DNA-directed RNA polymerase II-like protein

Quick info Annotations Localization Abundance Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

DNA-directed RNA polymerase II-like protein

Species:

Leishmania infantum

UniProt:

A4I2U7_LEIIN

TriTrypDb:

LINF_270022300

Length:

134

Annotations

Annotations by Jardim et al.

Polymerase, DNA-directed RNA polymerase II-like

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0000428	DNA-directed RNA polymerase complex	4	11
GO:0005665	RNA polymerase II, core complex	4	11
GO:0030880	RNA polymerase complex	3	11
GO:0032991	protein-containing complex	1	11
GO:0055029	nuclear DNA-directed RNA polymerase complex	3	11
GO:0061695	transferase complex, transferring phosphorus-containing groups	4	11
GO:0140513	nuclear protein-containing complex	2	11
GO:0140535	intracellular protein-containing complex	2	11
GO:1902494	catalytic complex	2	11
GO:1990234	transferase complex	3	11

Abundance

Amastigote (protein)


Source	Evidence on protein	Close homologs
Pescher et al. (upgregulation)	no	yes: 0

Promastigote and amastigote


Source	Evidence on protein	Close homologs
Lahav et al. - mRNA - Protein

Expansion

Sequence features

A4I2U7

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4I2U7

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0001055	RNA polymerase II activity	7	11
GO:0003676	nucleic acid binding	3	11
GO:0003677	DNA binding	4	11
GO:0003824	catalytic activity	1	11
GO:0003899	DNA-directed 5'-3' RNA polymerase activity	6	11
GO:0005488	binding	1	11
GO:0005515	protein binding	2	11
GO:0016740	transferase activity	2	11
GO:0016772	transferase activity, transferring phosphorus-containing groups	3	11
GO:0016779	nucleotidyltransferase activity	4	11
GO:0034062	5'-3' RNA polymerase activity	5	11
GO:0046983	protein dimerization activity	3	11
GO:0097159	organic cyclic compound binding	2	11
GO:0097747	RNA polymerase activity	4	11
GO:0140098	catalytic activity, acting on RNA	3	11
GO:0140640	catalytic activity, acting on a nucleic acid	2	11
GO:1901363	heterocyclic compound binding	2	11

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	121	123	PF00675	0.470
CLV_NRD_NRD_1	25	27	PF00675	0.418
CLV_PCSK_KEX2_1	121	123	PF00082	0.437
CLV_PCSK_SKI1_1	99	103	PF00082	0.220
DOC_MAPK_HePTP_8	55	67	PF00069	0.437
DOC_MAPK_MEF2A_6	58	67	PF00069	0.446
DOC_MAPK_MEF2A_6	77	84	PF00069	0.495
DOC_USP7_MATH_1	37	41	PF00917	0.362
DOC_WW_Pin1_4	12	17	PF00397	0.593
DOC_WW_Pin1_4	129	134	PF00397	0.601
DOC_WW_Pin1_4	59	64	PF00397	0.495
LIG_APCC_ABBA_1	113	118	PF00400	0.489
LIG_BIR_II_1	1	5	PF00653	0.508
LIG_BIR_III_1	1	5	PF00653	0.614
LIG_BIR_III_3	1	5	PF00653	0.614
LIG_BRCT_BRCA1_1	38	42	PF00533	0.355
LIG_Clathr_ClatBox_1	41	45	PF01394	0.405
LIG_GBD_Chelix_1	28	36	PF00786	0.498
LIG_GBD_Chelix_1	51	59	PF00786	0.205
LIG_LIR_Gen_1	61	72	PF02991	0.495
LIG_LIR_Nem_3	61	67	PF02991	0.495
LIG_NRBOX	50	56	PF00104	0.437
LIG_SH2_CRK	70	74	PF00017	0.405
LIG_SH3_3	17	23	PF00018	0.528
LIG_SH3_3	69	75	PF00018	0.408
LIG_SH3_3	92	98	PF00018	0.455
LIG_UBA3_1	41	46	PF00899	0.419
LIG_UBA3_1	54	58	PF00899	0.437
MOD_CK1_1	88	94	PF00069	0.405
MOD_GSK3_1	32	39	PF00069	0.485
MOD_N-GLC_1	37	42	PF02516	0.348
MOD_N-GLC_1	88	93	PF02516	0.289
MOD_N-GLC_2	107	109	PF02516	0.174
MOD_NEK2_1	36	41	PF00069	0.467
MOD_NEK2_1	7	12	PF00069	0.531
MOD_NEK2_2	37	42	PF00069	0.348
MOD_Plk_1	37	43	PF00069	0.349
MOD_Plk_1	47	53	PF00069	0.405
MOD_Plk_4	15	21	PF00069	0.406
MOD_Plk_4	37	43	PF00069	0.358
MOD_ProDKin_1	12	18	PF00069	0.586
MOD_ProDKin_1	59	65	PF00069	0.495
MOD_SUMO_for_1	42	45	PF00179	0.495
MOD_SUMO_rev_2	21	29	PF00179	0.420
TRG_ER_diArg_1	120	122	PF00400	0.460
TRG_NES_CRM1_1	104	118	PF08389	0.504
TRG_Pf-PMV_PEXEL_1	26	30	PF00026	0.391

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PBW2	Leptomonas seymouri	89%	100%
A0A0S4JK82	Bodo saltans	61%	94%
A0A1X0NR94	Trypanosomatidae	30%	99%
A0A1X0P5C3	Trypanosomatidae	68%	100%
A0A3R7MB01	Trypanosoma rangeli	69%	100%
A0A3S7X0R7	Leishmania donovani	99%	100%
A0A422NBI4	Trypanosoma rangeli	35%	99%
A4HFT2	Leishmania braziliensis	96%	100%
D0A622	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	65%	100%
E9ADD4	Leishmania major	98%	100%
E9AZ59	Leishmania mexicana (strain MHOM/GT/2001/U1103)	99%	100%
O08740	Mus musculus	36%	100%
P0DPB6	Homo sapiens	33%	100%
P28000	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	34%	94%
P38902	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	37%	100%
P52435	Homo sapiens	36%	100%
P87123	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	38%	100%
P97304	Mus musculus	31%	100%
Q1RMG8	Bos taurus	33%	100%
Q32P79	Bos taurus	36%	100%
Q38859	Arabidopsis thaliana	34%	100%
Q4XS21	Plasmodium chabaudi	29%	100%
Q4YZZ7	Plasmodium berghei (strain Anka)	29%	100%
Q60SM4	Caenorhabditis briggsae	39%	100%
Q7PVQ9	Anopheles gambiae	37%	100%
Q8IER7	Plasmodium falciparum (isolate 3D7)	30%	100%
Q9H1A7	Homo sapiens	39%	100%
Q9VIZ0	Drosophila melanogaster	30%	100%
Q9VJE4	Drosophila melanogaster	36%	100%
Q9XVH6	Caenorhabditis elegans	36%	100%
V5BGT6	Trypanosoma cruzi	30%	100%