LeishMANIAdb
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60S acidic ribosomal protein P0

Quick info Annotations Function or PPIs Localization Phosphorylation Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
60S acidic ribosomal protein P0
Gene product:
60S acidic ribosomal protein P0 - putative
Species:
Leishmania infantum
UniProt:
A4I2U1_LEIIN
TriTrypDb:
LINF_270020500
Length:
323

Annotations

Annotations by Jardim et al.

Ribosomal Protein, 60S acidic ribosomal P0

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. yes yes: 30
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 7
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. yes yes: 21
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 14
NetGPI no yes: 0, no: 14
Cellular components
Term Name Level Count
GO:0005840 ribosome 5 14
GO:0032991 protein-containing complex 1 15
GO:0043226 organelle 2 14
GO:0043228 non-membrane-bounded organelle 3 14
GO:0043229 intracellular organelle 3 14
GO:0043232 intracellular non-membrane-bounded organelle 4 14
GO:0110165 cellular anatomical entity 1 15
GO:1990904 ribonucleoprotein complex 2 15
GO:0005737 cytoplasm 2 1
GO:0015934 large ribosomal subunit 4 1
GO:0022625 cytosolic large ribosomal subunit 5 1
GO:0044391 ribosomal subunit 3 1

Phosphorylation

Promastigote: 286, 288, 302
Promastigote/Amastigote: 312

Expansion

Sequence features

A4I2U1
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4I2U1

Function

Biological processes
Term Name Level Count
GO:0009987 cellular process 1 15
GO:0022613 ribonucleoprotein complex biogenesis 4 14
GO:0042254 ribosome biogenesis 5 14
GO:0044085 cellular component biogenesis 3 14
GO:0071840 cellular component organization or biogenesis 2 15
GO:0000027 ribosomal large subunit assembly 7 1
GO:0002181 cytoplasmic translation 5 1
GO:0006412 translation 4 1
GO:0006518 peptide metabolic process 4 1
GO:0006807 nitrogen compound metabolic process 2 1
GO:0008152 metabolic process 1 1
GO:0009058 biosynthetic process 2 1
GO:0009059 macromolecule biosynthetic process 4 1
GO:0016043 cellular component organization 3 1
GO:0019538 protein metabolic process 3 1
GO:0022607 cellular component assembly 4 1
GO:0022618 ribonucleoprotein complex assembly 6 1
GO:0034641 cellular nitrogen compound metabolic process 3 1
GO:0034645 obsolete cellular macromolecule biosynthetic process 4 1
GO:0043043 peptide biosynthetic process 5 1
GO:0043170 macromolecule metabolic process 3 1
GO:0043603 amide metabolic process 3 1
GO:0043604 amide biosynthetic process 4 1
GO:0043933 protein-containing complex organization 4 1
GO:0044237 cellular metabolic process 2 1
GO:0044238 primary metabolic process 2 1
GO:0044249 cellular biosynthetic process 3 1
GO:0044260 obsolete cellular macromolecule metabolic process 3 1
GO:0044271 cellular nitrogen compound biosynthetic process 4 1
GO:0065003 protein-containing complex assembly 5 1
GO:0071704 organic substance metabolic process 2 1
GO:0071826 ribonucleoprotein complex subunit organization 5 1
GO:1901564 organonitrogen compound metabolic process 3 1
GO:1901566 organonitrogen compound biosynthetic process 4 1
GO:1901576 organic substance biosynthetic process 3 1
Molecular functions
Term Name Level Count
GO:0003676 nucleic acid binding 3 1
GO:0003723 RNA binding 4 1
GO:0003735 structural constituent of ribosome 2 1
GO:0005198 structural molecule activity 1 1
GO:0005488 binding 1 1
GO:0019843 rRNA binding 5 1
GO:0070180 large ribosomal subunit rRNA binding 6 1
GO:0097159 organic cyclic compound binding 2 1
GO:1901363 heterocyclic compound binding 2 1

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 107 111 PF00656 0.538
CLV_C14_Caspase3-7 172 176 PF00656 0.482
CLV_NRD_NRD_1 42 44 PF00675 0.278
CLV_PCSK_KEX2_1 42 44 PF00082 0.278
CLV_PCSK_KEX2_1 65 67 PF00082 0.285
CLV_PCSK_KEX2_1 77 79 PF00082 0.155
CLV_PCSK_KEX2_1 8 10 PF00082 0.291
CLV_PCSK_PC1ET2_1 65 67 PF00082 0.299
CLV_PCSK_PC1ET2_1 77 79 PF00082 0.155
CLV_PCSK_PC1ET2_1 8 10 PF00082 0.291
CLV_PCSK_SKI1_1 153 157 PF00082 0.311
CLV_PCSK_SKI1_1 165 169 PF00082 0.238
CLV_PCSK_SKI1_1 202 206 PF00082 0.421
CLV_PCSK_SKI1_1 253 257 PF00082 0.281
CLV_PCSK_SKI1_1 42 46 PF00082 0.374
DEG_SPOP_SBC_1 239 243 PF00917 0.456
DOC_CYCLIN_RxL_1 250 259 PF00134 0.482
DOC_MAPK_gen_1 153 161 PF00069 0.482
DOC_MAPK_MEF2A_6 21 30 PF00069 0.581
DOC_MAPK_MEF2A_6 253 260 PF00069 0.550
DOC_PP1_RVXF_1 200 207 PF00149 0.432
DOC_USP7_MATH_1 131 135 PF00917 0.581
DOC_USP7_MATH_1 239 243 PF00917 0.588
DOC_USP7_MATH_1 299 303 PF00917 0.571
DOC_USP7_MATH_1 309 313 PF00917 0.417
DOC_USP7_UBL2_3 61 65 PF12436 0.497
DOC_WW_Pin1_4 121 126 PF00397 0.561
DOC_WW_Pin1_4 185 190 PF00397 0.521
DOC_WW_Pin1_4 70 75 PF00397 0.511
LIG_BIR_III_2 71 75 PF00653 0.456
LIG_BRCT_BRCA1_1 262 266 PF00533 0.574
LIG_FHA_1 104 110 PF00498 0.482
LIG_FHA_1 176 182 PF00498 0.574
LIG_FHA_1 91 97 PF00498 0.500
LIG_FHA_2 133 139 PF00498 0.482
LIG_FHA_2 205 211 PF00498 0.520
LIG_FHA_2 260 266 PF00498 0.458
LIG_GBD_Chelix_1 150 158 PF00786 0.374
LIG_IRF3_LxIS_1 181 188 PF10401 0.482
LIG_LIR_Gen_1 142 151 PF02991 0.482
LIG_LIR_Gen_1 20 30 PF02991 0.502
LIG_LIR_Nem_3 142 148 PF02991 0.482
LIG_LIR_Nem_3 188 194 PF02991 0.374
LIG_LIR_Nem_3 20 25 PF02991 0.485
LIG_LIR_Nem_3 250 255 PF02991 0.482
LIG_LIR_Nem_3 84 89 PF02991 0.530
LIG_NBox_RRM_1 144 154 PF00076 0.482
LIG_PCNA_yPIPBox_3 193 202 PF02747 0.390
LIG_SH2_CRK 22 26 PF00017 0.491
LIG_SH2_CRK 86 90 PF00017 0.571
LIG_SH2_STAP1 11 15 PF00017 0.491
LIG_SH2_STAP1 22 26 PF00017 0.491
LIG_SH3_3 111 117 PF00018 0.439
LIG_SH3_3 125 131 PF00018 0.482
LIG_SH3_3 295 301 PF00018 0.526
LIG_SUMO_SIM_par_1 157 164 PF11976 0.482
LIG_SUMO_SIM_par_1 166 172 PF11976 0.482
LIG_SUMO_SIM_par_1 195 201 PF11976 0.515
LIG_SUMO_SIM_par_1 254 259 PF11976 0.574
LIG_TRAF2_1 101 104 PF00917 0.502
LIG_TRAF2_1 305 308 PF00917 0.494
LIG_TYR_ITSM 18 25 PF00017 0.491
MOD_CDK_SPxxK_3 70 77 PF00069 0.511
MOD_CK1_1 177 183 PF00069 0.482
MOD_CK1_1 259 265 PF00069 0.481
MOD_CK1_1 3 9 PF00069 0.556
MOD_CK1_1 90 96 PF00069 0.530
MOD_CK2_1 132 138 PF00069 0.482
MOD_CK2_1 259 265 PF00069 0.464
MOD_Cter_Amidation 53 56 PF01082 0.282
MOD_GlcNHglycan 285 288 PF01048 0.347
MOD_GlcNHglycan 301 304 PF01048 0.367
MOD_GlcNHglycan 89 92 PF01048 0.373
MOD_GSK3_1 256 263 PF00069 0.574
MOD_N-GLC_1 175 180 PF02516 0.282
MOD_N-GLC_1 185 190 PF02516 0.329
MOD_NEK2_1 256 261 PF00069 0.482
MOD_NEK2_1 283 288 PF00069 0.567
MOD_NEK2_1 95 100 PF00069 0.513
MOD_OFUCOSY 18 24 PF10250 0.381
MOD_PIKK_1 137 143 PF00454 0.574
MOD_PIKK_1 32 38 PF00454 0.482
MOD_PK_1 166 172 PF00069 0.530
MOD_Plk_1 103 109 PF00069 0.492
MOD_Plk_2-3 104 110 PF00069 0.538
MOD_Plk_4 104 110 PF00069 0.561
MOD_Plk_4 140 146 PF00069 0.516
MOD_Plk_4 177 183 PF00069 0.474
MOD_Plk_4 195 201 PF00069 0.207
MOD_ProDKin_1 121 127 PF00069 0.561
MOD_ProDKin_1 185 191 PF00069 0.523
MOD_ProDKin_1 70 76 PF00069 0.511
MOD_SUMO_for_1 305 308 PF00179 0.573
MOD_SUMO_for_1 7 10 PF00179 0.550
MOD_SUMO_rev_2 160 168 PF00179 0.482
MOD_SUMO_rev_2 71 79 PF00179 0.540
TRG_DiLeu_BaEn_1 84 89 PF01217 0.574
TRG_DiLeu_BaEn_4 84 90 PF01217 0.581
TRG_ENDOCYTIC_2 191 194 PF00928 0.390
TRG_ENDOCYTIC_2 22 25 PF00928 0.491
TRG_ENDOCYTIC_2 86 89 PF00928 0.557
TRG_ER_diArg_1 41 43 PF00400 0.478
TRG_Pf-PMV_PEXEL_1 220 224 PF00026 0.456
TRG_Pf-PMV_PEXEL_1 272 276 PF00026 0.374

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N0P2F2 Leptomonas seymouri 82% 100%
A0A1X0P470 Trypanosomatidae 70% 100%
A0A1X0P504 Trypanosomatidae 70% 100%
A0A3Q8IDC2 Leishmania donovani 100% 100%
A0A3S7X0P4 Leishmania donovani 100% 100%
A0A3S7XBL0 Leishmania donovani 22% 100%
A0A422NFR1 Trypanosoma rangeli 72% 99%
A3DNI2 Staphylothermus marinus (strain ATCC 43588 / DSM 3639 / JCM 9404 / F1) 25% 96%
A4FZS8 Methanococcus maripaludis (strain C5 / ATCC BAA-1333) 27% 96%
A4HFR5 Leishmania braziliensis 89% 100%
A4HFR6 Leishmania braziliensis 89% 100%
A4IDP3 Leishmania infantum 22% 100%
A5UKU8 Methanobrevibacter smithii (strain ATCC 35061 / DSM 861 / OCM 144 / PS) 26% 96%
A6UTF8 Methanococcus aeolicus (strain ATCC BAA-1280 / DSM 17508 / OCM 812 / Nankai-3) 26% 96%
A6VIP9 Methanococcus maripaludis (strain C7 / ATCC BAA-1331) 30% 96%
A8ABQ7 Ignicoccus hospitalis (strain KIN4/I / DSM 18386 / JCM 14125) 24% 93%
A9A838 Methanococcus maripaludis (strain C6 / ATCC BAA-1332) 29% 96%
B0R4W1 Halobacterium salinarum (strain ATCC 29341 / DSM 671 / R1) 28% 92%
B6YSX9 Thermococcus onnurineus (strain NA1) 28% 95%
C3MR85 Sulfolobus islandicus (strain L.S.2.15 / Lassen #1) 24% 96%
C3MXH4 Sulfolobus islandicus (strain M.14.25 / Kamchatka #1) 24% 96%
C3MZC0 Sulfolobus islandicus (strain M.16.27) 24% 96%
C3N7E1 Sulfolobus islandicus (strain Y.G.57.14 / Yellowstone #1) 24% 96%
C3NG93 Sulfolobus islandicus (strain Y.N.15.51 / Yellowstone #2) 24% 96%
C4KIJ9 Sulfolobus islandicus (strain M.16.4 / Kamchatka #3) 24% 96%
C5A428 Thermococcus gammatolerans (strain DSM 15229 / JCM 11827 / EJ3) 26% 95%
C6A1F5 Thermococcus sibiricus (strain DSM 12597 / MM 739) 28% 96%
D0A606 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 68% 99%
D0A607 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 68% 99%
E8NHJ8 Leishmania mexicana (strain MHOM/GT/2001/U1103) 96% 100%
E9ADB9 Leishmania major 98% 100%
E9ATP9 Leishmania mexicana (strain MHOM/GT/2001/U1103) 23% 100%
G0S616 Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719) 25% 100%
O04204 Arabidopsis thaliana 43% 100%
O24573 Zea mays 42% 100%
O27717 Methanothermobacter thermautotrophicus (strain ATCC 29096 / DSM 1053 / JCM 10044 / NBRC 100330 / Delta H) 26% 96%
O28781 Archaeoglobus fulgidus (strain ATCC 49558 / DSM 4304 / JCM 9628 / NBRC 100126 / VC-16) 23% 95%
O52705 Methanothermococcus thermolithotrophicus 28% 96%
O74109 Pyrococcus horikoshii (strain ATCC 700860 / DSM 12428 / JCM 9974 / NBRC 100139 / OT-3) 27% 94%
O74864 Schizosaccharomyces pombe (strain 972 / ATCC 24843) 44% 100%
P05317 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) 41% 100%
P05388 Homo sapiens 39% 100%
P13553 Halobacterium salinarum (strain ATCC 700922 / JCM 11081 / NRC-1) 28% 92%
P14869 Mus musculus 39% 100%
P15825 Haloarcula marismortui (strain ATCC 43049 / DSM 3752 / JCM 8966 / VKM B-1809) 25% 93%
P15826 Methanococcus vannielii (strain ATCC 35089 / DSM 1224 / JCM 13029 / OCM 148 / SB) 29% 96%
P19889 Drosophila melanogaster 39% 100%
P19945 Rattus norvegicus 39% 100%
P22685 Dictyostelium discoideum 40% 100%
P26796 Trypanosoma cruzi 68% 100%
P29764 Oxybasis rubra 41% 100%
P35023 Sulfolobus acidocaldarius (strain ATCC 33909 / DSM 639 / JCM 8929 / NBRC 15157 / NCIMB 11770) 27% 96%
P39096 Leishmania chagasi 98% 100%
P39097 Leishmania infantum 97% 100%
P41095 Oryza sativa subsp. japonica 41% 100%
P41198 Haloferax volcanii (strain ATCC 29605 / DSM 3757 / JCM 8879 / NBRC 14742 / NCIMB 2012 / VKM B-1768 / DS2) 27% 93%
P47826 Gallus gallus 40% 100%
P50345 Lupinus luteus 42% 100%
P50346 Glycine max 43% 100%
P54049 Methanocaldococcus jannaschii (strain ATCC 43067 / DSM 2661 / JAL-1 / JCM 10045 / NBRC 100440) 26% 96%
P57691 Arabidopsis thaliana 42% 100%
P57692 Thermoplasma acidophilum (strain ATCC 25905 / DSM 1728 / JCM 9062 / NBRC 15155 / AMRC-C165) 23% 100%
P96039 Saccharolobus solfataricus (strain ATCC 35092 / DSM 1617 / JCM 11322 / P2) 25% 96%
Q12UP8 Methanococcoides burtonii (strain DSM 6242 / NBRC 107633 / OCM 468 / ACE-M) 23% 96%
Q29214 Sus scrofa 39% 100%
Q2NEW2 Methanosphaera stadtmanae (strain ATCC 43021 / DSM 3091 / JCM 11832 / MCB-3) 24% 97%
Q3INI7 Natronomonas pharaonis (strain ATCC 35678 / DSM 2160 / CIP 103997 / JCM 8858 / NBRC 14720 / NCIMB 2260 / Gabara) 26% 91%
Q42112 Arabidopsis thaliana 42% 100%
Q46EU9 Methanosarcina barkeri (strain Fusaro / DSM 804) 26% 93%
Q4Q0U9 Leishmania major 22% 100%
Q5JH36 Thermococcus kodakarensis (strain ATCC BAA-918 / JCM 12380 / KOD1) 27% 95%
Q6L1X8 Picrophilus torridus (strain ATCC 700027 / DSM 9790 / JCM 10055 / NBRC 100828) 20% 100%
Q6M0L1 Methanococcus maripaludis (strain S2 / LL) 29% 96%
Q75DK9 Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056) 25% 100%
Q7S302 Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987) 26% 100%
Q8NHW5 Homo sapiens 37% 100%
Q8PY51 Methanosarcina mazei (strain ATCC BAA-159 / DSM 3647 / Goe1 / Go1 / JCM 11833 / OCM 88) 24% 93%
Q8SRJ7 Encephalitozoon cuniculi (strain GB-M1) 36% 100%
Q8TI80 Methanosarcina acetivorans (strain ATCC 35395 / DSM 2834 / JCM 12185 / C2A) 25% 93%
Q8TX50 Methanopyrus kandleri (strain AV19 / DSM 6324 / JCM 9639 / NBRC 100938) 29% 90%
Q8TZJ8 Pyrococcus furiosus (strain ATCC 43587 / DSM 3638 / JCM 8422 / Vc1) 28% 95%
Q8ZTT3 Pyrobaculum aerophilum (strain ATCC 51768 / DSM 7523 / JCM 9630 / CIP 104966 / NBRC 100827 / IM2) 26% 94%
Q90YX1 Ictalurus punctatus 40% 100%
Q93572 Caenorhabditis elegans 39% 100%
Q94660 Plasmodium falciparum (isolate 7G8) 39% 100%
Q95140 Bos taurus 39% 100%
Q967Y7 Eimeria tenella 35% 100%
Q96TJ5 Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987) 39% 100%
Q971J2 Sulfurisphaera tokodaii (strain DSM 16993 / JCM 10545 / NBRC 100140 / 7) 26% 97%
Q97BN3 Thermoplasma volcanium (strain ATCC 51530 / DSM 4299 / JCM 9571 / NBRC 15438 / GSS1) 25% 100%
Q9C3Z6 Podospora anserina 39% 100%
Q9DG68 Lithobates sylvaticus 40% 100%
Q9PV90 Danio rerio 39% 100%
Q9U3U0 Ceratitis capitata 38% 100%
Q9UXS5 Pyrococcus abyssi (strain GE5 / Orsay) 26% 95%
Q9Y8J3 Methanococcus voltae 29% 100%
V5BL26 Trypanosoma cruzi 68% 99%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS