| Source | Evidence on protein | Close homologs |
|---|---|---|
| Cuervo et al. | no | yes: 0 |
| Hassani et al. | no | yes: 0 |
| Forrest at al. (metacyclic) | no | yes: 0 |
| Forrest at al. (procyclic) | no | yes: 0 |
| Silverman et al. | no | yes: 0 |
| Pissara et al. | no | yes: 0 |
| Source | Evidence on protein | Close homologs |
|---|---|---|
| Pires et al. | no | yes: 0 |
| Source | Evidence on protein | Close homologs |
|---|---|---|
| Silverman et al. | no | yes: 0 |
| Source | Evidence on protein | Close homologs |
|---|---|---|
| Jamdhade et al. | no | yes: 0 |
| Source | Evidence on protein | Close homologs |
|---|---|---|
| DeepLoc | ||
| SignalP6 | no | yes: 0, no: 11 |
| NetGPI | no | yes: 0, no: 11 |
| Term | Name | Level | Count |
|---|---|---|---|
| GO:0005829 | cytosol | 2 | 10 |
| GO:0110165 | cellular anatomical entity | 1 | 10 |
| GO:0005737 | cytoplasm | 2 | 1 |
| GO:0016020 | membrane | 2 | 4 |
Related structures:
AlphaFold database: A4I2V9
| Term | Name | Level | Count |
|---|---|---|---|
| GO:0002097 | tRNA wobble base modification | 7 | 10 |
| GO:0002098 | tRNA wobble uridine modification | 8 | 10 |
| GO:0002143 | tRNA wobble position uridine thiolation | 8 | 10 |
| GO:0006139 | nucleobase-containing compound metabolic process | 3 | 10 |
| GO:0006396 | RNA processing | 6 | 10 |
| GO:0006399 | tRNA metabolic process | 7 | 10 |
| GO:0006400 | tRNA modification | 6 | 10 |
| GO:0006725 | cellular aromatic compound metabolic process | 3 | 10 |
| GO:0006807 | nitrogen compound metabolic process | 2 | 10 |
| GO:0008033 | tRNA processing | 8 | 10 |
| GO:0008152 | metabolic process | 1 | 10 |
| GO:0009451 | RNA modification | 5 | 10 |
| GO:0009987 | cellular process | 1 | 10 |
| GO:0016070 | RNA metabolic process | 5 | 10 |
| GO:0034227 | tRNA thio-modification | 7 | 10 |
| GO:0034470 | ncRNA processing | 7 | 10 |
| GO:0034641 | cellular nitrogen compound metabolic process | 3 | 10 |
| GO:0034660 | ncRNA metabolic process | 6 | 10 |
| GO:0043170 | macromolecule metabolic process | 3 | 10 |
| GO:0043412 | macromolecule modification | 4 | 10 |
| GO:0044237 | cellular metabolic process | 2 | 10 |
| GO:0044238 | primary metabolic process | 2 | 10 |
| GO:0046483 | heterocycle metabolic process | 3 | 10 |
| GO:0071704 | organic substance metabolic process | 2 | 10 |
| GO:0090304 | nucleic acid metabolic process | 4 | 10 |
| GO:1901360 | organic cyclic compound metabolic process | 3 | 10 |
| Term | Name | Level | Count |
|---|---|---|---|
| GO:0000166 | nucleotide binding | 3 | 12 |
| GO:0003824 | catalytic activity | 1 | 12 |
| GO:0004792 | thiosulfate sulfurtransferase activity | 5 | 10 |
| GO:0005488 | binding | 1 | 12 |
| GO:0005524 | ATP binding | 5 | 12 |
| GO:0008641 | ubiquitin-like modifier activating enzyme activity | 2 | 12 |
| GO:0016740 | transferase activity | 2 | 12 |
| GO:0016772 | transferase activity, transferring phosphorus-containing groups | 3 | 10 |
| GO:0016779 | nucleotidyltransferase activity | 4 | 10 |
| GO:0016782 | transferase activity, transferring sulphur-containing groups | 3 | 10 |
| GO:0016783 | sulfurtransferase activity | 4 | 10 |
| GO:0016874 | ligase activity | 2 | 12 |
| GO:0016877 | ligase activity, forming carbon-sulfur bonds | 3 | 12 |
| GO:0017076 | purine nucleotide binding | 4 | 12 |
| GO:0030554 | adenyl nucleotide binding | 5 | 12 |
| GO:0032553 | ribonucleotide binding | 3 | 12 |
| GO:0032555 | purine ribonucleotide binding | 4 | 12 |
| GO:0032559 | adenyl ribonucleotide binding | 5 | 12 |
| GO:0035639 | purine ribonucleoside triphosphate binding | 4 | 12 |
| GO:0036094 | small molecule binding | 2 | 12 |
| GO:0043167 | ion binding | 2 | 12 |
| GO:0043168 | anion binding | 3 | 12 |
| GO:0043169 | cation binding | 3 | 10 |
| GO:0046872 | metal ion binding | 4 | 10 |
| GO:0097159 | organic cyclic compound binding | 2 | 12 |
| GO:0097367 | carbohydrate derivative binding | 2 | 12 |
| GO:0140096 | catalytic activity, acting on a protein | 2 | 12 |
| GO:0140657 | ATP-dependent activity | 1 | 12 |
| GO:1901265 | nucleoside phosphate binding | 3 | 12 |
| GO:1901363 | heterocyclic compound binding | 2 | 12 |
| GO:0042292 | URM1 activating enzyme activity | 3 | 1 |
| Leishmania | From | To | Domain/Motif | Score |
|---|---|---|---|---|
| CLV_C14_Caspase3-7 | 145 | 149 | PF00656 | 0.248 |
| CLV_C14_Caspase3-7 | 205 | 209 | PF00656 | 0.352 |
| CLV_C14_Caspase3-7 | 391 | 395 | PF00656 | 0.680 |
| CLV_NRD_NRD_1 | 324 | 326 | PF00675 | 0.419 |
| CLV_NRD_NRD_1 | 406 | 408 | PF00675 | 0.286 |
| CLV_PCSK_KEX2_1 | 324 | 326 | PF00082 | 0.364 |
| CLV_PCSK_KEX2_1 | 356 | 358 | PF00082 | 0.388 |
| CLV_PCSK_KEX2_1 | 406 | 408 | PF00082 | 0.286 |
| CLV_PCSK_PC1ET2_1 | 356 | 358 | PF00082 | 0.399 |
| CLV_PCSK_SKI1_1 | 191 | 195 | PF00082 | 0.442 |
| CLV_PCSK_SKI1_1 | 229 | 233 | PF00082 | 0.512 |
| CLV_PCSK_SKI1_1 | 241 | 245 | PF00082 | 0.295 |
| CLV_PCSK_SKI1_1 | 253 | 257 | PF00082 | 0.266 |
| CLV_PCSK_SKI1_1 | 32 | 36 | PF00082 | 0.300 |
| CLV_PCSK_SKI1_1 | 324 | 328 | PF00082 | 0.394 |
| CLV_PCSK_SKI1_1 | 419 | 423 | PF00082 | 0.356 |
| CLV_PCSK_SKI1_1 | 439 | 443 | PF00082 | 0.381 |
| DEG_APCC_DBOX_1 | 405 | 413 | PF00400 | 0.440 |
| DEG_Nend_UBRbox_3 | 1 | 3 | PF02207 | 0.626 |
| DOC_MAPK_gen_1 | 324 | 332 | PF00069 | 0.581 |
| DOC_MAPK_MEF2A_6 | 324 | 332 | PF00069 | 0.575 |
| DOC_PP4_FxxP_1 | 194 | 197 | PF00568 | 0.248 |
| DOC_USP7_MATH_1 | 108 | 112 | PF00917 | 0.298 |
| DOC_USP7_MATH_1 | 14 | 18 | PF00917 | 0.555 |
| DOC_USP7_MATH_1 | 166 | 170 | PF00917 | 0.248 |
| DOC_USP7_MATH_1 | 295 | 299 | PF00917 | 0.670 |
| DOC_USP7_MATH_1 | 303 | 307 | PF00917 | 0.562 |
| DOC_USP7_MATH_1 | 316 | 320 | PF00917 | 0.635 |
| DOC_USP7_MATH_1 | 348 | 352 | PF00917 | 0.600 |
| DOC_USP7_MATH_1 | 388 | 392 | PF00917 | 0.715 |
| DOC_WW_Pin1_4 | 126 | 131 | PF00397 | 0.309 |
| DOC_WW_Pin1_4 | 273 | 278 | PF00397 | 0.614 |
| DOC_WW_Pin1_4 | 298 | 303 | PF00397 | 0.687 |
| DOC_WW_Pin1_4 | 376 | 381 | PF00397 | 0.659 |
| LIG_14-3-3_CanoR_1 | 135 | 144 | PF00244 | 0.340 |
| LIG_14-3-3_CanoR_1 | 249 | 257 | PF00244 | 0.485 |
| LIG_14-3-3_CanoR_1 | 324 | 329 | PF00244 | 0.586 |
| LIG_14-3-3_CanoR_1 | 407 | 413 | PF00244 | 0.487 |
| LIG_Actin_WH2_2 | 215 | 231 | PF00022 | 0.352 |
| LIG_Actin_WH2_2 | 235 | 251 | PF00022 | 0.117 |
| LIG_Actin_WH2_2 | 397 | 415 | PF00022 | 0.502 |
| LIG_BIR_III_2 | 274 | 278 | PF00653 | 0.558 |
| LIG_BIR_III_2 | 394 | 398 | PF00653 | 0.572 |
| LIG_EVH1_1 | 194 | 198 | PF00568 | 0.248 |
| LIG_FHA_1 | 137 | 143 | PF00498 | 0.317 |
| LIG_FHA_1 | 145 | 151 | PF00498 | 0.244 |
| LIG_FHA_1 | 325 | 331 | PF00498 | 0.543 |
| LIG_FHA_1 | 61 | 67 | PF00498 | 0.299 |
| LIG_FHA_1 | 95 | 101 | PF00498 | 0.284 |
| LIG_FHA_2 | 21 | 27 | PF00498 | 0.503 |
| LIG_FHA_2 | 75 | 81 | PF00498 | 0.352 |
| LIG_FXI_DFP_1 | 78 | 82 | PF00024 | 0.459 |
| LIG_GBD_Chelix_1 | 361 | 369 | PF00786 | 0.383 |
| LIG_Integrin_isoDGR_2 | 239 | 241 | PF01839 | 0.408 |
| LIG_Integrin_RGD_1 | 428 | 430 | PF01839 | 0.377 |
| LIG_LIR_Gen_1 | 80 | 89 | PF02991 | 0.248 |
| LIG_LIR_Nem_3 | 288 | 292 | PF02991 | 0.548 |
| LIG_LIR_Nem_3 | 457 | 463 | PF02991 | 0.547 |
| LIG_LIR_Nem_3 | 80 | 84 | PF02991 | 0.248 |
| LIG_SH2_CRK | 190 | 194 | PF00017 | 0.273 |
| LIG_SH2_CRK | 292 | 296 | PF00017 | 0.671 |
| LIG_SH2_CRK | 349 | 353 | PF00017 | 0.577 |
| LIG_SH2_STAP1 | 312 | 316 | PF00017 | 0.631 |
| LIG_SH2_STAT5 | 154 | 157 | PF00017 | 0.258 |
| LIG_SH2_STAT5 | 289 | 292 | PF00017 | 0.598 |
| LIG_SH2_STAT5 | 402 | 405 | PF00017 | 0.527 |
| LIG_SH2_STAT5 | 440 | 443 | PF00017 | 0.589 |
| LIG_SH2_STAT5 | 67 | 70 | PF00017 | 0.338 |
| LIG_SH3_3 | 192 | 198 | PF00018 | 0.239 |
| LIG_SH3_3 | 208 | 214 | PF00018 | 0.236 |
| LIG_SH3_3 | 296 | 302 | PF00018 | 0.655 |
| LIG_SH3_3 | 342 | 348 | PF00018 | 0.508 |
| LIG_Sin3_3 | 414 | 421 | PF02671 | 0.500 |
| LIG_TRAF2_1 | 198 | 201 | PF00917 | 0.293 |
| LIG_TYR_ITIM | 347 | 352 | PF00017 | 0.568 |
| MOD_CK1_1 | 18 | 24 | PF00069 | 0.626 |
| MOD_CK1_1 | 298 | 304 | PF00069 | 0.610 |
| MOD_CK2_1 | 305 | 311 | PF00069 | 0.573 |
| MOD_GlcNHglycan | 106 | 109 | PF01048 | 0.456 |
| MOD_GlcNHglycan | 168 | 171 | PF01048 | 0.445 |
| MOD_GlcNHglycan | 208 | 211 | PF01048 | 0.546 |
| MOD_GlcNHglycan | 267 | 270 | PF01048 | 0.388 |
| MOD_GlcNHglycan | 307 | 310 | PF01048 | 0.367 |
| MOD_GlcNHglycan | 318 | 321 | PF01048 | 0.409 |
| MOD_GlcNHglycan | 385 | 389 | PF01048 | 0.576 |
| MOD_GlcNHglycan | 445 | 448 | PF01048 | 0.387 |
| MOD_GlcNHglycan | 457 | 460 | PF01048 | 0.271 |
| MOD_GlcNHglycan | 70 | 73 | PF01048 | 0.408 |
| MOD_GSK3_1 | 104 | 111 | PF00069 | 0.278 |
| MOD_GSK3_1 | 14 | 21 | PF00069 | 0.574 |
| MOD_GSK3_1 | 202 | 209 | PF00069 | 0.250 |
| MOD_GSK3_1 | 290 | 297 | PF00069 | 0.668 |
| MOD_GSK3_1 | 298 | 305 | PF00069 | 0.602 |
| MOD_GSK3_1 | 384 | 391 | PF00069 | 0.757 |
| MOD_N-GLC_1 | 206 | 211 | PF02516 | 0.448 |
| MOD_N-GLC_1 | 443 | 448 | PF02516 | 0.386 |
| MOD_NEK2_1 | 15 | 20 | PF00069 | 0.570 |
| MOD_NEK2_1 | 248 | 253 | PF00069 | 0.521 |
| MOD_NEK2_1 | 341 | 346 | PF00069 | 0.590 |
| MOD_NEK2_1 | 60 | 65 | PF00069 | 0.300 |
| MOD_NEK2_1 | 68 | 73 | PF00069 | 0.300 |
| MOD_NEK2_2 | 177 | 182 | PF00069 | 0.238 |
| MOD_NEK2_2 | 408 | 413 | PF00069 | 0.533 |
| MOD_PIKK_1 | 360 | 366 | PF00454 | 0.537 |
| MOD_PKA_1 | 324 | 330 | PF00069 | 0.539 |
| MOD_PKA_2 | 248 | 254 | PF00069 | 0.525 |
| MOD_PKA_2 | 316 | 322 | PF00069 | 0.659 |
| MOD_PKA_2 | 324 | 330 | PF00069 | 0.510 |
| MOD_PKA_2 | 74 | 80 | PF00069 | 0.352 |
| MOD_Plk_4 | 177 | 183 | PF00069 | 0.238 |
| MOD_Plk_4 | 348 | 354 | PF00069 | 0.583 |
| MOD_Plk_4 | 357 | 363 | PF00069 | 0.597 |
| MOD_Plk_4 | 60 | 66 | PF00069 | 0.362 |
| MOD_Plk_4 | 74 | 80 | PF00069 | 0.302 |
| MOD_ProDKin_1 | 126 | 132 | PF00069 | 0.309 |
| MOD_ProDKin_1 | 273 | 279 | PF00069 | 0.615 |
| MOD_ProDKin_1 | 298 | 304 | PF00069 | 0.684 |
| MOD_ProDKin_1 | 376 | 382 | PF00069 | 0.661 |
| TRG_ENDOCYTIC_2 | 190 | 193 | PF00928 | 0.273 |
| TRG_ENDOCYTIC_2 | 349 | 352 | PF00928 | 0.584 |
| TRG_ER_diArg_1 | 257 | 260 | PF00400 | 0.461 |
| TRG_ER_diArg_1 | 324 | 326 | PF00400 | 0.612 |
| TRG_ER_diArg_1 | 330 | 333 | PF00400 | 0.575 |
| TRG_NES_CRM1_1 | 337 | 350 | PF08389 | 0.547 |
| TRG_Pf-PMV_PEXEL_1 | 153 | 158 | PF00026 | 0.448 |
| TRG_Pf-PMV_PEXEL_1 | 191 | 196 | PF00026 | 0.534 |
| Protein | Taxonomy | Sequence identity | Coverage |
|---|---|---|---|
| A0A0N0P8E8 | Leptomonas seymouri | 66% | 100% |
| A0A0S4JY12 | Bodo saltans | 47% | 96% |
| A0A1X0P4G1 | Trypanosomatidae | 46% | 86% |
| A0A3Q8IDE2 | Leishmania donovani | 100% | 100% |
| A0A422NC72 | Trypanosoma rangeli | 50% | 94% |
| A1A4L8 | Bos taurus | 38% | 100% |
| A1CAZ7 | Aspergillus clavatus (strain ATCC 1007 / CBS 513.65 / DSM 816 / NCTC 3887 / NRRL 1 / QM 1276 / 107) | 34% | 94% |
| A1DED8 | Neosartorya fischeri (strain ATCC 1020 / DSM 3700 / CBS 544.65 / FGSC A1164 / JCM 1740 / NRRL 181 / WB 181) | 34% | 96% |
| A2BDX3 | Mus musculus | 38% | 100% |
| A2R3H4 | Aspergillus niger (strain CBS 513.88 / FGSC A1513) | 37% | 96% |
| A3ACF3 | Oryza sativa subsp. japonica | 36% | 100% |
| A3LQF9 | Scheffersomyces stipitis (strain ATCC 58785 / CBS 6054 / NBRC 10063 / NRRL Y-11545) | 33% | 100% |
| A4HFU1 | Leishmania braziliensis | 80% | 98% |
| A4RPM5 | Magnaporthe oryzae (strain 70-15 / ATCC MYA-4617 / FGSC 8958) | 34% | 94% |
| A5DMB6 | Meyerozyma guilliermondii (strain ATCC 6260 / CBS 566 / DSM 6381 / JCM 1539 / NBRC 10279 / NRRL Y-324) | 33% | 100% |
| A5DSR2 | Lodderomyces elongisporus (strain ATCC 11503 / CBS 2605 / JCM 1781 / NBRC 1676 / NRRL YB-4239) | 32% | 100% |
| A5GFZ6 | Sus scrofa | 38% | 100% |
| A6ZT19 | Saccharomyces cerevisiae (strain YJM789) | 32% | 100% |
| A7F582 | Sclerotinia sclerotiorum (strain ATCC 18683 / 1980 / Ss-1) | 31% | 100% |
| A7THV5 | Vanderwaltozyma polyspora (strain ATCC 22028 / DSM 70294 / BCRC 21397 / CBS 2163 / NBRC 10782 / NRRL Y-8283 / UCD 57-17) | 32% | 100% |
| A8WRE3 | Caenorhabditis briggsae | 35% | 100% |
| B0W377 | Culex quinquefasciatus | 38% | 100% |
| B0Y0P7 | Neosartorya fumigata (strain CEA10 / CBS 144.89 / FGSC A1163) | 35% | 94% |
| B3LSM6 | Saccharomyces cerevisiae (strain RM11-1a) | 32% | 100% |
| B3MLX7 | Drosophila ananassae | 34% | 100% |
| B4FAT0 | Zea mays | 38% | 96% |
| B4GKQ3 | Drosophila persimilis | 35% | 100% |
| B4HYP0 | Drosophila sechellia | 35% | 100% |
| B4JBC4 | Drosophila grimshawi | 34% | 100% |
| B4KI53 | Drosophila mojavensis | 33% | 100% |
| B4LRB9 | Drosophila virilis | 34% | 100% |
| B4N7R4 | Drosophila willistoni | 34% | 100% |
| B4NXF7 | Drosophila yakuba | 35% | 100% |
| B5DS72 | Drosophila pseudoobscura pseudoobscura | 35% | 100% |
| B5VK45 | Saccharomyces cerevisiae (strain AWRI1631) | 32% | 100% |
| B6TNK6 | Zea mays | 38% | 99% |
| D0A640 | Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) | 51% | 92% |
| E9ADE6 | Leishmania major | 94% | 100% |
| E9AZ70 | Leishmania mexicana (strain MHOM/GT/2001/U1103) | 93% | 100% |
| O44510 | Caenorhabditis elegans | 35% | 100% |
| O59954 | Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139) | 36% | 96% |
| O95396 | Homo sapiens | 38% | 100% |
| P38820 | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) | 32% | 100% |
| P51335 | Porphyra purpurea | 31% | 100% |
| Q09810 | Schizosaccharomyces pombe (strain 972 / ATCC 24843) | 32% | 100% |
| Q0CFD4 | Aspergillus terreus (strain NIH 2624 / FGSC A1156) | 36% | 96% |
| Q17CA7 | Aedes aegypti | 36% | 100% |
| Q1XDF1 | Neopyropia yezoensis | 31% | 100% |
| Q29PG5 | Drosophila pseudoobscura pseudoobscura | 35% | 100% |
| Q2TWN3 | Aspergillus oryzae (strain ATCC 42149 / RIB 40) | 34% | 100% |
| Q4WV19 | Neosartorya fumigata (strain ATCC MYA-4609 / Af293 / CBS 101355 / FGSC A1100) | 35% | 94% |
| Q55FS0 | Dictyostelium discoideum | 34% | 100% |
| Q58E95 | Xenopus laevis | 35% | 100% |
| Q59WH7 | Candida albicans (strain SC5314 / ATCC MYA-2876) | 33% | 100% |
| Q6B908 | Gracilaria tenuistipitata var. liui | 28% | 100% |
| Q6BHZ2 | Debaryomyces hansenii (strain ATCC 36239 / CBS 767 / BCRC 21394 / JCM 1990 / NBRC 0083 / IGC 2968) | 33% | 100% |
| Q6CBK1 | Yarrowia lipolytica (strain CLIB 122 / E 150) | 36% | 100% |
| Q6CMC2 | Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37) | 32% | 100% |
| Q6FR35 | Candida glabrata (strain ATCC 2001 / CBS 138 / JCM 3761 / NBRC 0622 / NRRL Y-65) | 34% | 100% |
| Q756K6 | Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056) | 34% | 100% |
| Q7PY41 | Anopheles gambiae | 37% | 100% |
| Q8AWD2 | Danio rerio | 39% | 100% |
| Q9VLJ8 | Drosophila melanogaster | 35% | 100% |
| Q9ZNW0 | Arabidopsis thaliana | 38% | 100% |
| V5B0X0 | Trypanosoma cruzi | 49% | 94% |