Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein - conserved

Species:

Leishmania infantum

UniProt:

A4I2V3_LEIIN

TriTrypDb:

LINF_270022900

Length:

218

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 7
NetGPI	no	yes: 0, no: 7

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4I2V3

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4I2V3

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	200	202	PF00675	0.396
CLV_PCSK_FUR_1	198	202	PF00082	0.369
CLV_PCSK_KEX2_1	200	202	PF00082	0.396
CLV_PCSK_SKI1_1	154	158	PF00082	0.370
CLV_PCSK_SKI1_1	211	215	PF00082	0.492
DEG_APCC_DBOX_1	162	170	PF00400	0.341
DEG_APCC_DBOX_1	210	218	PF00400	0.433
DEG_SPOP_SBC_1	112	116	PF00917	0.466
DEG_SPOP_SBC_1	93	97	PF00917	0.548
DOC_CKS1_1	82	87	PF01111	0.585
DOC_CYCLIN_RxL_1	151	160	PF00134	0.406
DOC_CYCLIN_yCln2_LP_2	34	40	PF00134	0.388
DOC_MAPK_MEF2A_6	154	161	PF00069	0.400
DOC_MAPK_MEF2A_6	75	83	PF00069	0.306
DOC_PP2B_LxvP_1	34	37	PF13499	0.405
DOC_USP7_MATH_1	106	110	PF00917	0.668
DOC_USP7_MATH_1	112	116	PF00917	0.667
DOC_USP7_MATH_1	27	31	PF00917	0.469
DOC_USP7_MATH_1	5	9	PF00917	0.440
DOC_WW_Pin1_4	81	86	PF00397	0.578
LIG_14-3-3_CanoR_1	139	148	PF00244	0.337
LIG_BIR_II_1	1	5	PF00653	0.521
LIG_BRCT_BRCA1_1	40	44	PF00533	0.308
LIG_BRCT_BRCA1_1	63	67	PF00533	0.333
LIG_FHA_1	33	39	PF00498	0.398
LIG_FHA_1	74	80	PF00498	0.400
LIG_FHA_2	210	216	PF00498	0.404
LIG_LIR_Apic_2	87	93	PF02991	0.577
LIG_LIR_Gen_1	53	61	PF02991	0.350
LIG_LIR_Nem_3	13	18	PF02991	0.358
LIG_LIR_Nem_3	143	148	PF02991	0.503
LIG_LIR_Nem_3	43	49	PF02991	0.476
LIG_LIR_Nem_3	53	57	PF02991	0.393
LIG_PCNA_yPIPBox_3	200	214	PF02747	0.415
LIG_Pex14_2	40	44	PF04695	0.334
LIG_SH3_3	210	216	PF00018	0.421
LIG_SH3_3	79	85	PF00018	0.436
LIG_SUMO_SIM_anti_2	76	82	PF11976	0.388
LIG_TRAF2_1	147	150	PF00917	0.316
LIG_WRC_WIRS_1	54	59	PF05994	0.339
MOD_CK1_1	111	117	PF00069	0.578
MOD_CK1_1	178	184	PF00069	0.525
MOD_CK1_1	4	10	PF00069	0.472
MOD_CK1_1	56	62	PF00069	0.332
MOD_CK1_1	73	79	PF00069	0.330
MOD_CK2_1	113	119	PF00069	0.513
MOD_GlcNHglycan	110	113	PF01048	0.714
MOD_GlcNHglycan	25	28	PF01048	0.498
MOD_GlcNHglycan	3	6	PF01048	0.571
MOD_GlcNHglycan	30	33	PF01048	0.427
MOD_GlcNHglycan	7	10	PF01048	0.467
MOD_GlcNHglycan	86	89	PF01048	0.482
MOD_GSK3_1	1	8	PF00069	0.479
MOD_GSK3_1	106	113	PF00069	0.617
MOD_GSK3_1	178	185	PF00069	0.570
MOD_GSK3_1	23	30	PF00069	0.450
MOD_GSK3_1	32	39	PF00069	0.378
MOD_GSK3_1	53	60	PF00069	0.380
MOD_GSK3_1	70	77	PF00069	0.391
MOD_N-GLC_1	106	111	PF02516	0.410
MOD_N-GLC_1	21	26	PF02516	0.415
MOD_NEK2_1	1	6	PF00069	0.541
MOD_NEK2_1	157	162	PF00069	0.389
MOD_NEK2_1	209	214	PF00069	0.414
MOD_NEK2_1	38	43	PF00069	0.319
MOD_NEK2_1	57	62	PF00069	0.270
MOD_Plk_1	186	192	PF00069	0.437
MOD_Plk_1	73	79	PF00069	0.381
MOD_Plk_2-3	182	188	PF00069	0.506
MOD_Plk_4	157	163	PF00069	0.381
MOD_Plk_4	53	59	PF00069	0.360
MOD_Plk_4	74	80	PF00069	0.468
MOD_ProDKin_1	81	87	PF00069	0.580
TRG_DiLeu_BaEn_1	74	79	PF01217	0.325
TRG_DiLeu_BaLyEn_6	13	18	PF01217	0.374
TRG_ER_diArg_1	162	165	PF00400	0.348
TRG_ER_diArg_1	197	200	PF00400	0.420
TRG_Pf-PMV_PEXEL_1	146	150	PF00026	0.320

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P5S5	Leptomonas seymouri	35%	100%
A0A1X0P489	Trypanosomatidae	28%	100%
A0A3S7X0S9	Leishmania donovani	99%	100%
A4HFT6	Leishmania braziliensis	70%	100%
E9ADD9	Leishmania major	87%	100%
E9AZ63	Leishmania mexicana (strain MHOM/GT/2001/U1103)	89%	100%