LeishMANIAdb
  • Home
  • Browse
  • Manual
  • FAQ
  • Download

Putative cation transporter

Quick info Annotations Function or PPIs Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
Putative cation transporter
Gene product:
cation transporter - putative
Species:
Leishmania infantum
UniProt:
A4I2S7_LEIIN
TriTrypDb:
LINF_270019100
Length:
610

Annotations

Annotations by Jardim et al.

Transporters, cation transporter

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 8
NetGPI no yes: 0, no: 8
Cellular components
Term Name Level Count
GO:0016020 membrane 2 9
GO:0110165 cellular anatomical entity 1 9
GO:0005794 Golgi apparatus 5 1
GO:0043226 organelle 2 1
GO:0043227 membrane-bounded organelle 3 1
GO:0043229 intracellular organelle 3 1
GO:0043231 intracellular membrane-bounded organelle 4 1
GO:0005886 plasma membrane 3 1

Expansion

Sequence features

A4I2S7
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4I2S7

Function

Biological processes
Term Name Level Count
GO:0006873 intracellular monoatomic ion homeostasis 4 7
GO:0006875 obsolete intracellular metal ion homeostasis 6 7
GO:0006882 intracellular zinc ion homeostasis 7 7
GO:0009987 cellular process 1 8
GO:0019725 cellular homeostasis 2 7
GO:0030003 intracellular monoatomic cation homeostasis 5 7
GO:0042592 homeostatic process 3 7
GO:0046916 obsolete intracellular transition metal ion homeostasis 7 7
GO:0048878 chemical homeostasis 4 7
GO:0050801 monoatomic ion homeostasis 5 7
GO:0055065 obsolete metal ion homeostasis 7 7
GO:0055069 obsolete zinc ion homeostasis 8 7
GO:0055076 obsolete transition metal ion homeostasis 8 7
GO:0055080 monoatomic cation homeostasis 6 7
GO:0055082 intracellular chemical homeostasis 3 7
GO:0065007 biological regulation 1 7
GO:0065008 regulation of biological quality 2 7
GO:0072503 obsolete cellular divalent inorganic cation homeostasis 6 7
GO:0072507 obsolete divalent inorganic cation homeostasis 7 7
GO:0098771 inorganic ion homeostasis 6 7
GO:0006810 transport 3 2
GO:0006811 monoatomic ion transport 4 2
GO:0006812 monoatomic cation transport 5 2
GO:0030001 metal ion transport 6 2
GO:0051179 localization 1 2
GO:0051234 establishment of localization 2 2
GO:0000041 transition metal ion transport 7 1
GO:0006829 zinc ion transport 8 1
GO:0034220 monoatomic ion transmembrane transport 3 1
GO:0055085 transmembrane transport 2 1
GO:0071577 zinc ion transmembrane transport 6 1
GO:0098655 monoatomic cation transmembrane transport 4 1
GO:0098660 inorganic ion transmembrane transport 4 1
GO:0098662 inorganic cation transmembrane transport 5 1
Molecular functions
Term Name Level Count
GO:0005215 transporter activity 1 9
GO:0005385 zinc ion transmembrane transporter activity 7 8
GO:0008324 monoatomic cation transmembrane transporter activity 4 9
GO:0015075 monoatomic ion transmembrane transporter activity 3 9
GO:0015318 inorganic molecular entity transmembrane transporter activity 3 8
GO:0022857 transmembrane transporter activity 2 9
GO:0022890 inorganic cation transmembrane transporter activity 4 8
GO:0046873 metal ion transmembrane transporter activity 5 8
GO:0046915 transition metal ion transmembrane transporter activity 6 8

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 272 276 PF00656 0.601
CLV_NRD_NRD_1 108 110 PF00675 0.391
CLV_NRD_NRD_1 313 315 PF00675 0.312
CLV_NRD_NRD_1 582 584 PF00675 0.321
CLV_PCSK_FUR_1 106 110 PF00082 0.376
CLV_PCSK_KEX2_1 108 110 PF00082 0.401
CLV_PCSK_SKI1_1 112 116 PF00082 0.237
CLV_PCSK_SKI1_1 269 273 PF00082 0.400
CLV_PCSK_SKI1_1 314 318 PF00082 0.276
CLV_PCSK_SKI1_1 519 523 PF00082 0.271
CLV_PCSK_SKI1_1 537 541 PF00082 0.301
CLV_PCSK_SKI1_1 562 566 PF00082 0.292
CLV_PCSK_SKI1_1 584 588 PF00082 0.330
DEG_SCF_FBW7_2 556 563 PF00400 0.492
DOC_CYCLIN_RxL_1 266 277 PF00134 0.476
DOC_CYCLIN_RxL_1 516 524 PF00134 0.471
DOC_MAPK_gen_1 295 305 PF00069 0.671
DOC_MAPK_gen_1 312 322 PF00069 0.420
DOC_MAPK_MEF2A_6 298 307 PF00069 0.614
DOC_MAPK_MEF2A_6 312 320 PF00069 0.424
DOC_PP1_RVXF_1 267 274 PF00149 0.572
DOC_PP2B_LxvP_1 410 413 PF13499 0.255
DOC_PP2B_LxvP_1 523 526 PF13499 0.521
DOC_PP4_FxxP_1 409 412 PF00568 0.267
DOC_USP7_MATH_1 127 131 PF00917 0.436
DOC_USP7_MATH_1 232 236 PF00917 0.321
DOC_USP7_MATH_1 274 278 PF00917 0.622
DOC_USP7_MATH_1 336 340 PF00917 0.271
DOC_USP7_MATH_1 49 53 PF00917 0.572
DOC_USP7_MATH_1 496 500 PF00917 0.323
DOC_USP7_UBL2_3 159 163 PF12436 0.552
DOC_WW_Pin1_4 284 289 PF00397 0.675
DOC_WW_Pin1_4 548 553 PF00397 0.510
DOC_WW_Pin1_4 556 561 PF00397 0.503
DOC_WW_Pin1_4 56 61 PF00397 0.634
LIG_14-3-3_CanoR_1 106 116 PF00244 0.581
LIG_14-3-3_CanoR_1 65 74 PF00244 0.402
LIG_APCC_ABBA_1 605 610 PF00400 0.524
LIG_EH1_1 202 210 PF00400 0.282
LIG_FHA_1 12 18 PF00498 0.328
LIG_FHA_1 156 162 PF00498 0.609
LIG_FHA_1 166 172 PF00498 0.472
LIG_FHA_1 26 32 PF00498 0.251
LIG_FHA_1 287 293 PF00498 0.649
LIG_FHA_1 321 327 PF00498 0.281
LIG_FHA_1 515 521 PF00498 0.473
LIG_FHA_1 541 547 PF00498 0.496
LIG_FHA_1 585 591 PF00498 0.536
LIG_FHA_1 78 84 PF00498 0.298
LIG_FHA_2 246 252 PF00498 0.335
LIG_FHA_2 270 276 PF00498 0.600
LIG_LIR_Gen_1 136 147 PF02991 0.224
LIG_LIR_Gen_1 251 258 PF02991 0.297
LIG_LIR_Gen_1 34 44 PF02991 0.291
LIG_LIR_Gen_1 345 354 PF02991 0.248
LIG_LIR_Gen_1 416 426 PF02991 0.262
LIG_LIR_Nem_3 136 142 PF02991 0.253
LIG_LIR_Nem_3 243 249 PF02991 0.414
LIG_LIR_Nem_3 251 255 PF02991 0.254
LIG_LIR_Nem_3 34 39 PF02991 0.291
LIG_LIR_Nem_3 383 388 PF02991 0.300
LIG_LIR_Nem_3 416 422 PF02991 0.262
LIG_LIR_Nem_3 509 514 PF02991 0.290
LIG_NRBOX 469 475 PF00104 0.271
LIG_Pex14_1 32 36 PF04695 0.271
LIG_Pex14_2 42 46 PF04695 0.412
LIG_PTB_Apo_2 599 606 PF02174 0.518
LIG_SH2_PTP2 400 403 PF00017 0.271
LIG_SH2_SRC 466 469 PF00017 0.271
LIG_SH2_STAP1 361 365 PF00017 0.312
LIG_SH2_STAT5 400 403 PF00017 0.292
LIG_SH2_STAT5 419 422 PF00017 0.271
LIG_SH2_STAT5 466 469 PF00017 0.271
LIG_SH2_STAT5 487 490 PF00017 0.278
LIG_SH2_STAT5 532 535 PF00017 0.483
LIG_SH2_STAT5 579 582 PF00017 0.556
LIG_SH3_3 546 552 PF00018 0.503
LIG_Sin3_3 503 510 PF02671 0.282
LIG_SUMO_SIM_anti_2 196 202 PF11976 0.267
LIG_SUMO_SIM_anti_2 253 260 PF11976 0.310
LIG_SUMO_SIM_anti_2 34 41 PF11976 0.258
LIG_SUMO_SIM_anti_2 476 483 PF11976 0.271
LIG_SUMO_SIM_anti_2 502 509 PF11976 0.283
LIG_SUMO_SIM_par_1 124 131 PF11976 0.273
LIG_SUMO_SIM_par_1 303 309 PF11976 0.534
LIG_SUMO_SIM_par_1 419 424 PF11976 0.271
LIG_SUMO_SIM_par_1 502 509 PF11976 0.288
LIG_SUMO_SIM_par_1 519 524 PF11976 0.463
LIG_SUMO_SIM_par_1 6 11 PF11976 0.235
LIG_TRAF2_1 132 135 PF00917 0.378
LIG_Vh1_VBS_1 147 165 PF01044 0.275
LIG_WRC_WIRS_1 33 38 PF05994 0.271
LIG_WRC_WIRS_1 344 349 PF05994 0.198
LIG_WRC_WIRS_1 39 44 PF05994 0.271
LIG_WW_3 559 563 PF00397 0.498
MOD_CDK_SPK_2 548 553 PF00069 0.530
MOD_CDK_SPK_2 56 61 PF00069 0.617
MOD_CDK_SPxK_1 556 562 PF00069 0.495
MOD_CDK_SPxxK_3 56 63 PF00069 0.614
MOD_CK1_1 155 161 PF00069 0.498
MOD_CK1_1 235 241 PF00069 0.296
MOD_CK1_1 26 32 PF00069 0.267
MOD_CK1_1 277 283 PF00069 0.630
MOD_CK1_1 306 312 PF00069 0.486
MOD_CK1_1 499 505 PF00069 0.271
MOD_CK2_1 446 452 PF00069 0.461
MOD_GlcNHglycan 205 208 PF01048 0.271
MOD_GlcNHglycan 234 237 PF01048 0.271
MOD_GlcNHglycan 25 28 PF01048 0.621
MOD_GlcNHglycan 259 262 PF01048 0.310
MOD_GlcNHglycan 281 284 PF01048 0.415
MOD_GlcNHglycan 299 303 PF01048 0.389
MOD_GlcNHglycan 454 457 PF01048 0.275
MOD_GlcNHglycan 498 501 PF01048 0.271
MOD_GlcNHglycan 508 511 PF01048 0.271
MOD_GlcNHglycan 523 526 PF01048 0.349
MOD_GlcNHglycan 580 583 PF01048 0.424
MOD_GlcNHglycan 67 70 PF01048 0.290
MOD_GlcNHglycan 77 80 PF01048 0.250
MOD_GSK3_1 104 111 PF00069 0.631
MOD_GSK3_1 269 276 PF00069 0.630
MOD_GSK3_1 282 289 PF00069 0.596
MOD_GSK3_1 438 445 PF00069 0.494
MOD_GSK3_1 475 482 PF00069 0.271
MOD_GSK3_1 573 580 PF00069 0.556
MOD_GSK3_1 584 591 PF00069 0.588
MOD_GSK3_1 6 13 PF00069 0.367
MOD_GSK3_1 61 68 PF00069 0.614
MOD_N-GLC_1 574 579 PF02516 0.363
MOD_N-GLC_1 601 606 PF02516 0.314
MOD_N-GLC_2 531 533 PF02516 0.284
MOD_NEK2_1 116 121 PF00069 0.277
MOD_NEK2_1 182 187 PF00069 0.342
MOD_NEK2_1 203 208 PF00069 0.298
MOD_NEK2_1 25 30 PF00069 0.381
MOD_NEK2_1 257 262 PF00069 0.298
MOD_NEK2_1 273 278 PF00069 0.542
MOD_NEK2_1 291 296 PF00069 0.592
MOD_NEK2_1 320 325 PF00069 0.275
MOD_NEK2_1 402 407 PF00069 0.298
MOD_NEK2_1 421 426 PF00069 0.280
MOD_NEK2_1 438 443 PF00069 0.604
MOD_NEK2_1 473 478 PF00069 0.282
MOD_NEK2_1 514 519 PF00069 0.473
MOD_NEK2_1 521 526 PF00069 0.541
MOD_NEK2_1 540 545 PF00069 0.450
MOD_NEK2_1 75 80 PF00069 0.274
MOD_NEK2_1 8 13 PF00069 0.271
MOD_OFUCOSY 118 123 PF10250 0.275
MOD_PIKK_1 286 292 PF00454 0.604
MOD_PKA_1 108 114 PF00069 0.570
MOD_PKA_1 584 590 PF00069 0.523
MOD_PKA_2 107 113 PF00069 0.607
MOD_PKA_2 23 29 PF00069 0.398
MOD_PKA_2 573 579 PF00069 0.531
MOD_PKB_1 106 114 PF00069 0.586
MOD_Plk_1 165 171 PF00069 0.503
MOD_Plk_1 274 280 PF00069 0.591
MOD_Plk_1 562 568 PF00069 0.492
MOD_Plk_1 601 607 PF00069 0.510
MOD_Plk_4 175 181 PF00069 0.323
MOD_Plk_4 182 188 PF00069 0.390
MOD_Plk_4 235 241 PF00069 0.362
MOD_Plk_4 245 251 PF00069 0.388
MOD_Plk_4 26 32 PF00069 0.247
MOD_Plk_4 303 309 PF00069 0.535
MOD_Plk_4 352 358 PF00069 0.376
MOD_Plk_4 364 370 PF00069 0.299
MOD_Plk_4 38 44 PF00069 0.271
MOD_Plk_4 421 427 PF00069 0.283
MOD_Plk_4 475 481 PF00069 0.285
MOD_Plk_4 541 547 PF00069 0.524
MOD_Plk_4 601 607 PF00069 0.510
MOD_ProDKin_1 284 290 PF00069 0.677
MOD_ProDKin_1 548 554 PF00069 0.507
MOD_ProDKin_1 556 562 PF00069 0.505
MOD_ProDKin_1 56 62 PF00069 0.631
MOD_SUMO_rev_2 309 317 PF00179 0.531
MOD_SUMO_rev_2 367 374 PF00179 0.447
TRG_DiLeu_BaEn_1 194 199 PF01217 0.360
TRG_DiLeu_BaEn_1 253 258 PF01217 0.271
TRG_DiLeu_BaEn_1 416 421 PF01217 0.247
TRG_DiLeu_BaEn_2 134 140 PF01217 0.368
TRG_DiLeu_BaEn_2 312 318 PF01217 0.447
TRG_DiLeu_BaEn_3 299 305 PF01217 0.575
TRG_DiLeu_BaLyEn_6 509 514 PF01217 0.271
TRG_DiLeu_BaLyEn_6 62 67 PF01217 0.600
TRG_ENDOCYTIC_2 382 385 PF00928 0.447
TRG_ENDOCYTIC_2 400 403 PF00928 0.271
TRG_ENDOCYTIC_2 419 422 PF00928 0.271
TRG_ENDOCYTIC_2 466 469 PF00928 0.271
TRG_ER_diArg_1 106 109 PF00400 0.588
TRG_NLS_MonoExtC_3 582 588 PF00514 0.516

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N1PB11 Leptomonas seymouri 57% 100%
A0A3Q8IDA3 Leishmania donovani 99% 100%
A4HFQ2 Leishmania braziliensis 77% 100%
A4HJM3 Leishmania braziliensis 23% 100%
E9ADA5 Leishmania major 90% 100%
E9AZ30 Leishmania mexicana (strain MHOM/GT/2001/U1103) 90% 100%
Q4Q622 Leishmania major 23% 100%

Download

Download
LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS