LeishMANIAdb
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Arginine--tRNA ligase

Quick info Annotations Function or PPIs Localization Abundance Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
Arginine--tRNA ligase
Gene product:
arginyl-tRNA synthetase - putative
Species:
Leishmania infantum
UniProt:
A4I2T4_LEIIN
TriTrypDb:
LINF_270019800
Length:
692

Annotations

Annotations by Jardim et al.

tRNA synthetase, arginyl-tRNA synthetase

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. yes yes: 1
Forrest at al. (metacyclic) yes yes: 1
Forrest at al. (procyclic) yes yes: 1
Silverman et al. no yes: 1
Pissara et al. yes yes: 5
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 3
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 3
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 11
NetGPI no yes: 0, no: 11
Cellular components
Term Name Level Count
GO:0005737 cytoplasm 2 11
GO:0110165 cellular anatomical entity 1 11
GO:0032838 plasma membrane bounded cell projection cytoplasm 4 1
GO:0097014 ciliary plasm 5 1
GO:0099568 cytoplasmic region 3 1

Abundance

Amastigote (protein)
Source Evidence on protein Close homologs
Pescher et al. (upgregulation) no yes: 0
Promastigote and amastigote
Source Evidence on protein Close homologs
Lahav et al.
- mRNA
- Protein

Expansion

Sequence features

A4I2T4
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4I2T4

Function

Biological processes
Term Name Level Count
GO:0006082 organic acid metabolic process 3 12
GO:0006139 nucleobase-containing compound metabolic process 3 12
GO:0006399 tRNA metabolic process 7 12
GO:0006418 tRNA aminoacylation for protein translation 6 12
GO:0006420 arginyl-tRNA aminoacylation 7 12
GO:0006520 amino acid metabolic process 3 12
GO:0006725 cellular aromatic compound metabolic process 3 12
GO:0006807 nitrogen compound metabolic process 2 12
GO:0008152 metabolic process 1 12
GO:0009987 cellular process 1 12
GO:0016070 RNA metabolic process 5 12
GO:0019752 carboxylic acid metabolic process 5 12
GO:0034641 cellular nitrogen compound metabolic process 3 12
GO:0034660 ncRNA metabolic process 6 12
GO:0043038 amino acid activation 4 12
GO:0043039 tRNA aminoacylation 5 12
GO:0043170 macromolecule metabolic process 3 12
GO:0043436 oxoacid metabolic process 4 12
GO:0044237 cellular metabolic process 2 12
GO:0044238 primary metabolic process 2 12
GO:0044281 small molecule metabolic process 2 12
GO:0046483 heterocycle metabolic process 3 12
GO:0071704 organic substance metabolic process 2 12
GO:0090304 nucleic acid metabolic process 4 12
GO:1901360 organic cyclic compound metabolic process 3 12
GO:1901564 organonitrogen compound metabolic process 3 12
Molecular functions
Term Name Level Count
GO:0000166 nucleotide binding 3 12
GO:0003824 catalytic activity 1 12
GO:0004812 aminoacyl-tRNA ligase activity 4 12
GO:0004814 arginine-tRNA ligase activity 5 12
GO:0005488 binding 1 12
GO:0005524 ATP binding 5 12
GO:0016874 ligase activity 2 12
GO:0016875 ligase activity, forming carbon-oxygen bonds 3 12
GO:0017076 purine nucleotide binding 4 12
GO:0030554 adenyl nucleotide binding 5 12
GO:0032553 ribonucleotide binding 3 12
GO:0032555 purine ribonucleotide binding 4 12
GO:0032559 adenyl ribonucleotide binding 5 12
GO:0035639 purine ribonucleoside triphosphate binding 4 12
GO:0036094 small molecule binding 2 12
GO:0043167 ion binding 2 12
GO:0043168 anion binding 3 12
GO:0097159 organic cyclic compound binding 2 12
GO:0097367 carbohydrate derivative binding 2 12
GO:0140098 catalytic activity, acting on RNA 3 12
GO:0140101 catalytic activity, acting on a tRNA 4 12
GO:0140640 catalytic activity, acting on a nucleic acid 2 12
GO:1901265 nucleoside phosphate binding 3 12
GO:1901363 heterocyclic compound binding 2 12

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 288 292 PF00656 0.542
CLV_C14_Caspase3-7 305 309 PF00656 0.335
CLV_C14_Caspase3-7 485 489 PF00656 0.464
CLV_MEL_PAP_1 407 413 PF00089 0.341
CLV_NRD_NRD_1 301 303 PF00675 0.540
CLV_NRD_NRD_1 588 590 PF00675 0.264
CLV_NRD_NRD_1 99 101 PF00675 0.494
CLV_PCSK_KEX2_1 185 187 PF00082 0.254
CLV_PCSK_KEX2_1 588 590 PF00082 0.267
CLV_PCSK_PC1ET2_1 185 187 PF00082 0.264
CLV_PCSK_PC1ET2_1 588 590 PF00082 0.267
CLV_PCSK_SKI1_1 106 110 PF00082 0.504
CLV_PCSK_SKI1_1 206 210 PF00082 0.265
CLV_PCSK_SKI1_1 310 314 PF00082 0.481
CLV_PCSK_SKI1_1 358 362 PF00082 0.510
CLV_PCSK_SKI1_1 490 494 PF00082 0.264
DEG_APCC_DBOX_1 368 376 PF00400 0.496
DEG_APCC_DBOX_1 665 673 PF00400 0.475
DEG_CRL4_CDT2_1 199 211 PF00400 0.361
DEG_CRL4_CDT2_2 199 211 PF00400 0.361
DEG_Nend_UBRbox_4 1 3 PF02207 0.631
DEG_ODPH_VHL_1 379 392 PF01847 0.437
DOC_CKS1_1 606 611 PF01111 0.475
DOC_CYCLIN_RxL_1 152 163 PF00134 0.550
DOC_CYCLIN_RxL_1 273 283 PF00134 0.489
DOC_CYCLIN_RxL_1 674 687 PF00134 0.569
DOC_MAPK_DCC_7 384 392 PF00069 0.550
DOC_MAPK_FxFP_2 411 414 PF00069 0.464
DOC_MAPK_gen_1 123 130 PF00069 0.463
DOC_MAPK_gen_1 219 226 PF00069 0.515
DOC_MAPK_gen_1 384 392 PF00069 0.550
DOC_MAPK_gen_1 493 502 PF00069 0.541
DOC_MAPK_gen_1 678 686 PF00069 0.489
DOC_MAPK_HePTP_8 382 394 PF00069 0.541
DOC_MAPK_MEF2A_6 123 130 PF00069 0.487
DOC_MAPK_MEF2A_6 365 372 PF00069 0.525
DOC_MAPK_MEF2A_6 385 394 PF00069 0.541
DOC_MAPK_MEF2A_6 92 99 PF00069 0.550
DOC_PP1_RVXF_1 153 160 PF00149 0.550
DOC_PP4_FxxP_1 130 133 PF00568 0.464
DOC_PP4_FxxP_1 269 272 PF00568 0.475
DOC_PP4_FxxP_1 411 414 PF00568 0.464
DOC_SPAK_OSR1_1 437 441 PF12202 0.569
DOC_USP7_MATH_1 321 325 PF00917 0.603
DOC_USP7_UBL2_3 109 113 PF12436 0.549
DOC_USP7_UBL2_3 15 19 PF12436 0.541
DOC_USP7_UBL2_3 299 303 PF12436 0.439
DOC_USP7_UBL2_3 357 361 PF12436 0.443
DOC_WW_Pin1_4 605 610 PF00397 0.470
DOC_WW_Pin1_4 63 68 PF00397 0.492
DOC_WW_Pin1_4 87 92 PF00397 0.425
LIG_14-3-3_CanoR_1 410 414 PF00244 0.475
LIG_14-3-3_CanoR_1 620 625 PF00244 0.546
LIG_14-3-3_CanoR_1 674 678 PF00244 0.475
LIG_Actin_WH2_2 132 147 PF00022 0.475
LIG_Actin_WH2_2 536 554 PF00022 0.477
LIG_Actin_WH2_2 612 629 PF00022 0.505
LIG_Actin_WH2_2 663 680 PF00022 0.475
LIG_BRCT_BRCA1_1 648 652 PF00533 0.470
LIG_Clathr_ClatBox_1 683 687 PF01394 0.569
LIG_deltaCOP1_diTrp_1 172 177 PF00928 0.455
LIG_deltaCOP1_diTrp_1 467 476 PF00928 0.465
LIG_FAT_LD_1 372 380 PF03623 0.485
LIG_FHA_1 426 432 PF00498 0.507
LIG_FHA_1 497 503 PF00498 0.475
LIG_FHA_1 5 11 PF00498 0.526
LIG_FHA_1 621 627 PF00498 0.541
LIG_FHA_1 678 684 PF00498 0.550
LIG_FHA_2 259 265 PF00498 0.507
LIG_FHA_2 343 349 PF00498 0.505
LIG_FHA_2 462 468 PF00498 0.550
LIG_FHA_2 483 489 PF00498 0.475
LIG_FHA_2 606 612 PF00498 0.472
LIG_FHA_2 626 632 PF00498 0.447
LIG_LIR_Apic_2 129 133 PF02991 0.464
LIG_LIR_Apic_2 267 272 PF02991 0.475
LIG_LIR_Gen_1 249 258 PF02991 0.450
LIG_LIR_Gen_1 388 398 PF02991 0.541
LIG_LIR_Gen_1 432 443 PF02991 0.506
LIG_LIR_Gen_1 562 569 PF02991 0.527
LIG_LIR_Gen_1 639 648 PF02991 0.475
LIG_LIR_Nem_3 175 180 PF02991 0.495
LIG_LIR_Nem_3 249 254 PF02991 0.472
LIG_LIR_Nem_3 267 273 PF02991 0.464
LIG_LIR_Nem_3 388 394 PF02991 0.472
LIG_LIR_Nem_3 432 438 PF02991 0.526
LIG_LIR_Nem_3 573 579 PF02991 0.333
LIG_LIR_Nem_3 646 651 PF02991 0.495
LIG_MAD2 125 133 PF02301 0.489
LIG_MAD2 54 62 PF02301 0.513
LIG_MLH1_MIPbox_1 648 652 PF16413 0.475
LIG_PDZ_Class_3 687 692 PF00595 0.475
LIG_Pex14_1 173 177 PF04695 0.454
LIG_Pex14_2 391 395 PF04695 0.489
LIG_Pex14_2 648 652 PF04695 0.475
LIG_SH2_CRK 255 259 PF00017 0.505
LIG_SH2_CRK 270 274 PF00017 0.464
LIG_SH2_CRK 581 585 PF00017 0.475
LIG_SH2_SRC 579 582 PF00017 0.464
LIG_SH2_STAP1 559 563 PF00017 0.464
LIG_SH2_STAT3 383 386 PF00017 0.475
LIG_SH2_STAT5 183 186 PF00017 0.489
LIG_SH2_STAT5 191 194 PF00017 0.489
LIG_SH2_STAT5 242 245 PF00017 0.568
LIG_SH2_STAT5 255 258 PF00017 0.415
LIG_SH2_STAT5 424 427 PF00017 0.538
LIG_SH2_STAT5 448 451 PF00017 0.481
LIG_SH2_STAT5 548 551 PF00017 0.459
LIG_SH3_1 24 30 PF00018 0.550
LIG_SH3_3 24 30 PF00018 0.508
LIG_SH3_3 269 275 PF00018 0.467
LIG_SH3_4 361 368 PF00018 0.407
LIG_SUMO_SIM_anti_2 513 519 PF11976 0.489
LIG_SUMO_SIM_anti_2 680 685 PF11976 0.550
LIG_SUMO_SIM_par_1 276 283 PF11976 0.463
LIG_SUMO_SIM_par_1 595 603 PF11976 0.525
LIG_SUMO_SIM_par_1 622 628 PF11976 0.486
LIG_SUMO_SIM_par_1 668 673 PF11976 0.475
LIG_TRAF2_1 231 234 PF00917 0.489
LIG_TRAF2_1 247 250 PF00917 0.489
LIG_TRAF2_1 261 264 PF00917 0.457
LIG_TRAF2_1 30 33 PF00917 0.569
LIG_TRAF2_1 530 533 PF00917 0.453
LIG_TRAF2_1 594 597 PF00917 0.485
LIG_TRAF2_1 608 611 PF00917 0.431
LIG_TRFH_1 26 30 PF08558 0.569
LIG_TYR_ITAM 252 273 PF00017 0.508
LIG_TYR_ITIM 546 551 PF00017 0.466
LIG_UBA3_1 179 185 PF00899 0.464
LIG_UBA3_1 334 340 PF00899 0.453
LIG_UBA3_1 35 40 PF00899 0.454
LIG_UBA3_1 375 384 PF00899 0.434
LIG_UBA3_1 540 547 PF00899 0.505
MOD_CDK_SPK_2 87 92 PF00069 0.416
MOD_CDK_SPxxK_3 605 612 PF00069 0.475
MOD_CK1_1 199 205 PF00069 0.525
MOD_CK1_1 496 502 PF00069 0.464
MOD_CK1_1 570 576 PF00069 0.371
MOD_CK1_1 605 611 PF00069 0.550
MOD_CK2_1 244 250 PF00069 0.473
MOD_CK2_1 258 264 PF00069 0.464
MOD_CK2_1 342 348 PF00069 0.498
MOD_CK2_1 353 359 PF00069 0.444
MOD_CK2_1 527 533 PF00069 0.453
MOD_CK2_1 605 611 PF00069 0.501
MOD_Cter_Amidation 488 491 PF01082 0.264
MOD_GlcNHglycan 129 133 PF01048 0.373
MOD_GlcNHglycan 495 498 PF01048 0.274
MOD_GlcNHglycan 568 572 PF01048 0.403
MOD_GSK3_1 310 317 PF00069 0.491
MOD_GSK3_1 349 356 PF00069 0.443
MOD_GSK3_1 422 429 PF00069 0.464
MOD_GSK3_1 523 530 PF00069 0.499
MOD_GSK3_1 673 680 PF00069 0.550
MOD_N-GLC_1 646 651 PF02516 0.369
MOD_N-GLC_1 95 100 PF02516 0.289
MOD_NEK2_1 144 149 PF00069 0.475
MOD_NEK2_1 551 556 PF00069 0.473
MOD_NEK2_1 567 572 PF00069 0.336
MOD_NEK2_1 662 667 PF00069 0.489
MOD_PIKK_1 314 320 PF00454 0.507
MOD_PIKK_1 523 529 PF00454 0.505
MOD_PIKK_1 54 60 PF00454 0.550
MOD_PK_1 402 408 PF00069 0.541
MOD_PK_1 583 589 PF00069 0.464
MOD_PKA_2 144 150 PF00069 0.475
MOD_PKA_2 409 415 PF00069 0.475
MOD_PKA_2 673 679 PF00069 0.475
MOD_Plk_1 233 239 PF00069 0.464
MOD_Plk_1 349 355 PF00069 0.472
MOD_Plk_1 510 516 PF00069 0.475
MOD_Plk_1 602 608 PF00069 0.534
MOD_Plk_1 610 616 PF00069 0.511
MOD_Plk_1 670 676 PF00069 0.475
MOD_Plk_1 95 101 PF00069 0.489
MOD_Plk_2-3 472 478 PF00069 0.525
MOD_Plk_4 144 150 PF00069 0.474
MOD_Plk_4 265 271 PF00069 0.463
MOD_Plk_4 402 408 PF00069 0.541
MOD_Plk_4 620 626 PF00069 0.460
MOD_ProDKin_1 605 611 PF00069 0.470
MOD_ProDKin_1 63 69 PF00069 0.492
MOD_ProDKin_1 87 93 PF00069 0.425
MOD_SUMO_rev_2 356 362 PF00179 0.435
TRG_DiLeu_BaEn_4 350 356 PF01217 0.533
TRG_DiLeu_BaEn_4 532 538 PF01217 0.453
TRG_DiLeu_BaLyEn_6 152 157 PF01217 0.550
TRG_DiLeu_BaLyEn_6 269 274 PF01217 0.505
TRG_DiLeu_BaLyEn_6 31 36 PF01217 0.550
TRG_ENDOCYTIC_2 255 258 PF00928 0.464
TRG_ENDOCYTIC_2 270 273 PF00928 0.464
TRG_ENDOCYTIC_2 435 438 PF00928 0.464
TRG_ENDOCYTIC_2 455 458 PF00928 0.479
TRG_ENDOCYTIC_2 548 551 PF00928 0.466
TRG_ENDOCYTIC_2 563 566 PF00928 0.410
TRG_ENDOCYTIC_2 581 584 PF00928 0.464
TRG_ENDOCYTIC_2 642 645 PF00928 0.475
TRG_NES_CRM1_1 504 519 PF08389 0.489
TRG_Pf-PMV_PEXEL_1 125 129 PF00026 0.350
TRG_Pf-PMV_PEXEL_1 656 660 PF00026 0.312

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N0P4S4 Leptomonas seymouri 85% 100%
A0A0S4JSY3 Bodo saltans 60% 100%
A0A1X0P461 Trypanosomatidae 69% 100%
A0A3Q8IED7 Leishmania donovani 100% 100%
A0A3R7MEE6 Trypanosoma rangeli 71% 100%
A4HFQ8 Leishmania braziliensis 91% 100%
D0A5Z9 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 66% 100%
E9ADB2 Leishmania major 97% 100%
E9AZ37 Leishmania mexicana (strain MHOM/GT/2001/U1103) 97% 100%
Q7URC7 Rhodopirellula baltica (strain DSM 10527 / NCIMB 13988 / SH1) 32% 100%
Q8ZTA8 Pyrobaculum aerophilum (strain ATCC 51768 / DSM 7523 / JCM 9630 / CIP 104966 / NBRC 100827 / IM2) 23% 100%
Q971X1 Sulfurisphaera tokodaii (strain DSM 16993 / JCM 10545 / NBRC 100140 / 7) 24% 100%
V5BQK5 Trypanosoma cruzi 69% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2024 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS