Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein - conserved

Species:

Leishmania infantum

UniProt:

A4I2S9_LEIIN

TriTrypDb:

LINF_270019300

Length:

442

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4I2S9

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4I2S9

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	185	189	PF00656	0.436
CLV_MEL_PAP_1	105	111	PF00089	0.517
CLV_NRD_NRD_1	221	223	PF00675	0.423
CLV_NRD_NRD_1	23	25	PF00675	0.562
CLV_NRD_NRD_1	322	324	PF00675	0.529
CLV_NRD_NRD_1	380	382	PF00675	0.557
CLV_NRD_NRD_1	391	393	PF00675	0.404
CLV_NRD_NRD_1	429	431	PF00675	0.581
CLV_PCSK_KEX2_1	107	109	PF00082	0.564
CLV_PCSK_KEX2_1	221	223	PF00082	0.423
CLV_PCSK_KEX2_1	225	227	PF00082	0.425
CLV_PCSK_KEX2_1	23	25	PF00082	0.491
CLV_PCSK_KEX2_1	306	308	PF00082	0.609
CLV_PCSK_KEX2_1	322	324	PF00082	0.512
CLV_PCSK_KEX2_1	379	381	PF00082	0.583
CLV_PCSK_KEX2_1	391	393	PF00082	0.399
CLV_PCSK_KEX2_1	429	431	PF00082	0.581
CLV_PCSK_PC1ET2_1	107	109	PF00082	0.564
CLV_PCSK_PC1ET2_1	225	227	PF00082	0.448
CLV_PCSK_PC1ET2_1	306	308	PF00082	0.605
CLV_PCSK_PC7_1	221	227	PF00082	0.480
CLV_PCSK_SKI1_1	179	183	PF00082	0.445
CLV_PCSK_SKI1_1	221	225	PF00082	0.502
CLV_PCSK_SKI1_1	232	236	PF00082	0.349
CLV_PCSK_SKI1_1	263	267	PF00082	0.432
CLV_Separin_Metazoa	27	31	PF03568	0.528
DEG_APCC_DBOX_1	390	398	PF00400	0.465
DEG_Nend_UBRbox_3	1	3	PF02207	0.592
DEG_SCF_FBW7_1	85	90	PF00400	0.601
DOC_ANK_TNKS_1	321	328	PF00023	0.532
DOC_MAPK_FxFP_2	6	9	PF00069	0.595
DOC_MAPK_gen_1	137	147	PF00069	0.560
DOC_MAPK_gen_1	229	237	PF00069	0.461
DOC_MAPK_gen_1	404	413	PF00069	0.558
DOC_MAPK_gen_1	429	436	PF00069	0.526
DOC_PP2B_LxvP_1	411	414	PF13499	0.553
DOC_PP2B_LxvP_1	434	437	PF13499	0.548
DOC_PP4_FxxP_1	6	9	PF00568	0.595
DOC_USP7_MATH_1	139	143	PF00917	0.592
DOC_USP7_MATH_1	189	193	PF00917	0.439
DOC_USP7_MATH_1	350	354	PF00917	0.691
DOC_USP7_MATH_1	415	419	PF00917	0.553
DOC_USP7_MATH_1	87	91	PF00917	0.627
DOC_WW_Pin1_4	107	112	PF00397	0.515
DOC_WW_Pin1_4	132	137	PF00397	0.598
DOC_WW_Pin1_4	292	297	PF00397	0.582
DOC_WW_Pin1_4	30	35	PF00397	0.579
DOC_WW_Pin1_4	329	334	PF00397	0.616
DOC_WW_Pin1_4	341	346	PF00397	0.598
DOC_WW_Pin1_4	420	425	PF00397	0.690
DOC_WW_Pin1_4	64	69	PF00397	0.695
DOC_WW_Pin1_4	83	88	PF00397	0.618
DOC_WW_Pin1_4	91	96	PF00397	0.641
LIG_14-3-3_CanoR_1	116	121	PF00244	0.607
LIG_14-3-3_CanoR_1	124	133	PF00244	0.545
LIG_14-3-3_CanoR_1	256	265	PF00244	0.594
LIG_14-3-3_CanoR_1	274	279	PF00244	0.453
LIG_14-3-3_CanoR_1	30	34	PF00244	0.586
LIG_14-3-3_CanoR_1	369	376	PF00244	0.535
LIG_14-3-3_CanoR_1	37	43	PF00244	0.594
LIG_14-3-3_CanoR_1	391	395	PF00244	0.523
LIG_14-3-3_CanoR_1	416	420	PF00244	0.581
LIG_14-3-3_CanoR_1	78	83	PF00244	0.624
LIG_Actin_WH2_2	102	118	PF00022	0.725
LIG_BRCT_BRCA1_1	172	176	PF00533	0.340
LIG_BRCT_BRCA1_1	2	6	PF00533	0.544
LIG_BRCT_BRCA1_1	261	265	PF00533	0.438
LIG_BRCT_BRCA1_1	314	318	PF00533	0.535
LIG_BRCT_BRCA1_1	421	425	PF00533	0.567
LIG_Clathr_ClatBox_1	168	172	PF01394	0.447
LIG_FHA_1	104	110	PF00498	0.705
LIG_FHA_1	142	148	PF00498	0.622
LIG_LIR_Apic_2	3	9	PF02991	0.588
LIG_LIR_Gen_1	150	160	PF02991	0.524
LIG_LIR_Gen_1	188	197	PF02991	0.418
LIG_LIR_Gen_1	422	433	PF02991	0.620
LIG_LIR_Nem_3	150	155	PF02991	0.549
LIG_LIR_Nem_3	188	193	PF02991	0.414
LIG_LIR_Nem_3	422	428	PF02991	0.692
LIG_LIR_Nem_3	44	49	PF02991	0.553
LIG_MYND_1	433	437	PF01753	0.581
LIG_Pex14_2	176	180	PF04695	0.355
LIG_PTB_Apo_2	146	153	PF02174	0.506
LIG_SH2_CRK	49	53	PF00017	0.554
LIG_SH2_SRC	243	246	PF00017	0.368
LIG_SH2_SRC	49	52	PF00017	0.577
LIG_SH2_STAP1	239	243	PF00017	0.369
LIG_SH2_STAT5	100	103	PF00017	0.550
LIG_SH2_STAT5	356	359	PF00017	0.650
LIG_SH2_STAT5	7	10	PF00017	0.595
LIG_SH3_3	133	139	PF00018	0.552
LIG_SH3_3	344	350	PF00018	0.599
LIG_SH3_3	45	51	PF00018	0.584
LIG_SH3_3	70	76	PF00018	0.572
LIG_SH3_3	89	95	PF00018	0.651
LIG_Sin3_3	167	174	PF02671	0.417
LIG_SUMO_SIM_anti_2	192	198	PF11976	0.409
LIG_SUMO_SIM_anti_2	202	207	PF11976	0.376
LIG_SUMO_SIM_par_1	167	173	PF11976	0.443
LIG_SUMO_SIM_par_1	51	57	PF11976	0.524
LIG_TRAF2_1	406	409	PF00917	0.461
LIG_UBA3_1	193	201	PF00899	0.349
MOD_CDC14_SPxK_1	67	70	PF00782	0.678
MOD_CDC14_SPxK_1	94	97	PF00782	0.572
MOD_CDK_SPK_2	132	137	PF00069	0.574
MOD_CDK_SPK_2	341	346	PF00069	0.613
MOD_CDK_SPxK_1	64	70	PF00069	0.673
MOD_CDK_SPxK_1	91	97	PF00069	0.595
MOD_CDK_SPxxK_3	292	299	PF00069	0.614
MOD_CDK_SPxxK_3	30	37	PF00069	0.588
MOD_CK1_1	151	157	PF00069	0.496
MOD_CK1_1	192	198	PF00069	0.516
MOD_CK1_1	259	265	PF00069	0.538
MOD_CK1_1	273	279	PF00069	0.463
MOD_CK1_1	295	301	PF00069	0.608
MOD_CK1_1	331	337	PF00069	0.801
MOD_CK1_1	364	370	PF00069	0.611
MOD_CK1_1	38	44	PF00069	0.651
MOD_CK1_1	418	424	PF00069	0.562
MOD_CK1_1	54	60	PF00069	0.539
MOD_CK1_1	80	86	PF00069	0.717
MOD_DYRK1A_RPxSP_1	346	350	PF00069	0.601
MOD_GlcNHglycan	172	175	PF01048	0.374
MOD_GlcNHglycan	318	321	PF01048	0.550
MOD_GlcNHglycan	438	441	PF01048	0.615
MOD_GSK3_1	103	110	PF00069	0.589
MOD_GSK3_1	264	271	PF00069	0.554
MOD_GSK3_1	312	319	PF00069	0.567
MOD_GSK3_1	346	353	PF00069	0.675
MOD_GSK3_1	357	364	PF00069	0.658
MOD_GSK3_1	37	44	PF00069	0.635
MOD_GSK3_1	415	422	PF00069	0.606
MOD_GSK3_1	62	69	PF00069	0.679
MOD_GSK3_1	77	84	PF00069	0.657
MOD_GSK3_1	87	94	PF00069	0.599
MOD_N-GLC_1	148	153	PF02516	0.524
MOD_N-GLC_1	292	297	PF02516	0.613
MOD_NEK2_1	266	271	PF00069	0.564
MOD_NEK2_1	29	34	PF00069	0.608
MOD_NEK2_1	316	321	PF00069	0.551
MOD_NEK2_1	357	362	PF00069	0.627
MOD_NEK2_1	77	82	PF00069	0.591
MOD_NEK2_2	51	56	PF00069	0.562
MOD_PIKK_1	126	132	PF00454	0.576
MOD_PIKK_1	279	285	PF00454	0.556
MOD_PIKK_1	54	60	PF00454	0.539
MOD_PIKK_1	87	93	PF00454	0.619
MOD_PK_1	116	122	PF00069	0.558
MOD_PK_1	78	84	PF00069	0.554
MOD_PKA_2	19	25	PF00069	0.586
MOD_PKA_2	217	223	PF00069	0.421
MOD_PKA_2	273	279	PF00069	0.497
MOD_PKA_2	29	35	PF00069	0.501
MOD_PKA_2	328	334	PF00069	0.590
MOD_PKA_2	368	374	PF00069	0.552
MOD_PKA_2	38	44	PF00069	0.541
MOD_PKA_2	390	396	PF00069	0.502
MOD_PKA_2	415	421	PF00069	0.557
MOD_PKA_2	77	83	PF00069	0.691
MOD_PKB_1	272	280	PF00069	0.480
MOD_Plk_1	148	154	PF00069	0.486
MOD_Plk_4	151	157	PF00069	0.517
MOD_Plk_4	189	195	PF00069	0.598
MOD_Plk_4	312	318	PF00069	0.536
MOD_ProDKin_1	107	113	PF00069	0.514
MOD_ProDKin_1	132	138	PF00069	0.599
MOD_ProDKin_1	292	298	PF00069	0.581
MOD_ProDKin_1	30	36	PF00069	0.583
MOD_ProDKin_1	329	335	PF00069	0.617
MOD_ProDKin_1	341	347	PF00069	0.597
MOD_ProDKin_1	420	426	PF00069	0.690
MOD_ProDKin_1	64	70	PF00069	0.698
MOD_ProDKin_1	83	89	PF00069	0.618
MOD_ProDKin_1	91	97	PF00069	0.642
TRG_DiLeu_BaLyEn_6	159	164	PF01217	0.413
TRG_DiLeu_BaLyEn_6	430	435	PF01217	0.584
TRG_ENDOCYTIC_2	49	52	PF00928	0.577
TRG_ER_diArg_1	23	25	PF00400	0.491
TRG_ER_diArg_1	379	381	PF00400	0.570
TRG_ER_diArg_1	428	430	PF00400	0.582
TRG_ER_diArg_1	97	100	PF00400	0.611
TRG_Pf-PMV_PEXEL_1	222	227	PF00026	0.424
TRG_Pf-PMV_PEXEL_1	253	257	PF00026	0.434

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PCB3	Leptomonas seymouri	35%	96%
A0A3S7X0N8	Leishmania donovani	99%	100%
A4HFQ4	Leishmania braziliensis	62%	100%
E9ADA7	Leishmania major	87%	100%
E9AZ32	Leishmania mexicana (strain MHOM/GT/2001/U1103)	82%	100%