LeishMANIAdb
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Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:
Uncharacterized protein
Gene product:
hypothetical protein - conserved
Species:
Leishmania infantum
UniProt:
A4I2T7_LEIIN
TriTrypDb:
LINF_270020100
Length:
360

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 6
NetGPI no yes: 0, no: 6
Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4I2T7
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4I2T7

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 62 66 PF00656 0.563
CLV_NRD_NRD_1 133 135 PF00675 0.583
CLV_NRD_NRD_1 145 147 PF00675 0.424
CLV_NRD_NRD_1 260 262 PF00675 0.607
CLV_NRD_NRD_1 37 39 PF00675 0.614
CLV_PCSK_KEX2_1 145 147 PF00082 0.494
CLV_PCSK_KEX2_1 259 261 PF00082 0.571
CLV_PCSK_KEX2_1 314 316 PF00082 0.840
CLV_PCSK_KEX2_1 36 38 PF00082 0.571
CLV_PCSK_PC1ET2_1 314 316 PF00082 0.626
CLV_PCSK_PC7_1 256 262 PF00082 0.695
CLV_PCSK_SKI1_1 140 144 PF00082 0.606
CLV_PCSK_SKI1_1 322 326 PF00082 0.728
CLV_PCSK_SKI1_1 52 56 PF00082 0.723
CLV_PCSK_SKI1_1 89 93 PF00082 0.758
DEG_APCC_DBOX_1 155 163 PF00400 0.561
DEG_APCC_KENBOX_2 201 205 PF00400 0.552
DEG_Nend_UBRbox_1 1 4 PF02207 0.644
DEG_SCF_FBW7_1 78 85 PF00400 0.822
DEG_SPOP_SBC_1 329 333 PF00917 0.583
DOC_CKS1_1 269 274 PF01111 0.698
DOC_CKS1_1 39 44 PF01111 0.716
DOC_CYCLIN_yCln2_LP_2 39 45 PF00134 0.733
DOC_MAPK_gen_1 140 150 PF00069 0.647
DOC_MAPK_gen_1 156 164 PF00069 0.489
DOC_MAPK_gen_1 339 348 PF00069 0.639
DOC_MAPK_MEF2A_6 158 166 PF00069 0.655
DOC_MAPK_MEF2A_6 48 57 PF00069 0.698
DOC_PP1_RVXF_1 179 186 PF00149 0.634
DOC_PP1_RVXF_1 341 348 PF00149 0.575
DOC_PP4_FxxP_1 27 30 PF00568 0.549
DOC_PP4_MxPP_1 80 83 PF00568 0.749
DOC_SPAK_OSR1_1 172 176 PF12202 0.555
DOC_USP7_UBL2_3 48 52 PF12436 0.779
DOC_WW_Pin1_4 268 273 PF00397 0.697
DOC_WW_Pin1_4 297 302 PF00397 0.755
DOC_WW_Pin1_4 38 43 PF00397 0.768
DOC_WW_Pin1_4 78 83 PF00397 0.820
DOC_WW_Pin1_4 89 94 PF00397 0.608
LIG_14-3-3_CanoR_1 156 166 PF00244 0.521
LIG_14-3-3_CanoR_1 207 215 PF00244 0.532
LIG_14-3-3_CanoR_1 87 92 PF00244 0.745
LIG_APCC_ABBA_1 229 234 PF00400 0.519
LIG_APCC_ABBAyCdc20_2 228 234 PF00400 0.520
LIG_FHA_1 103 109 PF00498 0.453
LIG_FHA_1 330 336 PF00498 0.702
LIG_FHA_1 39 45 PF00498 0.791
LIG_FHA_1 86 92 PF00498 0.737
LIG_FHA_2 163 169 PF00498 0.542
LIG_FHA_2 331 337 PF00498 0.646
LIG_LIR_Gen_1 178 187 PF02991 0.564
LIG_LIR_Gen_1 212 223 PF02991 0.614
LIG_LIR_Nem_3 178 182 PF02991 0.580
LIG_LIR_Nem_3 212 218 PF02991 0.597
LIG_NRBOX 158 164 PF00104 0.552
LIG_Pex14_2 120 124 PF04695 0.579
LIG_SH2_STAP1 179 183 PF00017 0.518
LIG_SH2_STAP1 215 219 PF00017 0.549
LIG_SH2_STAT5 68 71 PF00017 0.715
LIG_SH3_3 271 277 PF00018 0.664
LIG_SH3_3 80 86 PF00018 0.748
LIG_SH3_4 48 55 PF00018 0.742
LIG_SUMO_SIM_par_1 162 168 PF11976 0.648
LIG_TRAF2_1 267 270 PF00917 0.669
MOD_CDK_SPK_2 82 87 PF00069 0.748
MOD_CDK_SPxxK_3 82 89 PF00069 0.651
MOD_CK1_1 268 274 PF00069 0.583
MOD_CK1_1 60 66 PF00069 0.709
MOD_CK1_1 74 80 PF00069 0.614
MOD_CK1_1 85 91 PF00069 0.658
MOD_CK2_1 162 168 PF00069 0.524
MOD_CK2_1 315 321 PF00069 0.789
MOD_CK2_1 347 353 PF00069 0.717
MOD_GlcNHglycan 115 118 PF01048 0.608
MOD_GlcNHglycan 265 268 PF01048 0.689
MOD_GlcNHglycan 317 320 PF01048 0.788
MOD_GlcNHglycan 321 325 PF01048 0.722
MOD_GlcNHglycan 61 65 PF01048 0.681
MOD_GSK3_1 123 130 PF00069 0.509
MOD_GSK3_1 287 294 PF00069 0.638
MOD_GSK3_1 309 316 PF00069 0.762
MOD_GSK3_1 5 12 PF00069 0.462
MOD_GSK3_1 60 67 PF00069 0.651
MOD_GSK3_1 74 81 PF00069 0.627
MOD_GSK3_1 85 92 PF00069 0.731
MOD_N-GLC_1 287 292 PF02516 0.798
MOD_NEK2_1 113 118 PF00069 0.695
MOD_NEK2_1 162 167 PF00069 0.507
MOD_NEK2_1 238 243 PF00069 0.654
MOD_NEK2_1 59 64 PF00069 0.663
MOD_PIKK_1 157 163 PF00454 0.484
MOD_PIKK_1 238 244 PF00454 0.543
MOD_PIKK_1 265 271 PF00454 0.589
MOD_PIKK_1 5 11 PF00454 0.596
MOD_PKA_2 157 163 PF00069 0.493
MOD_PKA_2 263 269 PF00069 0.643
MOD_Plk_1 64 70 PF00069 0.746
MOD_Plk_4 108 114 PF00069 0.619
MOD_Plk_4 64 70 PF00069 0.711
MOD_ProDKin_1 268 274 PF00069 0.697
MOD_ProDKin_1 297 303 PF00069 0.755
MOD_ProDKin_1 38 44 PF00069 0.768
MOD_ProDKin_1 78 84 PF00069 0.822
MOD_ProDKin_1 89 95 PF00069 0.606
TRG_DiLeu_BaEn_2 177 183 PF01217 0.538
TRG_DiLeu_BaEn_2 233 239 PF01217 0.518
TRG_DiLeu_BaEn_2 343 349 PF01217 0.485
TRG_ENDOCYTIC_2 179 182 PF00928 0.566
TRG_ENDOCYTIC_2 215 218 PF00928 0.521
TRG_ER_diArg_1 156 159 PF00400 0.652
TRG_ER_diArg_1 259 261 PF00400 0.519
TRG_ER_diArg_1 338 341 PF00400 0.605
TRG_ER_diArg_1 36 38 PF00400 0.571
TRG_ER_diArg_1 86 89 PF00400 0.651
TRG_Pf-PMV_PEXEL_1 146 151 PF00026 0.656
TRG_Pf-PMV_PEXEL_1 198 203 PF00026 0.680
TRG_Pf-PMV_PEXEL_1 217 221 PF00026 0.348

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N1PAE2 Leptomonas seymouri 41% 74%
A0A3S7X0P6 Leishmania donovani 99% 100%
A4HFR1 Leishmania braziliensis 55% 100%
E9ADB5 Leishmania major 86% 100%
E9AZ40 Leishmania mexicana (strain MHOM/GT/2001/U1103) 82% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS