Ubiquitin carboxyl-terminal hydrolase

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

ubiquitin carboxyl-terminal hydrolase - putative

Species:

Leishmania infantum

UniProt:

A4I2S8_LEIIN

TriTrypDb:

LINF_270019200

Length:

575

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4I2S8

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4I2S8

Function

Biological processes
Term	Name	Level	Count
GO:0006508	proteolysis	4	11
GO:0006511	ubiquitin-dependent protein catabolic process	7	11
GO:0006807	nitrogen compound metabolic process	2	11
GO:0008152	metabolic process	1	11
GO:0009056	catabolic process	2	11
GO:0009057	macromolecule catabolic process	4	11
GO:0009987	cellular process	1	11
GO:0016579	protein deubiquitination	6	11
GO:0019538	protein metabolic process	3	11
GO:0019941	modification-dependent protein catabolic process	6	11
GO:0036211	protein modification process	4	11
GO:0043170	macromolecule metabolic process	3	11
GO:0043412	macromolecule modification	4	11
GO:0043632	modification-dependent macromolecule catabolic process	5	11
GO:0044237	cellular metabolic process	2	11
GO:0044238	primary metabolic process	2	11
GO:0044248	cellular catabolic process	3	11
GO:0044260	obsolete cellular macromolecule metabolic process	3	11
GO:0044265	obsolete cellular macromolecule catabolic process	4	11
GO:0051603	proteolysis involved in protein catabolic process	5	11
GO:0070646	protein modification by small protein removal	5	11
GO:0070647	protein modification by small protein conjugation or removal	5	11
GO:0071704	organic substance metabolic process	2	11
GO:1901564	organonitrogen compound metabolic process	3	11
GO:1901575	organic substance catabolic process	3	11

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	11
GO:0004843	cysteine-type deubiquitinase activity	5	11
GO:0008233	peptidase activity	3	11
GO:0008234	cysteine-type peptidase activity	4	11
GO:0016787	hydrolase activity	2	11
GO:0019783	ubiquitin-like protein peptidase activity	4	11
GO:0101005	deubiquitinase activity	5	11
GO:0140096	catalytic activity, acting on a protein	2	11

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	132	136	PF00656	0.710
CLV_C14_Caspase3-7	333	337	PF00656	0.326
CLV_C14_Caspase3-7	561	565	PF00656	0.341
CLV_NRD_NRD_1	116	118	PF00675	0.499
CLV_NRD_NRD_1	122	124	PF00675	0.463
CLV_NRD_NRD_1	246	248	PF00675	0.314
CLV_NRD_NRD_1	377	379	PF00675	0.331
CLV_NRD_NRD_1	464	466	PF00675	0.331
CLV_PCSK_KEX2_1	116	118	PF00082	0.499
CLV_PCSK_KEX2_1	121	123	PF00082	0.451
CLV_PCSK_KEX2_1	245	247	PF00082	0.348
CLV_PCSK_KEX2_1	377	379	PF00082	0.388
CLV_PCSK_KEX2_1	482	484	PF00082	0.256
CLV_PCSK_KEX2_1	51	53	PF00082	0.430
CLV_PCSK_KEX2_1	85	87	PF00082	0.398
CLV_PCSK_PC1ET2_1	482	484	PF00082	0.256
CLV_PCSK_PC1ET2_1	51	53	PF00082	0.430
CLV_PCSK_PC1ET2_1	85	87	PF00082	0.398
CLV_PCSK_PC7_1	117	123	PF00082	0.528
CLV_PCSK_SKI1_1	180	184	PF00082	0.730
CLV_PCSK_SKI1_1	319	323	PF00082	0.331
CLV_PCSK_SKI1_1	342	346	PF00082	0.327
CLV_PCSK_SKI1_1	466	470	PF00082	0.256
CLV_PCSK_SKI1_1	63	67	PF00082	0.490
CLV_PCSK_SKI1_1	85	89	PF00082	0.443
DEG_APCC_DBOX_1	341	349	PF00400	0.300
DEG_Nend_Nbox_1	1	3	PF02207	0.462
DEG_SPOP_SBC_1	426	430	PF00917	0.263
DOC_CYCLIN_RxL_1	461	472	PF00134	0.258
DOC_CYCLIN_RxL_1	60	71	PF00134	0.446
DOC_CYCLIN_yClb5_NLxxxL_5	562	571	PF00134	0.331
DOC_MAPK_gen_1	245	252	PF00069	0.293
DOC_MAPK_gen_1	518	526	PF00069	0.388
DOC_MAPK_gen_1	97	105	PF00069	0.544
DOC_MAPK_MEF2A_6	413	421	PF00069	0.275
DOC_PIKK_1	160	167	PF02985	0.462
DOC_PP1_RVXF_1	168	174	PF00149	0.450
DOC_PP1_RVXF_1	357	363	PF00149	0.388
DOC_PP1_RVXF_1	464	471	PF00149	0.310
DOC_PP1_RVXF_1	61	68	PF00149	0.422
DOC_USP7_MATH_1	223	227	PF00917	0.621
DOC_USP7_MATH_1	278	282	PF00917	0.218
DOC_USP7_MATH_1	317	321	PF00917	0.386
DOC_USP7_MATH_1	426	430	PF00917	0.292
DOC_USP7_UBL2_3	3	7	PF12436	0.387
DOC_USP7_UBL2_3	97	101	PF12436	0.514
DOC_WW_Pin1_4	204	209	PF00397	0.789
DOC_WW_Pin1_4	265	270	PF00397	0.254
DOC_WW_Pin1_4	313	318	PF00397	0.289
LIG_14-3-3_CanoR_1	172	177	PF00244	0.640
LIG_14-3-3_CanoR_1	180	185	PF00244	0.589
LIG_14-3-3_CanoR_1	228	237	PF00244	0.550
LIG_14-3-3_CanoR_1	292	298	PF00244	0.259
LIG_14-3-3_CanoR_1	427	434	PF00244	0.412
LIG_APCC_ABBAyCdc20_2	63	69	PF00400	0.434
LIG_BIR_III_4	541	545	PF00653	0.388
LIG_BRCT_BRCA1_1	295	299	PF00533	0.335
LIG_BRCT_BRCA1_1	411	415	PF00533	0.256
LIG_BRCT_BRCA1_1	497	501	PF00533	0.391
LIG_BRCT_BRCA1_2	498	504	PF00533	0.370
LIG_Clathr_ClatBox_1	65	69	PF01394	0.440
LIG_deltaCOP1_diTrp_1	546	552	PF00928	0.300
LIG_eIF4E_1	60	66	PF01652	0.419
LIG_EVH1_2	474	478	PF00568	0.388
LIG_FAT_LD_1	164	172	PF03623	0.562
LIG_FHA_1	177	183	PF00498	0.661
LIG_FHA_1	229	235	PF00498	0.573
LIG_FHA_1	289	295	PF00498	0.321
LIG_FHA_1	503	509	PF00498	0.435
LIG_FHA_1	82	88	PF00498	0.497
LIG_FHA_2	369	375	PF00498	0.308
LIG_FHA_2	556	562	PF00498	0.388
LIG_FHA_2	76	82	PF00498	0.538
LIG_LIR_Apic_2	450	456	PF02991	0.256
LIG_LIR_Gen_1	197	206	PF02991	0.611
LIG_LIR_Gen_1	296	304	PF02991	0.274
LIG_LIR_Gen_1	339	348	PF02991	0.323
LIG_LIR_Gen_1	393	402	PF02991	0.331
LIG_LIR_Gen_1	519	527	PF02991	0.287
LIG_LIR_Gen_1	546	557	PF02991	0.335
LIG_LIR_Gen_1	9	18	PF02991	0.353
LIG_LIR_Nem_3	197	201	PF02991	0.618
LIG_LIR_Nem_3	296	300	PF02991	0.271
LIG_LIR_Nem_3	324	329	PF02991	0.265
LIG_LIR_Nem_3	339	343	PF02991	0.213
LIG_LIR_Nem_3	361	365	PF02991	0.360
LIG_LIR_Nem_3	393	397	PF02991	0.426
LIG_LIR_Nem_3	435	441	PF02991	0.388
LIG_LIR_Nem_3	519	524	PF02991	0.266
LIG_LIR_Nem_3	546	552	PF02991	0.273
LIG_LIR_Nem_3	9	13	PF02991	0.314
LIG_LYPXL_SIV_4	57	65	PF13949	0.414
LIG_MLH1_MIPbox_1	498	502	PF16413	0.286
LIG_PCNA_yPIPBox_3	161	172	PF02747	0.461
LIG_Pex14_1	380	384	PF04695	0.388
LIG_PTB_Apo_2	251	258	PF02174	0.256
LIG_PTB_Apo_2	53	60	PF02174	0.428
LIG_PTB_Phospho_1	251	257	PF10480	0.256
LIG_PTB_Phospho_1	53	59	PF10480	0.428
LIG_REV1ctd_RIR_1	499	508	PF16727	0.388
LIG_REV1ctd_RIR_1	65	73	PF16727	0.476
LIG_SH2_CRK	198	202	PF00017	0.625
LIG_SH2_CRK	453	457	PF00017	0.256
LIG_SH2_CRK	471	475	PF00017	0.256
LIG_SH2_CRK	521	525	PF00017	0.256
LIG_SH2_GRB2like	257	260	PF00017	0.256
LIG_SH2_GRB2like	54	57	PF00017	0.426
LIG_SH2_GRB2like	60	63	PF00017	0.416
LIG_SH2_NCK_1	198	202	PF00017	0.625
LIG_SH2_NCK_1	471	475	PF00017	0.364
LIG_SH2_NCK_1	54	58	PF00017	0.367
LIG_SH2_SRC	54	57	PF00017	0.426
LIG_SH2_STAP1	10	14	PF00017	0.371
LIG_SH2_STAP1	230	234	PF00017	0.505
LIG_SH2_STAP1	24	28	PF00017	0.456
LIG_SH2_STAP1	538	542	PF00017	0.335
LIG_SH2_STAP1	54	58	PF00017	0.321
LIG_SH2_STAT3	379	382	PF00017	0.284
LIG_SH2_STAT5	230	233	PF00017	0.412
LIG_SH2_STAT5	273	276	PF00017	0.388
LIG_SH2_STAT5	279	282	PF00017	0.256
LIG_SH2_STAT5	394	397	PF00017	0.395
LIG_SH2_STAT5	441	444	PF00017	0.256
LIG_SH2_STAT5	538	541	PF00017	0.292
LIG_SH2_STAT5	569	572	PF00017	0.256
LIG_SH2_STAT5	60	63	PF00017	0.303
LIG_SH3_3	188	194	PF00018	0.716
LIG_SH3_3	198	204	PF00018	0.668
LIG_SH3_3	207	213	PF00018	0.658
LIG_SH3_3	25	31	PF00018	0.517
LIG_TRAF2_1	396	399	PF00917	0.275
LIG_TYR_ITSM	517	524	PF00017	0.275
LIG_UBA3_1	477	482	PF00899	0.265
LIG_WRC_WIRS_1	294	299	PF05994	0.302
LIG_WW_1	195	198	PF00397	0.550
MOD_CAAXbox	572	575	PF01239	0.412
MOD_CDC14_SPxK_1	316	319	PF00782	0.335
MOD_CDK_SPxK_1	313	319	PF00069	0.335
MOD_CK1_1	159	165	PF00069	0.628
MOD_CK1_1	226	232	PF00069	0.546
MOD_CK1_1	238	244	PF00069	0.407
MOD_CK1_1	368	374	PF00069	0.383
MOD_CK1_1	430	436	PF00069	0.388
MOD_CK1_1	514	520	PF00069	0.378
MOD_CK2_1	160	166	PF00069	0.612
MOD_CK2_1	199	205	PF00069	0.752
MOD_CK2_1	368	374	PF00069	0.289
MOD_CK2_1	555	561	PF00069	0.246
MOD_CK2_1	6	12	PF00069	0.388
MOD_GlcNHglycan	132	135	PF01048	0.503
MOD_GlcNHglycan	223	226	PF01048	0.683
MOD_GlcNHglycan	313	316	PF01048	0.472
MOD_GlcNHglycan	319	322	PF01048	0.433
MOD_GlcNHglycan	399	403	PF01048	0.331
MOD_GlcNHglycan	471	474	PF01048	0.370
MOD_GSK3_1	155	162	PF00069	0.515
MOD_GSK3_1	172	179	PF00069	0.636
MOD_GSK3_1	309	316	PF00069	0.342
MOD_GSK3_1	411	418	PF00069	0.290
MOD_GSK3_1	426	433	PF00069	0.237
MOD_GSK3_1	491	498	PF00069	0.455
MOD_GSK3_1	507	514	PF00069	0.199
MOD_N-GLC_1	160	165	PF02516	0.626
MOD_N-GLC_1	180	185	PF02516	0.696
MOD_N-GLC_1	238	243	PF02516	0.492
MOD_N-GLC_1	265	270	PF02516	0.388
MOD_N-GLC_1	304	309	PF02516	0.320
MOD_N-GLC_1	330	335	PF02516	0.388
MOD_N-GLC_1	354	359	PF02516	0.327
MOD_N-GLC_1	386	391	PF02516	0.273
MOD_N-GLC_1	415	420	PF02516	0.331
MOD_N-GLC_1	496	501	PF02516	0.388
MOD_N-GLC_2	254	256	PF02516	0.256
MOD_N-GLC_2	62	64	PF02516	0.415
MOD_NEK2_1	13	18	PF00069	0.372
MOD_NEK2_1	148	153	PF00069	0.614
MOD_NEK2_1	252	257	PF00069	0.273
MOD_NEK2_1	283	288	PF00069	0.266
MOD_NEK2_1	293	298	PF00069	0.230
MOD_NEK2_1	311	316	PF00069	0.401
MOD_NEK2_1	329	334	PF00069	0.303
MOD_NEK2_1	415	420	PF00069	0.388
MOD_NEK2_1	447	452	PF00069	0.286
MOD_NEK2_1	469	474	PF00069	0.256
MOD_NEK2_1	477	482	PF00069	0.256
MOD_NEK2_1	502	507	PF00069	0.312
MOD_NEK2_1	512	517	PF00069	0.276
MOD_NEK2_2	240	245	PF00069	0.415
MOD_PIKK_1	330	336	PF00454	0.300
MOD_PIKK_1	75	81	PF00454	0.504
MOD_PK_1	172	178	PF00069	0.537
MOD_PK_1	386	392	PF00069	0.335
MOD_PKA_2	426	432	PF00069	0.316
MOD_PKB_1	170	178	PF00069	0.528
MOD_Plk_1	159	165	PF00069	0.538
MOD_Plk_1	180	186	PF00069	0.650
MOD_Plk_1	238	244	PF00069	0.476
MOD_Plk_1	386	392	PF00069	0.297
MOD_Plk_1	398	404	PF00069	0.297
MOD_Plk_1	415	421	PF00069	0.246
MOD_Plk_1	447	453	PF00069	0.380
MOD_Plk_1	496	502	PF00069	0.388
MOD_Plk_2-3	160	166	PF00069	0.564
MOD_Plk_4	257	263	PF00069	0.335
MOD_Plk_4	386	392	PF00069	0.256
MOD_Plk_4	448	454	PF00069	0.275
MOD_Plk_4	496	502	PF00069	0.395
MOD_Plk_4	507	513	PF00069	0.231
MOD_ProDKin_1	204	210	PF00069	0.790
MOD_ProDKin_1	265	271	PF00069	0.254
MOD_ProDKin_1	313	319	PF00069	0.289
MOD_SUMO_for_1	45	48	PF00179	0.456
MOD_SUMO_rev_2	102	110	PF00179	0.339
MOD_SUMO_rev_2	303	312	PF00179	0.286
MOD_SUMO_rev_2	90	98	PF00179	0.385
TRG_DiLeu_BaLyEn_6	289	294	PF01217	0.388
TRG_ENDOCYTIC_2	10	13	PF00928	0.317
TRG_ENDOCYTIC_2	107	110	PF00928	0.428
TRG_ENDOCYTIC_2	198	201	PF00928	0.624
TRG_ENDOCYTIC_2	326	329	PF00928	0.300
TRG_ENDOCYTIC_2	394	397	PF00928	0.331
TRG_ENDOCYTIC_2	487	490	PF00928	0.300
TRG_ENDOCYTIC_2	521	524	PF00928	0.256
TRG_ENDOCYTIC_2	58	61	PF00928	0.413
TRG_ER_diArg_1	121	123	PF00400	0.448
TRG_ER_diArg_1	170	173	PF00400	0.502
TRG_ER_diArg_1	244	247	PF00400	0.380
TRG_ER_diArg_1	377	379	PF00400	0.286
TRG_NLS_Bipartite_1	465	486	PF00514	0.388

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I1S4	Leptomonas seymouri	66%	97%
A0A0S4IVV7	Bodo saltans	29%	98%
A0A1X0P5M1	Trypanosomatidae	42%	100%
A0A3Q8IGB5	Leishmania donovani	100%	100%
A0A422NFS3	Trypanosoma rangeli	43%	100%
A4HFQ3	Leishmania braziliensis	84%	100%
A4IBF1	Leishmania infantum	25%	100%
B2GUX4	Rattus norvegicus	29%	100%
D0A5Z2	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	38%	100%
E9ADA6	Leishmania major	96%	100%
E9AZ31	Leishmania mexicana (strain MHOM/GT/2001/U1103)	96%	100%
O94269	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	24%	100%
P36026	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	25%	80%
Q2KJ72	Bos taurus	29%	100%
Q2NL57	Xenopus laevis	23%	73%
Q7ZXR7	Xenopus laevis	22%	71%
Q91W36	Mus musculus	26%	100%
Q9HFS7	Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37)	28%	72%
Q9QZL6	Mus musculus	29%	100%
Q9UK80	Homo sapiens	29%	100%
Q9Y6I4	Homo sapiens	26%	100%
V5BQL0	Trypanosoma cruzi	43%	100%
V5DKA1	Trypanosoma cruzi	27%	100%