LeishMANIAdb
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Putative amino acid transporter

Quick info Annotations Function or PPIs Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
Putative amino acid transporter
Gene product:
amino acid transporter - putative
Species:
Leishmania infantum
UniProt:
A4I2V2_LEIIN
TriTrypDb:
LINF_270022800 *
Length:
590

Annotations

LeishMANIAdb annotations

An enormously expanded group of various amino acid transporters.. Localization: Cell surface (by feature)

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 8
Forrest at al. (procyclic) no yes: 8
Silverman et al. no yes: 0
Pissara et al. no yes: 51
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 5
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 5
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 59
NetGPI no yes: 0, no: 59
Cellular components
Term Name Level Count
GO:0016020 membrane 2 48
GO:0110165 cellular anatomical entity 1 48

Expansion

Sequence features

A4I2V2
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4I2V2

Function

Biological processes
Term Name Level Count
GO:0003333 amino acid transmembrane transport 5 11
GO:0006810 transport 3 11
GO:0006865 amino acid transport 5 11
GO:0009987 cellular process 1 11
GO:0015849 organic acid transport 5 11
GO:0051179 localization 1 11
GO:0051234 establishment of localization 2 11
GO:0055085 transmembrane transport 2 11
GO:0071702 organic substance transport 4 11
GO:0071705 nitrogen compound transport 4 11
GO:1903825 organic acid transmembrane transport 3 11
GO:1905039 carboxylic acid transmembrane transport 4 11
Molecular functions
Term Name Level Count
GO:0003824 catalytic activity 1 9
GO:0016787 hydrolase activity 2 9
GO:0005215 transporter activity 1 11
GO:0005342 organic acid transmembrane transporter activity 3 11
GO:0015171 amino acid transmembrane transporter activity 5 11
GO:0015179 L-amino acid transmembrane transporter activity 6 11
GO:0022857 transmembrane transporter activity 2 11
GO:0046943 carboxylic acid transmembrane transporter activity 4 11

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_NRD_NRD_1 135 137 PF00675 0.233
CLV_NRD_NRD_1 416 418 PF00675 0.374
CLV_NRD_NRD_1 426 428 PF00675 0.363
CLV_NRD_NRD_1 464 466 PF00675 0.378
CLV_NRD_NRD_1 478 480 PF00675 0.368
CLV_NRD_NRD_1 511 513 PF00675 0.355
CLV_PCSK_FUR_1 414 418 PF00082 0.373
CLV_PCSK_KEX2_1 135 137 PF00082 0.233
CLV_PCSK_KEX2_1 416 418 PF00082 0.374
CLV_PCSK_KEX2_1 426 428 PF00082 0.363
CLV_PCSK_KEX2_1 463 465 PF00082 0.379
CLV_PCSK_KEX2_1 478 480 PF00082 0.368
CLV_PCSK_KEX2_1 504 506 PF00082 0.359
CLV_PCSK_KEX2_1 511 513 PF00082 0.354
CLV_PCSK_PC1ET2_1 504 506 PF00082 0.359
CLV_PCSK_PC7_1 507 513 PF00082 0.354
CLV_PCSK_SKI1_1 145 149 PF00082 0.349
CLV_PCSK_SKI1_1 495 499 PF00082 0.323
DEG_APCC_DBOX_1 60 68 PF00400 0.520
DOC_MAPK_gen_1 426 433 PF00069 0.585
DOC_MAPK_gen_1 511 521 PF00069 0.568
DOC_MAPK_MEF2A_6 340 347 PF00069 0.223
DOC_MAPK_MEF2A_6 426 433 PF00069 0.569
DOC_PP1_RVXF_1 436 443 PF00149 0.602
DOC_PP1_RVXF_1 505 511 PF00149 0.556
DOC_PP1_RVXF_1 562 569 PF00149 0.565
DOC_PP2B_LxvP_1 213 216 PF13499 0.359
DOC_USP7_MATH_1 481 485 PF00917 0.532
DOC_USP7_MATH_1 95 99 PF00917 0.325
DOC_USP7_MATH_2 216 222 PF00917 0.477
DOC_WW_Pin1_4 288 293 PF00397 0.481
DOC_WW_Pin1_4 531 536 PF00397 0.595
DOC_WW_Pin1_4 547 552 PF00397 0.546
LIG_14-3-3_CanoR_1 135 141 PF00244 0.433
LIG_14-3-3_CanoR_1 14 22 PF00244 0.625
LIG_14-3-3_CanoR_1 181 188 PF00244 0.222
LIG_14-3-3_CanoR_1 223 228 PF00244 0.575
LIG_14-3-3_CanoR_1 564 569 PF00244 0.567
LIG_14-3-3_CanoR_1 580 584 PF00244 0.568
LIG_14-3-3_CanoR_1 59 64 PF00244 0.575
LIG_BRCT_BRCA1_1 272 276 PF00533 0.300
LIG_CtBP_PxDLS_1 544 548 PF00389 0.579
LIG_DLG_GKlike_1 136 143 PF00625 0.422
LIG_FHA_1 105 111 PF00498 0.303
LIG_FHA_1 173 179 PF00498 0.388
LIG_FHA_1 47 53 PF00498 0.586
LIG_FHA_1 63 69 PF00498 0.550
LIG_FHA_2 8 14 PF00498 0.657
LIG_Integrin_isoDGR_2 251 253 PF01839 0.416
LIG_IRF3_LxIS_1 299 306 PF10401 0.420
LIG_LIR_Gen_1 122 130 PF02991 0.345
LIG_LIR_Gen_1 139 148 PF02991 0.557
LIG_LIR_Gen_1 273 284 PF02991 0.372
LIG_LIR_Gen_1 559 566 PF02991 0.561
LIG_LIR_Nem_3 118 124 PF02991 0.395
LIG_LIR_Nem_3 139 143 PF02991 0.558
LIG_LIR_Nem_3 221 227 PF02991 0.441
LIG_LIR_Nem_3 273 279 PF02991 0.387
LIG_LIR_Nem_3 369 375 PF02991 0.595
LIG_LIR_Nem_3 559 563 PF02991 0.559
LIG_NRBOX 63 69 PF00104 0.516
LIG_Pex14_1 161 165 PF04695 0.406
LIG_SH2_GRB2like 336 339 PF00017 0.214
LIG_SH2_PTP2 349 352 PF00017 0.345
LIG_SH2_SRC 171 174 PF00017 0.353
LIG_SH2_STAP1 121 125 PF00017 0.422
LIG_SH2_STAP1 138 142 PF00017 0.448
LIG_SH2_STAP1 54 58 PF00017 0.563
LIG_SH2_STAT5 124 127 PF00017 0.346
LIG_SH2_STAT5 154 157 PF00017 0.400
LIG_SH2_STAT5 171 174 PF00017 0.362
LIG_SH2_STAT5 224 227 PF00017 0.348
LIG_SH2_STAT5 314 317 PF00017 0.486
LIG_SH2_STAT5 322 325 PF00017 0.405
LIG_SH2_STAT5 349 352 PF00017 0.414
LIG_SH2_STAT5 373 376 PF00017 0.517
LIG_SH2_STAT5 476 479 PF00017 0.581
LIG_SH3_3 206 212 PF00018 0.358
LIG_SH3_3 38 44 PF00018 0.592
LIG_SUMO_SIM_anti_2 107 114 PF11976 0.273
LIG_SUMO_SIM_par_1 111 116 PF11976 0.343
LIG_SUMO_SIM_par_1 201 207 PF11976 0.239
LIG_SUMO_SIM_par_1 238 244 PF11976 0.287
LIG_SUMO_SIM_par_1 42 51 PF11976 0.577
LIG_SUMO_SIM_par_1 542 550 PF11976 0.575
LIG_SUMO_SIM_par_1 91 99 PF11976 0.278
LIG_TYR_ITIM 222 227 PF00017 0.481
LIG_TYR_ITIM 334 339 PF00017 0.255
LIG_TYR_ITIM 347 352 PF00017 0.348
LIG_UBA3_1 210 217 PF00899 0.425
LIG_Vh1_VBS_1 105 123 PF01044 0.272
LIG_WRC_WIRS_1 188 193 PF05994 0.245
LIG_WRC_WIRS_1 557 562 PF05994 0.561
MOD_CDK_SPxK_1 292 298 PF00069 0.462
MOD_CK1_1 167 173 PF00069 0.270
MOD_CK1_1 180 186 PF00069 0.250
MOD_CK1_1 187 193 PF00069 0.317
MOD_CK1_1 546 552 PF00069 0.554
MOD_CK1_1 62 68 PF00069 0.531
MOD_CK2_1 480 486 PF00069 0.529
MOD_CMANNOS 503 506 PF00535 0.359
MOD_Cter_Amidation 133 136 PF01082 0.221
MOD_GlcNHglycan 243 246 PF01048 0.532
MOD_GlcNHglycan 483 486 PF01048 0.314
MOD_GlcNHglycan 551 554 PF01048 0.350
MOD_GlcNHglycan 575 578 PF01048 0.369
MOD_GlcNHglycan 90 93 PF01048 0.320
MOD_GSK3_1 115 122 PF00069 0.228
MOD_GSK3_1 167 174 PF00069 0.355
MOD_GSK3_1 180 187 PF00069 0.260
MOD_GSK3_1 288 295 PF00069 0.471
MOD_GSK3_1 531 538 PF00069 0.622
MOD_GSK3_1 539 546 PF00069 0.603
MOD_GSK3_1 59 66 PF00069 0.544
MOD_GSK3_1 96 103 PF00069 0.250
MOD_NEK2_1 1 6 PF00069 0.640
MOD_NEK2_1 100 105 PF00069 0.301
MOD_NEK2_1 191 196 PF00069 0.319
MOD_NEK2_1 260 265 PF00069 0.330
MOD_NEK2_1 279 284 PF00069 0.245
MOD_NEK2_1 303 308 PF00069 0.382
MOD_NEK2_1 433 438 PF00069 0.674
MOD_NEK2_1 545 550 PF00069 0.565
MOD_NEK2_1 579 584 PF00069 0.570
MOD_PIKK_1 303 309 PF00454 0.238
MOD_PIKK_1 7 13 PF00454 0.653
MOD_PK_1 223 229 PF00069 0.455
MOD_PKA_2 13 19 PF00069 0.638
MOD_PKA_2 180 186 PF00069 0.221
MOD_PKA_2 297 303 PF00069 0.537
MOD_PKA_2 579 585 PF00069 0.571
MOD_PKB_1 57 65 PF00069 0.549
MOD_Plk_4 105 111 PF00069 0.387
MOD_Plk_4 116 122 PF00069 0.422
MOD_Plk_4 167 173 PF00069 0.321
MOD_Plk_4 187 193 PF00069 0.407
MOD_Plk_4 270 276 PF00069 0.425
MOD_Plk_4 329 335 PF00069 0.323
MOD_Plk_4 579 585 PF00069 0.571
MOD_Plk_4 63 69 PF00069 0.542
MOD_ProDKin_1 288 294 PF00069 0.481
MOD_ProDKin_1 531 537 PF00069 0.595
MOD_ProDKin_1 547 553 PF00069 0.545
TRG_DiLeu_BaEn_1 486 491 PF01217 0.505
TRG_ENDOCYTIC_2 124 127 PF00928 0.324
TRG_ENDOCYTIC_2 140 143 PF00928 0.481
TRG_ENDOCYTIC_2 224 227 PF00928 0.311
TRG_ENDOCYTIC_2 322 325 PF00928 0.469
TRG_ENDOCYTIC_2 336 339 PF00928 0.274
TRG_ENDOCYTIC_2 349 352 PF00928 0.351
TRG_ENDOCYTIC_2 372 375 PF00928 0.605
TRG_ER_diArg_1 135 137 PF00400 0.433
TRG_ER_diArg_1 416 418 PF00400 0.574
TRG_ER_diArg_1 425 427 PF00400 0.594
TRG_ER_diArg_1 463 465 PF00400 0.579
TRG_ER_diArg_1 477 479 PF00400 0.580
TRG_ER_diArg_1 510 512 PF00400 0.561
TRG_ER_diArg_1 58 61 PF00400 0.625
TRG_Pf-PMV_PEXEL_1 253 257 PF00026 0.411

Homologs

Protein Taxonomy Sequence identity Coverage
A0A3Q8ID74 Leishmania donovani 36% 100%
A0A3Q8IDG8 Leishmania donovani 99% 100%
A0A3Q8IG00 Leishmania donovani 35% 100%
A0A3Q8IHG8 Leishmania donovani 41% 100%
A0A3Q8IJX8 Leishmania donovani 38% 100%
A0A3Q8ILE0 Leishmania donovani 38% 100%
A0A3S5H6T4 Leishmania donovani 41% 100%
A0A3S7WQ39 Leishmania donovani 39% 100%
A0A3S7X443 Leishmania donovani 42% 100%
A0A3S7X458 Leishmania donovani 42% 100%
A0A3S7X4A1 Leishmania donovani 38% 100%
A0A3S7XA86 Leishmania donovani 24% 100%
A0A3S7XCE3 Leishmania donovani 25% 100%
A4HC75 Leishmania braziliensis 38% 100%
A4HFT5 Leishmania braziliensis 78% 100%
A4HJ06 Leishmania braziliensis 37% 100%
A4HJ07 Leishmania braziliensis 41% 100%
A4HJ09 Leishmania braziliensis 39% 100%
A4HJ63 Leishmania braziliensis 40% 100%
A4HNJ6 Leishmania braziliensis 26% 100%
A4HNJ7 Leishmania braziliensis 26% 100%
A4HTE2 Leishmania infantum 39% 100%
A4HZQ0 Leishmania infantum 38% 100%
A4I6I1 Leishmania infantum 39% 100%
A4I6J8 Leishmania infantum 36% 100%
A4I6J9 Leishmania infantum 42% 100%
A4I6L3 Leishmania infantum 35% 100%
A4I6L4 Leishmania infantum 39% 100%
A4IC53 Leishmania infantum 24% 100%
A4IC66 Leishmania infantum 27% 100%
A4ICC3 Leishmania infantum 25% 100%
E8NHF9 Leishmania mexicana (strain MHOM/GT/2001/U1103) 95% 100%
E9AD44 Leishmania major 41% 100%
E9AD45 Leishmania major 37% 100%
E9ADD7 Leishmania major 92% 100%
E9AG08 Leishmania major 26% 100%
E9AG09 Leishmania major 27% 100%
E9AHD7 Leishmania infantum 41% 100%
E9AHD9 Leishmania infantum 36% 100%
E9AHL2 Leishmania infantum 35% 100%
E9ALD5 Leishmania mexicana (strain MHOM/GT/2001/U1103) 39% 100%
E9AUB8 Leishmania mexicana (strain MHOM/GT/2001/U1103) 24% 100%
E9AVK6 Leishmania mexicana (strain MHOM/GT/2001/U1103) 38% 100%
E9AYW8 Leishmania mexicana (strain MHOM/GT/2001/U1103) 40% 100%
E9AYW9 Leishmania mexicana (strain MHOM/GT/2001/U1103) 37% 100%
E9AZ62 Leishmania mexicana (strain MHOM/GT/2001/U1103) 91% 100%
E9B1I4 Leishmania mexicana (strain MHOM/GT/2001/U1103) 41% 100%
E9B1K8 Leishmania mexicana (strain MHOM/GT/2001/U1103) 37% 100%
E9B1N8 Leishmania mexicana (strain MHOM/GT/2001/U1103) 39% 100%
E9B1N9 Leishmania mexicana (strain MHOM/GT/2001/U1103) 39% 100%
E9B761 Leishmania mexicana (strain MHOM/GT/2001/U1103) 23% 100%
E9B762 Leishmania mexicana (strain MHOM/GT/2001/U1103) 26% 100%
Q4Q072 Leishmania major 25% 100%
Q4Q6K6 Leishmania major 33% 100%
Q4Q6M8 Leishmania major 37% 100%
Q4Q6M9 Leishmania major 41% 100%
Q4Q6N0 Leishmania major 41% 100%
Q4QBX3 Leishmania major 37% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS