LeishMANIAdb
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Leucine-rich repeat protein

Quick info Annotations Function or PPIs Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:
Leucine-rich repeat protein
Gene product:
predicted leucine-rich repeat protein
Species:
Leishmania infantum
UniProt:
A4I2T1_LEIIN
TriTrypDb:
LINF_270019500
Length:
396

Annotations

LeishMANIAdb annotations

Leucine-rich repeat proteins with a hydrophobic terminal helix. Unlike its distant animal relatives, this cytoplasmic sensor protein might be anchored to the membrane.

Annotations by Jardim et al.

Uncharacterized Protein, Uncharacterized

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 11
NetGPI no yes: 0, no: 11
Cellular components
TermNameLevelCount
GO:0005929 cilium 4 12
GO:0042995 cell projection 2 12
GO:0043226 organelle 2 12
GO:0043227 membrane-bounded organelle 3 12
GO:0110165 cellular anatomical entity 1 12
GO:0120025 plasma membrane bounded cell projection 3 12
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Expansion

Sequence features

A4I2T1
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4I2T1

Putative motif mimicry

LeishmaniaFromToDomain/MotifScore
CLV_NRD_NRD_1 165 167 PF00675 0.666
CLV_NRD_NRD_1 378 380 PF00675 0.497
CLV_PCSK_KEX2_1 378 380 PF00082 0.497
CLV_PCSK_KEX2_1 45 47 PF00082 0.645
CLV_PCSK_PC1ET2_1 45 47 PF00082 0.552
CLV_PCSK_SKI1_1 79 83 PF00082 0.588
CLV_Separin_Metazoa 138 142 PF03568 0.391
DEG_ODPH_VHL_1 185 196 PF01847 0.424
DEG_SPOP_SBC_1 12 16 PF00917 0.547
DOC_CKS1_1 130 135 PF01111 0.448
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Homologs

ProteinTaxonomySequence identityCoverage
A0A0N1HUH0 Leptomonas seymouri 26% 84%
A0A0N1I317 Leptomonas seymouri 74% 99%
A0A0S4JL85 Bodo saltans 25% 93%
A0A0S4JV86 Bodo saltans 41% 100%
A0A1X0NTY3 Trypanosomatidae 27% 88%
A0A1X0P364 Trypanosomatidae 24% 92%
A0A1X0P4Z4 Trypanosomatidae 47% 100%
A0A3Q8IDE6 Leishmania donovani 100% 100%
A0A3R7L7Y9 Trypanosoma rangeli 27% 89%
A0A3R7NL91 Trypanosoma rangeli 49% 100%
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Download

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS