LeishMANIAdb
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Uncharacterized protein

Quick info Annotations Function or PPIs Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
Uncharacterized protein
Gene product:
BRO1-like domain/ALIX V-shaped domain binding to HIV - putative
Species:
Leishmania infantum
UniProt:
A4I2V6_LEIIN
TriTrypDb:
LINF_270023300
Length:
915

Annotations

Annotations by Jardim et al.

Uncharacterized Protein, Uncharacterized

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) yes yes: 2
Forrest at al. (procyclic) yes yes: 2
Silverman et al. no yes: 0
Pissara et al. yes yes: 9
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 5
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 10
NetGPI no yes: 0, no: 10
Cellular components
Term Name Level Count
GO:0005768 endosome 7 1
GO:0031410 cytoplasmic vesicle 6 1
GO:0031982 vesicle 4 1
GO:0043226 organelle 2 1
GO:0043227 membrane-bounded organelle 3 1
GO:0043229 intracellular organelle 3 1
GO:0043231 intracellular membrane-bounded organelle 4 1
GO:0097708 intracellular vesicle 5 1
GO:0110165 cellular anatomical entity 1 1

Expansion

Sequence features

A4I2V6
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4I2V6

Function

Biological processes
Term Name Level Count
GO:0006810 transport 3 11
GO:0016192 vesicle-mediated transport 4 11
GO:0051179 localization 1 11
GO:0051234 establishment of localization 2 11
GO:0071985 multivesicular body sorting pathway 5 11
GO:0006886 intracellular protein transport 4 1
GO:0007034 vacuolar transport 4 1
GO:0008104 protein localization 4 1
GO:0009987 cellular process 1 1
GO:0015031 protein transport 4 1
GO:0016197 endosomal transport 4 1
GO:0032509 endosome transport via multivesicular body sorting pathway 5 1
GO:0032511 late endosome to vacuole transport via multivesicular body sorting pathway 6 1
GO:0033036 macromolecule localization 2 1
GO:0033365 protein localization to organelle 5 1
GO:0043328 protein transport to vacuole involved in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway 5 1
GO:0045184 establishment of protein localization 3 1
GO:0045324 late endosome to vacuole transport 5 1
GO:0046907 intracellular transport 3 1
GO:0051641 cellular localization 2 1
GO:0051649 establishment of localization in cell 3 1
GO:0070727 cellular macromolecule localization 3 1
GO:0071702 organic substance transport 4 1
GO:0071705 nitrogen compound transport 4 1
GO:0072594 establishment of protein localization to organelle 4 1
GO:0072665 protein localization to vacuole 6 1
GO:0072666 establishment of protein localization to vacuole 5 1
Could not find GO molecular_function term for this entry.

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_NRD_NRD_1 298 300 PF00675 0.459
CLV_NRD_NRD_1 414 416 PF00675 0.551
CLV_NRD_NRD_1 506 508 PF00675 0.341
CLV_NRD_NRD_1 779 781 PF00675 0.547
CLV_PCSK_KEX2_1 194 196 PF00082 0.441
CLV_PCSK_KEX2_1 254 256 PF00082 0.304
CLV_PCSK_KEX2_1 506 508 PF00082 0.370
CLV_PCSK_KEX2_1 72 74 PF00082 0.444
CLV_PCSK_KEX2_1 778 780 PF00082 0.548
CLV_PCSK_PC1ET2_1 194 196 PF00082 0.462
CLV_PCSK_PC1ET2_1 254 256 PF00082 0.325
CLV_PCSK_PC1ET2_1 72 74 PF00082 0.444
CLV_PCSK_SKI1_1 107 111 PF00082 0.474
CLV_PCSK_SKI1_1 13 17 PF00082 0.463
CLV_PCSK_SKI1_1 299 303 PF00082 0.524
CLV_PCSK_SKI1_1 736 740 PF00082 0.357
CLV_Separin_Metazoa 446 450 PF03568 0.586
DEG_APCC_DBOX_1 194 202 PF00400 0.391
DEG_SCF_FBW7_2 548 554 PF00400 0.496
DOC_CKS1_1 548 553 PF01111 0.496
DOC_CYCLIN_RxL_1 101 115 PF00134 0.407
DOC_MAPK_gen_1 274 283 PF00069 0.459
DOC_MAPK_gen_1 299 308 PF00069 0.391
DOC_MAPK_gen_1 333 343 PF00069 0.459
DOC_MAPK_gen_1 397 406 PF00069 0.350
DOC_MAPK_MEF2A_6 274 283 PF00069 0.408
DOC_MAPK_NFAT4_5 276 284 PF00069 0.404
DOC_PP1_RVXF_1 105 112 PF00149 0.404
DOC_PP1_RVXF_1 566 572 PF00149 0.491
DOC_PP1_SILK_1 450 455 PF00149 0.513
DOC_USP7_MATH_1 337 341 PF00917 0.351
DOC_USP7_MATH_1 414 418 PF00917 0.457
DOC_USP7_MATH_1 447 451 PF00917 0.637
DOC_USP7_MATH_1 51 55 PF00917 0.459
DOC_USP7_MATH_1 75 79 PF00917 0.369
DOC_USP7_MATH_1 762 766 PF00917 0.547
DOC_USP7_MATH_1 838 842 PF00917 0.680
DOC_USP7_MATH_1 901 905 PF00917 0.665
DOC_USP7_MATH_1 99 103 PF00917 0.459
DOC_USP7_UBL2_3 160 164 PF12436 0.326
DOC_USP7_UBL2_3 190 194 PF12436 0.459
DOC_USP7_UBL2_3 661 665 PF12436 0.621
DOC_WW_Pin1_4 524 529 PF00397 0.586
DOC_WW_Pin1_4 547 552 PF00397 0.496
DOC_WW_Pin1_4 7 12 PF00397 0.544
DOC_WW_Pin1_4 71 76 PF00397 0.431
LIG_14-3-3_CanoR_1 310 319 PF00244 0.368
LIG_14-3-3_CanoR_1 336 342 PF00244 0.523
LIG_14-3-3_CanoR_1 34 40 PF00244 0.440
LIG_14-3-3_CanoR_1 371 380 PF00244 0.368
LIG_14-3-3_CanoR_1 415 422 PF00244 0.558
LIG_14-3-3_CanoR_1 736 742 PF00244 0.554
LIG_Actin_WH2_2 479 494 PF00022 0.513
LIG_AP2alpha_2 379 381 PF02296 0.344
LIG_APCC_ABBA_1 549 554 PF00400 0.538
LIG_APCC_ABBA_1 579 584 PF00400 0.522
LIG_BIR_II_1 1 5 PF00653 0.601
LIG_BRCT_BRCA1_1 339 343 PF00533 0.347
LIG_BRCT_BRCA1_1 434 438 PF00533 0.575
LIG_Dynein_DLC8_1 414 420 PF01221 0.499
LIG_EH1_1 466 474 PF00400 0.513
LIG_EVH1_1 803 807 PF00568 0.561
LIG_EVH1_1 812 816 PF00568 0.558
LIG_FHA_1 175 181 PF00498 0.516
LIG_FHA_1 311 317 PF00498 0.404
LIG_FHA_1 422 428 PF00498 0.510
LIG_FHA_1 43 49 PF00498 0.343
LIG_FHA_1 464 470 PF00498 0.518
LIG_FHA_1 63 69 PF00498 0.444
LIG_FHA_1 687 693 PF00498 0.586
LIG_FHA_2 119 125 PF00498 0.448
LIG_FHA_2 187 193 PF00498 0.485
LIG_FHA_2 327 333 PF00498 0.396
LIG_FHA_2 373 379 PF00498 0.434
LIG_FHA_2 393 399 PF00498 0.458
LIG_FHA_2 44 50 PF00498 0.459
LIG_FHA_2 477 483 PF00498 0.533
LIG_FHA_2 556 562 PF00498 0.537
LIG_FHA_2 640 646 PF00498 0.496
LIG_FHA_2 65 71 PF00498 0.424
LIG_FHA_2 72 78 PF00498 0.339
LIG_LIR_Apic_2 841 847 PF02991 0.655
LIG_LIR_Apic_2 888 894 PF02991 0.690
LIG_LIR_Apic_2 908 912 PF02991 0.733
LIG_LIR_Gen_1 12 21 PF02991 0.344
LIG_LIR_Gen_1 142 151 PF02991 0.326
LIG_LIR_Gen_1 340 351 PF02991 0.373
LIG_LIR_Gen_1 368 373 PF02991 0.448
LIG_LIR_Gen_1 527 537 PF02991 0.545
LIG_LIR_Gen_1 708 718 PF02991 0.491
LIG_LIR_Gen_1 832 840 PF02991 0.636
LIG_LIR_Gen_1 865 873 PF02991 0.648
LIG_LIR_Nem_3 12 17 PF02991 0.398
LIG_LIR_Nem_3 142 146 PF02991 0.326
LIG_LIR_Nem_3 161 166 PF02991 0.495
LIG_LIR_Nem_3 340 346 PF02991 0.373
LIG_LIR_Nem_3 368 372 PF02991 0.330
LIG_LIR_Nem_3 378 384 PF02991 0.342
LIG_LIR_Nem_3 514 520 PF02991 0.574
LIG_LIR_Nem_3 527 533 PF02991 0.540
LIG_LIR_Nem_3 708 713 PF02991 0.491
LIG_LIR_Nem_3 865 869 PF02991 0.648
LIG_MLH1_MIPbox_1 339 343 PF16413 0.344
LIG_MYND_1 860 864 PF01753 0.638
LIG_PDZ_Class_2 910 915 PF00595 0.642
LIG_Pex14_1 113 117 PF04695 0.326
LIG_SH2_CRK 530 534 PF00017 0.514
LIG_SH2_CRK 801 805 PF00017 0.674
LIG_SH2_CRK 820 824 PF00017 0.572
LIG_SH2_CRK 844 848 PF00017 0.591
LIG_SH2_CRK 866 870 PF00017 0.651
LIG_SH2_CRK 87 91 PF00017 0.344
LIG_SH2_CRK 891 895 PF00017 0.760
LIG_SH2_CRK 909 913 PF00017 0.727
LIG_SH2_GRB2like 58 61 PF00017 0.391
LIG_SH2_NCK_1 137 141 PF00017 0.326
LIG_SH2_NCK_1 173 177 PF00017 0.326
LIG_SH2_NCK_1 508 512 PF00017 0.421
LIG_SH2_PTP2 143 146 PF00017 0.387
LIG_SH2_SRC 143 146 PF00017 0.441
LIG_SH2_SRC 239 242 PF00017 0.344
LIG_SH2_SRC 508 511 PF00017 0.586
LIG_SH2_SRC 801 804 PF00017 0.650
LIG_SH2_SRC 824 827 PF00017 0.631
LIG_SH2_SRC 844 847 PF00017 0.636
LIG_SH2_SRC 891 894 PF00017 0.737
LIG_SH2_STAP1 239 243 PF00017 0.344
LIG_SH2_STAP1 508 512 PF00017 0.421
LIG_SH2_STAT5 143 146 PF00017 0.397
LIG_SH2_STAT5 214 217 PF00017 0.373
LIG_SH2_STAT5 342 345 PF00017 0.328
LIG_SH2_STAT5 35 38 PF00017 0.449
LIG_SH2_STAT5 530 533 PF00017 0.591
LIG_SH2_STAT5 741 744 PF00017 0.645
LIG_SH2_STAT5 87 90 PF00017 0.326
LIG_SH3_1 801 807 PF00018 0.618
LIG_SH3_3 347 353 PF00018 0.331
LIG_SH3_3 441 447 PF00018 0.404
LIG_SH3_3 801 807 PF00018 0.634
LIG_SH3_3 810 816 PF00018 0.611
LIG_SH3_3 857 863 PF00018 0.751
LIG_SH3_3 874 880 PF00018 0.567
LIG_TRAF2_1 558 561 PF00917 0.496
LIG_TRAF2_1 617 620 PF00917 0.524
LIG_TYR_ITIM 85 90 PF00017 0.459
LIG_UBA3_1 452 460 PF00899 0.586
LIG_WRC_WIRS_1 243 248 PF05994 0.391
LIG_WW_1 863 866 PF00397 0.622
LIG_WW_2 860 863 PF00397 0.639
MOD_CDK_SPxK_1 7 13 PF00069 0.474
MOD_CK1_1 125 131 PF00069 0.460
MOD_CK1_1 245 251 PF00069 0.397
MOD_CK1_1 30 36 PF00069 0.406
MOD_CK1_1 322 328 PF00069 0.373
MOD_CK1_1 417 423 PF00069 0.543
MOD_CK1_1 42 48 PF00069 0.329
MOD_CK1_1 463 469 PF00069 0.581
MOD_CK1_1 638 644 PF00069 0.593
MOD_CK1_1 71 77 PF00069 0.391
MOD_CK1_1 871 877 PF00069 0.680
MOD_CK2_1 113 119 PF00069 0.460
MOD_CK2_1 125 131 PF00069 0.435
MOD_CK2_1 152 158 PF00069 0.333
MOD_CK2_1 372 378 PF00069 0.398
MOD_CK2_1 392 398 PF00069 0.459
MOD_CK2_1 476 482 PF00069 0.509
MOD_CK2_1 535 541 PF00069 0.645
MOD_CK2_1 555 561 PF00069 0.599
MOD_CK2_1 634 640 PF00069 0.504
MOD_CK2_1 64 70 PF00069 0.391
MOD_CK2_1 643 649 PF00069 0.504
MOD_CK2_1 71 77 PF00069 0.303
MOD_GlcNHglycan 1 4 PF01048 0.748
MOD_GlcNHglycan 101 104 PF01048 0.459
MOD_GlcNHglycan 325 328 PF01048 0.391
MOD_GlcNHglycan 434 437 PF01048 0.504
MOD_GlcNHglycan 462 465 PF01048 0.422
MOD_GlcNHglycan 493 497 PF01048 0.338
MOD_GlcNHglycan 533 536 PF01048 0.379
MOD_GlcNHglycan 591 594 PF01048 0.386
MOD_GlcNHglycan 692 695 PF01048 0.434
MOD_GlcNHglycan 840 843 PF01048 0.679
MOD_GlcNHglycan 903 906 PF01048 0.745
MOD_GSK3_1 113 120 PF00069 0.295
MOD_GSK3_1 123 130 PF00069 0.377
MOD_GSK3_1 146 153 PF00069 0.500
MOD_GSK3_1 241 248 PF00069 0.328
MOD_GSK3_1 310 317 PF00069 0.391
MOD_GSK3_1 319 326 PF00069 0.363
MOD_GSK3_1 35 42 PF00069 0.381
MOD_GSK3_1 361 368 PF00069 0.319
MOD_GSK3_1 417 424 PF00069 0.546
MOD_GSK3_1 463 470 PF00069 0.541
MOD_GSK3_1 472 479 PF00069 0.493
MOD_GSK3_1 531 538 PF00069 0.648
MOD_GSK3_1 58 65 PF00069 0.353
MOD_GSK3_1 634 641 PF00069 0.521
MOD_GSK3_1 649 656 PF00069 0.456
MOD_GSK3_1 682 689 PF00069 0.586
MOD_GSK3_1 71 78 PF00069 0.342
MOD_GSK3_1 737 744 PF00069 0.506
MOD_GSK3_1 867 874 PF00069 0.769
MOD_GSK3_1 901 908 PF00069 0.662
MOD_GSK3_1 99 106 PF00069 0.423
MOD_LATS_1 413 419 PF00433 0.592
MOD_LATS_1 624 630 PF00433 0.513
MOD_N-GLC_1 337 342 PF02516 0.360
MOD_N-GLC_1 42 47 PF02516 0.356
MOD_N-GLC_1 458 463 PF02516 0.386
MOD_N-GLC_1 7 12 PF02516 0.418
MOD_N-GLC_1 75 80 PF02516 0.434
MOD_N-GLC_2 405 407 PF02516 0.557
MOD_N-GLC_2 478 480 PF02516 0.375
MOD_N-GLC_2 705 707 PF02516 0.304
MOD_NEK2_1 117 122 PF00069 0.351
MOD_NEK2_1 139 144 PF00069 0.326
MOD_NEK2_1 175 180 PF00069 0.459
MOD_NEK2_1 246 251 PF00069 0.370
MOD_NEK2_1 372 377 PF00069 0.456
MOD_NEK2_1 448 453 PF00069 0.596
MOD_NEK2_1 634 639 PF00069 0.503
MOD_NEK2_1 68 73 PF00069 0.428
MOD_NEK2_2 217 222 PF00069 0.391
MOD_NEK2_2 337 342 PF00069 0.404
MOD_PIKK_1 146 152 PF00454 0.459
MOD_PIKK_1 310 316 PF00454 0.391
MOD_PIKK_1 415 421 PF00454 0.597
MOD_PIKK_1 458 464 PF00454 0.471
MOD_PIKK_1 639 645 PF00454 0.512
MOD_PIKK_1 762 768 PF00454 0.631
MOD_PIKK_1 769 775 PF00454 0.569
MOD_PIKK_1 793 799 PF00454 0.687
MOD_PKA_1 194 200 PF00069 0.423
MOD_PKA_1 415 421 PF00069 0.609
MOD_PKA_2 194 200 PF00069 0.490
MOD_PKA_2 309 315 PF00069 0.368
MOD_PKA_2 414 420 PF00069 0.563
MOD_PKA_2 448 454 PF00069 0.575
MOD_PKA_2 643 649 PF00069 0.471
MOD_Plk_1 217 223 PF00069 0.375
MOD_Plk_1 27 33 PF00069 0.404
MOD_Plk_1 337 343 PF00069 0.326
MOD_Plk_1 43 49 PF00069 0.204
MOD_Plk_1 731 737 PF00069 0.586
MOD_Plk_1 75 81 PF00069 0.362
MOD_Plk_4 139 145 PF00069 0.356
MOD_Plk_4 175 181 PF00069 0.459
MOD_Plk_4 246 252 PF00069 0.400
MOD_Plk_4 314 320 PF00069 0.466
MOD_Plk_4 337 343 PF00069 0.430
MOD_Plk_4 365 371 PF00069 0.386
MOD_Plk_4 448 454 PF00069 0.561
MOD_Plk_4 58 64 PF00069 0.376
MOD_Plk_4 643 649 PF00069 0.560
MOD_Plk_4 705 711 PF00069 0.504
MOD_Plk_4 716 722 PF00069 0.504
MOD_Plk_4 75 81 PF00069 0.326
MOD_ProDKin_1 524 530 PF00069 0.586
MOD_ProDKin_1 547 553 PF00069 0.496
MOD_ProDKin_1 7 13 PF00069 0.541
MOD_ProDKin_1 71 77 PF00069 0.431
MOD_SUMO_for_1 215 218 PF00179 0.326
MOD_SUMO_for_1 674 677 PF00179 0.513
MOD_SUMO_rev_2 155 162 PF00179 0.378
MOD_SUMO_rev_2 326 334 PF00179 0.519
MOD_SUMO_rev_2 457 461 PF00179 0.538
MOD_SUMO_rev_2 482 491 PF00179 0.594
MOD_SUMO_rev_2 604 610 PF00179 0.526
MOD_SUMO_rev_2 613 623 PF00179 0.489
TRG_DiLeu_BaEn_2 364 370 PF01217 0.444
TRG_ENDOCYTIC_2 143 146 PF00928 0.404
TRG_ENDOCYTIC_2 163 166 PF00928 0.204
TRG_ENDOCYTIC_2 172 175 PF00928 0.290
TRG_ENDOCYTIC_2 239 242 PF00928 0.344
TRG_ENDOCYTIC_2 530 533 PF00928 0.496
TRG_ENDOCYTIC_2 710 713 PF00928 0.491
TRG_ENDOCYTIC_2 820 823 PF00928 0.739
TRG_ENDOCYTIC_2 833 836 PF00928 0.776
TRG_ENDOCYTIC_2 866 869 PF00928 0.632
TRG_ENDOCYTIC_2 87 90 PF00928 0.326
TRG_ER_diArg_1 441 444 PF00400 0.570
TRG_ER_diArg_1 506 508 PF00400 0.568
TRG_ER_diArg_1 778 780 PF00400 0.619
TRG_NES_CRM1_1 196 208 PF08389 0.431
TRG_NES_CRM1_1 867 879 PF08389 0.614
TRG_Pf-PMV_PEXEL_1 557 561 PF00026 0.337
TRG_Pf-PMV_PEXEL_1 603 607 PF00026 0.361
TRG_Pf-PMV_PEXEL_1 745 750 PF00026 0.383

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N1I2T8 Leptomonas seymouri 75% 100%
A0A1X0P4J9 Trypanosomatidae 49% 100%
A0A3S7X0S6 Leishmania donovani 100% 100%
A0A422N9P5 Trypanosoma rangeli 46% 100%
A4HFU0 Leishmania braziliensis 86% 100%
D0A635 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 45% 100%
E9ADE3 Leishmania major 96% 100%
E9AZ67 Leishmania mexicana (strain MHOM/GT/2001/U1103) 90% 98%
F4HXZ1 Arabidopsis thaliana 20% 100%
P79020 Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139) 22% 100%
Q4X0Z5 Neosartorya fumigata (strain ATCC MYA-4609 / Af293 / CBS 101355 / FGSC A1100) 21% 94%
Q8T7K0 Dictyostelium discoideum 21% 100%
Q8WUM4 Homo sapiens 24% 100%
Q9QZA2 Rattus norvegicus 24% 100%
Q9WU78 Mus musculus 24% 100%
V5BQH3 Trypanosoma cruzi 50% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS