Putative histone H1

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Putative histone H1

Gene product:

Protein of unknown function (DUF2946), putative

Species:

Leishmania infantum

UniProt:

A4I2S4_LEIIN

TriTrypDb:

Length:

102

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 2
NetGPI	no	yes: 0, no: 2

Cellular components
Term	Name	Level	Count
GO:0000786	nucleosome	3	3
GO:0032991	protein-containing complex	1	3
GO:0032993	protein-DNA complex	2	3
GO:0044815	DNA packaging complex	2	3

Expansion

Sequence features

A4I2S4

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4I2S4

Function

Biological processes
Term	Name	Level	Count
GO:0006325	chromatin organization	4	3
GO:0006334	nucleosome assembly	7	3
GO:0006338	chromatin remodeling	5	3
GO:0009987	cellular process	1	3
GO:0016043	cellular component organization	3	3
GO:0022607	cellular component assembly	4	3
GO:0034728	nucleosome organization	6	3
GO:0043933	protein-containing complex organization	4	3
GO:0065003	protein-containing complex assembly	5	3
GO:0065004	protein-DNA complex assembly	6	3
GO:0071824	protein-DNA complex subunit organization	5	3
GO:0071840	cellular component organization or biogenesis	2	3

Molecular functions
Term	Name	Level	Count
GO:0003676	nucleic acid binding	3	3
GO:0003677	DNA binding	4	3
GO:0005198	structural molecule activity	1	3
GO:0005488	binding	1	3
GO:0030527	structural constituent of chromatin	2	3
GO:0097159	organic cyclic compound binding	2	3
GO:1901363	heterocyclic compound binding	2	3

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	49	51	PF00675	0.766
CLV_PCSK_SKI1_1	51	55	PF00082	0.704
CLV_PCSK_SKI1_1	57	61	PF00082	0.729
CLV_PCSK_SKI1_1	65	69	PF00082	0.555
CLV_PCSK_SKI1_1	73	77	PF00082	0.522
CLV_PCSK_SKI1_1	81	85	PF00082	0.520
CLV_PCSK_SKI1_1	89	93	PF00082	0.509
CLV_PCSK_SKI1_1	97	101	PF00082	0.499
DOC_CKS1_1	52	57	PF01111	0.763
DOC_USP7_UBL2_3	27	31	PF12436	0.686
DOC_USP7_UBL2_3	32	36	PF12436	0.691
DOC_USP7_UBL2_3	37	41	PF12436	0.709
DOC_USP7_UBL2_3	42	46	PF12436	0.764
DOC_USP7_UBL2_3	47	51	PF12436	0.701
DOC_USP7_UBL2_3	56	60	PF12436	0.572
DOC_USP7_UBL2_3	61	65	PF12436	0.496
DOC_USP7_UBL2_3	68	72	PF12436	0.577
DOC_USP7_UBL2_3	73	77	PF12436	0.509
DOC_USP7_UBL2_3	80	84	PF12436	0.482
DOC_USP7_UBL2_3	85	89	PF12436	0.503
DOC_USP7_UBL2_3	92	96	PF12436	0.455
DOC_USP7_UBL2_3	97	101	PF12436	0.487
DOC_WW_Pin1_4	13	18	PF00397	0.715
DOC_WW_Pin1_4	21	26	PF00397	0.534
DOC_WW_Pin1_4	51	56	PF00397	0.764
LIG_BIR_II_1	1	5	PF00653	0.676
LIG_SH3_2	55	60	PF14604	0.755
LIG_SH3_3	49	55	PF00018	0.652
LIG_SH3_4	57	64	PF00018	0.749
LIG_SH3_4	69	76	PF00018	0.573
LIG_SH3_4	81	88	PF00018	0.569
LIG_SH3_4	89	96	PF00018	0.447
MOD_CDC14_SPxK_1	16	19	PF00782	0.735
MOD_CDC14_SPxK_1	24	27	PF00782	0.654
MOD_CDK_SPK_2	17	22	PF00069	0.750
MOD_CDK_SPK_2	51	56	PF00069	0.764
MOD_CDK_SPxK_1	13	19	PF00069	0.722
MOD_CDK_SPxK_1	21	27	PF00069	0.536
MOD_CDK_SPxK_1	51	57	PF00069	0.764
MOD_CK1_1	2	8	PF00069	0.663
MOD_CK1_1	20	26	PF00069	0.756
MOD_GlcNHglycan	10	13	PF01048	0.602
MOD_GlcNHglycan	4	7	PF01048	0.660
MOD_GSK3_1	17	24	PF00069	0.514
MOD_GSK3_1	8	15	PF00069	0.683
MOD_ProDKin_1	13	19	PF00069	0.722
MOD_ProDKin_1	21	27	PF00069	0.536
MOD_ProDKin_1	51	57	PF00069	0.764

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A3S7X0Q1	Leishmania donovani	98%	100%