66 Bodo saltans 28% 100%
A0A1X0P4A3 Trypanosomatidae 45% 100%
A0A1X0P4L1 Trypanosomatidae 26% 92%
A0A3R7NID6 Trypanosoma rangeli 26% 92%
A0A3S7X0T0 Leishmania donovani 100% 100%
A0A3S7X0T8 Leishmania donovani 26% 87%
A4HFU3 Leishmania braziliensis 87% 100%
A4HFU4 Leishmania braziliensis 26% 100%
A4I2W1 Leishmania infantum 26% 87%
D0A641 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 39% 100%
D0A644 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 28% 100%
E9ADE7 Leishmania major 96% 100%
E9ADE8 Leishmania major 25% 100%
E9AZ71 Leishmania mexicana (strain MHOM/GT/2001/U1103) 92% 100%
E9AZ72 Leishmania mexicana (strain MHOM/GT/2001/U1103) 25% 100%
V5B0W6 Trypanosoma cruzi 26% 93%
V5BQG4 Trypanosoma cruzi 44% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS