LeishMANIAdb
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Guanine nucleotide-binding protein subunit beta-like protein

Quick info Annotations Function or PPIs Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
Guanine nucleotide-binding protein subunit beta-like protein
Gene product:
WD domain - G-beta repeat - putative
Species:
Leishmania infantum
UniProt:
A4I2V5_LEIIN
TriTrypDb:
LINF_270023200
Length:
841

Annotations

Annotations by Jardim et al.

Flagella, inner dynein arm I1 intermediate chain, axonemal

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 11
NetGPI no yes: 0, no: 11
Cellular components
Term Name Level Count
GO:0005737 cytoplasm 2 1
GO:0005858 axonemal dynein complex 4 1
GO:0005875 microtubule associated complex 2 1
GO:0005930 axoneme 2 1
GO:0030286 dynein complex 3 1
GO:0032991 protein-containing complex 1 1
GO:0036156 inner dynein arm 5 1
GO:0110165 cellular anatomical entity 1 2
GO:1902494 catalytic complex 2 1
GO:0005929 cilium 4 1
GO:0031514 motile cilium 5 1
GO:0042995 cell projection 2 1
GO:0043226 organelle 2 1
GO:0043227 membrane-bounded organelle 3 1
GO:0120025 plasma membrane bounded cell projection 3 1

Expansion

Sequence features

A4I2V5
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4I2V5

Function

Biological processes
Term Name Level Count
GO:0001539 cilium or flagellum-dependent cell motility 3 1
GO:0003341 cilium movement 4 1
GO:0007017 microtubule-based process 2 1
GO:0007018 microtubule-based movement 3 1
GO:0009987 cellular process 1 1
GO:0016043 cellular component organization 3 1
GO:0022607 cellular component assembly 4 1
GO:0036159 inner dynein arm assembly 7 1
GO:0043933 protein-containing complex organization 4 1
GO:0048870 cell motility 2 1
GO:0060285 cilium-dependent cell motility 4 1
GO:0060294 cilium movement involved in cell motility 5 1
GO:0065003 protein-containing complex assembly 5 1
GO:0070286 axonemal dynein complex assembly 6 1
GO:0071840 cellular component organization or biogenesis 2 1
Molecular functions
Term Name Level Count
GO:0005488 binding 1 1
GO:0005515 protein binding 2 1
GO:0045503 dynein light chain binding 3 1
GO:0045504 dynein heavy chain binding 3 1

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 182 186 PF00656 0.584
CLV_C14_Caspase3-7 511 515 PF00656 0.538
CLV_C14_Caspase3-7 604 608 PF00656 0.476
CLV_C14_Caspase3-7 85 89 PF00656 0.595
CLV_NRD_NRD_1 159 161 PF00675 0.575
CLV_NRD_NRD_1 171 173 PF00675 0.450
CLV_NRD_NRD_1 260 262 PF00675 0.534
CLV_NRD_NRD_1 271 273 PF00675 0.537
CLV_NRD_NRD_1 296 298 PF00675 0.614
CLV_NRD_NRD_1 486 488 PF00675 0.505
CLV_NRD_NRD_1 559 561 PF00675 0.590
CLV_NRD_NRD_1 690 692 PF00675 0.585
CLV_NRD_NRD_1 721 723 PF00675 0.487
CLV_NRD_NRD_1 734 736 PF00675 0.353
CLV_NRD_NRD_1 794 796 PF00675 0.727
CLV_NRD_NRD_1 81 83 PF00675 0.643
CLV_PCSK_KEX2_1 159 161 PF00082 0.644
CLV_PCSK_KEX2_1 171 173 PF00082 0.636
CLV_PCSK_KEX2_1 273 275 PF00082 0.539
CLV_PCSK_KEX2_1 296 298 PF00082 0.528
CLV_PCSK_KEX2_1 559 561 PF00082 0.590
CLV_PCSK_KEX2_1 690 692 PF00082 0.565
CLV_PCSK_KEX2_1 734 736 PF00082 0.414
CLV_PCSK_KEX2_1 794 796 PF00082 0.727
CLV_PCSK_KEX2_1 83 85 PF00082 0.635
CLV_PCSK_PC1ET2_1 273 275 PF00082 0.502
CLV_PCSK_PC1ET2_1 83 85 PF00082 0.632
CLV_PCSK_PC7_1 269 275 PF00082 0.523
CLV_PCSK_SKI1_1 211 215 PF00082 0.544
CLV_PCSK_SKI1_1 230 234 PF00082 0.323
CLV_PCSK_SKI1_1 315 319 PF00082 0.402
CLV_PCSK_SKI1_1 487 491 PF00082 0.515
CLV_PCSK_SKI1_1 523 527 PF00082 0.514
CLV_PCSK_SKI1_1 54 58 PF00082 0.532
CLV_PCSK_SKI1_1 726 730 PF00082 0.402
CLV_PCSK_SKI1_1 8 12 PF00082 0.518
CLV_Separin_Metazoa 144 148 PF03568 0.597
CLV_Separin_Metazoa 395 399 PF03568 0.716
DEG_APCC_DBOX_1 639 647 PF00400 0.457
DEG_COP1_1 558 568 PF00400 0.702
DEG_SPOP_SBC_1 254 258 PF00917 0.483
DOC_CKS1_1 9 14 PF01111 0.513
DOC_CYCLIN_RxL_1 207 217 PF00134 0.553
DOC_CYCLIN_RxL_1 312 322 PF00134 0.514
DOC_CYCLIN_RxL_1 51 61 PF00134 0.578
DOC_CYCLIN_yClb1_LxF_4 442 447 PF00134 0.397
DOC_CYCLIN_yCln2_LP_2 308 314 PF00134 0.466
DOC_MAPK_gen_1 272 280 PF00069 0.414
DOC_MAPK_gen_1 296 304 PF00069 0.467
DOC_MAPK_gen_1 559 565 PF00069 0.680
DOC_MAPK_gen_1 611 621 PF00069 0.482
DOC_MAPK_gen_1 690 698 PF00069 0.525
DOC_MAPK_MEF2A_6 98 105 PF00069 0.565
DOC_PP1_RVXF_1 442 448 PF00149 0.460
DOC_PP2B_LxvP_1 318 321 PF13499 0.413
DOC_PP2B_LxvP_1 617 620 PF13499 0.529
DOC_USP7_MATH_1 338 342 PF00917 0.516
DOC_USP7_MATH_1 37 41 PF00917 0.718
DOC_USP7_MATH_1 42 46 PF00917 0.735
DOC_USP7_MATH_1 533 537 PF00917 0.513
DOC_USP7_MATH_1 540 544 PF00917 0.397
DOC_USP7_MATH_1 675 679 PF00917 0.467
DOC_USP7_MATH_1 770 774 PF00917 0.593
DOC_USP7_MATH_1 94 98 PF00917 0.617
DOC_USP7_UBL2_3 367 371 PF12436 0.671
DOC_USP7_UBL2_3 826 830 PF12436 0.532
DOC_USP7_UBL2_3 83 87 PF12436 0.610
DOC_WW_Pin1_4 634 639 PF00397 0.425
DOC_WW_Pin1_4 8 13 PF00397 0.728
LIG_14-3-3_CanoR_1 114 124 PF00244 0.568
LIG_14-3-3_CanoR_1 159 163 PF00244 0.602
LIG_14-3-3_CanoR_1 230 239 PF00244 0.576
LIG_14-3-3_CanoR_1 559 566 PF00244 0.714
LIG_14-3-3_CanoR_1 575 581 PF00244 0.345
LIG_14-3-3_CanoR_1 690 698 PF00244 0.467
LIG_14-3-3_CanoR_1 716 724 PF00244 0.519
LIG_14-3-3_CanoR_1 742 750 PF00244 0.513
LIG_14-3-3_CanoR_1 82 90 PF00244 0.648
LIG_14-3-3_CanoR_1 98 104 PF00244 0.541
LIG_Actin_WH2_2 389 406 PF00022 0.698
LIG_Actin_WH2_2 49 66 PF00022 0.521
LIG_APCC_ABBA_1 101 106 PF00400 0.691
LIG_APCC_ABBA_1 222 227 PF00400 0.442
LIG_BIR_II_1 1 5 PF00653 0.700
LIG_BIR_III_2 532 536 PF00653 0.372
LIG_BIR_III_4 88 92 PF00653 0.636
LIG_BRCT_BRCA1_1 18 22 PF00533 0.686
LIG_BRCT_BRCA1_1 677 681 PF00533 0.472
LIG_Clathr_ClatBox_1 245 249 PF01394 0.520
LIG_CSL_BTD_1 501 504 PF09270 0.400
LIG_CSL_BTD_1 635 638 PF09270 0.464
LIG_CtBP_PxDLS_1 48 52 PF00389 0.617
LIG_deltaCOP1_diTrp_1 437 447 PF00928 0.517
LIG_deltaCOP1_diTrp_1 740 743 PF00928 0.542
LIG_eIF4E_1 692 698 PF01652 0.474
LIG_FHA_1 468 474 PF00498 0.492
LIG_FHA_1 51 57 PF00498 0.537
LIG_FHA_1 572 578 PF00498 0.459
LIG_FHA_1 666 672 PF00498 0.508
LIG_FHA_1 731 737 PF00498 0.511
LIG_FHA_2 180 186 PF00498 0.558
LIG_FHA_2 231 237 PF00498 0.505
LIG_FHA_2 239 245 PF00498 0.476
LIG_FHA_2 285 291 PF00498 0.552
LIG_FHA_2 462 468 PF00498 0.462
LIG_FHA_2 509 515 PF00498 0.575
LIG_FHA_2 553 559 PF00498 0.545
LIG_FHA_2 595 601 PF00498 0.392
LIG_FHA_2 602 608 PF00498 0.343
LIG_FHA_2 83 89 PF00498 0.489
LIG_IBAR_NPY_1 808 810 PF08397 0.685
LIG_LIR_Apic_2 217 223 PF02991 0.543
LIG_LIR_Gen_1 275 285 PF02991 0.442
LIG_LIR_Gen_1 459 468 PF02991 0.429
LIG_LIR_Gen_1 547 554 PF02991 0.488
LIG_LIR_Gen_1 654 663 PF02991 0.509
LIG_LIR_Gen_1 817 827 PF02991 0.589
LIG_LIR_Nem_3 226 232 PF02991 0.459
LIG_LIR_Nem_3 275 280 PF02991 0.448
LIG_LIR_Nem_3 387 393 PF02991 0.731
LIG_LIR_Nem_3 459 465 PF02991 0.424
LIG_LIR_Nem_3 499 505 PF02991 0.447
LIG_LIR_Nem_3 654 659 PF02991 0.479
LIG_LIR_Nem_3 678 684 PF02991 0.449
LIG_LIR_Nem_3 704 710 PF02991 0.339
LIG_MYND_1 417 421 PF01753 0.411
LIG_PCNA_yPIPBox_3 195 205 PF02747 0.622
LIG_PDZ_Class_1 836 841 PF00595 0.682
LIG_PTB_Apo_2 137 144 PF02174 0.624
LIG_PTB_Phospho_1 137 143 PF10480 0.622
LIG_SH2_CRK 220 224 PF00017 0.546
LIG_SH2_CRK 615 619 PF00017 0.522
LIG_SH2_NCK_1 622 626 PF00017 0.466
LIG_SH2_PTP2 708 711 PF00017 0.453
LIG_SH2_SRC 220 223 PF00017 0.538
LIG_SH2_SRC 253 256 PF00017 0.554
LIG_SH2_STAP1 225 229 PF00017 0.549
LIG_SH2_STAP1 537 541 PF00017 0.449
LIG_SH2_STAP1 692 696 PF00017 0.485
LIG_SH2_STAP1 739 743 PF00017 0.509
LIG_SH2_STAT3 480 483 PF00017 0.547
LIG_SH2_STAT3 590 593 PF00017 0.410
LIG_SH2_STAT3 692 695 PF00017 0.492
LIG_SH2_STAT5 123 126 PF00017 0.609
LIG_SH2_STAT5 225 228 PF00017 0.541
LIG_SH2_STAT5 253 256 PF00017 0.432
LIG_SH2_STAT5 316 319 PF00017 0.497
LIG_SH2_STAT5 480 483 PF00017 0.534
LIG_SH2_STAT5 570 573 PF00017 0.653
LIG_SH2_STAT5 602 605 PF00017 0.319
LIG_SH2_STAT5 708 711 PF00017 0.440
LIG_SH3_1 622 628 PF00018 0.421
LIG_SH3_2 93 98 PF14604 0.655
LIG_SH3_3 135 141 PF00018 0.696
LIG_SH3_3 188 194 PF00018 0.584
LIG_SH3_3 308 314 PF00018 0.412
LIG_SH3_3 328 334 PF00018 0.228
LIG_SH3_3 394 400 PF00018 0.593
LIG_SH3_3 411 417 PF00018 0.337
LIG_SH3_3 498 504 PF00018 0.463
LIG_SH3_3 6 12 PF00018 0.697
LIG_SH3_3 62 68 PF00018 0.615
LIG_SH3_3 622 628 PF00018 0.509
LIG_SH3_3 635 641 PF00018 0.436
LIG_SH3_3 87 93 PF00018 0.677
LIG_SUMO_SIM_anti_2 243 249 PF11976 0.505
LIG_SUMO_SIM_anti_2 299 307 PF11976 0.473
LIG_SUMO_SIM_par_1 243 249 PF11976 0.455
LIG_SUMO_SIM_par_1 47 53 PF11976 0.610
LIG_SUMO_SIM_par_1 642 648 PF11976 0.339
LIG_SUMO_SIM_par_1 651 657 PF11976 0.335
LIG_SUMO_SIM_par_1 784 793 PF11976 0.713
LIG_TRAF2_1 194 197 PF00917 0.659
LIG_TRAF2_1 320 323 PF00917 0.545
LIG_TRAF2_1 77 80 PF00917 0.624
LIG_TRFH_1 708 712 PF08558 0.508
LIG_WRC_WIRS_1 356 361 PF05994 0.539
LIG_WRC_WIRS_1 565 570 PF05994 0.677
LIG_WRC_WIRS_1 702 707 PF05994 0.337
MOD_CDC14_SPxK_1 637 640 PF00782 0.426
MOD_CDK_SPxK_1 634 640 PF00069 0.393
MOD_CK1_1 129 135 PF00069 0.568
MOD_CK1_1 164 170 PF00069 0.597
MOD_CK1_1 264 270 PF00069 0.385
MOD_CK1_1 300 306 PF00069 0.526
MOD_CK1_1 35 41 PF00069 0.654
MOD_CK1_1 358 364 PF00069 0.579
MOD_CK1_1 527 533 PF00069 0.550
MOD_CK1_1 552 558 PF00069 0.496
MOD_CK1_1 715 721 PF00069 0.463
MOD_CK1_1 74 80 PF00069 0.517
MOD_CK2_1 238 244 PF00069 0.572
MOD_CK2_1 284 290 PF00069 0.483
MOD_CK2_1 422 428 PF00069 0.432
MOD_CK2_1 461 467 PF00069 0.475
MOD_CK2_1 552 558 PF00069 0.511
MOD_CK2_1 715 721 PF00069 0.496
MOD_CK2_1 74 80 PF00069 0.517
MOD_Cter_Amidation 259 262 PF01082 0.570
MOD_Cter_Amidation 270 273 PF01082 0.371
MOD_GlcNHglycan 1 4 PF01048 0.670
MOD_GlcNHglycan 117 120 PF01048 0.677
MOD_GlcNHglycan 263 266 PF01048 0.512
MOD_GlcNHglycan 269 272 PF01048 0.521
MOD_GlcNHglycan 34 37 PF01048 0.656
MOD_GlcNHglycan 361 364 PF01048 0.589
MOD_GlcNHglycan 39 42 PF01048 0.651
MOD_GlcNHglycan 44 47 PF01048 0.619
MOD_GlcNHglycan 494 497 PF01048 0.641
MOD_GlcNHglycan 526 529 PF01048 0.487
MOD_GlcNHglycan 542 545 PF01048 0.400
MOD_GlcNHglycan 718 721 PF01048 0.425
MOD_GlcNHglycan 772 775 PF01048 0.665
MOD_GlcNHglycan 838 841 PF01048 0.632
MOD_GSK3_1 122 129 PF00069 0.579
MOD_GSK3_1 158 165 PF00069 0.642
MOD_GSK3_1 28 35 PF00069 0.625
MOD_GSK3_1 355 362 PF00069 0.480
MOD_GSK3_1 463 470 PF00069 0.496
MOD_GSK3_1 564 571 PF00069 0.661
MOD_GSK3_1 686 693 PF00069 0.491
MOD_GSK3_1 697 704 PF00069 0.277
MOD_GSK3_1 712 719 PF00069 0.398
MOD_GSK3_1 741 748 PF00069 0.541
MOD_GSK3_1 762 769 PF00069 0.590
MOD_LATS_1 557 563 PF00433 0.665
MOD_N-GLC_1 230 235 PF02516 0.573
MOD_N-GLC_1 456 461 PF02516 0.533
MOD_NEK2_1 1 6 PF00069 0.671
MOD_NEK2_1 214 219 PF00069 0.534
MOD_NEK2_1 359 364 PF00069 0.631
MOD_NEK2_1 422 427 PF00069 0.540
MOD_NEK2_1 524 529 PF00069 0.505
MOD_NEK2_1 576 581 PF00069 0.498
MOD_NEK2_1 697 702 PF00069 0.438
MOD_NEK2_1 762 767 PF00069 0.550
MOD_PIKK_1 162 168 PF00454 0.509
MOD_PIKK_1 214 220 PF00454 0.534
MOD_PIKK_1 552 558 PF00454 0.545
MOD_PIKK_1 690 696 PF00454 0.515
MOD_PIKK_1 71 77 PF00454 0.614
MOD_PK_1 559 565 PF00069 0.680
MOD_PK_1 627 633 PF00069 0.456
MOD_PKA_1 261 267 PF00069 0.508
MOD_PKA_1 559 565 PF00069 0.680
MOD_PKA_1 690 696 PF00069 0.540
MOD_PKA_1 82 88 PF00069 0.648
MOD_PKA_2 115 121 PF00069 0.620
MOD_PKA_2 158 164 PF00069 0.646
MOD_PKA_2 558 564 PF00069 0.674
MOD_PKA_2 686 692 PF00069 0.538
MOD_PKA_2 715 721 PF00069 0.531
MOD_PKA_2 730 736 PF00069 0.366
MOD_PKA_2 741 747 PF00069 0.384
MOD_PKA_2 762 768 PF00069 0.582
MOD_Plk_1 298 304 PF00069 0.533
MOD_Plk_2-3 134 140 PF00069 0.701
MOD_Plk_2-3 745 751 PF00069 0.564
MOD_Plk_4 300 306 PF00069 0.463
MOD_Plk_4 355 361 PF00069 0.533
MOD_Plk_4 451 457 PF00069 0.563
MOD_Plk_4 467 473 PF00069 0.500
MOD_Plk_4 549 555 PF00069 0.463
MOD_Plk_4 559 565 PF00069 0.614
MOD_Plk_4 627 633 PF00069 0.438
MOD_Plk_4 68 74 PF00069 0.618
MOD_ProDKin_1 634 640 PF00069 0.425
MOD_ProDKin_1 8 14 PF00069 0.728
MOD_SUMO_for_1 194 197 PF00179 0.599
MOD_SUMO_rev_2 446 454 PF00179 0.440
MOD_SUMO_rev_2 715 725 PF00179 0.568
TRG_DiLeu_BaEn_1 654 659 PF01217 0.481
TRG_DiLeu_BaEn_3 818 824 PF01217 0.604
TRG_DiLeu_BaEn_4 196 202 PF01217 0.631
TRG_DiLeu_BaEn_4 322 328 PF01217 0.528
TRG_DiLeu_BaLyEn_6 501 506 PF01217 0.414
TRG_DiLeu_BaLyEn_6 786 791 PF01217 0.689
TRG_ENDOCYTIC_2 143 146 PF00928 0.596
TRG_ENDOCYTIC_2 615 618 PF00928 0.521
TRG_ER_diArg_1 113 116 PF00400 0.570
TRG_ER_diArg_1 158 160 PF00400 0.649
TRG_ER_diArg_1 171 173 PF00400 0.636
TRG_ER_diArg_1 690 692 PF00400 0.585
TRG_ER_diArg_1 734 736 PF00400 0.408
TRG_ER_diArg_1 794 796 PF00400 0.712
TRG_ER_diArg_1 81 84 PF00400 0.578
TRG_NES_CRM1_1 55 69 PF08389 0.573
TRG_NLS_MonoExtN_4 485 491 PF00514 0.501
TRG_Pf-PMV_PEXEL_1 315 319 PF00026 0.443

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0G2KIZ8 Danio rerio 26% 87%
A0A0N1PF46 Leptomonas seymouri 69% 97%
A0A0S4JPP6 Bodo saltans 42% 100%
A0A1X0P495 Trypanosomatidae 47% 100%
A0A3Q8IEC3 Leishmania donovani 100% 100%
A0A422N9T1 Trypanosoma rangeli 47% 100%
A4HFT9 Leishmania braziliensis 86% 100%
A4HK88 Leishmania braziliensis 24% 100%
B2RY71 Mus musculus 24% 91%
D0A634 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 46% 100%
E9ADE2 Leishmania major 97% 100%
E9AZ66 Leishmania mexicana (strain MHOM/GT/2001/U1103) 92% 99%
Q8IWG1 Homo sapiens 24% 94%
Q95JP0 Macaca fascicularis 23% 94%
V5BGF1 Trypanosoma cruzi 46% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS